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公开(公告)号：US09181563B2
公开(公告)日：2015-11-10
申请号：US14111415
申请日：2012-04-11
申请人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
发明人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
IPC分类号： C12N1/00 , C12N1/19 , C12N1/22 , C12P7/06 , C07K14/39 , C12N9/04 , C12N9/10 , C12N9/12 , C12N9/90 , C12N9/92 , C12P7/10 , C12N15/81
CPC分类号： C12P7/10 , C07K14/39 , C12N9/0006 , C12N9/1022 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N15/815 , C12P7/06 , C12P7/54 , C12Y101/01 , C12Y101/01009 , C12Y101/0101 , C12Y202/01001 , C12Y202/01002 , C12Y207/01016 , C12Y207/01017 , C12Y501/03001 , C12Y501/03004 , C12Y503/01003 , C12Y503/01005 , C12Y503/01006 , Y02E50/16 , Y02E50/17
摘要： The present application discloses the identification of the novel K. marxianus xylose transporter genes KHT105 and RAG4, as well as the identification of a novel set of I. orientalis pentose phosphate pathway genes The present application further discloses a series of genetically modified yeast cells comprising various combinations of arabinose fermentation pathways, xylose fermentation pathways, pentose phosphate pathways, and/or xylose transporter genes, and methods of culturing these cells to produce ethanol in fermentation media containing xylose.
摘要翻译： 本申请公开了新型马克斯黄连木糖转运蛋白基因KHT105和RAG4的鉴定，以及一种新型东方山羊戊糖磷酸途径基因的鉴定本申请还公开了一系列基因修饰的酵母细胞，其包含各种 阿拉伯糖发酵途径的组合，木糖发酵途径，戊糖磷酸途径和/或木糖转运蛋白基因，以及培养这些细胞以在含有木糖的发酵培养基中产生乙醇的方法。
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2.发明申请公开(公告)号：US20140038253A1
公开(公告)日：2014-02-06
申请号：US14111415
申请日：2012-04-11
申请人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
发明人： Holly J. Jessen , Jian Yi , Joshua Lundorff , Hans Liao , Ana Negrete-Raymond , Pirkko Suominen , Aristos Aristidou
CPC分类号： C12P7/10 , C07K14/39 , C12N9/0006 , C12N9/1022 , C12N9/1205 , C12N9/90 , C12N9/92 , C12N15/815 , C12P7/06 , C12P7/54 , C12Y101/01 , C12Y101/01009 , C12Y101/0101 , C12Y202/01001 , C12Y202/01002 , C12Y207/01016 , C12Y207/01017 , C12Y501/03001 , C12Y501/03004 , C12Y503/01003 , C12Y503/01005 , C12Y503/01006 , Y02E50/16 , Y02E50/17
摘要： The present application discloses the identification of the novel K. marxianus xylose transporter genes KHT105 and RAG4, as well as the identification of a novel set of I. orientalis pentose phosphate pathway genes The present application further discloses a series of genetically modified yeast cells comprising various combinations of arabinose fermentation pathways, xylose fermentation pathways, pentose phosphate pathways, and/or xylose transporter genes, and methods of culturing these cells to produce ethanol in fermentation media containing xylose.
摘要翻译： 本申请公开了新型马克斯黄连木糖转运蛋白基因KHT105和RAG4的鉴定，以及一种新型东方山羊戊糖磷酸途径基因的鉴定本申请还公开了一系列基因修饰的酵母细胞，其包含各种 阿拉伯糖发酵途径的组合，木糖发酵途径，戊糖磷酸途径和/或木糖转运蛋白基因，以及培养这些细胞以在含有木糖的发酵培养基中产生乙醇的方法。
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公开(公告)号：US07846712B2
公开(公告)日：2010-12-07
申请号：US11912493
申请日：2007-03-19
申请人： Min Zhang , Arjun Singh , Eric Knoshaug , Mary Ann Franden , Eric Jarvis , Pirkko Suominen
发明人： Min Zhang , Arjun Singh , Eric Knoshaug , Mary Ann Franden , Eric Jarvis , Pirkko Suominen
IPC分类号： C12N1/14
摘要： An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains.
