Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis
    1.
    发明授权
    Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis 有权
    通过频谱控制氢氘交换

    公开(公告)号:US09484194B2

    公开(公告)日:2016-11-01

    申请号:US13885913

    申请日:2011-11-16

    Abstract: A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.

    Abstract translation: 公开了一种质谱仪,其包括用于分离离子的液相色谱装置。 气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。 控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置,其中在第一操作模式中,使至少一些母体或前体离子在反应中反应 器件,并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

    MALDI Imaging and Ion Source
    4.
    发明申请
    MALDI Imaging and Ion Source 有权
    MALDI成像和离子源

    公开(公告)号:US20150034814A1

    公开(公告)日:2015-02-05

    申请号:US14130453

    申请日:2012-07-06

    Abstract: An ion source for a mass spectrometer is disclosed comprising a lens and mirror arrangement which focuses a laser beam onto the upper surface of a target substrate. The lens has an effective focal length ≦300 mm. The laser beam is directed onto the target substrate at an angle θ with respect to the perpendicular to the target substrate, wherein θ≦3°. One or more ion guides receive ions released from the target substrate and onwardly transmit the ions along an ion path which substantially bypasses the lens and mirror.

    Abstract translation: 公开了一种用于质谱仪的离子源,其包括将激光束聚焦到目标衬底的上表面上的透镜和反射镜装置。 镜头具有有效的焦距≦̸ 300 mm。 激光束以一定角度被引导到靶基底上; 相对于与靶基板的垂直度,其中& nlE; 3°。 一个或多个离子导向器接收从目标衬底释放的离子,并沿基本上绕过透镜和反射镜的离子路径向上透射离子。

    Mass Spectrometer Incorporating Hydrogen-Deuterium Exchange
    8.
    发明申请
    Mass Spectrometer Incorporating Hydrogen-Deuterium Exchange 有权
    合成氢氘交换的质谱仪

    公开(公告)号:US20130206974A1

    公开(公告)日:2013-08-15

    申请号:US13578397

    申请日:2011-02-14

    CPC classification number: H01J49/0031 G01N27/622 H01J49/0077 H01J49/02

    Abstract: A mass spectrometer is disclosed comprising a hydrogen-deuterium exchange cell. Isomeric ions having different conformations but substantially similar ion mobilities can be differentiated by subjecting the ions to hydrogen-deuterium exchange. Two ions having similar ion mobilities can be differentiated more effectively if they have different surface conformations by determining the relative degree of hydrogen-deuterium exchange.

    Abstract translation: 公开了一种包含氢 - 氘交换电池的质谱仪。 具有不同构象但基本上相似的离子迁移率的异构离子可以通过使离子进行氢氘交换来分化。 具有相似离子迁移率的两个离子如果通过确定氢 - 氘交换的相对程度而具有不同的表面构象,可以更有效地区分。

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