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公开(公告)号：US08574261B2
公开(公告)日：2013-11-05
申请号：US13170054
申请日：2011-06-27
IPC分类号： A61M29/00
CPC分类号： A61F2/01 , A61B90/39 , A61F2002/016 , A61F2220/0016 , A61F2230/005 , A61F2230/0067 , A61F2230/008 , A61F2250/0037 , A61F2250/0039 , A61F2250/0067 , A61F2250/0098
摘要： A removable blood clot filter includes a number of locator members and anchor members disposed radially and extending angularly downward from a hub. The locator members include a number of linear portions having distinct axes configured to place a tip portion approximately parallel to the walls of a blood vessel when implanted and to apply sufficient force to the vessel walls to position the filter near the vessel centerline. The anchor members each include a hook configured to penetrate the vessel wall to prevent longitudinal movement due to blood flow. The hooks may have a cross section sized to allow for a larger radius of curvature under strain so that the filter can be removed without damaging the vessel wall.
摘要翻译： 可移除的血液凝块过滤器包括多个定位器构件和锚定构件，其径向设置并且从轮毂向下倾斜延伸。 定位器构件包括多个线性部分，其具有不同的轴线，其被配置为在植入时使尖端部分大致平行于血管的壁，并且向血管壁施加足够的力以将过滤器定位在血管中心线附近。 锚定构件各自包括构造成穿透血管壁以防止由于血流引起的纵向运动的钩。 钩可以具有尺寸适于在应变下允许更大的曲率半径的横截面，使得可以移除过滤器而不损坏容器壁。
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公开(公告)号：US20120078238A1
公开(公告)日：2012-03-29
申请号：US13247403
申请日：2011-09-28
申请人： Robert M. Carr, JR.
发明人： Robert M. Carr, JR.
IPC分类号： A61B17/00
CPC分类号： A61B5/6842 , A61B90/39 , A61B2090/3908 , A61B2090/3987
摘要： Tissue markers, systems for marking tissue, and methods of using tissue markers. A tissue marker may have a body with a first surface and a second surface, a plurality of coupling sites, and a plurality of elongate members. The tissue marker may include a remotely visible material. The tissue marker may have a delivery configuration that is different from a deployed configuration.
摘要翻译： 组织标记，用于标记组织的系统和使用组织标记的方法。 组织标记可以具有带有第一表面和第二表面的主体，多个联接位置和多个细长构件。 组织标记可以包括远程可见的材料。 组织标记可以具有不同于展开配置的传送配置。
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公开(公告)号：US07967838B2
公开(公告)日：2011-06-28
申请号：US11429975
申请日：2006-05-09
CPC分类号： A61F2/01 , A61B90/39 , A61F2002/016 , A61F2220/0016 , A61F2230/005 , A61F2230/0067 , A61F2230/008 , A61F2250/0037 , A61F2250/0039 , A61F2250/0067 , A61F2250/0098
摘要： A removable blood clot filter includes a number of locator members and anchor members disposed radially and extending angularly downward from a hub. The locator members include a number of linear portions having distinct axes configured to place a tip portion approximately parallel to the walls of a blood vessel when implanted and to apply sufficient force to the vessel walls to position the filter near the vessel centerline. The anchor members each include a hook configured to penetrate the vessel wall to prevent longitudinal movement due to blood flow. The hooks may have a cross section sized to allow for a larger radius of curvature under strain so that the filter can be removed without damaging the vessel wall.
摘要翻译： 可移除的血液凝块过滤器包括多个定位器构件和锚定构件，其径向设置并且从轮毂向下倾斜延伸。 定位器构件包括多个线性部分，其具有不同的轴线，其被配置为在植入时使尖端部分大致平行于血管的壁，并且向血管壁施加足够的力以将过滤器定位在血管中心线附近。 锚定构件各自包括构造成穿透血管壁以防止由于血流引起的纵向运动的钩。 钩可以具有尺寸适于在应变下允许更大的曲率半径的横截面，使得可以移除过滤器而不损坏容器壁。
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公开(公告)号：US07214242B2
公开(公告)日：2007-05-08
申请号：US10378178
申请日：2003-03-03
IPC分类号： A61F2/06
CPC分类号： A61L27/3629 , A61L27/24 , A61L27/3641 , A61L27/3687 , A61L27/40 , A61L27/507 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
摘要翻译： 本发明涉及从源自动物来源的清洁的组织材料制备的生物工程管状移植假体。 本发明的生物工程化移植假体是使用保持加工的组织基质的细胞相容性，强度和生物可塑性的方法来制备的。 生物工程移植假体用于哺乳动物宿主植入，修复或使用。
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公开(公告)号：US07041131B2
公开(公告)日：2006-05-09
申请号：US10411816
申请日：2003-04-11
IPC分类号： A61F2/06
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3629 , A61L27/40 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
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公开(公告)号：US06890351B2
公开(公告)日：2005-05-10
申请号：US09949043
申请日：2001-09-07
CPC分类号： A61L27/58 , A61F2/02 , A61F2/06 , A61F2002/30062 , A61F2002/3024 , A61F2002/30971 , A61F2210/0004 , A61F2230/0069 , A61F2240/001 , A61L27/24 , A61L27/34 , Y10S623/917 , C08L89/06
摘要： A bioremodelable prosthesis for treating a patient with a diseased or damaged organs comprising a first layer that contains acid-extracted fibrillar or non-fibrillar collagen, and a second layer derived from the tunica submucosa of the small intestine that provides structural stability, is pliable and is semi-permeable,pe1 59564443.npc wherein the prosthesis undergoes controlled biodegradation occurring with adequate living cell replacement such that the original prosthesis is replaced by the patient's living cells.
