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1.发明授权Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效乳铁蛋白水解物用作抗菌剂和酪氨酸酶抑制剂
公开(公告)号：US5389611A
公开(公告)日：1995-02-14
申请号：US803955
申请日：1991-12-09
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
IPC分类号： A01N63/02 , A23J3/32 , A23J3/34 , A23L3/3526 , A61K8/64 , A61K38/01 , A61Q19/02 , C07K3/10 , C07K1/12
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent, and which have remarkably more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
摘要翻译： 乳铁蛋白水解物，通过甲酸滴定测定的分解率为6％-20％，用作抗菌剂，并且具有比未水解的乳铁蛋白显着更强的活性; 和通过甲酸滴定测定的分解率为4-50％的乳铁蛋白水解物，用作酪氨酸酶抑制剂，可通过用酸或酶水解的常规方法获得，并且对加热稳定。
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2.发明授权Lactoferrin hydrolyzate for use as an antibacterial agent and as a tyrosinase inhibition agent 失效用作抗菌剂和作为酪氨酸酶抑制剂的LACTOFERRIN水解产物
公开(公告)号：US5214028A
公开(公告)日：1993-05-25
申请号：US634763
申请日：1990-12-27
申请人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
发明人： Mamoru Tomita , Kouzou Kawase , Yoshitaka Tamura , Mitsunori Takase , Hiroshi Miyakawa , Koji Yamauchi , Hitoshi Saito , Hiroaki Abe , Seiichi Shimamura , Susumu Kobayashi
CPC分类号： A61Q17/005 , A01N63/02 , A23J3/32 , A23J3/343 , A23L3/3526 , A61K38/40 , A61K8/64 , A61Q19/02 , A61K2800/782
摘要： Lactoferrin hydrolyzates, having a decomposition rate between 6%-20% as measured by formol titration, for use as an antibacterial agent and which have remarkly more potent activity than unhydrolyzed lactoferrin; and lactoferrin hydrolyzates, having a decomposition rate between 4-50% as measured by formol titration, for use as a tyrosinase inhibition agent, are obtainable by conventional methods for hydrolysis with acids or enzymes, and are stable to heating.
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3.发明授权Method for heat treatment of lactoferrin without losing physiological activities thereof 失效乳铁蛋白的热处理方法，而不会失去其生理活性
公开(公告)号：US5340924A
公开(公告)日：1994-08-23
申请号：US860224
申请日：1992-03-27
申请人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
发明人： Mamoru Tomita , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Hiroaki Abe , Eiji Nagao
CPC分类号： A23J1/20 , A23J3/08 , C07K14/79 , Y10S530/832
摘要： A method for treatment of a matter which contains moisturized or liquified lactoferrin which has been isolated from mammalian milk, processed mammalian milk and by-products in mammalian milk-processing, without losing the physiological activities of lactoferrin, which comprises adjusting pH of said moisturized or liquefied lactoferrin contained in said matter within an acidic range between 2.0 and 6.0 both inclusive by adding acid or aqueous solution of acid when the pH of said moisturized or liquefied lactoferrin is out of said pH range, and heating said matter in the range from 60.degree. C. to 130.degree. C. for a span of time which may assure 60% or more of undenaturization rate of lactoferrin.
摘要翻译： 一种处理含有保湿或液化的乳铁蛋白的物质的方法，其已从哺乳动物乳，加工的哺乳动物乳和哺乳动物乳加工中的副产物中分离出来，而不损失乳铁蛋白的生理活性，其包括调节所述保湿或 当所述保湿或液化的乳铁蛋白的pH在所述pH范围之外时，通过加入酸或酸的水溶液，在所述物质中含有的液化乳铁蛋白在2.0至6.0之间的酸性范围内，并且将所述物质加热到60℃ 在130℃下，可以确保乳铁蛋白的未饱和化率达到60％以上。
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4.发明授权Bioactive agents, compositions and materials comprising said bioactive agents 失效包含所述生物活性剂的生物活性剂，组合物和材料
公开(公告)号：US5322836A
公开(公告)日：1994-06-21
申请号：US917693
申请日：1991-03-06
IPC分类号： A61K38/16 , A23C9/123 , A23K1/16 , A23L1/30 , A61K38/00 , A61P1/12 , C07K14/79 , C12N1/20 , C12N1/38 , C12R1/01 , A61K37/14 , A23C9/12 , A23C17/00
CPC分类号： C12N1/38 , A23C9/1234 , A23K20/147 , C07K14/79 , A61K38/00 , Y10S530/832
摘要： Bioactive agents, having growth-promoting activity upon Bifidobacteria, consisting of one or more lactoferrin-compounds selected from the group consisting of bovine lactoferrin, bovine apolactoferrin and bovine Fe-lactoferrin, which can be used as it is as agents to promote proliferation of Bifidobacteria both in vivo and in vitro, and as additives to prepare compositions, materials and products to afford growth-promoting activity thereto, and to improve survivability of Bifidobacteria, if contained therein.
