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公开(公告)号:US20050154056A1
公开(公告)日:2005-07-14
申请号:US10981128
申请日:2004-11-03
申请人: Fan Yang , Bo Zhang , Nancy Wicnienski , Jeffrey Pfefferkorn , Meredith Greene , Ke Chen , Richard Nugent , Matthew Reding , Robert Kelly , Mark Mitchell , Lee Funk , Richard Heier , Rebecca Anderson
发明人: Fan Yang , Bo Zhang , Nancy Wicnienski , Jeffrey Pfefferkorn , Meredith Greene , Ke Chen , Richard Nugent , Matthew Reding , Robert Kelly , Mark Mitchell , Lee Funk , Richard Heier , Rebecca Anderson
IPC分类号: A61K31/255 , A61K31/335 , C07C251/86 , C07C309/67 , C07C309/73 , C07C309/74 , C07C309/75 , C07C309/77 , C07C311/21 , C07C311/49 , C07C317/28 , C07C317/32 , C07C317/44 , C07C323/62 , C07D207/277 , C07D207/337 , C07D209/18 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/18 , C07D233/28 , C07D233/64 , C07D263/32 , C07D277/32 , C07D285/14 , C07D307/24 , C07D307/54 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/34 , C07D409/04 , C07D413/04 , C07C39/46
CPC分类号: C07C251/86 , C07C309/67 , C07C309/73 , C07C309/74 , C07C309/75 , C07C309/77 , C07C311/21 , C07C311/49 , C07C317/28 , C07C317/32 , C07C317/44 , C07C323/62 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D207/277 , C07D207/337 , C07D209/18 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/18 , C07D233/28 , C07D233/64 , C07D263/32 , C07D277/32 , C07D285/14 , C07D307/24 , C07D307/54 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/34 , C07D409/04 , C07D413/04
摘要: The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.
摘要翻译: 本发明涉及化合物,其合成方法,用于治疗和预防丙型肝炎病毒(HCV)感染的组合物和方法。 特别地,本发明提供新型化合物,含有这些化合物的药物组合物和使用这些化合物治疗或预防HCV感染的方法。 本发明还提供了合成这些化合物的方法和中间体。
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2.
公开(公告)号:US20050197338A1
公开(公告)日:2005-09-08
申请号:US10970769
申请日:2004-10-21
申请人: He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
发明人: He Huang , Michael Stealey , Gunnar Hanson , Patrick Lennon , Bruce Hamper , Jin Xie , David Oburn , Serge Wolfson , Theresa Fletcher , Richard Heier , Matthew Reding , Michael Clare
IPC分类号: A61K31/415 , A61K31/416 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/53 , C07D231/38 , C07D231/40 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
CPC分类号: C07D403/10 , C04B35/632 , C07D231/38 , C07D401/12 , C07D403/04 , C07D405/10 , C07D409/10 , C07D413/10
摘要: Compounds of Formula I: wherein X1, X2, L1, A, R, L2, R1, R12, R12a, R13, R14 and R14a are as defined herein, are disclosed.
摘要翻译: 式I的化合物:其中X 1,X 2,L 1,A,R,L 2, R 1,R 12,R 12,R 13,R 14和R 14,和 R 14a如本文所定义。
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