利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.025 秒)

    Micro-fluidic system using micro-apertures for high throughput detection of cells
    1.
    发明授权
    Micro-fluidic system using micro-apertures for high throughput detection of cells 有权
    微流体系统使用微孔用于细胞的高通量检测

    公开(公告)号：US09494557B2

    公开(公告)日：2016-11-15

    申请号：US14001963

    申请日：2012-04-05

    申请人： Cagri A. Savran ,  Chung-Li Chang ,  Philip S. Low

    发明人： Cagri A. Savran ,  Chung-Li Chang ,  Philip S. Low

    IPC分类号： G01N33/553 ,  G01N27/74 ,  G01N33/543 ,  B01L3/00 ,  G01N33/574 ,  G01N1/40

    CPC分类号： B01L3/502761 ,  B01L3/50273 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/0877 ,  B01L2400/043 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/574 ,  G01N33/57434 ,  G01N33/57492 ,  G01N2001/4016

    摘要： A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.

    摘要翻译： 用于微米尺寸实体（例如生物细胞）的微流体检测系统包括结合有多个开口的板的检测器部件，该板分离两个室，一个与包含与磁珠结合的靶细胞的流体源连通。 这些开口的尺寸设置成总是允许磁珠通过其进入下部的一个室，并且进一步的尺寸设计成总是防止靶细胞从上部的一个室中通过。 检测器部件还包括磁铁，该磁体定位成将未结合的磁珠拉过开口并捕获与板表面上的磁珠结合的靶细胞。 微流体检测系统包括泵以高分子量/分钟的速度流过检测器部件，用于目标细胞的高通量检测。

    Treatment of macrophage mediated disease
    3.
    发明授权
    Treatment of macrophage mediated disease 有权
    治疗巨噬细胞介导的疾病

    公开(公告)号：US07740854B2

    公开(公告)日：2010-06-22

    申请号：US10138275

    申请日：2002-05-02

    申请人： Philip S. Low ,  Mary Jo Turk

    发明人： Philip S. Low ,  Mary Jo Turk

    IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/385

    CPC分类号： A61K51/0482 ,  A61K9/127 ,  A61K47/646 ,  A61K47/6849 ,  A61K51/1027

    摘要： The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.

    摘要翻译： 本发明涉及一种治疗或监测/诊断由活化的巨噬细胞介导的疾病状态的方法。 该方法包括向患有巨噬细胞介导的疾病状态的患者施用有效量的包含通式Ab-X的缀合物或复合物的组合物，其中基团Ab包含能够结合活化的巨噬细胞的配体，以及 当缀合物用于治疗疾病状态时，组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的化合物，并且当所述缀合物用于监测/诊断疾病状态时，X包括 成像剂。 该方法可用于治疗患有选自类风湿性关节炎，溃疡性结肠炎，克罗恩病，炎症，感染，骨髓炎，动脉粥样硬化，器官移植排斥，肺纤维化，结节病和系统性硬化症的疾病的患者。

    Diagnosis of macrophage mediated disease
    8.
    发明授权
    Diagnosis of macrophage mediated disease 有权
    诊断巨噬细胞介导的疾病

    公开(公告)号：US08388977B2

    公开(公告)日：2013-03-05

    申请号：US13529823

    申请日：2012-06-21

    申请人： Philip S Low ,  Mary Jo Turk

    发明人： Philip S Low ,  Mary Jo Turk

    IPC分类号： A61K39/385 ,  A61K35/26

    CPC分类号： A61K51/0482 ,  A61K9/127 ,  A61K47/646 ,  A61K47/6849 ,  A61K51/1027

    摘要： The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.

    摘要翻译： 本发明涉及一种治疗或监测/诊断由活化的巨噬细胞介导的疾病状态的方法。 该方法包括向患有巨噬细胞介导的疾病状态的患者施用有效量的包含通式Ab-X的缀合物或复合物的组合物，其中基团Ab包含能够结合活化的巨噬细胞的配体，以及 当缀合物用于治疗疾病状态时，组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的化合物，并且当所述缀合物用于监测/诊断疾病状态时，X包括 成像剂。 该方法可用于治疗患有选自类风湿性关节炎，溃疡性结肠炎，克罗恩病，炎症，感染，骨髓炎，动脉粥样硬化，器官移植排斥，肺纤维化，结节病和系统性硬化症的疾病的患者。

