公开(公告)号：US06709622B2

公开(公告)日：2004-03-23

申请号：US10101033

申请日：2002-03-11

Applicant: Romain Billiet ,  Hanh T. Nguyen

Inventor： Romain Billiet ,  Hanh T. Nguyen

IPC: C04B3332

CPC classification number: C04B38/0054 ,  B22F3/1103 ,  B22F9/04 ,  B22F2009/043 ,  B22F2999/00 ,  B82Y30/00 ,  C04B35/486 ,  C04B35/6261 ,  C04B35/62625 ,  C04B35/63 ,  C04B35/632 ,  C04B35/634 ,  C04B35/63408 ,  C04B35/64 ,  C04B2235/3225 ,  C04B2235/3246 ,  C04B2235/5409 ,  C04B2235/5454 ,  C04B2235/6021 ,  C04B2235/667 ,  C04B2235/77 ,  C04B35/00 ,  C04B38/0058 ,  C04B38/045 ,  C04B38/0615 ,  B22F1/0018

Abstract: A method of fabricating nanostructures containing isotropically distributed, interconnected pores having cross-sectional diameters in the nanometer and Angstrom range by integrating the steps of attriting precursor nanometer-sized particulate materials, desorbing the exposed surfaces of the attrited nanoparticulates, adsorbing a surfactant on 25-50% of the desorbed surfaces and dispersing the surfactant-coated nanoparticulates in an organic matrix to form a homogeneous thermoplastic compound from which green nanostructures are formed, dewaxed and sintered to the desired degree of microporosity.

Abstract translation: 一种制造纳米结构的方法，其包含各向同性分布的互连孔，其横截面直径在纳米和埃范围内，通过整合磨合前体纳米尺寸颗粒材料的步骤，解吸磨碎的纳米颗粒的暴露表面，在25℃下吸附表面活性剂， 50％的解吸表面，并将表面活性剂包被的纳米颗粒分散在有机基质中以形成均匀的热塑性化合物，从其形成绿色纳米结构，脱蜡并烧结至所需的微孔程度。

公开(公告)号：US20130302790A1

公开(公告)日：2013-11-14

申请号：US13978839

申请日：2012-01-10

Applicant: Suzanne U. Emerson ,  Priyanka Shukla ,  Hanh T. Nguyen ,  Robert H. Purcell ,  Harry R. Dalton ,  Richard Bendall

Inventor： Suzanne U. Emerson ,  Priyanka Shukla ,  Hanh T. Nguyen ,  Robert H. Purcell ,  Harry R. Dalton ,  Richard Bendall

IPC: C12N7/00 ,  C12Q1/70 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K39/00 ,  C07K14/005 ,  C07K14/47 ,  C12N15/86 ,  C12N2770/28121 ,  C12N2770/28122 ,  C12N2770/28134 ,  C12N2770/28143 ,  C12N2770/28151 ,  C12N2770/28152 ,  C12Q1/707

Abstract: The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.

Abstract translation: 本发明涉及从长期感染的患者中发现HEV毒株。 病毒在许多细胞培养物中异常生长。 因此，本发明提供了基于病毒的细胞培养物，载体和疫苗组合物。 本发明部分地涉及鉴定新型HEV基因型3病毒株。 使用从慢性感染患者中分离的HEV菌株Kernow-C1（基因型3），用于鉴定允许感染的人，猪和鹿细胞系。 将Kernow-C 1菌株适应于人肝癌细胞中生长，其选择含有人核糖体蛋白基因的174个核糖核苷酸（58个氨基酸）和另外的突变的稀有病毒重组体。

公开(公告)号：US20090054275A1

公开(公告)日：2009-02-26

申请号：US11894095

申请日：2007-08-21

Applicant: Romain L. Billiet ,  Hanh T. Nguyen

Inventor： Romain L. Billiet ,  Hanh T. Nguyen

IPC: C04B35/5833 ,  C10M103/00

CPC classification number: C10M111/00 ,  B22F3/1021 ,  C10M2201/053 ,  C10M2201/0613 ,  C10N2220/082 ,  C10N2230/06 ,  C10N2240/02 ,  C10N2250/18 ,  C10N2270/00 ,  C22C29/16

Abstract: Pressureless sintered high density materials containing hexagonal boron nitride have low coefficients of friction and high wear resistance and are useful for bearings, bushings and other articles subjected to bearing loads.

