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公开(公告)号：US09761850B2
公开(公告)日：2017-09-12
申请号：US13445458
申请日：2012-04-12
IPC分类号： H01M10/44 , H01M10/48 , H01M2/10 , H01M10/04 , H01M10/625 , H01M10/647 , H01M10/6557 , H01M10/6567 , H01M10/613 , H01M10/0525 , B29L7/00 , B29L31/00 , B29C47/00
CPC分类号： H01M2/1077 , B29C47/0019 , B29C47/0033 , B29L2007/002 , B29L2031/7146 , H01M10/0481 , H01M10/0525 , H01M10/613 , H01M10/625 , H01M10/647 , H01M10/6557 , H01M10/6567 , Y02E60/122
摘要： A battery assembly including: a plurality of prismatic battery cells; first and second fluid manifolds; and a plurality of corrugated flow plates interleaved with the plurality of battery cells, each the flow plates extending from the first manifold to the second manifold and providing an array of flow channels for carrying fluid from the first manifold to the second manifold, wherein each plate of the plurality of corrugated flow plates is an extruded plastic structure comprising first and second fluid impermeable sheets and a plurality of parallel ribs between and connecting the first and second sheets, said plurality of ribs forming the array of flow channels.
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公开(公告)号：US08328755B2
公开(公告)日：2012-12-11
申请号：US12906525
申请日：2010-10-18
申请人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
发明人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
IPC分类号： A61M5/30
CPC分类号： H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
摘要： A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译： 用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。 称为洛伦兹力致动器的致动器包括固定磁体组件和移动线圈组件。 线圈组件移动具有位于储存器内的端部的活塞。 致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。 力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。 有利的是，执行器可以根据电气输入沿不同方向移动。
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公开(公告)号：US20120205534A1
公开(公告)日：2012-08-16
申请号：US13396321
申请日：2012-02-14
申请人： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
发明人： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
CPC分类号： H01J49/30 , H01J49/0013 , H01J49/0031 , H01J49/022 , H01J49/147 , H01J49/24
摘要： A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
摘要翻译： 一种小型，低成本的质谱仪，能够在10至50 AMU的质量范围内进行单位分辨率。 质谱仪结合了几个功能，可以提高设计的性能，而不是可比较的仪器。 高效的离子源能够在不牺牲测量分辨率的情况下实现相对较低的功耗。 可变几何机械滤镜允许可变分辨率。 机载离子泵不需要外部泵浦源。 磁轭和磁轭产生具有不同磁通密度的磁场区域以运行离子泵和磁性扇区质量分析器。 真空室内的数字控制器和电源转换电路允许在质谱仪的操作上具有很大的灵活性，同时不需要高压电气馈通。 微型质谱仪感测入口气体百分比的分数，并将质谱数据返回到计算机。
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公开(公告)号：US08172790B2
公开(公告)日：2012-05-08
申请号：US12310456
申请日：2007-08-31
申请人： Ian W. Hunter , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Andrew J. Taberner , Nathan B. Ball
发明人： Ian W. Hunter , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Andrew J. Taberner , Nathan B. Ball
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/204 , A61M5/31525 , A61M5/31546 , A61M5/482 , A61M5/484 , A61M2005/31588 , A61M2205/8287
摘要： A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to be transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.
摘要翻译： 无针透皮输送装置包括：用于保持待注射物质的腔室（900），与腔室流体连通的喷嘴（910）;以及用于储存要转移到腔室的物质的药物储存器（950） 。 无针透皮传送装置还包括与腔室连通的可控磁体和线圈电磁致动器（242）。 执行器接收电输入并响应于力产生。 该力然后使物质从腔室无针转移到生物体。 该力是响应于在致动期间接收的输入的变化而变化的。 执行器从药物储存器抽取物质，或者，物质可以通过压力源从药物贮存器加压到腔室中。
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公开(公告)号：US20100016827A1
公开(公告)日：2010-01-21
申请号：US12310456
申请日：2007-08-31
申请人： Ian W. Hunter , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Andrew J. Taberner , Nathan B. Ball
发明人： Ian W. Hunter , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Andrew J. Taberner , Nathan B. Ball
CPC分类号： A61M5/30 , A61M5/204 , A61M5/31525 , A61M5/31546 , A61M5/482 , A61M5/484 , A61M2005/31588 , A61M2205/8287
摘要： A needle-free transdermal transport device includes a chamber (900) for holding the substance to be injected, a nozzle (910) in fluid communication with the chamber, and a drug reservoir (950) for storing the substance to he transferred to the chamber. The needle-free transdermal transport device also includes a controllable magnet and coil electromagnetic actuator (242) in communication with the chamber. The actuator receives an electrical input and generates in response a force. The force then causes a needle-free transfer of the substance from the chamber to the biological body. The force is variable responsive to variations in the received input during actuation. The actuator draws the substance from the drug reservoir or alternatively, the substance can be pressurized from the drug reservoir into the chamber by a pressure source.
