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    Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule
    5.
    发明授权
    Devices containing cells or tissue and an agent that inhibits damage by a host cell molecule 失效
    含有细胞或组织的装置以及抑制宿主细胞分子损伤的药剂

    公开(公告)号：US06287558B1

    公开(公告)日：2001-09-11

    申请号：US08904808

    申请日：1997-08-01

    申请人： Robert P. Lanza ,  Dawn M. Ecker ,  John Ringeling ,  Joanne P. Marsh ,  William Chick

    发明人： Robert P. Lanza ,  Dawn M. Ecker ,  John Ringeling ,  Joanne P. Marsh ,  William Chick

    IPC分类号： A61K3512

    CPC分类号： A61K9/0024 ,  A61K9/5031 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/817

    摘要： A device that includes a living cell or tissue and an agent that inhibits the ability of a host molecule to damage the cell or tissue. The device can be constructed in various forms including an implantable device, a composite microreactor and a double composite microreactor. The composite microreactor includes an internal particle that includes a living cell or tissue, an internal particle matrix that includes the living cell or tissue and an internal semipermeable coating enclosing the internal particle matrix, a gel super matrix in which the internal particle is embedded, and an agent that inhibits the ability of a host molecule to damage the cell or tissue. The double composite microreactor includes an internal particle, a particle that includes a particle matrix in which the internal particle is embedded, a super matrix in which the particle is embedded, and an agent that inhibits the ability of a host molecule to damage the living cell or tissue.

    摘要翻译： 包括活细胞或组织的装置和抑制宿主分子损伤细胞或组织的能力的试剂。 该装置可以以各种形式构造，包括可植入装置，复合微反应器和双重复合微反应器。 复合微反应器包括包含活细胞或组织的内部颗粒，包括活细胞或组织的内部颗粒基质和包围内部颗粒基质的内部半透明涂层，嵌入内部颗粒的凝胶超级基质，以及 抑制宿主分子破坏细胞或组织的能力的药剂。 双重复合微反应器包括内部颗粒，包含其中嵌入内部颗粒的颗粒基质的颗粒，其中嵌入颗粒的超级基质和抑制宿主分子损伤活细胞的能力的试剂 或组织。

    Microcapsules and composite microreactors for immunoisolation of cells
    8.
    发明授权
    Microcapsules and composite microreactors for immunoisolation of cells 失效

    公开(公告)号：US6126936A

    公开(公告)日：2000-10-03

    申请号：US402209

    申请日：1995-03-10

    申请人： Robert P. Lanza ,  Willem M. Kuhtreiber ,  William L. Chick

    发明人： Robert P. Lanza ,  Willem M. Kuhtreiber ,  William L. Chick

    IPC分类号： C12N11/00 ,  A61K9/16 ,  A61K9/50 ,  A61K35/12 ,  A61K35/39 ,  A61K45/00 ,  A61K47/30 ,  A61K48/00 ,  C12N5/00 ,  C12N11/04 ,  C12N11/10

    CPC分类号： C12N5/0012 ,  A61K48/00 ,  C12N11/04 ,  C12N2533/32 ,  C12N2533/74

    摘要： Microcapsules and composite microreactors are prepared that immunoisolate living cells such as islet cells or genetically engineered cells. A reduced volume microcapsule is formed by coating a gel matrix particle with a polyamino acid of 15,000 daltons or less molecular weight to reduce volume of the particle by at least 30% as compared to volume prior to coating. A composite microreactor includes the microcapsule containing cell embedded in a gel matrix and provides a molecular weight cutoff that prevents molecules larger than about 400,000 daltons from containing the living cell. A double composite microreactor includes an internal particle that includes an internal particle gel matrix containing a living cell and having a coating, a particle that includes the internal particle embedded in a particle gel matrix and a coating, and a gel super matrix in which the particle is embedded. At least one of the coatings is a volume reducing coating of polyamino acid of 15,000 daltons or less molecular weight. The gel matrices may be alginate, the polyamino acid may be polylysine or polyornithine, and at least one of the gel matrices or coatings may be treated by aging for between 2 hours and 14 days. The internal particle, particle and composite microreactor may have diameters respectively between 50 and 700 microns, 400 and 800 microns and 300 and 1500 microns. to be implanted so there is little or no need for immunosuppressant or antifibrotic drugs. A reduced volume microcapsule is formed by coating a gel matrix particle with a polyamino acid of 15,000 daltons or less molecular weight to reduce volume of the particle by at least 30% as compared to volume prior to coating. A composite microreactor is provided by embedding the microcapsule when containing a living cell in a gel matrix to obtain a molecular weight cutoff that prevents molecules larger than about 400,000 daltons from contacting the living cell. A double composite microreactor is formed containing an internal particle including an internal particle gel matrix containing a living cell and having a coating, a particle including the internal particle embedded in a particle gel matrix having a coating, and a gel super matrix in which the particle is embedded. At least one of the coatings is a volume reducing coating of polyamino acid of 15,000 daltons or less molecular weight. The gel matrices may be alginate, the polyamino acid may be polylysine or polyornithine, and at least one of the gel matrices or coatings may be treated by aging for between 2 hours and 14 days. The internal particle, particle and composite microreactor may have diameters respectively between 50 and 700 microns, 400 and 800 microns and 300 and 1500 microns.