Water-soluble compositions of bioactive lipophilic compounds
    4.
    发明授权
    Water-soluble compositions of bioactive lipophilic compounds 有权
    生物活性亲脂性化合物的水溶性组合物

    公开(公告)号:US06632443B2

    公开(公告)日:2003-10-14

    申请号:US09773592

    申请日:2001-02-02

    IPC分类号: A61K900

    摘要: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y  (I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is &agr;-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.

    摘要翻译: 包含亲水性化合物和通式如下的增溶剂的水溶性组合物:其中:X是疏水部分的残基,Y是亲水部分的残基, / PTEXT> p是1或2, m是0或1,并且 n是大于或等于0的整数。 亲脂性化合物优选选自水不溶性泛醌,泛醇,维生素,前维生素,多烯大环内酯抗生素及其混合物。 疏水部分优选为固醇或生育酚,亲水部分优选为聚亚烷基二醇。 在一些实施方案中,甾醇为胆固醇或谷甾醇,生育酚为α-(+) - 生育酚,聚亚烷基二醇为平均分子量在400至1000之间的聚乙二醇或其甲基单醚,p等于1或2 ,m等于0或1,n是2和18之间的整数。

    Refuse bag cart
    8.
    发明授权
    Refuse bag cart 失效
    垃圾袋车

    公开(公告)号:US5906382A

    公开(公告)日:1999-05-25

    申请号:US975639

    申请日:1997-11-21

    申请人: Roy Walker

    发明人: Roy Walker

    摘要: A cart for a refuse bag has a base panel with left, right and rear upright panels attached to it. The panels have top flaps that fold over into the boxy structure formed by the panels to engage the inside of a refuse bag to hold the refuse bag upright. The cart has wheels and a handle for moving the cart and easily transporting the refuse bag.

    摘要翻译: 用于垃圾袋的推车具有底板,附有左,右和后立式面板。 这些面板具有顶板,其折叠到由面板形成的框架结构中,以接合垃圾袋的内部以将垃圾袋保持直立。 推车具有车轮和用于移动车的手柄并且容易地运送垃圾袋。

    Water-soluble compositions of bioactive lipophilic compounds
    9.
    发明授权
    Water-soluble compositions of bioactive lipophilic compounds 有权
    生物活性亲脂性化合物的水溶性组合物

    公开(公告)号:US08524696B2

    公开(公告)日:2013-09-03

    申请号:US12431610

    申请日:2009-04-28

    IPC分类号: A01N43/00 A61K31/33

    摘要: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y  (I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is α-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.

    摘要翻译: 包含亲水性化合物和通式为:(X-OOC - [(CH2)n-COO)m} pY(I)的增溶剂的水溶性组合物,其中:X为疏水部分的残基,Y为 亲水部分的残基,p为1或2,m为0或1,并且n为大于或等于0的整数。 亲脂性化合物优选选自水不溶性泛醌,泛醇,维生素,前维生素,多烯大环内酯抗生素及其混合物。 疏水部分优选为固醇或生育酚,亲水部分优选为聚亚烷基二醇。 在一些实施方案中,甾醇为胆固醇或谷甾醇,生育酚为α-(+) - 生育酚,聚亚烷基二醇为平均分子量在400至1000之间的聚乙二醇或其甲基单醚,p等于1或2 ,m等于0或1,n是2和18之间的整数。

    Water-soluble compositions of bioactive lipophilic compounds
    10.
    发明授权
    Water-soluble compositions of bioactive lipophilic compounds 有权
    生物活性亲脂性化合物的水溶性组合物

    公开(公告)号:US07645816B2

    公开(公告)日:2010-01-12

    申请号:US10648371

    申请日:2003-08-27

    IPC分类号: A61K47/28

    摘要: Water-soluble compositions comprising a lipophilic compound and a solubilizing agent of the general formula: {X—OOC—[(CH2)n—COO]m}p—Y  (I) wherein: X is a residue of a hydrophobic moiety, Y is a residue of a hydrophilic moiety, p is 1 or 2, m is 0 or 1, and n is an integer greater than or equal to 0 are disclosed. The lipophilic compound is preferably selected from the group consisting of water-insoluble ubiquinones, ubiquinols, vitamins, provitamins, polyene macrolide antibiotics, and mixtures thereof. The hydrophobic moiety is preferably a sterol or a tocopherol and the hydrophilic moiety is preferably a polyalkylene glycol. In some embodiments, the sterol is cholesterol or sitosterol, the tocopherol is α-(+)-tocopherol, the polyalkylene glycol is a polyethylene glycol or its methyl monoether having an average molecular weight between 400 and 1000, p is equal to 1 or 2, m is equal to 0 or 1 and n is an integer between 2 and 18.

    摘要翻译: 包含亲水性化合物和通式为:(X-OOC - [(CH2)n-COO)m} pY(I)的增溶剂的水溶性组合物,其中:X为疏水部分的残基,Y为 亲水部分的残基,p为1或2,m为0或1,并且n为大于或等于0的整数。 亲脂性化合物优选选自水不溶性泛醌,泛醇,维生素,前维生素,多烯大环内酯抗生素及其混合物。 疏水部分优选为固醇或生育酚,亲水部分优选为聚亚烷基二醇。 在一些实施方案中,甾醇为胆固醇或谷甾醇,生育酚为α-(+) - 生育酚,聚亚烷基二醇为平均分子量在400至1000之间的聚乙二醇或其甲基单醚,p等于1或2 ,m等于0或1,n是2和18之间的整数。