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    Methods for targeting pulmonary diseases with agents that bind a target in pulmonary tissue
    1.
    发明授权
    Methods for targeting pulmonary diseases with agents that bind a target in pulmonary tissue 有权
    用于结合肺组织中靶标的试剂靶向肺部疾病的方法

    公开(公告)号：US08497244B2

    公开(公告)日：2013-07-30

    申请号：US13356228

    申请日：2012-01-23

    申请人： Rudolf M. T. de Wildt ,  Steve Holmes ,  Ian M. Tomlinson ,  Gregory P. Winter ,  Mary F. Fitzgerald ,  Justian Craig Fox ,  Armin Sepp ,  Jennifer Luckett ,  Benjamin P. Woolven

    发明人： Rudolf M. T. de Wildt ,  Steve Holmes ,  Ian M. Tomlinson ,  Gregory P. Winter ,  Mary F. Fitzgerald ,  Justian Craig Fox ,  Armin Sepp ,  Jennifer Luckett ,  Benjamin P. Woolven

    IPC分类号： A61K38/00

    CPC分类号： C07K16/2875 ,  A61K9/0043 ,  A61K9/007 ,  A61K39/3955 ,  C07K16/28 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/76

    摘要： Disclosed is the use of an agent (e.g., antibody fragment, antagonist, ligand, dAb monomer) that binds a target in pulmonary tissue for the manufacture of a long action or long therapeutic window formulation for local delivery to pulmonary tissue, and methods for administering an agent that binds a target in pulmonary tissue to a subject to produce a long therapeutic window in pulmonary tissue. The formulation is for, and the method comprises, administering locally to pulmonary tissue. Also disclosed is the use of antagonists of TNFR1 for the manufacture of a formulation or medicament for treating, preventing or suppressing lung inflammation or a respiratory disease, and methods of treating such diseases. Also disclosed are the use of agents a for the manufacture of a delivery device (e.g., inhaler, intranasal delivery device) for the treatment or prevention of lung inflammation or a respiratory disease, and a delivery device for the treatment or prevention of lung inflammation or a respiratory disease that contains an agent as described herein.

    摘要翻译： 公开了结合肺组织中的靶标以制备用于局部递送至肺组织的长效或长治疗窗口制剂的试剂（例如，抗体片段，拮抗剂，配体，dAb单体）的用途，以及用于施用 将肺组织中的靶标结合到受试者以在肺组织中产生长治疗窗的药剂。 该制剂用于，并且该方法包括局部给予肺组织。 还公开了使用TNFR1的拮抗剂来制造用于治疗，预防或抑制肺部炎症或呼吸系统疾病的制剂或药物，以及治疗这些疾病的方法。 还公开了使用试剂a来制造用于治疗或预防肺部炎症或呼吸系统疾病的输送装置（例如，吸入器，鼻内递送装置），以及用于治疗或预防肺部炎症或 包含本文所述的药剂的呼吸系统疾病。

    Recombinant viruses displaying a nonviral polypeptide on their external surface
    9.
    发明授权
    Recombinant viruses displaying a nonviral polypeptide on their external surface 失效
    在其外表面上显示非病毒多肽的重组病毒

    公开(公告)号：US06297004B1

    公开(公告)日：2001-10-02

    申请号：US09032084

    申请日：1998-02-27

    申请人： Stephen J. Russell ,  Robert E. Hawkins ,  Gregory P. Winter

    发明人： Stephen J. Russell ,  Robert E. Hawkins ,  Gregory P. Winter

    IPC分类号： C12Q170

    CPC分类号： C40B40/02 ,  A61K48/00 ,  C12N15/1037 ,  C12N15/86 ,  C12N15/87 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2810/859

    摘要： We have made retrovirus particles displaying a functional antibody fragment. We fused the gene encoding an antibody fragment directed against a hapten with that encoding the viral envelope protein (Pr80env) of the ecotropic Moloney murine leukemia virus. The fusion gene was co-expressed in ecotropic retroviral packaging cells with a retroviral plasmid carrying the neomycin phosphotransferase gene (neo), and retroviral particles with specific hapten biding activities were recovered. Furthermore the hapten-binding particles were able to transfer the neo gene and the antibody-envelope fusion gene to mouse fibroblasts. In principle, the display of antibody fragments on the surface of recombinant retroviral particles could be used to target virus to cells for gene delivery, or to retain the virus in target tissues, or for the construction of libraries of viral display packages.

    摘要翻译： 我们已经制备出显示功能性抗体片段的逆转录病毒颗粒。 我们将编码针对半抗原的抗体片段的基因与编码亲和性莫洛尼鼠白血病病毒的病毒包膜蛋白（Pr80env）的基因融合。 融合基因在携带新霉素磷酸转移酶基因（neo）的逆转录病毒质粒的亲和逆转录病毒包装细胞中共表达，并回收具有特异性半抗原活性的逆转录病毒颗粒。 此外，半抗原结合颗粒能够将neo基因和抗体 - 包膜融合基因转移至小鼠成纤维细胞。 原则上，重组逆转录病毒颗粒表面上的抗体片段的显示可以用于将病毒靶向到细胞进行基因递送，或将病毒保留在靶组织中，或用于构建病毒显示包的文库。