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公开(公告)号：US11365218B2
公开(公告)日：2022-06-21
申请号：US16882648
申请日：2020-05-25
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
摘要： Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.
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公开(公告)号：US20200283481A1
公开(公告)日：2020-09-10
申请号：US16882648
申请日：2020-05-25
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
摘要： Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.
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公开(公告)号：US09849190B2
公开(公告)日：2017-12-26
申请号：US15234396
申请日：2016-08-11
IPC分类号： A61K38/00 , A61K47/64 , C07K14/47 , C07K7/08 , C12Q1/26 , C12Q1/58 , C12Q1/66 , A61K47/48 , G01N33/574 , A61K31/704 , A61K49/00
CPC分类号： A61K47/64 , A61K31/704 , A61K38/00 , A61K49/0056 , C07K7/08 , C07K14/47 , C07K2319/10 , C12Q1/26 , C12Q1/58 , C12Q1/66 , C12Y301/13 , G01N33/574
摘要： A method of treating breast cancer is described, in which a peptide having cancer selective translocation function-doxoribicin conjugate is administered. The conjugate includes doxorubicin chemically linked to the N-terminus or C-terminus of a VEGF-binding protein transduction domain (VPTD) peptide represented as SEQ ID NO: 1, wherein the VPTD peptide and doxorubicin are linked to each other by a disulfide bond, and wherein the VPTD peptide binds specifically to vascular endothelial growth factor (VEGF) in tumor cells or tumor tissues.
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4.发明申请ANTICANCER PEPTIDE FOR INHIBITING PROLIFERATION OF CANCER STEM CELLS AND USE THEREOF 有权用于抑制癌细胞增殖的抗癌肽及其用途公开(公告)号：US20170042963A1
公开(公告)日：2017-02-16
申请号：US15113823
申请日：2016-03-03
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.
摘要： The present invention relates to an anticancer composition comprising a peptide that inhibits the proliferation of cancer stem cells present in tumor tissue and that induces apoptosis of such cancer stem cells, and more particularly, to an anticancer peptide that inhibits the activity of NF-κB which is overexpressed specifically in cancer stem cells present in tumors.
摘要翻译： 本发明涉及包含抑制肿瘤组织中存在的癌干细胞增殖并诱导这种癌干细胞凋亡的肽的抗癌成分，更具体地，涉及抑制NF-κB活性的抗癌肽， 特异性地在肿瘤中存在的癌干细胞中过度表达。
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5.发明申请公开(公告)号：US20160367694A1
公开(公告)日：2016-12-22
申请号：US15234396
申请日：2016-08-11
IPC分类号： A61K47/48 , A61K31/704 , A61K38/46
CPC分类号： A61K47/64 , A61K31/704 , A61K38/00 , A61K49/0056 , C07K7/08 , C07K14/47 , C07K2319/10 , C12Q1/26 , C12Q1/58 , C12Q1/66 , C12Y301/13 , G01N33/574
摘要： The present invention relates a peptide having cancer selective translocation function, and the use thereof, and more particularly to a VEGF-binding protein transduction domain (VPTD) represented as SEQ ID NO: 1 or a heparin-binding protein transduction domain (HPTD) represented as SEQ ID NO: 2, which bind specifically to VEGF and heparin, which are overexpressed specifically in tumor cells or tumor tissues, and to a conjugate comprising a drug linked to the peptide.The peptide and the peptide-drug conjugate bind specifically to VEGF and heparin in tumor cells or tumor tissue and accumulate in the tumor cells or tumor tissue, and thus can be used for the accurate diagnosis and treatment of cancer. Also, the non-specific distribution of the peptide or the conjugate in the body after administration is inhibited, and thus the side effects thereof can be minimized. Accordingly, the peptide or the conjugate is useful for the diagnosis and treatment of cancer.
摘要翻译： 肽和肽 - 药物缀合物在肿瘤细胞或肿瘤组织中特异性结合VEGF和肝素并积聚在肿瘤细胞或肿瘤组织中，因此可用于癌症的准确诊断和治疗。 此外，肽或结合物在给药后体内的非特异性分布被抑制，因此其副作用可以最小化。 因此，肽或缀合物可用于癌症的诊断和治疗。
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6.发明申请公开(公告)号：US20190382446A1
公开(公告)日：2019-12-19
申请号：US16464099
申请日：2017-12-27
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION. CO. LTD
摘要： The present invention relates to a novel peptide derived from the copine 7 protein and having both cell permeability and bone tissue regeneration ability, and to a use of the peptide. The peptide according to the present invention has excellent bone tissue regeneration ability and is therefore useful for treating a disease requiring bone regeneration, such as osteoporosis. Particularly, by also having cell permeability, the peptide does not require the attachment of a separate peptide or addition of another preparation for the cell permeation thereof and thus can be conveniently applied in orthopedics and the like requiring various surgical regeneration treatments.
