公开(公告)号：US20050166911A1

公开(公告)日：2005-08-04

申请号：US10516362

申请日：2003-05-28

Applicant: Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

Inventor： Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

IPC: C13B50/00 ,  A23K1/16 ,  A23L1/30 ,  A23P1/06 ,  A61K31/7016 ,  A61P1/00 ,  C13B20/16 ,  C13K13/00 ,  C13K5/00

CPC classification number: A61K31/7016 ,  A23K20/163 ,  A23V2002/00 ,  A23V2250/614 ,  A23V2250/54246 ,  A23V2250/1582 ,  A23V2250/54252 ,  A23V2250/5488

Abstract: A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.

Abstract translation: 通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份 乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

公开(公告)号：US5417995A

公开(公告)日：1995-05-23

申请号：US953883

申请日：1992-09-30

Applicant: Mamoru Tomita ,  Kazuyoshi Sotoyama ,  Ryo Kato ,  Yuzo Asano ,  Kiyotaka Takahashi

Inventor： Mamoru Tomita ,  Kazuyoshi Sotoyama ,  Ryo Kato ,  Yuzo Asano ,  Kiyotaka Takahashi

IPC: A23D7/015 ,  A23D7/02 ,  A23D7/00

CPC classification number: A23D7/02 ,  A23D7/015

Abstract: The present invention provides a method for production of a spread, comprising the steps of:(a) two aqueous phases with different particle sizes in a fatty phase, of which at least one aqueous phase is dispersed into the fatty phase through a microporous membrane, to prepare a mixed water-in-oil type emulsion;(b) rapidly cooling the emulsion to plasticize; and(c) kneading the plasticized emulsion.According to the present invention, it is possible to produce a low-fat spread having good taste easily, which does not require a stabilizer or a gelling agent, is excellent in stability and preservativity on a level never achieved by any conventional methods.

Abstract translation: 本发明提供了一种生产扩散物的方法，包括以下步骤：（a）在脂肪相中具有不同粒度的两个水相，其中至少一个水相通过微孔膜分散到脂肪相中， 制备混合油包水型乳液; （b）快速冷却乳液进行增塑; 和（c）捏合增塑乳液。 根据本发明，可以通过常规方法从未达到的水平，稳定性和保存性优异，而且不需要稳定剂或胶凝剂，容易地制造具有良好味道的低脂肪散布。

公开(公告)号：US08248586B2

公开(公告)日：2012-08-21

申请号：US12427280

申请日：2009-04-21

Applicant: Mamoru Tomita

Inventor： Mamoru Tomita

IPC: G01N33/48 ,  G01N21/00 ,  G01B11/00 ,  G01B11/14

CPC classification number: G01N21/07 ,  G01N21/59 ,  G01N35/00584 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/1247

Abstract: A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion having an aperture which allows light to pass therethrough and holding a μ-TAS chip for holding a measurement liquid; a rotary body on which the chip holding portion is mounted; a light source; and a light-receiving unit. A measurement position of the rotary body at which the measurement liquid is to be measured with the light from the light source is set by: rotating the rotary body to obtain a light value of light which is emitted from the light source and received by the light-receiving unit through the aperture; and setting a rotational position of the rotary body where the light value is a threshold value or more, as the measurement position.

Abstract translation: 提供血液分析装置。 血液分析装置包括：芯片保持部，具有允许光通过的孔，并保持用于保持测量液体的μ-TAS芯片; 旋转体，其上安装有芯片保持部; 光源; 和光接收单元。 利用来自光源的光来测量测量液体的旋转体的测量位置是通过旋转旋转体来获得从光源发射并被光接收的光的光值 - 接收单元通过孔径; 并且将光值为阈值以上的旋转体的旋转位置设定为测量位置。

