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公开(公告)号：US09228933B2
公开(公告)日：2016-01-05
申请号：US12624399
申请日：2009-11-23
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
IPC分类号： C12M1/00 , C12M3/00 , C12M1/34 , G01N21/03 , B01L3/00 , B82Y30/00 , C12Q1/68 , G01N35/00 , B01L7/00 , G01N21/64 , G01N21/76 , G01N35/04
CPC分类号： C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要： The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
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公开(公告)号：US08252581B2
公开(公告)日：2012-08-28
申请号：US12009953
申请日：2008-01-22
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji
CPC分类号： C12Q1/686 , B01L7/525 , B01L7/5255 , B01L7/54 , B01L2200/10 , B01L2200/147 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/0893 , B01L2300/1805 , B01L2300/1827 , B01L2300/1844 , B01L2300/1894 , G01N21/0332 , G01N21/253
摘要： Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.
摘要翻译： 本文提供了进行大量同时化学反应的装置，系统，芯片和方法。 本发明的芯片包括可根据要运行的反应温度来寻址的寻址单元。 主题装置，系统和芯片特别适用于在数千个核酸序列上进行聚合酶链反应，直到并包括感兴趣的生物体的整个基因组的序列。
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公开(公告)号：US07311794B2
公开(公告)日：2007-12-25
申请号：US11137263
申请日：2005-05-24
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
IPC分类号： B29C65/14
CPC分类号： C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要： The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
摘要翻译： 本发明提供了在需要或需要反应温度的控制下进行化学反应的小型化仪器。 具体地，本发明提供用于执行和监测温度依赖性化学反应的芯片和光学系统。 本发明中体现的装置和方法对于核酸的高通量和低成本扩增特别有用。
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公开(公告)号：US20060073491A1
公开(公告)日：2006-04-06
申请号：US11137304
申请日：2005-05-24
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
CPC分类号： C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要： The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
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公开(公告)号：US20060030036A1
公开(公告)日：2006-02-09
申请号：US11136841
申请日：2005-05-24
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
IPC分类号： C12M1/34
CPC分类号： C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要： The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
摘要翻译： 本发明提供了在需要或需要反应温度的控制下进行化学反应的小型化仪器。 具体地，本发明提供用于执行和监测温度依赖性化学反应的芯片和光学系统。 本发明中体现的装置和方法对于核酸的高通量和低成本扩增特别有用。
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公开(公告)号：US07622296B2
公开(公告)日：2009-11-24
申请号：US11137304
申请日：2005-05-24
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
CPC分类号： C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要： The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
摘要翻译： 本发明提供了在需要或需要反应温度的控制下进行化学反应的小型化仪器。 具体地，本发明提供用于执行和监测温度依赖性化学反应的芯片和光学系统。 本发明中体现的装置和方法对于核酸的高通量和低成本扩增特别有用。
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公开(公告)号：US20080176290A1
公开(公告)日：2008-07-24
申请号：US12009953
申请日：2008-01-22
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji
CPC分类号： C12Q1/686 , B01L7/525 , B01L7/5255 , B01L7/54 , B01L2200/10 , B01L2200/147 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/0893 , B01L2300/1805 , B01L2300/1827 , B01L2300/1844 , B01L2300/1894 , G01N21/0332 , G01N21/253
摘要： Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.
摘要翻译： 本文提供了进行大量同时化学反应的装置，系统，芯片和方法。 本发明的芯片包括可根据要运行的反应温度来寻址的寻址单元。 主题装置，系统和芯片特别适用于在数千个核酸序列上进行聚合酶链反应，直到并包括感兴趣的生物体的整个基因组的序列。
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公开(公告)号：US09132427B2
公开(公告)日：2015-09-15
申请号：US13594562
申请日：2012-08-24
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji
CPC分类号： C12Q1/686 , B01L7/525 , B01L7/5255 , B01L7/54 , B01L2200/10 , B01L2200/147 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/0893 , B01L2300/1805 , B01L2300/1827 , B01L2300/1844 , B01L2300/1894 , G01N21/0332 , G01N21/253
摘要： Apparatus, systems, chips, and methods of performing a large number of simultaneous chemical reactions are provided herein. The chips of the invention comprise addressable units that can be addressed according to the temperature of the reaction to be run. The subject apparatus, systems, and chips are particularly suited for performing polymerase chain reactions on thousands of nucleic acid sequences, up to and including sequences of an entire genome of an organism of interest.
摘要翻译： 本文提供了进行大量同时化学反应的装置，系统，芯片和方法。 本发明的芯片包括可根据要运行的反应温度来寻址的寻址单元。 主题装置，系统和芯片特别适用于在数千个核酸序列上进行聚合酶链反应，直到并包括感兴趣的生物体的整个基因组的序列。
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公开(公告)号：US20100233698A1
公开(公告)日：2010-09-16
申请号：US12624399
申请日：2009-11-23
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
CPC分类号： C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要： The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
摘要翻译： 本发明提供了在需要或需要反应温度的控制下进行化学反应的小型化仪器。 具体地，本发明提供用于执行和监测温度依赖性化学反应的芯片和光学系统。 本发明中体现的装置和方法对于核酸的高通量和低成本扩增特别有用。
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公开(公告)号：US20060027317A1
公开(公告)日：2006-02-09
申请号：US11137263
申请日：2005-05-24
申请人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
发明人： Victor Joseph , Amjad Huda , Alnoor Shivji , Jie Zhou
IPC分类号： B32B37/00
CPC分类号： C12Q1/686 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L7/54 , B01L2200/0689 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0819 , B01L2300/0829 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B82Y30/00 , C12Q1/6806 , C12Q1/6844 , G01N21/01 , G01N21/0332 , G01N21/6408 , G01N21/6452 , G01N21/76 , G01N35/0099 , G01N2021/6417 , G01N2021/6484 , G01N2035/0405 , G01N2201/0231 , H01L27/1443 , H01L31/0203 , H01L31/02325 , H01L31/024 , H01L31/105 , H01L31/18 , C12Q2565/501
摘要： The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides chips and optical systems for performing and monitoring temperature-dependent chemical reactions. The apparatus and methods embodied in the present invention are particularly useful for high-throughput and low-cost amplification of nucleic acids.
摘要翻译： 本发明提供了在需要或需要反应温度的控制下进行化学反应的小型化仪器。 具体地，本发明提供用于执行和监测温度依赖性化学反应的芯片和光学系统。 本发明中体现的装置和方法对于核酸的高通量和低成本扩增特别有用。
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