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公开(公告)号：US10604791B2
公开(公告)日：2020-03-31
申请号：US13551486
申请日：2012-07-17
IPC分类号： C12Q1/68 , C12P19/34 , C12Q1/6823 , C12Q1/6809 , C12Q1/6853 , C12Q1/6858
摘要： Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.
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公开(公告)号：US20130017960A1
公开(公告)日：2013-01-17
申请号：US13551486
申请日：2012-07-17
CPC分类号： C12Q1/6823 , C12Q1/6809 , C12Q1/6853 , C12Q1/6858 , C12Q2563/167 , C12Q2565/518 , C12Q2537/143
摘要： Provided herein are products and processes for detecting the presence or absence of multiple target nucleic acids. Certain methods include amplifying the target nucleic acids, or portion thereof; extending oligonucleotides that specifically hybridize to the amplicons, where the extended oligonucleotides include a capture agent; capturing the extended oligonucleotides to a solid phase via the capture agent; releasing the extended oligonucleotide by competition with a competitor; detecting the extended oligonucleotide, and thereby determining the presence or absence of each target nucleic acid by the presence or absence of the extended oligonucleotide.
摘要翻译： 本文提供了用于检测多个靶核酸的存在或不存在的产物和方法。 某些方法包括扩增靶核酸或其部分; 扩增与扩增子杂交的寡核苷酸，其中延伸的寡核苷酸包括捕获剂; 通过捕获剂将延伸的寡核苷酸捕获到固相; 通过与竞争对手的竞争释放延伸的寡核苷酸; 检测延伸的寡核苷酸，从而通过存在或不存在延伸的寡核苷酸来确定每种靶核酸的存在或不存在。
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公开(公告)号：US20120276542A1
公开(公告)日：2012-11-01
申请号：US13457978
申请日：2012-04-27
申请人： Anders NYGREN
发明人： Anders NYGREN
CPC分类号： C12Q1/6851 , C12Q1/6879 , C12Q1/6881 , C12Q1/6883 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/166 , C12Q2521/331 , C12Q2525/204 , C12Q2537/16 , C12Q2545/107
摘要： The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.
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公开(公告)号：US06891303B2
公开(公告)日：2005-05-10
申请号：US08973305
申请日：1997-05-27
IPC分类号： H02K3/04 , H01F3/10 , H01F3/14 , H01F27/28 , H01F27/32 , H01F27/34 , H01F29/14 , H02H3/02 , H02J3/01 , H02J3/10 , H02K3/14 , H02K3/28 , H02K3/40 , H02K3/48 , H02K9/19 , H02K15/00 , H02K15/12 , H02K3/12
CPC分类号： H02K15/12 , H01F3/10 , H01F3/14 , H01F27/288 , H01F27/323 , H01F27/34 , H01F29/14 , H01F2027/329 , H02H3/025 , H02J3/01 , H02K3/14 , H02K3/28 , H02K3/40 , H02K3/48 , H02K9/19 , H02K11/40 , H02K15/00 , H02K2203/15 , Y02E40/40 , Y10S174/14 , Y10S174/20 , Y10S174/28
摘要： An electric high voltage AC machine intended to be directly connected to a distribution or transmission network (16) comprises at least one winding. This winding comprises at least one current-carrying conductor, a first layer having semiconducting properties provided around said conductor, a solid insulating layer provided around said first layer, and a second layer having semiconducting properties provided around said insulating layer. In addition grounding means (18, 24, 26, 28) are provided to connect at least one point of said winding to ground.