公开(公告)号：US07037377B2

公开(公告)日：2006-05-02

申请号：US10516362

申请日：2003-05-28

Applicant: Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

Inventor： Mamoru Tomita ,  Sadayuki Kokubo ,  Teruhiko Mizota ,  Nobuo Ichihashi ,  Nobuo Seki ,  Kenji Nishi

IPC: C13F3/00 ,  C13D3/16

CPC classification number: A61K31/7016 ,  A23K20/163 ,  A23V2002/00 ,  A23V2250/614 ,  A23V2250/54246 ,  A23V2250/1582 ,  A23V2250/54252 ,  A23V2250/5488

Abstract: A lactulose-containing powder composition is produced by preparing a raw material liquid so that a lactulose content within a powder produced following spray drying is 10 to 50% by weight, a protein content is 0.2 to 9.0 parts by weight per 1 part by weight of lactulose, and a chlorine content is no more than 0.08 parts by weight per 1 part by weight of protein, and subsequently subjecting this raw material liquid to spray drying.

Abstract translation: 通过制备原料液制备含乳果糖的粉末组合物，使得喷雾干燥后产生的粉末中的乳果糖含量为10〜50重量％，蛋白质含量为每1重量份的蛋白质含量为0.2〜9.0重量份 乳果糖和氯含量相对于每1重量份蛋白质不超过0.08重量份，随后使该原料液体喷雾干燥。

公开(公告)号：US06319895B1

公开(公告)日：2001-11-20

申请号：US09341316

申请日：1999-09-02

Applicant: Mamoru Tomita ,  Ryo Kato ,  Yuzo Asano ,  Kenji Nishi ,  Yuriko Iiyama ,  Tsutomu Kudo

Inventor： Mamoru Tomita ,  Ryo Kato ,  Yuzo Asano ,  Kenji Nishi ,  Yuriko Iiyama ,  Tsutomu Kudo

IPC: A61K3840

CPC classification number: A61K9/2018 ,  A61K35/741 ,  A61K38/40 ,  Y10S435/822 ,  Y10S435/853 ,  Y10S435/885 ,  A61K2300/00

Abstract: Lactoferrin tablets comprising as the active ingredients lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg; and lactoferrin tablets comprising as the active ingredients a microbial cell powder of at least one microorganism selected from among lactic acid bacteria, lactoferrin and lactulose and having a horizontal hardness of at least 4 kg and a vertical hardness of at least 3 kg. These tablets can be produced by using the conventional tableting apparatuses and yet have high hardness. Thus, they do not adhere to the inner wall of the oral cavity and have a favorable taste. Since no excessive tableting pressure is needed in the production process, moreover, these tablets can contain much viable cells of lactic acid bacteria, though they are in the form of rigid tablet.

Abstract translation: 乳铁蛋白片剂包含作为活性成分的乳铁蛋白和乳果糖，并且具有至少4kg的水平硬度和至少3kg的垂直硬度; 以及乳铁蛋白片，其包含至少一种选自乳酸菌，乳铁蛋白和乳果糖中的微生物的微生物细胞粉末作为活性成分，并且具有至少4kg的水平硬度和至少3kg的垂直硬度。 这些片剂可以通过使用常规的压片装置制造，但是具有高的硬度。 因此，它们不粘附到口腔的内壁并具有良好的味道。 由于在生产过程中不需要过量的压片压力，所以这些片剂可以含有很多活细胞的乳酸菌，尽管它们是刚性片剂的形式。

公开(公告)号：US5804555A

公开(公告)日：1998-09-08

申请号：US381984

申请日：1995-04-11

Applicant: Mamoru Tomita ,  Seiichi Shimamura ,  Kouzo Kawase ,  Yasuo Fukuwatari ,  Mitsunori Takase ,  Wayne Robert Bellamy ,  Koji Yamauchi ,  Hiroyuki Wakabayashi ,  Yukiko Tokida

