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公开(公告)号：US09545445B2
公开(公告)日：2017-01-17
申请号：US12823715
申请日：2010-06-25
IPC分类号： A01N43/78 , A61K31/425 , A61K45/06 , A61K31/426
CPC分类号： A61K45/06 , A61K31/426 , A61K2300/00
摘要： The present invention relates to a therapeutic drug or a preventive drug for hypertension or high-normal blood pressure, comprising (a) and (b) as active ingredients: (a) a 2-phenylthiazole compound represented by formula (I) or a pharmaceutically acceptable salt thereof; (b) at least one compound or a pharmaceutically acceptable salt thereof selected from the group consisting of calcium antagonists, renin-angiotensin system inhibitors, diuretics, sympatholytic agents, vasodilators, and medicinally acceptable salts of these. The present invention also relates to a therapeutic method or a preventive method for hypertension or high-normal blood pressure, comprising administering the above (a) and (b) in amounts effective for treating or preventing hypertension or high-normal blood pressure.
摘要翻译： 本发明还涉及高血压或高正常血压的治疗方法或预防方法，包括以有效治疗或预防高血压或高正常血压的量施用上述（a）和（b）。
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2.发明授权公开(公告)号：US07763974B2
公开(公告)日：2010-07-27
申请号：US10545021
申请日：2004-02-13
IPC分类号： H01L23/34
CPC分类号： H01L25/072 , H01L24/45 , H01L24/48 , H01L24/49 , H01L25/162 , H01L2224/16225 , H01L2224/32225 , H01L2224/45015 , H01L2224/45124 , H01L2224/45144 , H01L2224/48091 , H01L2224/48137 , H01L2224/48139 , H01L2224/48227 , H01L2224/48247 , H01L2224/48472 , H01L2224/49111 , H01L2224/49171 , H01L2224/49175 , H01L2224/73204 , H01L2224/73265 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01015 , H01L2924/01018 , H01L2924/01019 , H01L2924/01023 , H01L2924/01027 , H01L2924/01028 , H01L2924/01029 , H01L2924/01033 , H01L2924/01037 , H01L2924/01039 , H01L2924/01042 , H01L2924/01046 , H01L2924/01047 , H01L2924/01051 , H01L2924/01074 , H01L2924/01075 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/01088 , H01L2924/014 , H01L2924/09701 , H01L2924/1305 , H01L2924/13055 , H01L2924/1306 , H01L2924/13091 , H01L2924/14 , H01L2924/181 , H01L2924/19041 , H01L2924/19043 , H01L2924/19105 , H01L2924/19107 , H01L2924/30105 , H01L2924/30107 , H02M1/08 , H01L2924/00014 , H01L2924/00 , H01L2924/00012
摘要： An integrated circuit for driving a semiconductor device, which is adaptable for demands, such as a higher output (larger current), a higher voltage, and a smaller loss, and has a small size, is produced at a low cost, and has high reliability. A power converter including such an integrated circuit is also provided. Circuit elements constituting a drive section of an upper arm drive circuit 212, a level shift circuit 20 including a current sensing circuit 210, a drive section of a lower arm drive circuit 222, and a drive signal processing circuit 224 are integrated and built in one high withstand voltage IC chip 200. Circuit elements constituting a final output stage buffer section 213 of the upper arm drive circuit 212 are built in a vertical p-channel MOS-FET chip 213p and a vertical n-channel MOS-FET chip 213n. Circuit elements constituting a final output stage buffer section 223 of the lower arm drive circuit 222 are built in a vertical p-channel MOS-FET chip 223p and a vertical n-channel MOS-FET chip 223n. Thus, a driver IC 2 is fabricated.
