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    MICROFLUIDIC CELL
    1.
    发明申请
    MICROFLUIDIC CELL 审中-公开
    微流感细胞

    公开(公告)号：US20110139621A1

    公开(公告)日：2011-06-16

    申请号：US12853920

    申请日：2010-08-10

    申请人： Michael Stumber ,  Martina Daub ,  Jochen Rupp ,  Massimo Kubon ,  Peter Rothacher ,  Meike Moschallski ,  Martin Stelzle ,  Christian Dorrer

    发明人： Michael Stumber ,  Martina Daub ,  Jochen Rupp ,  Massimo Kubon ,  Peter Rothacher ,  Meike Moschallski ,  Martin Stelzle ,  Christian Dorrer

    IPC分类号： G01N27/453 ,  G01N27/447

    CPC分类号： G01N27/44704 ,  G01N27/44791

    摘要： A microfluidic cell for the dielectrophoretic separation, accumulation, and/or lysis of polarizable bioparticles, including an interdigital electrode system composed of two electrode groups having interdigitated electrodes, a flat electrode in which the interdigital electrode system and the flat electrode are situated on opposite sides of the cell in order to improve the separation, accumulation and/or lysis characteristics. Moreover, a microfluidic system which includes such a microfluidic cell, and use thereof, and a method for separating, accumulating, and/or lysing polarizable bioparticles is also described.

    摘要翻译： 用于可极化生物颗粒的介电电泳分离，积累和/或裂解的微流体细胞，包括由具有交叉指向电极的两个电极组构成的交叉指状电极系统，其中叉指电极系统和平面电极位于相对侧上的扁平电极 以提高分离，积累和/或裂解特性。 此外，还描述了包括这种微流体细胞的微流体系统及其用途，以及用于分离，积聚和/或裂解可极化生物颗粒的方法。

    Microfluidic system and method for assembling and for subsequently cultivating, and subsequent analysis of complex cell arrangements
    3.
    发明授权
    Microfluidic system and method for assembling and for subsequently cultivating, and subsequent analysis of complex cell arrangements 有权
    微流体系统以及用于组装和随后培养以及随后分析复杂细胞装置的方法

    公开(公告)号：US08968543B2

    公开(公告)日：2015-03-03

    申请号：US13427733

    申请日：2012-03-22

    申请人： Martin Stelzle ,  Brigitte Angres ,  Massimo Kubon ,  Julia Schuette ,  Britta Hagmeyer ,  Felix Holzner

    发明人： Martin Stelzle ,  Brigitte Angres ,  Massimo Kubon ,  Julia Schuette ,  Britta Hagmeyer ,  Felix Holzner

    IPC分类号： B01D57/02 ,  C12M3/06 ,  C12M3/00 ,  C12M1/42 ,  C12M1/26 ,  B01L3/00

    CPC分类号： C12M23/16 ,  B01L3/5027 ,  C12M21/08 ,  C12M33/00 ,  C12M35/02

    摘要： The present invention provides an apparatus and a method to assemble organotypical tissues which can then be perfused and investigated under preferably physiological conditions. This is achieved by a microfluidic system for assembling and subsequently cultivating complex cell arrangements, comprising: a three-dimensional microstructure in which the cell arrangement is assembled and cultivated, at least two microchannel segments running in the microstructure and defining a flow direction, through which microchannel segments the microstructure can be perfused from outside with a medium, whereby the microchannel segments run approximately parallel or equidistant to one another at least in sections, a wall structure which separates the at least two microchannel segments and in which at least one aperture connecting the at least two microchannel segments is provided, and an electrode arrangement provided in or on the microstructure in order to generate an inhomogeneous electric field in the region of the at least one aperture.

    摘要翻译： 本发明提供了一种组装器官组织的装置和方法，其可以在优选的生理条件下进行灌注和研究。 这通过用于组装和随后培养复杂细胞结构的微流体系统实现，其包括：其中组装和培养细胞排列的三维微结构，在微结构中运行并限定流动方向的至少两个微通道区段， 微通道段可以从外部用介质灌注微结构，由此微通道段至少在部分上相互平行或等距离地延伸，壁结构分隔至少两个微通道段，其中至少一个孔连接 提供至少两个微通道段，以及设置在微结构中或其上的电极布置，以便在至少一个孔的区域中产生不均匀的电场。

    Method and device for collecting suspended particles
    4.
    发明授权
    Method and device for collecting suspended particles 失效
    用于收集悬浮颗粒的方法和装置

    公开(公告)号：US07879214B2

    公开(公告)日：2011-02-01

    申请号：US11568895

    申请日：2005-05-06

    申请人： Thomas Schnelle ,  Torsten Muller ,  Jorg Kentsch ,  Frank Grom ,  Martin Stelzle