Inventor： Mamoru Tomita ,  Seiichi Shimamura ,  Kouzo Kawase ,  Yasuo Fukuwatari ,  Mitsunori Takase ,  Wayne Robert Bellamy ,  Koji Yamauchi ,  Hiroyuki Wakabayashi ,  Yukiko Tokida

IPC: A61K8/96 ,  A23L3/3526 ,  A23L3/3571 ,  A61K8/00 ,  A61K8/64 ,  A61K8/66 ,  A61K8/98 ,  A61K38/00 ,  A61K38/16 ,  A61P39/06 ,  A61P43/00 ,  A61Q11/00 ,  A61Q19/00 ,  C09K15/18 ,  C09K15/22 ,  C11B5/00 ,  A61K38/01 ,  C07K14/79

CPC classification number: C09K15/18 ,  A23L3/3526 ,  A23L3/3571 ,  C09K15/22 ,  C11B5/0007

Abstract: The present invention provides a safe antioxidant applicable for food, drug medicine, non-medical drug and other products. The antioxidant of the present invention contains, as an effective ingredient, an antioxidant substance selected from the group consisting of a hydrolysate of lactoferrin, one or more peptides isolated from a hydrolysate of lactoferrins, one or more synthetic peptides having the same sequence as that of the peptide isolated from the hydrolysate of lactoferrins, and any mixture thereof, or said antioxidant substance and oxidant preventive agent. This antioxidant has an excellent antioxidant action for various lipids, and is very safe even when used in foods and drug medicine. Scince it exhibits antioxidant effect with only small quantity, there is almost no adverse effect on flavor even when applied in foods and the like.

Abstract translation: PCT No.PCT / JP93 / 01090 Sec。 371日期1995年04月11日 102（e）日期1995年4月11日PCT提交1993年8月4日PCT公布。 第WO94 / 03555号公报 日期1994年2月17日本发明提供了适用于食品，药物，非医药等产品的安全抗氧化剂。 本发明的抗氧化剂含有选自乳铁蛋白的水解产物，从乳铁蛋白水解产物分离的一种或多种肽的一种或多种肽，作为有效成分的一种或多种合成肽，具有与 分离自乳铁蛋白的水解产物的肽，及其任何混合物，或所述抗氧化物质和氧化剂预防剂。 这种抗氧化剂对各种脂质具有优异的抗氧化作用，即使用于食品和药物也非常安全。 Scince它仅具有少量的抗氧化作用，即使应用于食品等也几乎没有不利影响。

公开(公告)号：US5543392A

公开(公告)日：1996-08-06

申请号：US374785

申请日：1995-04-03

Applicant: Mamoru Tomita ,  Seiichi Shimamura ,  Yasuo Fukuwatari ,  Ichizo Shinoda

Inventor： Mamoru Tomita ,  Seiichi Shimamura ,  Yasuo Fukuwatari ,  Ichizo Shinoda

IPC: A61K38/00 ,  A61K38/01 ,  A61K38/16 ,  A61K38/40 ,  A61P1/00 ,  A61P43/00 ,  A61K38/14 ,  A61K38/18

CPC classification number: A61K38/1808 ,  A61K38/40

Abstract: The present invention provides an activating agent of digestive tract cells, which contains an epidermal growth factor, lactoferrins, a hydrolysate of the lactoferrins, or a mixture thereof.The activating agent of digestive tract cells of the present invention has such effects as prevention and improvement of a damage to the digestive tract, improvement of digestive tract functions deteriorating with age, and acceleration of growth and proliferation of digestive tract cells of a newborn. It is also possible to add it to, or mixed with, various food products to obtain digestive tract cels activating foods.