摘要翻译： 提供利用酵母菌株的L-阿拉伯糖，用于通过引入和表达细菌araA，araB和araD基因来生产乙醇。 还将L-阿拉伯糖转运蛋白引入酵母中以增强阿拉伯糖的摄取。 酵母携带额外的基因组突变，使其能够消耗L-阿拉伯糖，甚至作为唯一的碳源，并产生乙醇。 生产乙醇的方法包括利用这些改良的酵母菌株。
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公开(公告)号：US20100144041A1
公开(公告)日：2010-06-10
申请号：US11912493
申请日：2007-03-19
申请人： Min Zhang , Arjun Singh , Pirkko Suominen , Eric Knoshaug , Mary Ann Franden , Eric Jarvis
发明人： Min Zhang , Arjun Singh , Pirkko Suominen , Eric Knoshaug , Mary Ann Franden , Eric Jarvis
摘要： An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. Methods of producing ethanol include utilizing these modified yeast strains.
摘要翻译： 提供利用酵母菌株的L-阿拉伯糖，用于通过引入和表达细菌araA，araB和araD基因来生产乙醇。 还将L-阿拉伯糖转运蛋白引入酵母中以增强阿拉伯糖的摄取。 酵母携带额外的基因组突变，使其能够消耗L-阿拉伯糖，甚至作为唯一的碳源，并产生乙醇。 生产乙醇的方法包括利用这些改良的酵母菌株。
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公开(公告)号：US06184019B2
公开(公告)日：2001-02-06
申请号：US09329350
申请日：1999-06-10
申请人： Arja Miettinen-Oinonen , John Londesborough , Jari Vehmaanperä , Heli Haakana , Arja Mäntylä , Raija Lantto , Minna Elovainio , Vesa Joutsjoki , Marja Paloheimo , Pirkko Suominen
发明人： Arja Miettinen-Oinonen , John Londesborough , Jari Vehmaanperä , Heli Haakana , Arja Mäntylä , Raija Lantto , Minna Elovainio , Vesa Joutsjoki , Marja Paloheimo , Pirkko Suominen
IPC分类号： C12N942
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01004 , C12Y302/01091
摘要： Genes encoding novel cellulases, and a gene encoding a protein that facilitates the action of such novel cellulases, the novel cellulases and a protein that facilitates the action of such cellulases, and enzyme preparations containing such proteins are described The native hosts and the culture medium of said hosts containing said novel cellulases are also disclosed. These proteins are especially useful in the textile and detergent industry and in pulp and paper industry.
摘要翻译： 编码新型纤维素酶的基因和编码促进这种新型纤维素酶的作用的蛋白质的基因，新型纤维素酶和促进这种纤维素酶作用的蛋白质以及含有这种蛋白质的酶制剂被描述为天然宿主和培养基 还公开了含有所述新型纤维素酶的宿主。 这些蛋白质在纺织和洗涤剂行业以及纸浆和造纸工业中特别有用。
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公开(公告)号：US5922579A
公开(公告)日：1999-07-13
申请号：US768374
申请日：1996-12-17
CPC分类号： C12Y302/01032 , A21D8/042 , A23K20/189 , A23L7/107 , C12N9/248 , C12Y302/01008 , D21C5/005 , C07K2319/00
摘要： Enzyme compositions containing thermostabile xylanases of Chaetomium thermophilum, purified enzyme preparations of such xylanases, and the use of such compositions and preparations in the bleaching of plant pulp and in feed and baking applications are described.