摘要翻译： 由双歧杆菌生长促进活性的生物活性剂，由一种或多种选自牛乳铁蛋白，牛非球蛋白铁和牛铁铁乳蛋白的乳铁蛋白化合物组成，可作为促进双歧杆菌增殖的药剂 以及用作制备组合物，材料和产品以提供生长促进活性的添加剂，以及如果其中包含双歧杆菌的生存能力的添加剂。
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5.发明授权Bioactive agents and compositions for materials comprising the bioactive agent and a method for treating materials therewith 失效用于包含生物活性剂的材料的生物活性剂和组合物以及用于处理材料的方法
公开(公告)号：US5296464A
公开(公告)日：1994-03-22
申请号：US780535
申请日：1991-10-21
IPC分类号： A01N63/02 , A23C9/152 , A23J1/20 , A23K1/16 , A23K1/175 , A23L3/3463 , A23L3/3526 , A61K38/00 , C07K14/79 , A61K37/14 , C07K15/22 , C12N1/38
CPC分类号： C07K14/79 , A01N63/02 , A23C9/1522 , A23J1/20 , A23K20/147 , A23K20/30 , A23L3/3463 , A23L3/3526 , A61K38/00
摘要： Bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin and having selective biological activities, i.e. growth-inhibitory activity against certain harmful microorganisms on one hand and growth-promoting activity upon certain useful microorganisms on the other hand; as well as compositions, products or materials therefor comprising the bioactive agents consisting of one or more lactoferrin-compounds selected from the group; and a method for treating materials, which are edible for human beings or animals or which are applicable to a portion of body of human beings or animals, with the bioactive agents consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin or the compositions comprising the bioactive agent consisting of one or more lactoferrin-compounds selected from the group consisting of Zn-, Cu- and Mn-lactoferrin as an effective component.
摘要翻译： 由选自Zn-，Cu-和Mn-乳铁蛋白的一种或多种乳铁蛋白化合物组成并具有选择性生物活性的生物活性剂，即一方面对某些有害微生物的生长抑制活性，以及一定程度上的生长促进活性 另一方面有用的微生物; 以及其组合物，产品或材料，其包含由选自该组的一种或多种乳铁蛋白化合物组成的生物活性剂; 以及用于处理可用于人类或动物或适用于人或动物的一部分身体的材料的方法，所述生物活性剂由一种或多种选自以下的乳铁蛋白化合物组成：Zn- ，Cu-和Mn-乳铁蛋白或包含由一种或多种选自Zn-，Cu-和Mn-乳铁蛋白作为有效成分的乳铁蛋白化合物组成的生物活性剂的组合物。
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公开(公告)号：US06395508B1
公开(公告)日：2002-05-28
申请号：US09316957
申请日：1999-05-24
申请人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
发明人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
IPC分类号： A23C2102
CPC分类号： A61K38/018 , A23J3/08 , A23J3/343 , A23L33/18 , A61K38/01 , Y10S530/833
摘要： A method for producing a peptide mixture from a starting protein by (1) adding at least one protease to an aqueous solution of at least one starting protein to hydrolyse the starting protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the starting protein, (3) calculating the amount of the free amino acid with respect to the total amount of amino acid contained in the starting protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the starting protein falls within a predetermined range. The inventive method provides a starting protein hydrolysate of uniform and consistent quality.
摘要翻译： （1）在至少一种起始蛋白质的水溶液中加入至少一种蛋白酶以水解起始蛋白质的方法，从起始蛋白质制备肽混合物的方法，（2）测量游离氨基酸的量 在起始蛋白水解期间产生的赖氨酸，苯丙氨酸，亮氨酸和精氨酸组成的组，（3）计算游离氨基酸相对于起始蛋白质中所含氨基酸总量的量，以及（4）终止 当游离氨基酸的计算量相对于起始蛋白质中含有的氨基酸总量的计算量落在预定范围内时，水解。 本发明的方法提供均匀且一致质量的起始蛋白质水解产物。
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公开(公告)号：US5952193A
公开(公告)日：1999-09-14
申请号：US817095
申请日：1997-04-14
申请人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
发明人： Seiichi Shimamura , Yoshitaka Tamura , Hiroshi Miyakawa , Hitoshi Saito , Yasushi Kawaguchi , Naoko Isomura , Yoko Akazome , Hiroshi Ochi , Mihoko Kawamoto
CPC分类号： A61K38/018 , A23J3/08 , A23J3/343 , A23L33/18 , A61K38/01 , Y10S530/833
摘要： A method for producing a peptide mixture from whey protein by (1) adding at least one protease to an aqueous solution of at least one whey protein to hydrolyze the whey protein, (2) measuring the amount of a free amino acid selected from the group consisting of lysine, phenylalanine, leucine and arginine produced during the hydrolysis of the whey protein, (3) calculating the amount of the free amino acid with respect to the total amount of the amino acid contained in the whey protein, and (4) terminating the hydrolysis when the calculated amount of the free amino acid with respect to the total amount of the amino acid contained in the whey protein falls within a predetermined range. The inventive method provides a whey protein hydrolysate of consistent quality.
