摘要:
A cell stack comprising a plurality of fuel cells or electrolysis cells has a combination of flow patterns between anode gas and cathode gas internally in each of the cells and between the cells relative to each other such that cathode and anode gas internally in a cell flows in either co-flow, counter-flow or cross-flow and further that anode and cathode gas flow in one cell has co-flow, counter-flow or cross-flow relative to the anode and cathode gas flow in adjacent cells.
摘要:
Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair damaged tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to an ischemia-associated molecule; and (b) an activator domain that that detectably modulates the activity of a cellular network.
摘要:
The present invention relates to an injection device for administering doses of liquid drug. The injection device comprises a user operable dose adjustment structure configured to adjust, in a prepared state of the device, a dose of liquid drug of a first size to set a dose of a second size. The present injection device is particularly suitable for self-injection of liquid drugs such as insulin for treating diabetes by the user or patient.
摘要:
Disclosed are bispecific binding agents that specifically target both of the IGF-1 and the ErbB intracellular signaling pathways. For example, bispecific binding agents that comprise an anti-IGF-1R antibody and an anti-ErbB3 antibody connected by a linker are described herein. These bispecific agents are capable of antagonizing signal transduction by both of the IGF-1 and the ErbB signaling pathways and are useful in inhibiting the proliferation of tumor cells whose growth involves the signaling activity of both pathways.
摘要:
Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.
摘要:
An injection device with a travelling clutch which can be shifted between two different positions by the activation of an injection button. In the first position, the injection button and the driver is allowed to rotate relatively to the piston rod, which is blocked from rotation by the clicker element. In the second position, the drive sleeve and the injection button is axially movable while the piston rod is allowed to rotate.
摘要:
An injection device with a dose delivering mechanism being adapted to provide a non-visual, e.g. audible and/or tactile, feedback signal when a set dose has been at least substantially injected. A first and a second part of the injection device are adapted to perform a relative rotational movement with respect to each other. The relative rotational movement causes at least two parts of the injection device to abut or engage, and this abutment or engagement causes the non-visual feedback signal to be generated. A very distinct and precise feedback is provided as compared to prior art axial solutions because the generation of the feedback signal is initiated by the relative rotational movement. Feedback signal may be generated by a change in a rotational velocity of at least one part, e.g. by changing the pitch of a threaded portion or by engaging a non-rotating part and a rotating part, thereby causing the non-rotating part to start rotating. May alternatively be generated by building up and releasing a tension. The injection device is suitable for injecting insulin.
摘要:
A compression assembly for distributing an external compression force to a solid oxide fuel cell stack, the compression assembly comprising a force distributing plate, and a force distributing layer so that when said compression assembly is mounted together with the solid oxide fuel cell stack, the external compression force is exerted on the force distributing plate and the force distributing layer is provided next to a surface of at least one end plate, opposite to the surface facing the solid oxide fuel cells. The force distributing layer has a rigid frame extending next to a region of a sealing area of the solid oxide fuel cell stack. One or more resilient elements are placed inside the space enclosed by the rigid frame and positioned next to an electrochemically active area of the solid oxide fuel cell stack, so that when the compression assembly mounted with the solid oxide fuel cell is in use, the force distributing layer provides an unequally pressure distribution across the region of the sealing area and the electrochemically active area.
摘要:
Disclosed are products and methods to facilitate the identification of compounds that are capable of interacting with biological macromolecules of interest, especially when such macromolecules are attached to a support surface in microarray. Aspects of the invention concern attachment chemistry, peptide labeling, antibody preparation, applications and so on.
摘要:
A dressing for dosing one or more medicaments comprising at least one medicament containing layer (2, 2a, 2b) and a barrier layer (1, 1a, 1b) arranged between the medicament containing layer and the release face (6, 6a), said barrier layer consisting of a continuous hydrophobic phase and a discontinuous hydrophilic phase which is dispersed therein and which is water soluble or water swellable. Desired medicament release rates and release profiles within very wide limits may be obtained with the dressing.