-
公开(公告)号：US08911684B2
公开(公告)日：2014-12-16
申请号：US13487707
申请日：2012-06-04
申请人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
CPC分类号： B01F1/0027 , B01F9/0014 , B01F11/0002 , B01F13/0059 , B01F15/0203 , B01F15/0233 , B01L3/502746 , B01L2200/16 , B01L2400/0409 , B01L2400/086
摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.
摘要翻译： 提供了用于分析其中包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。 微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。 试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得 液体样品可以流入旋转轴远端试剂室。 至少一个试剂室含有与液体样品反应的试剂。
-
公开(公告)号：US20120301371A1
公开(公告)日：2012-11-29
申请号：US13487707
申请日：2012-06-04
申请人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Carlo Effenhauser , Rijk Edwin Oosterbroek , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01F1/0027 , B01F9/0014 , B01F11/0002 , B01F13/0059 , B01F15/0203 , B01F15/0233 , B01L3/502746 , B01L2200/16 , B01L2400/0409 , B01L2400/086
摘要： A microfluidic element for analyzing a bodily fluid sample for an analyte contained therein is provided, the element having a substrate, a channel structure that is enclosed by the substrate, and a cover layer, and is rotatable around a rotational axis. The channel structure of the microfluidic element includes a feed channel having a feed opening, a ventilation channel having a ventilation opening, and at least two reagent chambers. The reagent chambers are connected to one another via two connection channels in such a manner that a fluid exchange is possible between the reagent chambers, one of the reagent chambers having an inlet opening, which has a fluid connection to the feed channel, so that a liquid sample can flow into the rotational-axis-distal reagent chamber. At least one of the reagent chambers contains a reagent, which reacts with the liquid sample.
摘要翻译： 提供了用于分析其中包含的分析物的体液样品的微流体元件，所述元件具有衬底，由衬底包围的沟道结构和覆盖层，并且可围绕旋转轴线旋转。 微流体元件的通道结构包括具有进料口的进料通道，具有通风口的通风通道和至少两个试剂室。 试剂室通过两个连接通道彼此连接，使得可以在试剂室之间进行流体交换，其中一个试剂室具有与进料通道的流体连接的入口，从而使得 液体样品可以流入旋转轴远端试剂室。 至少一个试剂室含有与液体样品反应的试剂。
-
公开(公告)号：US20130004964A1
公开(公告)日：2013-01-03
申请号：US13410336
申请日：2012-03-02
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0631 , B01L2300/0806 , B01L2300/087 , B01L2300/0887 , B01L2400/0409 , G01N35/00069
摘要： Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.
摘要翻译： 公开了进行异质化学或生物反应的方法和系统。 该方法包括提供具有至少一个液体处理单元的分析装置，所述液体处理单元具有至少一个反应室和与反应室流体连通的第一入口通道。 该方法还包括经由第一入口通道或第二入口通道分析物捕获颗粒向反应室供应，经由第一入口通道或第二入口通道向反应室供应含有感兴趣分析物的液体样品，并通过 分析物捕获颗粒在反应室内的颗粒重排区中的力的平衡。 力包括通过流动液体产生的牵引力Fd和反向取向力Fg。 该方法还包括用颗粒重排区中的颗粒捕获存在于液体样品中的分析物。
-
公开(公告)号：US09151750B2
公开(公告)日：2015-10-06
申请号：US13410336
申请日：2012-03-02
IPC分类号： B01L3/00 , G01N33/543 , G01N35/00
CPC分类号： G01N33/54366 , B01L3/502753 , B01L2200/0631 , B01L2300/0806 , B01L2300/087 , B01L2300/0887 , B01L2400/0409 , G01N35/00069
摘要： Method and system for carrying out heterogeneous chemical or biological reactions are disclosed. The method comprising providing an analytical device having at least one liquid processing unit having at least one reaction chamber and a first inlet channel in fluid communication with the reaction chamber. The method further comprises supplying to the reaction chamber via the first inlet channel or a second inlet channel analyte capturing particles, supplying to the reaction chamber via the first inlet channel or the second inlet channel a liquid sample containing an analyte of interest, and confining by an equilibrium of forces the analyte capturing particles in a particle rearrangement zone within the reaction chamber. The forces comprise a drag force Fd generated by flowing liquids and a counter-oriented force Fg. The method also comprises capturing analytes present in the liquid sample with the particles in the particle rearrangement zone.
