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    CHROMATOGRAPHY COLUMN ASSEMBLY
    2.
    发明申请
    CHROMATOGRAPHY COLUMN ASSEMBLY 审中-公开
    色谱柱组装

    公开(公告)号：US20140166562A1

    公开(公告)日：2014-06-19

    申请号：US14238278

    申请日：2012-08-23

    申请人： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille, Sr. ,  Raymond P. Fisk ,  Frank John Marzalkowski, Jr.

    发明人： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille, Sr. ,  Raymond P. Fisk ,  Frank John Marzalkowski, Jr.

    IPC分类号： B01D15/22

    CPC分类号： B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

    摘要： Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.

    摘要翻译： 描述了一种色谱柱组件，其包括永久变形的外管，中间管，内管和设置在内管内的吸附剂床。 吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。 在组件的纵向位置处由一个或多个均匀的径向卷曲提供径向密封。 均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三管之间的高压液密封。 精确地形成每个卷曲的长度和深度以适应特定应用的要求。 防止管道组件的泄漏，减少或消除空隙体积。 不需要外部套圈或套圈型锻机构; 因此色谱柱组件易于适用于各种色谱柱配置。

    CHROMATOGRAPHY APPARATUS HAVING DIFFUSION BONDED COUPLER
    6.
    发明申请
    CHROMATOGRAPHY APPARATUS HAVING DIFFUSION BONDED COUPLER 审中-公开
    具有扩散键合耦合器的色谱装置

    公开(公告)号：US20140157988A1

    公开(公告)日：2014-06-12

    申请号：US14233033

    申请日：2012-08-23

    申请人： Joseph D. Michienzi

    发明人： Joseph D. Michienzi

    IPC分类号： G01N30/60

    CPC分类号： B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

    摘要： Described is a chromatography a chromatography apparatus that includes a microfluidic substrate, a coupler and a sealing fitting. The microfluidic substrate can include one or more chromatography columns, such as analytical columns or trap columns, and an inlet in communication with the one or more chromatography columns. The coupler is diffusion bonded to the surface of the microfluidic substrate so that an opening in the coupler is aligned to the inlet in the microfluidic substrate. The sealing fitting includes a heat-resistant sealant disposed in the opening of the coupler and in contact with the surface of the substrate. The coupler and sealing fitting enable a compact fluid-tight connection to the inlet of the microfluidic substrate that exhibits high tensile and torsional strength, and does not require the use of adhesives.

    摘要翻译： 描述了一种色谱分离装置，其包括微流体基板，耦合器和密封配件。 微流体底物可以包括一个或多个色谱柱，例如分析柱或捕集柱，以及与一个或多个色谱柱连通的入口。 耦合器扩散接合到微流体衬底的表面，使得耦合器中的开口与微流体衬底中的入口对准。 密封配件包括设置在耦合器的开口中并与衬底的表面接触的耐热密封剂。 耦合器和密封配件能够实现紧凑的流体密封连接到微流体衬底的入口，其显示出高的拉伸和扭转强度，并且不需要使用粘合剂。

    LIQUID CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH PRESSURE SEALS
    8.
    发明申请
    LIQUID CHROMATOGRAPHY CONDUIT ASSEMBLIES HAVING HIGH PRESSURE SEALS 审中-公开
    具有高压密封的液相色谱仪组件

    公开(公告)号：US20140158599A1

    公开(公告)日：2014-06-12

    申请号：US14233212

    申请日：2012-08-23

    申请人： Joseph D. Michienzi

    发明人： Joseph D. Michienzi

    IPC分类号： G01N30/60 ,  F16L9/14

    CPC分类号： G01N30/6026 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  B05B5/16 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

    摘要： Described is a tubing assembly which includes a permanently deformable outer tube, an intermediate tube and an inner tube. A radial seal is provided by a uniform radial crimp having a non-zero longitudinal length at a longitudinal location on the tubing assembly. In some embodiments one or both ends of the assembly have a uniform radial crimp and are polished so that the ends of two or more of the tubes are substantially flush with each other to thereby block the passage of fluids between the ends of the tubes. In other embodiments the uniform radial crimps are at other longitudinal locations where a high pressure seal is desired. The longitudinal length and the depth of each uniform radial crimp can be formed to accommodate the requirements of a particular application so that leakage along the tubing assembly is prevented and void volume is reduced or eliminated.

    摘要翻译： 描述了一种管组件，其包括永久变形的外管，中间管和内管。 通过在管组件上的纵向位置处具有非零纵向长度的均匀径向压接件来提供径向密封。 在一些实施例中，组件的一端或两端具有均匀的径向压接并且被抛光，使得两个或更多个管的端部彼此基本齐平，从而阻止流体在管的端部之间的通过。 在其它实施例中，均匀的径向卷曲位于需要高压密封的其它纵向位置处。 可以形成每个均匀径向卷曲的纵向长度和深度以适应特定应用的要求，从而防止沿着管道组件的泄漏并减少或消除空隙体积。

    Reusable fitting for attaching a conduit to a port
    9.
    发明授权
    Reusable fitting for attaching a conduit to a port 有权

    公开(公告)号：US10022736B2

    公开(公告)日：2018-07-17

    申请号：US14232711

    申请日：2012-08-23

    申请人： Joseph D. Michienzi

    发明人： Joseph D. Michienzi

    IPC分类号： B05B5/16 ,  B01D15/10 ,  G01N30/60 ,  B01D15/22 ,  B01D15/18 ,  G01N30/72

    摘要： Described is a reusable fitting for attaching a conduit to a port. The fitting includes a housing, a spring, a retainer and a cap. The retainer is capable of locking and unlocking a conduit in the fitting. The fitting provides a high pressure fluid-tight seal and a substantially zero void volume at the junction of two fluidic conduits. The fitting is removable, reusable and replaceable, and allows a user to make and remake connections of a capillary to a fluidic port without permanently binding a ferrule to a specific capillary and thus to a specific port. The fitting can be replaced if part or all of the fitting is damaged during use.