专利检索 ap:("David Barnes" OR "Gregory Raymond Bebernitz" OR "Scott Louis Cohen" OR "Robert Edson Damon" OR "Robert Francis Day" OR "Monish Jain" OR "Rajeshri Ganesh Karki" OR "Louise Clare Kirman" OR "Tajesh Jayprakash Patel" OR "Brian Kenneth Raymer" OR "Herbert Franz Schuster" OR "Wei Zhang") AND inv:"Rajeshri Ganesh Karki" 第 1 页

1.

发明授权
Cyclohexane derivatives and uses thereof 有权
标题翻译：环己烷衍生物及其用途

公开(公告)号：US08394858B2

公开(公告)日：2013-03-12

申请号：US12956146

申请日：2010-11-30

申请人： David Barnes , Gregory Raymond Bebernitz , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Herbert Franz Schuster , Wei Zhang

发明人： David Barnes , Gregory Raymond Bebernitz , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Herbert Franz Schuster , Wei Zhang

IPC分类号： A01N37/18 , A61K31/16 , C07C327/48

CPC分类号： C07D413/10 , C07B2200/05 , C07C311/20 , C07C311/29 , C07C311/37 , C07C311/46 , C07C311/47 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/44 , C07C2603/74 , C07D207/06 , C07D207/08 , C07D207/263 , C07D211/16 , C07D211/18 , C07D213/40 , C07D213/71 , C07D241/04 , C07D241/08 , C07D265/30 , C07D277/26 , C07D279/12 , C07D295/088 , C07D401/06

摘要： The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式I化合物; 制备本发明化合物的方法及其治疗用途。本发明还提供药理活性剂和药物组合物的组合。

2.

发明授权
Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof 有权
标题翻译：双环乙酰辅酶A羧化酶抑制剂及其用途

公开(公告)号：US08697739B2

公开(公告)日：2014-04-15

申请号：US13189760

申请日：2011-07-25

申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su

发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su

IPC分类号： C07D215/00 , C07D235/04 , A61K31/4985 , A61K31/47

CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002

摘要： The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.

摘要翻译： 本发明提供式（I）化合物; 或其药学上可接受的盐，其中变量如本文所定义。本发明提供了制备式（I）化合物，其治疗用途，与其他药理学活性剂的组合以及药物组合物的方法。

3.

发明授权
Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof 有权

公开(公告)号：US09789118B2

公开(公告)日：2017-10-17

申请号：US14188647

申请日：2014-02-24

申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng

发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng

IPC分类号： C07D215/36 , C07D235/18 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/12 , C07D471/04 , C07D513/04 , A61K31/542 , A61K31/4184 , A61K9/00 , A61K9/08 , A61K9/107 , C12N9/00 , A61K31/404 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/30 , C07D405/14

CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002

摘要： The present invention provides compounds of formula (IV); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (IV), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.

4.

发明授权
Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5A receptor modulators 有权
标题翻译：四氢吡啶并吡啶和四氢吡啶并嘧啶化合物及其作为C5A受体调节剂的用途

公开(公告)号：US09505755B2

公开(公告)日：2016-11-29

申请号：US14455848

申请日：2014-08-08

申请人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay

发明人： Christopher Michael Adams , Veronique Darsigny , Alec Nathanson Flyer , Christine Fang Gelin , Timothy Brian Hurley , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Erik Meredith , Chang Rao , Michael H. Serrano-Wu , Catherine Fooks Solovay

IPC分类号： C07D471/04 , C07D491/107 , C07D491/044 , C07D471/10 , C07D471/08

CPC分类号： C07D471/04 , C07D471/08 , C07D471/10 , C07D491/044 , C07D491/107

摘要： The present invention provides a compound of formula I: a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

5.

发明授权
Complement factor B inhibitors and uses there of 有权
标题翻译：补体因子B抑制剂及其用途

公开(公告)号：US09475806B2

公开(公告)日：2016-10-25

申请号：US14774430

申请日：2014-03-13

申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

发明人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

IPC分类号： C07D401/14 , A61K31/4353 , A61K31/437 , C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.

6.

发明授权
Substituted aminopropionic derivatives as neprilysin inhibitors 有权
标题翻译：取代的氨基丙酸衍生物作为尿丙氨酸抑制剂

公开(公告)号：US08394853B2

公开(公告)日：2013-03-12

申请号：US12788766

申请日：2010-05-27

申请人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun

发明人： Gary Mark Coppola , Yuki Iwaki , Rajeshri Ganesh Karki , Toshio Kawanami , Gary Michael Ksander , Muneto Mogi , Robert Sun

IPC分类号： A61K31/235 , C07C229/34

CPC分类号： C07D317/34 , A61K31/197 , A61K31/216 , A61K31/325 , A61K31/351 , A61K31/357 , A61K31/41 , A61K31/421 , A61K31/44 , A61K31/505 , A61K31/5375 , A61K45/00 , A61K45/06 , C07B2200/05 , C07C233/47 , C07C233/49 , C07C233/51 , C07C233/56 , C07C233/63 , C07C235/12 , C07C235/78 , C07C237/16 , C07C237/22 , C07C255/60 , C07C271/22 , C07C275/24 , C07C311/08 , C07C311/51 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D213/82 , C07D239/28 , C07D239/34 , C07D239/36 , C07D257/04 , C07D261/18 , C07D263/32 , C07D265/30 , C07D271/06 , C07D295/15 , C07D309/32

摘要： The present invention provides a compound of formula I′; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R5, B1, X and n are defined herein. The invention also relates a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式I'化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 5，B 1，X和n如本文所定义。本发明还涉及制备本发明化合物及其治疗用途的方法。本发明还提供药理活性剂和药物组合物的组合。