    发明人： Thomas Schnelle ,  Torsten Muller ,  Jorg Kentsch ,  Frank Grom ,  Martin Stelzle

    IPC分类号： B03C5/02

    CPC分类号： B03C5/026

    摘要： A description is given of methods for collecting particles (1, 2) which are suspended in a liquid, including the following steps: providing the liquid containing the suspended particles (1, 2) in a compartment (10) having lateral surfaces (11), wherein at least one electrode (21) is arranged on at least one of the lateral surfaces (11), and generating high-frequency electric fields by means of the at least one electrode (21) so as to form at least one circulating flow (30), by means of which the particles (1, 2) are guided to at least one predetermined collecting area (40) in the compartment (10), wherein the flow (30) is formed in such a way that at least one branch of the flow runs along a longitudinal extent of the at least one electrode (21), and the flow (30) circulates about an axis (31) which is oriented perpendicular to the respectively adjacent lateral surface (11) with the electrode (21). Corresponding devices for collecting particles are also described.

    摘要翻译： 给出了用于收集悬浮在液体中的颗粒（1,2）的方法的描述，包括以下步骤：将含有悬浮颗粒（1,2）的液体提供在具有侧表面（11）的隔室（10）中， ，其中至少一个电极（21）布置在所述侧表面（11）中的至少一个上，并且通过所述至少一个电极（21）产生高频电场，以便形成至少一个循环流 （30），所述颗粒（1,2）通过所述颗粒（1,2）被引导到所述隔室（10）中的至少一个预定收集区域（40），其中所述流动（30）形成为使得至少一个 流动的分支沿着至少一个电极（21）的纵向延伸，并且流动（30）围绕垂直于相邻的侧表面（11）的电极（21）的轴线（31）循环 ）。 还描述了用于收集颗粒的相应装置。

    Active retina implant with a multiplicity of pixel elements
    5.
    发明申请
    Active retina implant with a multiplicity of pixel elements 有权
    活性视网膜植入物具有多个像素元素

    公开(公告)号：US20060184245A1

    公开(公告)日：2006-08-17

    申请号：US11305920

    申请日：2005-12-19

    申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    IPC分类号： A61F2/14

    CPC分类号： A61N1/36046

    摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

    摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

    Retina implant assembly and methods for manufacturing the same
    6.
    发明授权
    Retina implant assembly and methods for manufacturing the same 有权
    视网膜植入组件及其制造方法

    公开(公告)号：US06847847B2

    公开(公告)日：2005-01-25

    申请号：US10011641

    申请日：2001-11-07

    申请人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

    发明人： Wilfried Nisch ,  Alfred Stett ,  Markus Schubert ,  Michael Graf ,  Heinz Gerhard Graf ,  Hugo Hämmerle ,  Eberhart Zrenner ,  Martin Stelzle ,  Helmut Sachs

    IPC分类号： A61F2/14 ,  A61F9/08 ,  A61N1/36

    CPC分类号： A61N1/0543 ,  A61F2/14 ,  A61F9/08 ,  A61N1/3787

    摘要： A retina implant including a chip adapted to be implanted into the interior of eye in subretinal contact with the retina. The chip has a plurality of pixel elements on a side thereof facing the lens for receiving an image projected into the retina and a plurality of electrodes for stimulating retina cells. The implants further includes a receiver coil for inductively coupling thereinto electromagnetic energy. The receiver coil coupled to a means for converting an alternating voltage induced into the receiver coil in a direct voltage suited for supplying the chip. The receiver coil is configured as a component separate from the chip, and for being positioned on the eye ball outside the sclera. The chip is connected to the receiver coil via a connecting lead which, in the implanted condition interconnects the interior and the exterior of the eye ball.

    摘要翻译： 一种视网膜植入物，包括适于植入眼睛内部的芯片，视网膜视网膜与视网膜接触。 该芯片在面向透镜的一侧具有多个像素元件，用于接收投影到视网膜中的图像，以及多个用于刺激视网膜细胞的电极。 植入物还包括用于感应地耦合到其中的电磁能的接收器线圈。 接收器线圈耦合到用于将感应到接收器线圈的交流电压以适于供应芯片的直流电压的装置。 接收器线圈被配置为与芯片分离的部件，并且用于定位在巩膜外的眼球上。 芯片通过连接引线连接到接收器线圈，该连接引线在植入条件下将眼球的内部和外部互连。

    Microelement device
    7.
    发明授权
    Microelement device 失效
    微量元件

    公开(公告)号：US06315940B1

    公开(公告)日：2001-11-13

    申请号：US09311780

    申请日：1999-05-13

    申请人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

    发明人： Wilfried Nisch ,  Alfred Stett ,  Ulrich Egert ,  Martin Stelzle

    IPC分类号： G01N2726

    CPC分类号： G01N33/48728 ,  C12M23/12 ,  C12M35/02 ,  C12M41/46 ,  G01N21/763

    摘要： A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment. The cells are guided onto the microelectrodes, are isolated or are mechanically attracted to the microelectrodes. A negative-pressure force or a hydrodynamic force may be applied on the cells. Also described are a method for making contact to the cells, and a method for manufacturing the microelement device is disclosed.