摘要翻译： 公开了进行异质化学或生物反应的方法和系统。 该方法包括提供具有至少一个液体处理单元的分析装置，所述液体处理单元具有至少一个反应室和与反应室流体连通的第一入口通道。 该方法还包括通过第一入口通道或第二入口通道分析物捕获颗粒向反应室供应，经由第一入口通道或第二入口通道向反应室供应含有感兴趣分析物的液体样品，并通过 分析物捕获颗粒在反应室内的颗粒重排区中的力的平衡。 力包括通过流动液体产生的牵引力Fd和反向取向力Fg。 该方法还包括用颗粒重排区中的颗粒捕获存在于液体样品中的分析物。
-
5.发明申请Microfluidic Test Carrier for Apportioning a Liquid Quantity Into Subquantities 有权用于将液体数量分配到子品质中的微流体测试载体公开(公告)号：US20130236376A1
公开(公告)日：2013-09-12
申请号：US13871720
申请日：2013-04-26
申请人： Manfred Augstein , Christoph Boehm , Susanne Wuerl
发明人： Manfred Augstein , Christoph Boehm , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01L3/502723 , B01L3/502738 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2200/0684 , B01L2200/141 , B01L2300/0806 , B01L2300/0851 , B01L2300/087 , B01L2400/0409 , B01L2400/0688
摘要： A microfluidic test carrier having a substrate, covering layer, and capillary structure formed in the substrate is provided. The capillary structure is enclosed by the substrate and covering layer and comprises a receiving chamber, sample chamber and connection channel between the receiving and sample chambers. The receiving chamber has two boundary surfaces and a side wall, wherein one boundary surface forms the bottom and the other forms the cover. The receiving chamber has a surrounding venting channel and dam between the receiving chamber and venting channel. The dam and venting channel form a capillary stop configured as a geometric valve, through which air from the receiving chamber can escape into the venting channel. The connecting channel between the venting channel outflow and sample chamber inflow controls fluid transport from the receiving chamber into the sample chamber. The capillary stop is configured to prevent autonomous fluid transport from the receiving chamber.
摘要翻译： 提供了一种在基板上形成的具有基板，覆盖层和毛细结构的微流体测试载体。 毛细管结构由衬底和覆盖层包围，并包括接收室，样品室和接收室和样品室之间的连接通道。 接收室具有两个边界面和侧壁，其中一个边界表面形成底部，另一个形成盖。 接收室具有周围的通风通道，并且在接收室和通风通道之间具有阻塞。 大坝和排气通道形成一个被设计为几何阀的毛细管阻塞，来自接收室的空气可以通过该几何阀排出到通风通道中。 排气通道出口和样品室流入之间的连接通道控制从接收室进入样品室的流体输送。 毛细管止动件被构造成防止自主流体从接收室输送。
-
6.发明申请TEST ELEMENT FOR ANALYZING AN ANALYTE PRESENT IN A SAMPLE OF A BODY FLUID, ANALYSIS SYSTEM AND METHOD FOR CONTROLLING THE MOVEMENT OF A FLUID CONTAINED IN A CHANNEL OF A TEST ELEMENT 审中-公开用于分析体液中分析物的分析测试元件，分析系统和控制测试单元的通道中流体运动的方法公开(公告)号：US20110183432A1
公开(公告)日：2011-07-28
申请号：US13008104
申请日：2011-01-18
申请人： Manfred Augstein , Susanne Wuerl
发明人： Manfred Augstein , Susanne Wuerl
CPC分类号： F04F3/00 , B01L3/502723 , B01L3/50273 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0867 , B01L2400/0406 , B01L2400/0409 , B01L2400/0463 , B01L2400/049 , B01L2400/0688 , F04F5/24 , G01N21/03 , G01N2021/0328 , G01N2021/0346 , Y10T436/25
摘要： Embodiments disclosed herein include an analysis system for the analysis of a body fluid sample for an analyte contained therein, comprising a test element and an evaluation device having a measuring station for measuring a measuring variable on the measuring zone of the test element. Also included is a mounting to hold a test element, the test element having an airflow channel with two expansion sections and a narrow section located between these expansion sections. The expansion sections may have a cross-sectional area that increases in comparison to the narrow section in the direction away therefrom. A connection channel is located between the narrow section and the analysis function channel such that an air exchange connection is formed. The airflow channel is located in such a manner that a partial vacuum, which is generated using an airflow flowing through the airflow channel, acts on the analysis function channel.