Abstract translation: PCT No.PCT / JP93 / 00235 Sec。 371日期：1995年4月3日 102（e）日期1995年4月3日PCT提交1993年2月25日PCT公布。 公开号WO94 / 03203 日期：1994年2月17日本发明提供消化道细胞活化剂，其含有表皮生长因子，乳铁蛋白，乳铁蛋白的水解物或其混合物。 本发明的消化道细胞的活化剂具有预防和改善消化道损伤，改善消化道功能随年龄恶化，加速新生儿消化道细胞生长和增殖的作用。 也可以将其添加到各种食品中或与其混合以获得消化道丝激活食物。

公开(公告)号：US5322836A

公开(公告)日：1994-06-21

申请号：US917693

申请日：1991-03-06

Applicant: Mamoru Tomita ,  Seiichi Shimamura ,  Yasuo Fukuwatari ,  Hiroshi Miyakawa ,  Hitoshi Saito

Inventor： Mamoru Tomita ,  Seiichi Shimamura ,  Yasuo Fukuwatari ,  Hiroshi Miyakawa ,  Hitoshi Saito

IPC: A61K38/16 ,  A23C9/123 ,  A23K1/16 ,  A23L1/30 ,  A61K38/00 ,  A61P1/12 ,  C07K14/79 ,  C12N1/20 ,  C12N1/38 ,  C12R1/01 ,  A61K37/14 ,  A23C9/12 ,  A23C17/00

CPC classification number: C12N1/38 ,  A23C9/1234 ,  A23K20/147 ,  C07K14/79 ,  A61K38/00 ,  Y10S530/832

Abstract: Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.

Abstract translation: 由双歧杆菌生长促进活性的生物活性剂，由一种或多种选自牛乳铁蛋白，牛非球蛋白铁和牛铁铁乳蛋白的乳铁蛋白化合物组成，可作为促进双歧杆菌增殖的药剂 以及用作制备组合物，材料和产品以提供生长促进活性的添加剂，以及如果其中包含双歧杆菌的生存能力的添加剂。

公开(公告)号：US5214028A

公开(公告)日：1993-05-25

申请号：US634763

申请日：1990-12-27

Applicant: Mamoru Tomita ,  Kouzou Kawase ,  Yoshitaka Tamura ,  Mitsunori Takase ,  Hiroshi Miyakawa ,  Koji Yamauchi ,  Hitoshi Saito ,  Hiroaki Abe ,  Seiichi Shimamura ,  Susumu Kobayashi

Inventor： Mamoru Tomita ,  Kouzou Kawase ,  Yoshitaka Tamura ,  Mitsunori Takase ,  Hiroshi Miyakawa ,  Koji Yamauchi ,  Hitoshi Saito ,  Hiroaki Abe ,  Seiichi Shimamura ,  Susumu Kobayashi

IPC: A01N63/02 ,  A23J3/32 ,  A23J3/34 ,  A23L3/3526 ,  A61K8/64 ,  A61K38/01 ,  A61Q19/02

CPC classification number: A61Q17/005 ,  A01N63/02 ,  A23J3/32 ,  A23J3/343 ,  A23L3/3526 ,  A61K38/40 ,  A61K8/64 ,  A61Q19/02 ,  A61K2800/782

Abstract: Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.

公开(公告)号：US4057655A

公开(公告)日：1977-11-08

申请号：US702680

申请日：1976-07-06

Applicant: Katsuto Okada ,  Katsuhiro Ogasa ,  Mamoru Tomita

Inventor： Katsuto Okada ,  Katsuhiro Ogasa ,  Mamoru Tomita

IPC: C13K13/00 ,  A23K1/08

CPC classification number: C13K13/005 ,  Y10S426/807

Abstract: A process for preparing a free-flowing lactulose-containing powder from a solution containing lactose, by adding calcium hydroxide to the solution to adjust the pH of said solution to from 9.4 to 11.2; heating the resulting solution so that the pH is reduced to from 7.5 to 9.0; the homogenizing, concentrating and drying.

Abstract translation: 通过向溶液中加入氢氧化钙以将所述溶液的pH调节至9.4至11.2，由含有乳糖的溶液制备含自由流动含乳果糖的粉末的方法; 加热所得溶液使pH降至7.5至9.0; 均质，浓缩和干燥。