Abstract translation: 含有六方氮化硼的无压烧结高密度材料具有低摩擦系数和高耐磨性，并且可用于承受轴承载荷的轴承，衬套和其它制品。

公开(公告)号：US07083757B2

公开(公告)日：2006-08-01

申请号：US10082867

申请日：2002-02-18

Applicant: Romain L. Billiet ,  Hanh T. Nguyen

Inventor： Romain L. Billiet ,  Hanh T. Nguyen

IPC: C04B35/64 ,  B23K35/00

CPC classification number: C04B35/638 ,  C04B35/119 ,  C04B35/56 ,  C04B35/634 ,  H01L24/78 ,  H01L2224/05599 ,  H01L2224/45015 ,  H01L2224/45144 ,  H01L2224/85399 ,  H01L2924/10253 ,  H01L2924/14 ,  H01L2924/20752 ,  H01L2924/00014 ,  H01L2924/00 ,  H01L2924/20751

Abstract: Semiconductor wire bonding tools used in the assembly and interconnection of integrated circuits (ICs) are micromolded from a mixture of ultrafine particulate materials mixed with an organic binder. Following extraction of the binder the green bonding tools are sintered during which they undergo isotropic, constant and accurately predetermined shrinkage. Hence semiconductor wire bonding tools can be produced with virtually no limit to miniaturization, thus allowing the fabrication of higher integrated semiconductor products.

Abstract translation: 在集成电路（IC）的组装和互连中使用的半导体线焊接工具由与有机粘合剂混合的超细颗粒材料的混合物微型成型。 在提取粘合剂之后，将绿色粘结工具烧结，在此期间它们经历各向同性，恒定且准确的预定收缩。 因此，可以实际上没有限制小型化地制造半导体引线接合工具，从而允许制造更高级的集成半导体产品。

公开(公告)号：US06770242B2

公开(公告)日：2004-08-03

申请号：US10139462

申请日：2002-04-26

Applicant: Romain L. Billiet ,  Hanh T. Nguyen

Inventor： Romain L. Billiet ,  Hanh T. Nguyen

IPC: B22F100

CPC classification number: B22F3/225 ,  B22F2998/00 ,  B22F2998/10 ,  B22F2999/00 ,  H01F41/0266 ,  H01F41/0273 ,  H02K15/03 ,  H02K41/0354 ,  B22F9/04 ,  B22F1/0081 ,  B22F3/22 ,  B22F3/20 ,  B22F2202/05

Abstract: Permanent magnet for voice coil actuator motors used to actuate head-arm assemblies in small form disk drives are produced from a dispersion of prealloyed rare earth magnetic particles in a thermoplastic binder. Upon shaping of green parts the magnetic axis of the particles is aligned with the field lines of a magnetic field. Following extraction of the binder the green parts are sintered to net shape. Improved magnetic properties, smaller dimensions, better than tolerances and 100% material utilization are claimed.

Abstract translation: 用于致动小型盘驱动器中的头臂组件的音圈致动器电动机的永磁体由预合金化的稀土磁性颗粒在热塑性粘合剂中的分散体产生。 在绿色部件成形时，颗粒的磁轴与磁场的场线对齐。 在提取粘合剂之后，将绿色部分烧结成网状。 要求改进的磁性能，更小的尺寸，优于公差和100％的材料利用率。

公开(公告)号：US06780353B2

公开(公告)日：2004-08-24

申请号：US09976393

申请日：2001-10-08

Applicant: Romain L. Billiet ,  Hanh T. Nguyen

Inventor： Romain L. Billiet ,  Hanh T. Nguyen

IPC: C04B3332

CPC classification number: C04B35/622 ,  B22F1/0059 ,  B22F5/007 ,  B22F2998/00 ,  B28B7/346 ,  B29C37/005 ,  B29C61/02 ,  B29C67/04 ,  B29K2105/246 ,  B29K2995/0049 ,  C04B35/634 ,  C04B35/638 ,  H01L21/565 ,  H01L23/293 ,  H01L23/295 ,  H01L2924/0002 ,  B22F1/0018 ,  H01L2924/00

Abstract: Ultrasmall, complex-shaped high-precision micromolds are produced by controlled shrinkage upon sintering of green parts molded from mixtures of micrometer- or nanometer-sized particulates dispersed in an organic binder.