摘要翻译： 以低成本生产用于驱动半导体器件的集成电路，其具有较高的输出（较大的电流），更高的电压和更小的损耗，并且尺寸更小的需求，并且具有高的 可靠性。 还提供了一种包括这种集成电路的功率转换器。 构成上臂驱动电路212的驱动部的电路元件，包括电流检测电路210的电平移动电路20，下臂驱动电路222的驱动部以及驱动信号处理电路224被一体化并内置于一个 构成上臂驱动电路212的最终输出级缓冲器部分213的电路元件内置在垂直p沟道MOS-FET芯片213p和垂直n沟道MOS-FET芯片213n中。 构成下臂驱动电路222的最终输出级缓冲部分223的电路元件内置在垂直p沟道MOS-FET芯片223p和垂直n沟道MOS-FET芯片223n中。 因此，制造驱动器IC2。
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公开(公告)号：US20070215316A1
公开(公告)日：2007-09-20
申请号：US10587283
申请日：2004-01-26
申请人： Atsushi Saito , Katsuhiro Higuchi , Osamu Otsuka , Hidekazu Nishidai , Hiroshi Houzouji , Toshiaki Morita , Yoshimasa Takahashi , Toshiya Sato
发明人： Atsushi Saito , Katsuhiro Higuchi , Osamu Otsuka , Hidekazu Nishidai , Hiroshi Houzouji , Toshiaki Morita , Yoshimasa Takahashi , Toshiya Sato
CPC分类号： H02M7/003 , H05K7/20927
摘要： A semiconductor device in which the lifetime of mounted components can be prolonged. A cooling system for controlling the temperature of a refrigerant through a heating section (1) and a radiator (2) is provided. The semiconductor device (100) is connected to the cooling system and is cooled. A variation width (ΔT1) of temperature controlled by the cooling system through the heating section (1) and the radiator (2) is larger than a temperature variation (ΔT2) of the refrigerant caused by variations in operating conditions of the semiconductor device (100) (ΔT1>ΔT2).
摘要翻译： 可以延长安装部件的寿命的半导体器件。 提供一种用于通过加热部（1）和散热器（2）控制制冷剂的温度的冷却系统。 半导体器件（100）连接到冷却系统并被冷却。 由冷却系统通过加热部分（1）和散热器（2）控制的温度的变化宽度（DeltaT 1）大于由半导体器件的操作条件的变化引起的制冷剂的温度变化（DeltaT 2） （100）（DeltaT 1> DeltaT 2）。
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公开(公告)号：US4219843A
公开(公告)日：1980-08-26
申请号：US887767
申请日：1978-03-17
申请人： Yoshimasa Takahashi
发明人： Yoshimasa Takahashi
IPC分类号： H04N9/31
CPC分类号： H04N9/31
摘要： A projection type color television system of the present disclosure comprises three cathode ray tubes for projecting a color picture on a projecting screen. The three cathode ray tubes have phosphor screens for producing and projecting onto the projecting screen respective three primary colors of light beam containing an image information in the beam. These cathode ray tubes are positioned with their respective phosphor screens placed on a first imaginary plane parallel to the projecting screen and in alignment with each other along a first imaginary line parallel to a horizontal scanning direction of the light beam. Of these tubes, a cathode ray tube producing a color having the highest amount of brightness measured in lumen is positioned intermediately between the other cathode ray tubes. Color signals applied to the two cathode ray tubes positioned one on each side of the intermediate cathode ray tube are corrected in such a manner that the ratio of the brightness of the primary colors is maintained at a predetermined ratio.
摘要翻译： 本公开的投影型彩色电视系统包括用于在投影屏幕上投影彩色图像的三个阴极射线管。 三个阴极射线管具有荧光屏，用于在投影屏幕上产生和投影相应的包含光束中的图像信息的三原色光束。 这些阴极射线管被定位成使它们各自的荧光屏放置在平行于投影屏幕的第一假想平面上并且沿着平行于光束的水平扫描方向的第一假想线相互对准。 在这些管中，产生具有在内腔中测量的最高亮度的颜色的阴极射线管位于其它阴极射线管之间。 施加到位于中间阴极射线管的每一侧的两个阴极射线管的颜色信号被校正为使原色的亮度比保持在预定的比率。
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公开(公告)号：US08617841B2
公开(公告)日：2013-12-31
申请号：US10575626
申请日：2004-10-21
申请人： Kei Yamana , Yasunori Nakayama , Yoshimasa Takahashi , Eiji Ochiai , Hitoshi Wada , Yoshiaki Azuma
发明人： Kei Yamana , Yasunori Nakayama , Yoshimasa Takahashi , Eiji Ochiai , Hitoshi Wada , Yoshiaki Azuma
CPC分类号： C12P21/02 , A01K2217/05 , A01K2267/0306 , A61K38/00 , C07K14/4703
摘要： [PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc.[MEANS FOR SOLVING PROBLEMS] A novel soluble polypeptide protein.