摘要翻译： 用于治疗患有或受损器官的患者的生物可修改假体，其包括含有酸提取的纤维状或非纤维状胶原的第一层，以及衍生自提供结构稳定性的小肠粘膜下层的第二层，是柔韧的，并且 是半渗透性的，其中假体经受受控的生物降解，其具有足够的活细胞置换，使得原始假体被患者的活细胞代替。
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7.发明授权Reconstituted collagen fiber segment compositions and methods of preparation thereof 失效重组胶原纤维节段组合物及其制备方法
公开(公告)号：US5997896A
公开(公告)日：1999-12-07
申请号：US973571
申请日：1998-05-11
CPC分类号： A61L27/24 , A61K38/1841 , A61K38/39 , A61F2310/00365
摘要： The invention provides injectable collagen compositions that are reconstituted collagen fiber segments made from acid extracted collagen with telopeptides in a biocompatible carrier, with the collagen concentration in the composition ranging up to 200 mg/mL.
摘要翻译： PCT No.PCT / US96 / 09861 Sec。 371日期：1998年5月11日 102（e）日期1998年5月11日PCT提交1996年6月7日PCT公布。 出版物WO96 / 40216 PCT 日期：1996年12月19日本发明提供了可注射的胶原组合物，其是由生物相容性载体中的具有端肽的酸提取胶原构成的重组胶原纤维片段，组合物中的胶原浓度范围高达200mg / mL。
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8.发明授权Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix 失效化学处理，无洗涤剂或酶，组织形成无细胞，胶原基质
公开(公告)号：US5993844A
公开(公告)日：1999-11-30
申请号：US853372
申请日：1997-05-08
IPC分类号： A61F13/00 , A01N1/02 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/28 , A61K35/12 , A61L27/24 , A61L27/36 , C12N5/08
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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公开(公告)号：US5256418A
公开(公告)日：1993-10-26
申请号：US505678
申请日：1990-04-06
IPC分类号： A61F2/06 , A61F2/00 , A61L27/00 , A61L27/24 , A61L27/36 , D01F4/00 , A61F2/28 , A61K9/14 , A61K37/12 , C07K15/20
CPC分类号： D01F4/00 , A61L27/24 , A61L27/3808 , A61L27/3813 , A61L27/507 , A61L27/60 , A61F2310/00365 , Y10S623/901
摘要： The present invention provides collagen constructs and methods of making and using such constructs. The present invention also provides tissue equivalents having improved characteristics and methods of making and using such tissue equivalents. This invention also provides methods of producing highly concentrated solutions of collagen.
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公开(公告)号：US20110034952A1
公开(公告)日：2011-02-10
申请号：US12880839
申请日：2010-09-13
申请人： Alexander W. TESSMER , David G. SPILKA , David W. RAUCH , Andrzej J. CHANDUSZKO , Robert M. CARR, JR.
发明人： Alexander W. TESSMER , David G. SPILKA , David W. RAUCH , Andrzej J. CHANDUSZKO , Robert M. CARR, JR.
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： A filter delivery device for implanting a vessel filter within a blood vessel of a patient's body. The filter delivery device includes a mechanism for preventing hooks and/or legs on a vessel filter from entangling with each other while the vessel filter is loaded within the delivery device. In one variation, the filter delivery device includes a delivery catheter with grooves at the distal end lumen opening. When a vessel filter with radially expanding legs is compressed and inserted into the distal end of the delivery catheter, the hooks on the distal end of the legs are received and separated by the corresponding grooves on the delivery catheter. In another variation, a pusher rod, with a receptacle for receiving the hooks, is positioned within a delivery catheter to prevent the entanglement of the hooks and/or legs of a filter loaded within the delivery catheter.
摘要翻译： 一种用于将血管过滤器植入患者身体的血管内的过滤器输送装置。 过滤器输送装置包括用于防止容器过滤器上的钩和/或腿彼此缠结的机构，同时容器过滤器被装载在输送装置内。 在一个变型中，过滤器输送装置包括在远端腔开口处具有凹槽的输送导管。 当具有径向扩张的腿的血管过滤器被压缩并插入输送导管的远端时，腿的远端上的钩被输送导管上的相应凹槽容纳并分离。 在另一个实施例中，具有用于接收钩的容器的推杆位于输送导管内，以防止装载在输送导管内的过滤器的钩和/或腿的缠结。
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