摘要翻译： 无针透皮输送装置包括用于保持待注射物质的腔室（900），与腔室流体连通的喷嘴（910）和用于将物质储存在其中的药物储存器（950） 。 无针透皮传送装置还包括与腔室连通的可控磁体和线圈电磁致动器（242）。 执行器接收电输入并响应于力产生。 该力然后使物质从腔室无针转移到生物体。 该力是响应于在致动期间接收的输入的变化而变化的。 执行器从药物储存器抽取物质，或者，物质可以通过压力源从药物贮存器加压到腔室中。
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公开(公告)号：US20170316928A1
公开(公告)日：2017-11-02
申请号：US15645147
申请日：2017-07-10
申请人： Ian W. HUNTER , Brian D. HEMOND , Harold F. HEMOND
发明人： Ian W. HUNTER , Brian D. HEMOND , Harold F. HEMOND
CPC分类号： H01J49/30 , H01J49/0013 , H01J49/0031 , H01J49/022 , H01J49/147 , H01J49/24
摘要： A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
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公开(公告)号：US20140326866A1
公开(公告)日：2014-11-06
申请号：US14268599
申请日：2014-05-02
申请人： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
发明人： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
CPC分类号： H01J49/30 , H01J49/0013 , H01J49/0031 , H01J49/022 , H01J49/147 , H01J49/24
摘要： A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
摘要翻译： 一种小型，低成本的质谱仪，能够在10至50 AMU的质量范围内进行单位分辨率。 质谱仪结合了几个功能，可以提高设计的性能，而不是可比较的仪器。 高效的离子源能够在不牺牲测量分辨率的情况下实现相对较低的功耗。 可变几何机械滤镜允许可变分辨率。 机载离子泵不需要外部泵浦源。 磁轭和磁轭产生具有不同磁通密度的磁场区域以运行离子泵和磁性扇区质量分析器。 真空室内的数字控制器和电源转换电路允许在质谱仪的操作上具有很大的灵活性，同时不需要高压电气馈通。 微型质谱仪感测入口气体百分比的分数，并将质谱数据返回到计算机。
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公开(公告)号：US08740838B2
公开(公告)日：2014-06-03
申请号：US13269421
申请日：2011-10-07
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/24 , A61M5/46 , A61M5/486 , A61M2205/3331 , A61M2205/3358 , A61M2205/3368 , A61M2205/50 , A61M2205/8287
摘要： A method for injecting a substance through a biological body surface includes providing a needle-free transdermal transport device configured to inject the substance through the surface. The substance is injected into the biological body with the transport device while a parameter of the injection is sensed and a servo-controller is used to dynamically adjust at least one injection characteristic based on the sensed parameter. The substance is injected for (i) a first time period during which a first portion of a volume of the substance is injected at a first injection pressure, and (ii) a second time period during which a remainder of the volume of the substance is injected at a second injection pressure. A viscosity of the substance may be determined, and a pressure calculated for injecting the substance based on the viscosity. The substance may be injected with the transport device by using the calculated pressure.
