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    PEPTIDE HAVING CANCER SELECTIVE TRANSLOCATION FUNCTION AND USE THEREOF
    4.
    发明申请
    PEPTIDE HAVING CANCER SELECTIVE TRANSLOCATION FUNCTION AND USE THEREOF 审中-公开
    具有癌症选择性转录功能的肽和其使用

    公开(公告)号：US20160367694A1

    公开(公告)日：2016-12-22

    申请号：US15234396

    申请日：2016-08-11

    申请人： SNU R&DB FOUNDATION ,  Nano Intelligent Biomedical Engineering Corporation Co. Ltd

    发明人： Yoon Jeong Park ,  Chong-Pyoung Chung ,  Jin Sook Suh ,  Yoon Jung Choi

    IPC分类号： A61K47/48 ,  A61K31/704 ,  A61K38/46

    CPC分类号： A61K47/64 ,  A61K31/704 ,  A61K38/00 ,  A61K49/0056 ,  C07K7/08 ,  C07K14/47 ,  C07K2319/10 ,  C12Q1/26 ,  C12Q1/58 ,  C12Q1/66 ,  C12Y301/13 ,  G01N33/574

    摘要： The present invention relates a peptide having cancer selective translocation function, and the use thereof, and more particularly to a VEGF-binding protein transduction domain (VPTD) represented as SEQ ID NO: 1 or a heparin-binding protein transduction domain (HPTD) represented as SEQ ID NO: 2, which bind specifically to VEGF and heparin, which are overexpressed specifically in tumor cells or tumor tissues, and to a conjugate comprising a drug linked to the peptide.The peptide and the peptide-drug conjugate bind specifically to VEGF and heparin in tumor cells or tumor tissue and accumulate in the tumor cells or tumor tissue, and thus can be used for the accurate diagnosis and treatment of cancer. Also, the non-specific distribution of the peptide or the conjugate in the body after administration is inhibited, and thus the side effects thereof can be minimized. Accordingly, the peptide or the conjugate is useful for the diagnosis and treatment of cancer.

    摘要翻译： 肽和肽 - 药物缀合物在肿瘤细胞或肿瘤组织中特异性结合VEGF和肝素并积聚在肿瘤细胞或肿瘤组织中，因此可用于癌症的准确诊断和治疗。 此外，肽或结合物在给药后体内的非特异性分布被抑制，因此其副作用可以最小化。 因此，肽或缀合物可用于癌症的诊断和治疗。

    MIMETIC TISSUE STRUCTURE CONTAINING EXTRACELLULAR MATRIX PROTEIN-BONE MINERAL COMPLEX AND METHOD FOR MANUFACTURING SAME
    8.
    发明申请
    MIMETIC TISSUE STRUCTURE CONTAINING EXTRACELLULAR MATRIX PROTEIN-BONE MINERAL COMPLEX AND METHOD FOR MANUFACTURING SAME 审中-公开
    含有细胞外基质蛋白质骨矿物复合物的组合物组织结构及其制造方法

    公开(公告)号：US20160058909A1

    公开(公告)日：2016-03-03

    申请号：US14779339

    申请日：2014-04-01

    申请人： NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO., LTD.

    发明人： Chong-Pyoung Chung ,  Yoon Jeong Park ,  Jue-Yeon Lee

    IPC分类号： A61L27/36 ,  B29B13/04 ,  B29B11/08

    CPC分类号： A61L27/3608 ,  A61L27/02 ,  A61L27/22 ,  A61L27/24 ,  A61L27/3633 ,  B29B11/08 ,  B29B13/04 ,  B29K2005/00 ,  B29K2489/00 ,  B29L2031/7532

    摘要： Provided are a tissue structure mimetic used for regenerating a tissue and a method for manufacturing the same, and more particularly, a 3-dimensional tissue structure mimetic which consists of a complex of extracellular matrix protein and bone mineral, wherein the complex is specifically bound to a regeneration-functional peptide to thereby be capable of implementing environment of a tissue requiring restoration, and a method for manufacturing the same. In the tissue structure mimetic according to the present invention, bone mineral components are finely dispersed in the extracellular matrix protein to have excellent mechanical strength of the tissue structure mimetic and conductivity which provides a migration path of cells involved in tissue regeneration. Further, environment of the tissue may be implemented by the peptide contained in the tissue structure mimetic to finally remarkably increase tissue regeneration capacity.

    摘要翻译： 提供了用于再生组织的组织结构模拟物及其制造方法，更具体地，涉及由细胞外基质蛋白和骨矿物质的复合物组成的三维组织结构模拟物，其中所述复合物特异性结合 再生功能肽，从而能够实现需要恢复的组织的环境及其制造方法。 在根据本发明的组织结构模拟物中，骨矿物质组分细分散在细胞外基质蛋白中以具有组织结构模拟物和导电性的优异的机械强度，其提供参与组织再生的细胞的迁移途径。 此外，组织的环境可以通过包含在组织结构模拟物中的肽来实现，以最终显着增加组织再生能力。