MIMETIC TISSUE STRUCTURE CONTAINING EXTRACELLULAR MATRIX PROTEIN-BONE MINERAL COMPLEX AND METHOD FOR MANUFACTURING SAME
    5.
    发明申请
    MIMETIC TISSUE STRUCTURE CONTAINING EXTRACELLULAR MATRIX PROTEIN-BONE MINERAL COMPLEX AND METHOD FOR MANUFACTURING SAME 审中-公开
    含有细胞外基质蛋白质骨矿物复合物的组合物组织结构及其制造方法

    公开(公告)号:US20160058909A1

    公开(公告)日:2016-03-03

    申请号:US14779339

    申请日:2014-04-01

    IPC分类号: A61L27/36 B29B13/04 B29B11/08

    摘要: Provided are a tissue structure mimetic used for regenerating a tissue and a method for manufacturing the same, and more particularly, a 3-dimensional tissue structure mimetic which consists of a complex of extracellular matrix protein and bone mineral, wherein the complex is specifically bound to a regeneration-functional peptide to thereby be capable of implementing environment of a tissue requiring restoration, and a method for manufacturing the same. In the tissue structure mimetic according to the present invention, bone mineral components are finely dispersed in the extracellular matrix protein to have excellent mechanical strength of the tissue structure mimetic and conductivity which provides a migration path of cells involved in tissue regeneration. Further, environment of the tissue may be implemented by the peptide contained in the tissue structure mimetic to finally remarkably increase tissue regeneration capacity.

    摘要翻译: 提供了用于再生组织的组织结构模拟物及其制造方法,更具体地,涉及由细胞外基质蛋白和骨矿物质的复合物组成的三维组织结构模拟物,其中所述复合物特异性结合 再生功能肽,从而能够实现需要恢复的组织的环境及其制造方法。 在根据本发明的组织结构模拟物中,骨矿物质组分细分散在细胞外基质蛋白中以具有组织结构模拟物和导电性的优异的机械强度,其提供参与组织再生的细胞的迁移途径。 此外,组织的环境可以通过包含在组织结构模拟物中的肽来实现,以最终显着增加组织再生能力。