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    Microfluidic element for analyzing a liquid sample
    1.
    发明授权
    Microfluidic element for analyzing a liquid sample 有权
    用于分析液体样品的微流体元件

    公开(公告)号：US08911684B2

    公开(公告)日：2014-12-16

    申请号：US13487707

    申请日：2012-06-04

    申请人： Manfred Augstein ,  Christoph Boehm ,  Carlo Effenhauser ,  Rijk Edwin Oosterbroek ,  Susanne Wuerl

    发明人： Manfred Augstein ,  Christoph Boehm ,  Carlo Effenhauser ,  Rijk Edwin Oosterbroek ,  Susanne Wuerl

    IPC分类号： B01L99/00 ,  B01F11/00 ,  B01F1/00 ,  B01F13/00 ,  B01L3/00 ,  B01F15/02 ,  B01F9/00

    CPC分类号： B01F1/0027 ,  B01F9/0014 ,  B01F11/0002 ,  B01F13/0059 ,  B01F15/0203 ,  B01F15/0233 ,  B01L3/502746 ,  B01L2200/16 ,  B01L2400/0409 ,  B01L2400/086

    摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.

    摘要翻译： 提供了用于分析其中​​包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。 微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。 试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得 液体样品可以流入旋转轴远端试剂室。 至少一个试剂室含有与液体样品反应的试剂。

    MICROFLUIDIC ELEMENT FOR ANALYZING A LIQUID SAMPLE
    2.
    发明申请
    MICROFLUIDIC ELEMENT FOR ANALYZING A LIQUID SAMPLE 有权
    用于分析液体样品的微流体元件

    公开(公告)号：US20120301371A1

    公开(公告)日：2012-11-29

    申请号：US13487707

    申请日：2012-06-04

    申请人： Manfred Augstein ,  Christoph Boehm ,  Carlo Effenhauser ,  Rijk Edwin Oosterbroek ,  Susanne Wuerl

    发明人： Manfred Augstein ,  Christoph Boehm ,  Carlo Effenhauser ,  Rijk Edwin Oosterbroek ,  Susanne Wuerl

    IPC分类号： B01L3/00

    CPC分类号： B01F1/0027 ,  B01F9/0014 ,  B01F11/0002 ,  B01F13/0059 ,  B01F15/0203 ,  B01F15/0233 ,  B01L3/502746 ,  B01L2200/16 ,  B01L2400/0409 ,  B01L2400/086

    摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.

    摘要翻译： 提供了用于分析其中​​包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。 微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。 试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得 液体样品可以流入旋转轴远端试剂室。 至少一个试剂室含有与液体样品反应的试剂。

    Separation method and device for protein mixtures
    7.
    发明授权
    Separation method and device for protein mixtures 失效
    蛋白质混合物的分离方法和装置

    公开(公告)号：US07645369B2

    公开(公告)日：2010-01-12

    申请号：US11120098

    申请日：2005-05-02

    申请人： Hans-Joachim Hoeltke ,  Albert Roeder ,  Alois Rainer ,  Peter Berndt ,  Carlo Effenhauser ,  Hanno Langen ,  Remo Anton Hochstrasser

    发明人： Hans-Joachim Hoeltke ,  Albert Roeder ,  Alois Rainer ,  Peter Berndt ,  Carlo Effenhauser ,  Hanno Langen ,  Remo Anton Hochstrasser

    IPC分类号： G01N27/447 ,  G01N27/453

    CPC分类号： G01N27/44773

    摘要： A separation device and a separation method for biomolecular sample material and in particular protein mixtures. For this purpose a separation element 10 for the two-dimensional and preferable electrophoretic separation of components of the sample material is provided in area 30 of a separation plane. According to the invention it is proposed that the separation element 10 has a channel or transfer structure 14 for the locally resolved discharge of separated sample components in a transport direction that is at right angles to the separation plane onto a support surface 16 that is preferably suitable for mass spectroscopic analyses.

    摘要翻译： 用于生物分子样品材料，特别是蛋白质混合物的分离装置和分离方法。 为此，在分离平面的区域30中提供用于样品材料的组分的二维和优选的电泳分离的分离元件10。 根据本发明，提出了分离元件10具有通道或转移结构14，用于将分离的样品组分在与分离平面成直角的运输方向上局部分解排放到支撑表面16上，其优选地适合 用于质谱分析。

    Method and separating module for the separation of particles from a dispersion, in particular of blood corpuscles from blood
    8.
    发明授权
    Method and separating module for the separation of particles from a dispersion, in particular of blood corpuscles from blood 有权
    用于从分散体，特别是血液中分离颗粒的方法和分离模块

    公开(公告)号：US07527740B2

    公开(公告)日：2009-05-05

    申请号：US10492256

    申请日：2002-09-14

    申请人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

    发明人： Carlo Effenhauser ,  Gregor Ocvirk ,  Wolfgang Fiedler

    IPC分类号： B01D37/00 ,  B01D11/00

    CPC分类号： G01N15/05 ,  A61M1/3693 ,  B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0816 ,  G01N33/491 ,  G01N2015/055 ,  G01N2015/1486 ,  Y10T436/25 ,  Y10T436/25375

    摘要： A method for separating particles from a fluid dispersion, particularly for separating corpuscular components from biological samples, above all from blood. A separating module suitable for performing the method has a substrate with flow channels, comprising a feed channel for supplying the dispersion to a junction, a first drain channel for draining fluid having a reduced particle concentration away from the junction, and a second drain channel for draining fluid having an increased particle concentration away from the junction. The fluid flows so much faster in the second drain channel than in the first drain channel that due to the different flow speeds the dispersed particles preferentially flow at the junction further in the second drain channel.