摘要翻译： 旨在直接连接到分配或传输网络（16）的电高压交流电机包括至少一个绕组。 该绕组包括至少一个载流导体，具有围绕所述导体设置的半导体性质的第一层，围绕所述第一层设置的固体绝缘层，以及在所述绝缘层周围设置的具有半导体性质的第二层。 此外，提供接地装置（18,24,26,28）以将所述绕组的至少一个点连接到地。
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5.发明申请PROCESSES AND COMPOSITIONS FOR METHYLATION-BASED ENRICHMENT OF FETAL NUCLEIC ACID FROM A MATERNAL SAMPLE USEFUL FOR NON-INVASIVE PRENATAL DIAGNOSES 审中-公开用于非侵入性临床诊断的材料样品中用于甲基化的核酸的方法和组合物公开(公告)号：US20130150249A1
公开(公告)日：2013-06-13
申请号：US13517532
申请日：2012-06-13
申请人： Mathias EHRICH , Anders Nygren
发明人： Mathias EHRICH , Anders Nygren
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6804 , C12Q1/6806 , C12Q1/6809 , C12Q1/6879 , C12Q1/6888 , C12Q2600/154 , G01N33/5308 , G01N2800/385 , C12Q2537/164 , C12Q2522/101 , C12Q2565/501
摘要： Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
摘要翻译： 提供的是使用在母亲和胎儿之间差异甲基化的基因组区域以从母体样品分离，分离或富集胎儿核酸的组合物和方法。 本文描述的组合物和方法可用于非侵入性产前诊断，包括检测染色体异型体。
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6.发明授权公开(公告)号：US06525504B1
公开(公告)日：2003-02-25
申请号：US09511366
申请日：2000-02-23
申请人： Jan-Anders Nygren , Bertil Berggren
发明人： Jan-Anders Nygren , Bertil Berggren
IPC分类号： H02P910
CPC分类号： H02K19/365 , H02K3/40 , H02K19/34 , H02K19/36 , H02K2203/15 , H02P9/105 , Y10S174/15 , Y10S174/16
摘要： A rotating electric machine for direct connection to high-voltage networks, in which the magnetic circuit adapted for high voltage comprises a rotor, stator and main and auxiliary windings in operative relation. At least one of the windings is a conductor surrounded by a magnetically permeable, field confining insulation system.
摘要翻译： 用于直接连接到高压网络的旋转电机，其中适用于高电压的磁路包括操作关系的转子，定子和主和辅绕组。 绕组中至少有一个是导磁体，它由一个可磁化的磁场约束绝缘系统包围。
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公开(公告)号：US06828701B1
公开(公告)日：2004-12-07
申请号：US09355728
申请日：1999-10-04
IPC分类号： H02H706
CPC分类号： H02P9/305 , H02H7/06 , Y10S174/19 , Y10S174/29
摘要： A synchronous machine for power and/or voltage control comprises a stator with a stator winding and a rotor with a field winding. The stator winding comprises a high-voltage cable with solid insulation. A rotor has a thermally based rotor current limit intersecting with a thermally based stator current limit in a capability graph at a power factor considerably below the rated power factor or has the thermally based rotor current limit above the thermally based stator current limit. In the capability graph. Means are provided for limiting the currents in order to avoid thermal damage. In a method for power and/or voltage control of such a synchronous machine, the machine operates with the stator current exceeding the thermally based stator current limit for a certain time period less than the maxim an permissible time limit, whereafter the overload is reduced by reduction of either the active power or the field current or a combination of both.
摘要翻译： 用于电力和/或电压控制的同步电机包括具有定子绕组的定子和具有励磁绕组的转子。 定子绕组包括具有固体绝缘的高压电缆。 转子具有与基于热定子电流限制相交的热基转子电流极限，功率曲线的功率因数明显低于额定功率因数，或具有高于热定子电流极限的基于热的转子电流限制。 在能力图中。 提供了用于限制电流以避免热损伤的装置。 在这种同步电机的功率和/或电压控制方法中，机器以超过热定子电流限制的定子电流工作一段时间，小于允许时间限制的最大值，之后过载被减少 降低有功功率或励磁电流或二者的组合。
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公开(公告)号：US08455221B2
公开(公告)日：2013-06-04
申请号：US13458036
申请日：2012-04-27
申请人： Anders Nygren
发明人： Anders Nygren
IPC分类号： C12P19/34
CPC分类号： C12Q1/6851 , C12Q1/6879 , C12Q1/6881 , C12Q1/6883 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/166 , C12Q2521/331 , C12Q2525/204 , C12Q2537/16 , C12Q2545/107
摘要： The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.
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公开(公告)号：US20120322072A1
公开(公告)日：2012-12-20
申请号：US13458341
申请日：2012-04-27
申请人： Anders NYGREN
发明人： Anders NYGREN
CPC分类号： C12Q1/6851 , C12Q1/6879 , C12Q1/6881 , C12Q1/6883 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/166 , C12Q2521/331 , C12Q2525/204 , C12Q2537/16 , C12Q2545/107
摘要： The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.
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公开(公告)号：US20120264618A1
公开(公告)日：2012-10-18
申请号：US13458036
申请日：2012-04-27
申请人： Anders NYGREN
发明人： Anders NYGREN
CPC分类号： C12Q1/6851 , C12Q1/6879 , C12Q1/6881 , C12Q1/6883 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/166 , C12Q2521/331 , C12Q2525/204 , C12Q2537/16 , C12Q2545/107
摘要： The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.
摘要翻译： 该技术部分涉及从核酸样品中定量少数核酸物种。 在一些实施方案中，提供了用于确定母体样品中胎儿核酸量（例如绝对量，相对量）的方法。
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