摘要翻译： 描述了含有嗜热毛细菌的热稳定性木聚糖酶，这种木聚糖酶的纯化酶制剂的酶组合物，以及这些组合物和制剂在漂白植物纸浆和饲料和烘烤应用中的用途。
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公开(公告)号：US20120129241A1
公开(公告)日：2012-05-24
申请号：US12909523
申请日：2010-10-21
申请人： MIN ZHANG , ARJUN SINGH , PIRKKO SUOMINEN , ERIC KNOSHAUG , MARY ANN FRANDEN , ERIC JARVIS
发明人： MIN ZHANG , ARJUN SINGH , PIRKKO SUOMINEN , ERIC KNOSHAUG , MARY ANN FRANDEN , ERIC JARVIS
摘要： An L-arabinose utilizing yeast strain is provided for the production of ethanol by introducing and expressing bacterial araA, araB and araD genes. L-arabinose transporters are also introduced into the yeast to enhance the uptake of arabinose. The yeast carries additional genomic mutations enabling it to consume L-arabinose, even as the only carbon source, and to produce ethanol. A yeast strain engineered to metabolize arabinose through a novel pathway is also disclosed. Methods of producing ethanol include utilizing these modified yeast strains.
摘要翻译： 提供利用酵母菌株的L-阿拉伯糖，用于通过引入和表达细菌araA，araB和araD基因来生产乙醇。 还将L-阿拉伯糖转运蛋白引入酵母中以增强阿拉伯糖的摄取。 酵母携带额外的基因组突变，使其能够消耗L-阿拉伯糖，甚至作为唯一的碳源，并产生乙醇。 还公开了通过新途径工程化代谢阿拉伯糖的酵母菌株。 生产乙醇的方法包括利用这些改良的酵母菌株。
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8.发明授权Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells 有权具有非功能性L-或D-乳酸的产酸酵母细胞：铁染色质C氧化还原酶细胞公开(公告)号：US08137953B2
公开(公告)日：2012-03-20
申请号：US12093757
申请日：2006-11-17
申请人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
发明人： Matthew Miller , Pirkko Suominen , Aristos Aristidou , Benjamin Matthew Hause , Pim Van Hoek , Catherine Asleson Dundon
CPC分类号： C12N9/0006 , C12P7/56 , C12Y101/02003
摘要： Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of lactate by the cell and can increase overall lactate yields in a fermentation process. Cells having the reduced L- or D-lactate:ferricytochrome c oxidoreductase activity can be screened for by resistance to organic acids such as lactic or glycolic acid.
摘要翻译： 酵母细胞具有通过减少细胞中的L-或D-乳酸：铁染色体氧化还原酶活性而修饰的外源性乳酸脱氢酶基因。 这导致细胞对乳酸盐的消耗降低，并且可以增加发酵过程中的总体乳酸盐产量。 具有降低的L-乳酸或D-乳酸：细胞色素C氧化还原酶活性的细胞可通过耐有机酸如乳酸或乙醇酸进行筛选。
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9.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287506A1
公开(公告)日：2011-11-24
申请号：US13107882
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeastcells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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10.发明申请GENETICALLY MODIFIED YEAST SPECIES, AND FERMENTATION PROCESSES USING GENETICALLY MODIFIED YEAST 有权遗传修饰的YEAST物种和使用基因改造的YEAST的发酵过程公开(公告)号：US20110287505A1
公开(公告)日：2011-11-24
申请号：US13107881
申请日：2011-05-14
申请人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
发明人： Vineet Rajgarhia , Kari Koivuranta , Merja Penttilä , Marja Ilmen , Pirkko Suominen , Aristos Aristidou , Christopher Kenneth Miller , Stacey Olson , Laura Ruohonen
CPC分类号： C12P7/14 , C12N1/16 , C12N9/0006 , C12N9/1205 , C12N9/1217 , C12N9/248 , C12N9/88 , C12N9/92 , C12N15/81 , C12N15/815 , C12P7/06 , C12P7/56 , C12Y101/01009 , C12Y207/01017 , C12Y207/02003 , C12Y302/01037 , C12Y401/01001 , C12Y501/03002 , C12Y503/01005 , Y02E50/17 , Y02P20/52
摘要： Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
摘要翻译： 酵母细胞用外源木糖异构酶基因转化。 另外的遗传修饰增强转化细胞将木糖发酵成乙醇或其它所需发酵产物的能力。 这些修饰包括非特异性或特异性醛糖还原酶基因的缺失，木糖醇脱氢酶基因的缺失和/或木酮糖激酶的过表达。
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