    摘要翻译： 一种用于从流体分散体中分离颗粒的方法，特别是用于从生物样品中分离出红细胞成分，尤其是血液。 适于执行该方法的分离模块具有带有流动通道的基底，包括用于将分散体供应到结点的进料通道，用于排出离开结点的具有降低的粒子浓度的流体的第一排出通道和用于 具有离开结点的具有增加的颗粒浓度的排出流体。 在第二排水通道中流体流动比在第一排水通道中要快得多，由于不同的流速，分散的颗粒优先在第二排水通道中的结点处流动。

    Micro Chamber
    9.
    发明申请
    Micro Chamber 有权
    微室

    公开(公告)号：US20090016932A1

    公开(公告)日：2009-01-15

    申请号：US12142019

    申请日：2008-06-19

    申请人： Mario Curcio ,  Carlo Effenhauser ,  Michael Glauser

    发明人： Mario Curcio ,  Carlo Effenhauser ,  Michael Glauser

    IPC分类号： B01J19/00 ,  B05D3/04 ,  B01F15/00 ,  B01F15/02

    CPC分类号： B01F13/0084 ,  B01F13/0064 ,  B01F13/0071 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00833 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01J2219/00889 ,  B01L3/5027 ,  B01L2300/0867 ,  B01L2300/165 ,  B01L2400/0694 ,  B01L2400/088

    摘要： A microfluidic device is provided including at least one chamber accessible by microfiuidic channels characterized in that the surface of the channels and the chambers are patterned and comprise hydrophilic and hydrophobic areas. The surface energy in correspondence of the areas, i.e., the capillary force, being such that a liquid can be guided along the hydrophilic path, enter the chamber from one side, wet part of one surface of the chamber as a thin layer without touching the opposite surface of the chamber, thus avoiding to fill the volume inside the chamber in correspondence of the hydrophilic pattern until a second liquid, either sequentially or in parallel, comes to wet part of the opposite surface of the chamber and eventually touches the first liquid layer, resulting in a sudden coalescence and efficient mixing between the liquids.

    摘要翻译： 提供了一种微流体装置，其包括至少一个可通过微流体通道进入的腔室，其特征在于通道和腔室的表面被图案化并且包括亲水和疏水区域。 对应于面积的表面能，即毛细管力，使得液体可以沿着亲水路径被引导，从一侧进入腔室，将腔室的一个表面的湿部分作为薄层而不接触 因此避免了填充室内的体积，与亲水图形相对应，直到第二液体顺序地或平行地到达室的相对表面的湿润部分，并最终接触第一液体层 ，导致液体之间突然的聚结和有效的混合。

    Bent Microstructures For Sampling, Transporting Or Dispensing A Fluid Media
    10.
    发明申请
    Bent Microstructures For Sampling, Transporting Or Dispensing A Fluid Media 有权
    用于采样，运输或分配流体介质的弯曲微结构

    公开(公告)号：US20070292314A1

    公开(公告)日：2007-12-20

    申请号：US11791251

    申请日：2005-11-22

    申请人： Carlo Effenhauser ,  Emad Sarofim ,  Stephan Korner

    发明人： Carlo Effenhauser ,  Emad Sarofim ,  Stephan Korner

    IPC分类号： B01L3/02

    CPC分类号： G01N1/20 ,  B01L3/0244 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2400/025 ,  B01L2400/0406 ,  Y10T29/49826 ,  Y10T436/110833 ,  Y10T436/2575

    摘要： A device for sampling, transporting and/or disposal of fluid media in the nl and μl-range comprises a substrate with and open or closed capillary-like groove or channel respectively, the substrate with the open or closed groove or capillary respectively is bent or arcuated at least at one location. The substrate comprises at least one end into which the open closed capillary-like groove or channel respectively is extended, which end is shaped according to its application or use as e.g. needle-like, straight-lined cut, tip-like, at least most half circle-shape, rounded, etc.

    摘要翻译： 用于在n1和m范围内采样，运输和/或处理流体介质的装置包括分别具有和开放或封闭的毛细管状沟槽或通道的基板，分别具有开放或封闭的凹槽或毛细管的基板被弯曲或 至少在一个位置弧形。 衬底包括至少一个端部，开放或封闭的毛细管状沟槽或沟槽分别延伸到其中，该端部根据其应用或用途被成形为例如形状。 针状，直线切割，尖端状，至少半圆形，圆形等