    Diagnostic method for atherosclerosis
    9.
    发明授权
    Diagnostic method for atherosclerosis 有权
    动脉粥样硬化的诊断方法

    公开(公告)号：US08383354B2

    公开(公告)日：2013-02-26

    申请号：US13083121

    申请日：2011-04-08

    申请人： Philip S. Low

    发明人： Philip S. Low

    IPC分类号： G01N33/53

    CPC分类号： A61K49/0043 ,  A61K49/0041 ,  A61K49/0052 ,  A61K49/006 ,  A61K51/0474 ,  A61K51/0497 ,  G01N33/5061 ,  G01N33/92 ,  G01N2800/323

    摘要： The invention relates to a method of identifying/monitoring active atherosclerotic plaques associated with blood vessel walls wherein the plaques comprise activated macrophages having accessible binding sites for a ligand. The method comprises the steps of administering to a patient being evaluated for atherosclerosis an effective amount of a composition comprising a conjugate of a ligand and a chromophore capable of emitting light under predetermined conditions, allowing sufficient time for the ligand conjugate to bind to the activated macrophages, subjecting the blood vessels to the predetermined conditions using a catheter-based device, and identifying active plaques by detecting light emitted by the chromophore using a catheter-based device or by using an external imaging technique. The invention also relates to a similar method wherein a chemical moiety capable of emitting radiation is conjugated to the ligand.

    摘要翻译： 本发明涉及鉴定/监测与血管壁相关的活动性动脉粥样硬化斑块的方法，其中斑块包含具有可配位结合位点的活化巨噬细胞。 该方法包括以下步骤：向被评估动脉粥样硬化的患者施用有效量的包含配体和能够在预定条件下发光的发色团的缀合物的组合物，允许配体缀合物足够的时间结合活化的巨噬细胞 使用基于导管的装置对血管进行预定条件，并且使用基于导管的装置或通过使用外部成像技术检测由发色团发出的光来识别活性斑块。 本发明还涉及一种类似的方法，其中能够发射辐射的化学部分与配体缀合。

    Treatment and Diagnosis of Macrophage Mediated Disease
    10.
    发明申请
    Treatment and Diagnosis of Macrophage Mediated Disease 审中-公开
    治疗和诊断巨噬细胞介导的疾病

    公开(公告)号：US20120276191A1

    公开(公告)日：2012-11-01

    申请号：US13463447

    申请日：2012-05-03

    申请人： Philip S. Low ,  Mary Jo Turk

    发明人： Philip S. Low ,  Mary Jo Turk

    IPC分类号： A61K31/519 ,  A61P37/06 ,  A61P19/02 ,  A61K9/127 ,  A61K31/58

    CPC分类号： A61K51/0482 ,  A61K9/127 ,  A61K47/646 ,  A61K47/6849 ,  A61K51/1027

    摘要： The invention relates to a method of treating or monitoring/diagnosing a disease state mediated by activated macrophages. The method comprises the step of administering to a patient suffering from a macrophage mediated disease state an effective amount of a composition comprising a conjugate or complex of the general formula Ab-X where the group Ab comprises a ligand capable of binding to activated macrophages, and when the conjugate is being used for treatment of the disease state, the group X comprises an immunogen, a cytotoxin, or a compound capable of altering macrophage function, and when the conjugate is being used for monitoring/diagnosing the disease state, X comprises an imaging agent. The method is useful for treating a patient suffering from a disease selected from the group consisting of rheumatoid arthritis, ulcerative colitis, Crohn's disease, inflammation, infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, and systemic sclerosis.

    摘要翻译： 本发明涉及一种治疗或监测/诊断由活化的巨噬细胞介导的疾病状态的方法。 该方法包括向患有巨噬细胞介导的疾病状态的患者施用有效量的包含通式Ab-X的缀合物或复合物的组合物，其中基团Ab包含能够结合活化的巨噬细胞的配体，以及 当缀合物用于治疗疾病状态时，组X包含免疫原，细胞毒素或能够改变巨噬细胞功能的化合物，并且当所述缀合物用于监测/诊断疾病状态时，X包括 成像剂。 该方法可用于治疗患有选自类风湿性关节炎，溃疡性结肠炎，克罗恩病，炎症，感染，骨髓炎，动脉粥样硬化，器官移植排斥，肺纤维化，结节病和系统性硬化症的疾病的患者。