摘要翻译： 通过生物体表面注入物质的方法包括提供构造成通过所述表面注入物质的无针透皮输送装置。 当感测到注射的参数并且使用伺服控制器基于所感测的参数来动态地调整至少一个喷射特性时，将物质与输送装置一起注入生物体。 注射物质（i）在第一时间段期间，以第一注射压力注射物质的体积的第一部分，和（ii）第二时间段，其中物质的剩余体积为 在第二注射压力下注射。 可以确定物质的粘度，并计算基于粘度注入物质的压力。 物质可以通过使用计算的压力与输送装置一起注入。
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公开(公告)号：US07833189B2
公开(公告)日：2010-11-16
申请号：US11354279
申请日：2006-02-13
申请人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
发明人： Ian W. Hunter , Andrew J. Taberner , Brian D. Hemond , Dawn M. Wendell , Nora Catherine Hogan , Nathan B. Ball
IPC分类号： A61M5/30
CPC分类号： H02K41/02 , A61B17/20 , A61B17/205 , A61D7/00 , A61M5/19 , A61M5/30 , A61M2205/50 , A61M2205/6009 , A61M2205/825 , A61M2250/00
摘要： A needle-free transdermal transport device for transferring a substance across a surface of a biological body includes a reservoir for storing the substance, a nozzle in fluid communication with the reservoir and a controllable electromagnetic actuator in communication with the reservoir. The actuator, referred to as a Lorentz force actuator, includes a stationary magnet assembly and a moving coil assembly. The coil assembly moves a piston having an end portion positioned within the reservoir. The actuator receives an electrical input and generates in response a corresponding force acting on the piston and causing a needle-free transfer of the substance between the reservoir and the biological body. The magnitude, direction and duration of the force are dynamically controlled (e.g., servo-controlled) by the electrical input and can be altered during the course of an actuation cycle. Beneficially, the actuator can be moved in different directions according to the electrical input.
摘要翻译： 用于将物质转移到生物体的表面上的无针透皮传送装置包括用于储存物质的储存器，与储存器流体连通的喷嘴和与储存器连通的可控电磁致动器。 称为洛伦兹力致动器的致动器包括固定磁体组件和移动线圈组件。 线圈组件移动具有位于储存器内的端部的活塞。 致动器接收电输入并且响应于相应的力产生作用在活塞上的相应的力并导致物质在储存器和生物体之间的无针转移。 力的大小，方向和持续时间由电输入动态控制（例如，伺服控制），并且可以在致动循环的过程中改变。 有利地，致动器可以根据电气输入沿不同方向移动。
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公开(公告)号：US08754371B2
公开(公告)日：2014-06-17
申请号：US13396321
申请日：2012-02-14
申请人： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
发明人： Ian W. Hunter , Brian D. Hemond , Harold F. Hemond
CPC分类号： H01J49/30 , H01J49/0013 , H01J49/0031 , H01J49/022 , H01J49/147 , H01J49/24
摘要： A miniature, low cost mass spectrometer capable of unit resolution over a mass range of 10 to 50 AMU. The mass spectrometer incorporates several features that enhance the performance of the design over comparable instruments. An efficient ion source enables relatively low power consumption without sacrificing measurement resolution. Variable geometry mechanical filters allow for variable resolution. An onboard ion pump removes the need for an external pumping source. A magnet and magnetic yoke produce magnetic field regions with different flux densities to run the ion pump and a magnetic sector mass analyzer. An onboard digital controller and power conversion circuit inside the vacuum chamber allows a large degree of flexibility over the operation of the mass spectrometer while eliminating the need for high-voltage electrical feedthroughs. The miniature mass spectrometer senses fractions of a percentage of inlet gas and returns mass spectra data to a computer.
摘要翻译： 一种小型，低成本的质谱仪，能够在10至50 AMU的质量范围内进行单位分辨率。 质谱仪结合了几个功能，可以提高设计的性能，而不是可比较的仪器。 高效的离子源能够在不牺牲测量分辨率的情况下实现相对较低的功耗。 可变几何机械滤镜允许可变分辨率。 机载离子泵不需要外部泵浦源。 磁轭和磁轭产生具有不同磁通密度的磁场区域以运行离子泵和磁性扇区质量分析器。 真空室内的数字控制器和电源转换电路允许在质谱仪的操作上具有很大的灵活性，同时不需要高压电气馈通。 微型质谱仪感测入口气体百分比的分数，并将质谱数据返回到计算机。
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