摘要翻译： PCT No.PCT / JP95 / 02109 Sec。 371日期1997年04月14日 102（e）1997年4月14日PCT 1995年10月13日PCT PCT。 公开号WO96 / 11584 日期：1996年04月25日（一）通过（1）向至少一种乳清蛋白的水溶液中加入至少一种蛋白酶以水解乳清蛋白，从乳清蛋白制备肽混合物的方法，（2）测量游离氨基 选自在乳清蛋白水解期间产生的赖氨酸，苯丙氨酸，亮氨酸和精氨酸的酸，（3）计算游离氨基酸相对于乳清蛋白中所含氨基酸总量的量， 和（4）当游离氨基酸的计算量相对于乳清蛋白中所含氨基酸总量的计算量落在预定范围内时，终止水解。 本发明的方法提供了质量一致的乳清蛋白水解产物。
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公开(公告)号：US07022676B2
公开(公告)日：2006-04-04
申请号：US10496200
申请日：2002-11-21
申请人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
发明人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
IPC分类号： A61K38/00
CPC分类号： C07K14/4732 , A61K38/00 , C07K5/081
摘要： A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs.
摘要翻译： 用酪蛋白水解化学合成获得的肽Met-Lys-Pro作为血管紧张素转换酶抑制剂或降血压药物的有效成分。
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公开(公告)号：US20050004041A1
公开(公告)日：2005-01-06
申请号：US10496200
申请日：2002-11-21
申请人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
发明人： Yoshitaka Tamura , Hiroshi Miyakawa , Akio Yamada , Hitoshi Saito , Yasushi Kawaguchi , Hiroshi Ochi , Tomoko Ide , Eri Inoue
CPC分类号： C07K14/4732 , A61K38/00 , C07K5/081
摘要： A peptide Met-Lys-Pro, which is obtained by chemical synthesis ot hydrolysis of casein, is used as the active ingredient of angiotensin converting enzyme inhibitors or hypotensive drugs.
摘要翻译： 用酪蛋白水解化学合成获得的肽Met-Lys-Pro作为血管紧张素转换酶抑制剂或降血压药物的有效成分。
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公开(公告)号：US08795750B2
公开(公告)日：2014-08-05
申请号：US13497646
申请日：2010-09-24
申请人： Nobuo Seki , Masatoshi Ohnishi , Kie Kinoshita , Yoshitaka Tamura , Hitoshi Saito , Hiroshi Ochi , Takafumi Kimura
发明人： Nobuo Seki , Masatoshi Ohnishi , Kie Kinoshita , Yoshitaka Tamura , Hitoshi Saito , Hiroshi Ochi , Takafumi Kimura
CPC分类号： A23C9/1425 , A23C9/146 , A23J3/08 , A23L33/40 , A23V2002/00 , A23V2250/54252 , A23V2300/30 , A23V2300/34
摘要： A method of manufacturing a low-phosphorus whey, the method including subjecting a raw whey liquid to a demineralization treatment using a nanofiltration method to obtain a low-chloride whey liquid in which the chloride content has been reduced to not more than 30 mmol per 100 g of solids, and passing the low-chloride whey liquid through an ion exchange resin to obtain an ion-exchanged whey liquid having a reduced phosphorus content, wherein the ion exchange resin is composed of an anion exchange resin, and at least an anion exchange resin in chloride form is used as the anion exchange resin. The method of manufacturing a low-phosphorus whey can reduce the phosphorus content within the whey while suppressing reduction in the calcium and magnesium content.
摘要翻译： 一种低磷乳清的制造方法，其特征在于，使用纳滤法对原料乳清液进行脱盐处理，得到氯化物含量降低至不足30mmol / L以下的低氯化物乳清液 g的固体，并使低氯化物乳清液通过离子交换树脂，得到具有降低的磷含量的离子交换乳清液，其中所述离子交换树脂由阴离子交换树脂构成，并且至少阴离子交换 使用氯化物形式的树脂作为阴离子交换树脂。 制备低磷乳清的方法可以降低乳清中的磷含量，同时抑制钙和镁含量的降低。
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