    摘要翻译： 微元件具有多个微元件，其可以被配置为微电极，布置在基板上并且适于与存在于液体环境中的电池接触。 细胞被引导到微电极上，被隔离或机械地吸引到微电极。 可以在电池上施加负压力或流体动力。 还描述了与细胞接触的方法，并且公开了一种用于制造微量元件的方法。

    Active retina implant with a multiplicity of pixel elements
    9.
    发明授权
    Active retina implant with a multiplicity of pixel elements 有权
    活性视网膜植入物具有多个像素元素

    公开(公告)号：US07751896B2

    公开(公告)日：2010-07-06

    申请号：US11305920

    申请日：2005-12-19

    申请人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    发明人： Heinz-Gerhard Graf ,  Alexander Dollberg ,  Bernd Hoefflinger ,  Wilfried Nisch ,  Hugo Haemmerle ,  Alfred Stett ,  Martin Stelzle ,  Eberhart Zrenner

    IPC分类号： A61F2/14

    CPC分类号： A61N1/36046

    摘要： An active retina implant has a multiplicity of pixel elements that convert incident light into electric stimulation signals for cells of the retina with which stimulation electrodes are to make contact. Each pixel element is provided with at least one image cell that converts incident light into electric signals, there being provided at least one amplifier whose input is connected to the image cell and whose output is connected to at least one stimulation electrode to which it supplies a stimulation signal. Also provided is an energy supply which provides externally coupled external energy as supply voltage for the image cells and the amplifiers. The image cell has a logarithmic characteristic according to which incident light of specific intensity is converted into electric signals of specific amplitude. The stimulation signal is supplied in the form of analog voltage pulses of specific pulse length and pulse spacings, the pulse amplitude being a function of the intensity of the incident light.

    摘要翻译： 活性视网膜植入物具有多个像素元件，其将入射光转换成用于刺激电极与之接触的视网膜细胞的电刺激信号。 每个像素元件设置有将入射光转换成电信号的至少一个图像单元，其中提供至少一个放大器，其输入端连接到图像单元，其输出端连接至至少一个刺激电极， 刺激信号。 还提供了一种将外部耦合的外部能量作为图像单元和放大器的电源电压的能量供给。 图像单元具有对数特性，根据该特性，将特定强度的入射光转换成特定幅度的电信号。 刺激信号以特定脉冲长度和脉冲间隔的模拟电压脉冲的形式提供，脉冲幅度是入射光强度的函数。

    PAIR OF MEASURING ELECTRODES, BIOSENSOR COMPRISING A PAIR OF MEASURING ELECTRODES OF THIS TYPE, AND PRODUCTION PROCESS
    10.
    发明申请
    PAIR OF MEASURING ELECTRODES, BIOSENSOR COMPRISING A PAIR OF MEASURING ELECTRODES OF THIS TYPE, AND PRODUCTION PROCESS 审中-公开
    测量电极对，包含该类型的测量电极的生物传感器和生产过程

    公开(公告)号：US20100084267A1

    公开(公告)日：2010-04-08

    申请号：US12567621

    申请日：2009-09-25

    申请人： Martin Stelzle ,  Wilfried Nisch

    发明人： Martin Stelzle ,  Wilfried Nisch

    IPC分类号： G01N27/26 ,  B05D5/12 ,  B44C1/22

    CPC分类号： G01N27/3278 ,  Y10S977/957 ,  Y10T29/49002

    摘要： A pair of measuring electrodes comprising a first and a second, preferably in each case sheet-like electrode comprises an insulation layer arranged between said electrodes. One or more nanopores, which extend through said insulation layer as far as said first electrode, the surface of which is at least partially uncovered by said nanopores, are provided in each second electrode. The invention also describes a biosensor comprising a pair of measuring electrodes of this type, an electrochemical cell comprising a biosensor of this type and a process for producing said pair of measuring electrodes.

    摘要翻译： 包括第一和第二测量电极的一对测量电极，优选地在每种情况下都是片状电极，包括布置在所述电极之间的绝缘层。 在每个第二电极中设置有一个或多个纳米孔，其延伸穿过所述绝缘层，直到所述第一电极的表面至少部分地不被所述纳米孔覆盖。 本发明还描述了一种生物传感器，其包括一对这种测量电极，包括这种类型的生物传感器的电化学电池和用于产生所述一对测量电极的工艺。