摘要翻译： 本文公开的实施方案包括用于分析其中包含的分析物的体液样品的分析系统，包括测试元件和具有用于测量测试元件的测量区域上的测量变量的测量站的评估装置。 还包括用于保持测试元件的安装件，测试元件具有带有两个膨胀部分的气流通道和位于这些膨胀部分之间的窄部分。 膨胀部分可以具有与沿着远离其的方向与窄部分相比增加的横截面面积。 连接通道位于狭窄部分和分析功能通道之间，从而形成空气交换连接。 气流通道以这样的方式定位，即使用流过气流通道的气流产生的部分真空作用在分析功能通道上。
-
7.发明授权Method for providing a dried reagent in a microfluidic system and microfluidic system 有权在微流体系统和微流体系统中提供干燥试剂的方法公开(公告)号：US08790932B2
公开(公告)日：2014-07-29
申请号：US12573472
申请日：2009-10-05
CPC分类号： B01L3/502707 , B01L7/00 , B01L2200/12 , B01L2200/16 , F26B5/06
摘要： A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization.
摘要翻译： 提供了一种在微流体系统中提供干燥试剂的方法，该方法包括以下步骤：提供具有微流体结构的微流体系统，将含有试剂的可流动载体介质引入微流体结构中，并干燥微流体中的试剂 冻结结构。
-
8.发明申请Method for Providing a Dried Reagent in a Microfluidic System and Microfluidic System 有权在微流体系统和微流体系统中提供干试剂的方法公开(公告)号：US20100112717A1
公开(公告)日：2010-05-06
申请号：US12573472
申请日：2009-10-05
CPC分类号： B01L3/502707 , B01L7/00 , B01L2200/12 , B01L2200/16 , F26B5/06
摘要： A method for providing a dried reagent in a microfluidic system is provided, the method comprising the following steps: providing a microfluidic system having a microfluidic structure, introducing a flowable carrier medium containing a reagent in the microfluidic structure, and drying the reagent in the microfluidic structure by lyophilization.
摘要翻译： 提供了一种在微流体系统中提供干燥试剂的方法，该方法包括以下步骤：提供具有微流体结构的微流体系统，将含有试剂的可流动载体介质引入微流体结构中，并干燥微流体中的试剂 冻结结构。
-
公开(公告)号：US20130243664A1
公开(公告)日：2013-09-19
申请号：US13872686
申请日：2013-04-29
申请人： Christoph Boehm , Susanne Wuerl
发明人： Christoph Boehm , Susanne Wuerl
IPC分类号： B01L3/00
CPC分类号： B01L3/502723 , B01L3/502738 , B01L2200/0684 , B01L2200/12 , B01L2300/0803 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , F16K99/0017 , F16K99/0063 , F16K2099/0084
摘要： A microfluidic element for analysis of a fluid sample having a substrate and a microfluidic transport system having a channel structure enclosed by the substrate and a covering layer. The channel structure comprises a channel with two side walls as well as a chamber that is in fluid communication with the channel. The chamber has a chamber wall with an inlet orifice. The channel comprises a channel section and a valve section adjoining the channel section, wherein the valve section is in fluid communication with the inlet orifice in the chamber wall in such a way that a fluid can flow from the channel through the valve section and into the chamber. The valve section has a fluid transport cross-section, which enlarges in flow direction. The fluid transport cross-section in the valve section is greater than the fluid transport cross-section in the preceding channel section.
摘要翻译： 用于分析具有基底的流体样品的微流体元件和具有由基底和覆盖层包围的通道结构的微流体输送系统。 通道结构包括具有两个侧壁的通道以及与通道流体连通的室。 该室具有一个具有入口孔的室壁。 通道包括通道部分和毗邻通道部分的阀部分，其中阀部分与腔室壁中的入口孔流体连通，使得流体可以从通道流过阀部分并进入 房间。 阀部分具有流体输送横截面，其在流动方向上扩大。 阀部分中的流体输送横截面大于前一通道部分中的流体输送横截面。
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.024 秒)