Abstract translation: 通过在分散在有机粘合剂中的微米级或纳米级颗粒的混合物模制的生坯部分的烧结时通过控制收缩来生产超小型复杂形状的高精度微型金属。

公开(公告)号：US09181530B2

公开(公告)日：2015-11-10

申请号：US13978839

申请日：2012-01-10

Applicant: Suzanne U. Emerson ,  Priyanka Shukla ,  Hanh T. Nguyen ,  Robert H. Purcell ,  Harry R. Dalton ,  Richard Bendall

Inventor： Suzanne U. Emerson ,  Priyanka Shukla ,  Hanh T. Nguyen ,  Robert H. Purcell ,  Harry R. Dalton ,  Richard Bendall

IPC: A61K39/29 ,  A61K39/12 ,  C07H21/00 ,  C12N7/00 ,  C12N15/86 ,  C12Q1/70 ,  C07K14/005 ,  A61K39/00

CPC classification number: C12N7/00 ,  A61K39/00 ,  C07K14/005 ,  C07K14/47 ,  C12N15/86 ,  C12N2770/28121 ,  C12N2770/28122 ,  C12N2770/28134 ,  C12N2770/28143 ,  C12N2770/28151 ,  C12N2770/28152 ,  C12Q1/707

Abstract: The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.

Abstract translation: 本发明涉及从长期感染的患者中发现HEV毒株。 病毒在许多细胞培养物中异常生长。 因此，本发明提供了基于病毒的细胞培养物，载体和疫苗组合物。 本发明部分地涉及鉴定新型HEV基因型3病毒株。 使用从慢性感染患者中分离的HEV菌株Kernow-C1（基因型3），用于鉴定允许感染的人，猪和鹿细胞系。 将Kernow-C 1菌株适应于人肝癌细胞中生长，其选择含有人核糖体蛋白基因的174个核糖核苷酸（58个氨基酸）和另外的突变的稀有病毒重组体。

公开(公告)号：US07741254B2

公开(公告)日：2010-06-22

申请号：US11894095

申请日：2007-08-21

Applicant: Romain L. Billiet ,  Hanh T. Nguyen

Inventor： Romain L. Billiet ,  Hanh T. Nguyen

IPC: F16C33/20 ,  C01B35/00 ,  C01B35/14 ,  C01B21/064

CPC classification number: C10M111/00 ,  B22F3/1021 ,  C10M2201/053 ,  C10M2201/0613 ,  C10N2220/082 ,  C10N2230/06 ,  C10N2240/02 ,  C10N2250/18 ,  C10N2270/00 ,  C22C29/16

Abstract: Pressureless sintered high density materials containing hexagonal boron nitride have low coefficients of friction and high wear resistance and are useful for bearings, bushings and other articles subjected to bearing loads.

Abstract translation: 含有六方氮化硼的无压烧结高密度材料具有低摩擦系数和高耐磨性，并且可用于承受轴承载荷的轴承，衬套和其它制品。

公开(公告)号：US06740287B2

公开(公告)日：2004-05-25

申请号：US10078070

申请日：2002-02-11

Applicant: Romain Louis Billiet ,  Hanh T. Nguyen

Inventor： Romain Louis Billiet ,  Hanh T. Nguyen

IPC: B28B100

CPC classification number: C04B35/6264 ,  B22F1/0018 ,  B22F9/04 ,  B22F2009/043 ,  B82Y30/00 ,  C04B35/63 ,  C04B35/632 ,  C04B35/634 ,  C04B2235/3217 ,  C04B2235/3463 ,  C04B2235/3804 ,  C04B2235/3817 ,  C04B2235/3852 ,  C04B2235/3891 ,  C04B2235/72

Abstract: A method of fabricating nanostructure bodies by integrating the steps of attriting precursor nanometer-sized particulate materials, desorbing the exposed surfaces of the attrited nanoparticulates, adsorbing a surfactant on at most 50% of the desorbed surfaces and dispersing the surfactant-coated nanoparticulates in an organic matrix to form a homogeneous thermoplastic compound from which green bodies are shaped, dewaxed and sintered.

Abstract translation: 通过整合磨合前体纳米尺寸的颗粒材料，脱附磨碎的纳米颗粒的暴露表面的步骤，在至多50％的解吸表面上吸附表面活性剂并将表面活性剂包被的纳米颗粒分散在有机物中的步骤来制备纳米结构体的方法 基质以形成均匀的热塑性化合物，生坯从其形成，脱蜡和烧结。