ACOUSTIC WAVES IN MICROFLUIDICS
    3.
    发明申请
    ACOUSTIC WAVES IN MICROFLUIDICS 有权
    微波中的声波

    公开(公告)号:US20130213488A1

    公开(公告)日:2013-08-22

    申请号:US13818146

    申请日:2011-08-23

    IPC分类号: C12M3/06 F17D3/01

    摘要: Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using surface acoustic waves. The droplets may contain cells or other species. In some cases, the surface acoustic waves may be created using a surface acoustic wave generator such as an interdigitated transducer, and/or a material such as a piezoelectric substrate. The piezoelectric substrate may be isolated from the microfluidic substrate except at or proximate the location where the droplets are sorted, e.g., into first or second microfluidic channels. At such locations, the microfluidic substrate may be coupled to the piezoelectric substrate (or other material) by one or more coupling regions. In some cases, relatively high sorting rates may be achieved, e.g., at rates of at least about 1,000 Hz, at least about 10,000 Hz, or at least about 100,000 Hz, and in some embodiments, with high cell viability after sorting.

    摘要翻译: 本发明的各个方面涉及流体物质的控制和操作,例如在微流体系统中。 在一组实施例中,可以使用表面声波对液滴进行分类。 液滴可能含有细胞或其他物种。 在一些情况下,表面声波可以使用表面声波发生器(例如交叉换能器)和/或诸如压电基板的材料来产生。 压电衬底可以与微流体衬底隔离,除了在液滴被分类的位置处或附近,例如,进入第一或第二微流体通道。 在这样的位置处,微流体衬底可以通过一个或多个耦合区域耦合到压电衬底(或其它材料)。 在一些情况下,可以例如以至少约1000Hz,至少约10,000Hz或至少约100,000Hz的速率实现相对较高的分选率,并且在一些实施方案中,分选后具有高的细胞活力。

    Method and device for manipulating small amounts of liquid on surfaces
    5.
    发明授权
    Method and device for manipulating small amounts of liquid on surfaces 失效
    用于在表面上操作少量液体的方法和装置

    公开(公告)号:US07198813B2

    公开(公告)日:2007-04-03

    申请号:US10475957

    申请日:2002-04-24

    申请人: Achim Wixforth

    发明人: Achim Wixforth

    IPC分类号: B05D1/32 B05D5/04 B32B3/04

    摘要: The invention relates to methods and devices for manipulation of small amounts of liquid on surfaces, preferably on chip surfaces. According to the present invention, a quantity of liquid held together by its surface tension is applied on an area of a surface with at least one intermediate region, which borders at least in one lateral direction on a guide strip. According to the present invention, the guide strips have different surface characteristics relative to the intermediate region, such that they are more strongly wetted by a liquid, or the intermediate region is raised relative to the guide strips, whereby the height of the step is small relative to the height of the quantity of liquid.

    摘要翻译: 本发明涉及用于在表面上,优选在芯片表面上操作少量液体的方法和装置。 根据本发明,通过表面张力将一定数量的液体保持在表面张力的区域上,该表面张力具有至少一个中间区域,该至少一个中间区域在导带上至少在一个横向上相接。 根据本发明,引导条相对于中间区域具有不同的表面特性,使得它们被液体更强地润湿,或者中间区域相对于引导条升高,由此台阶的高度小 相对于液体的高度。