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公开(公告)号：US20190284237A1
公开(公告)日：2019-09-19
申请号：US16297670
申请日：2019-03-10
申请人： Seoul National University R&DB Foundation , Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
摘要： Disclosed are a bifunctional peptide having the capability to reduce inflammation and the capability to facilitate differentiation of stem cells into chondrocytes and the use thereof. Advantageously, the bifunctional peptide is useful for the prevention or treatment of arthritis accompanied by inflammation and damage of cartilage tissue due to excellent effects of reducing inflammation and facilitating differentiation of stem cells into chondrocytes, can be easily applied to various surgical regenerative treatments including orthopedic treatments, and can shorten the treatment period.
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公开(公告)号：US10406264B2
公开(公告)日：2019-09-10
申请号：US15545679
申请日：2017-03-07
申请人： NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION. CO. LTD , SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
发明人： Chong-Pyoung Chung , Yoon Jeong Park , Jue-Yeon Lee , Yeonsu Kim , Dong Woo Lee
IPC分类号： A61K47/62 , A61L27/54 , A61L27/22 , C07K14/51 , C07K7/08 , A61K47/18 , A61L27/06 , C07K17/14
摘要： The present invention relates to a peptide having the ability to bind specifically to the surface of titanium. The titanium-binding peptide according to the present invention is fixed securely to the titanium surface so that the activity of a physiologically active substance linked to the peptide can be stably maintained over a long period of time. Thus, the peptide can be effectively used for surgical regeneration therapy.
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公开(公告)号：US20170296695A1
公开(公告)日：2017-10-19
申请号：US15504035
申请日：2016-04-05
申请人： SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION , NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO. LTD
发明人： Yoon Jeong Park , Jin Sook Suh , Chong-Pyoung Chung , Jue-Yeon Lee , Yeonsu Kim
CPC分类号： A61L27/04 , A61L27/00 , A61L27/306 , A61L27/50 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2430/02 , A61L2430/12 , C07K7/00 , C07K7/08 , C07K19/00 , C07K2319/00 , C07K2319/20
摘要： The present invention relates to a peptide that binds specifically to the surface of zirconia, and more particularly, to a peptide conjugate obtained by linking a functional drug to the peptide so as to enable the drug to be securely fixed to the surface of zirconia to thereby maintain the activity of the drug over a long period of time. The zirconia-binding peptide according to the present invention can be securely fixed to the surface of zirconia so that the activity of a physiologically active substance introduced into the peptide can be maintained on the zirconia surface over a long period of time. Thus, the zirconia-binding peptide is useful for surgical regenerative treatment.
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10.发明申请MIMETIC TISSUE STRUCTURE CONTAINING EXTRACELLULAR MATRIX PROTEIN-BONE MINERAL COMPLEX AND METHOD FOR MANUFACTURING SAME 审中-公开含有细胞外基质蛋白质骨矿物复合物的组合物组织结构及其制造方法公开(公告)号：US20160058909A1
公开(公告)日：2016-03-03
申请号：US14779339
申请日：2014-04-01
CPC分类号： A61L27/3608 , A61L27/02 , A61L27/22 , A61L27/24 , A61L27/3633 , B29B11/08 , B29B13/04 , B29K2005/00 , B29K2489/00 , B29L2031/7532
摘要： Provided are a tissue structure mimetic used for regenerating a tissue and a method for manufacturing the same, and more particularly, a 3-dimensional tissue structure mimetic which consists of a complex of extracellular matrix protein and bone mineral, wherein the complex is specifically bound to a regeneration-functional peptide to thereby be capable of implementing environment of a tissue requiring restoration, and a method for manufacturing the same. In the tissue structure mimetic according to the present invention, bone mineral components are finely dispersed in the extracellular matrix protein to have excellent mechanical strength of the tissue structure mimetic and conductivity which provides a migration path of cells involved in tissue regeneration. Further, environment of the tissue may be implemented by the peptide contained in the tissue structure mimetic to finally remarkably increase tissue regeneration capacity.
摘要翻译： 提供了用于再生组织的组织结构模拟物及其制造方法，更具体地，涉及由细胞外基质蛋白和骨矿物质的复合物组成的三维组织结构模拟物，其中所述复合物特异性结合 再生功能肽，从而能够实现需要恢复的组织的环境及其制造方法。 在根据本发明的组织结构模拟物中，骨矿物质组分细分散在细胞外基质蛋白中以具有组织结构模拟物和导电性的优异的机械强度，其提供参与组织再生的细胞的迁移途径。 此外，组织的环境可以通过包含在组织结构模拟物中的肽来实现，以最终显着增加组织再生能力。
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