摘要翻译： [问题]提供具有新结构并显示出抑制血管发生的活性或抑制破骨细胞发生的活性的多肽，并通过构建纯化上述蛋白质的方法来提供重组蛋白质。 提供用于设计腱炎，类风湿性关节炎，关节畸形症，恶性肿瘤等的补充剂的成分。[解决问题的方法]一种新型可溶性多肽蛋白质。
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公开(公告)号：US08481676B2
公开(公告)日：2013-07-09
申请号：US12368219
申请日：2009-02-09
申请人： Kei Yamana , Yasunori Nakayama , Yoshimasa Takahashi , Eiji Ochiai , Hitoshi Wada , Yoshiaki Azuma
发明人： Kei Yamana , Yasunori Nakayama , Yoshimasa Takahashi , Eiji Ochiai , Hitoshi Wada , Yoshiaki Azuma
CPC分类号： C07K14/515 , C07K14/51 , C07K2319/21 , C07K2319/43
摘要： [Problems] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc.[Means for Solving Problems] A novel soluble polypeptide protein.
摘要翻译： [问题]提供具有新结构并显示抑制血管发生或抑制破骨细胞发生活性的活性的多肽，并通过构建纯化上述蛋白质的方法来提供重组蛋白。 提供用于设计腱炎，类风湿性关节炎，关节畸形症，恶性肿瘤等的补充剂的成分。[解决问题的方法]一种新型可溶性多肽蛋白质。
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公开(公告)号：US20110046192A1
公开(公告)日：2011-02-24
申请号：US12823715
申请日：2010-06-25
IPC分类号： A61K31/426 , A61P9/12
CPC分类号： A61K45/06 , A61K31/426 , A61K2300/00
摘要： The present invention relates to a therapeutic drug or a preventive drug for hypertension or high-normal blood pressure, comprising (a) and (b) as active ingredients: (a) a 2-phenylthiazole compound represented by formula (I) or a pharmaceutically acceptable salt thereof; (b) at least one compound or a pharmaceutically acceptable salt thereof selected from the group consisting of calcium antagonists, renin-angiotensin system inhibitors, diuretics, sympatholytic agents, vasodilators, and medicinally acceptable salts of these. The present invention also relates to a therapeutic method or a preventive method for hypertension or high-normal blood pressure, comprising administering the above (a) and (b) in amounts effective for treating or preventing hypertension or high-normal blood pressure.
摘要翻译： 本发明涉及用于高血压或高血压正常的治疗药物或预防药物，其包含（a）和（b）作为活性成分：（a）由式（I）表示的2-苯基噻唑化合物或其药学上可接受的盐 其可接受的盐; （b）至少一种选自钙拮抗剂，肾素 - 血管紧张素系统抑制剂，利尿剂，交感神经溶解剂，血管舒张剂及其医药上可接受的盐的化合物或其药学上可接受的盐。 本发明还涉及高血压或高正常血压的治疗方法或预防方法，包括以有效治疗或预防高血压或高正常血压的量施用上述（a）和（b）。
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公开(公告)号：US20090313711A1
公开(公告)日：2009-12-17
申请号：US10575626
申请日：2004-10-21
申请人： Kei Yamana , Yasunori Nakayama , Yoshimasa Takahashi , Eiji Ochiai , Hitoshi Wada , Yoshiaki Azuma
发明人： Kei Yamana , Yasunori Nakayama , Yoshimasa Takahashi , Eiji Ochiai , Hitoshi Wada , Yoshiaki Azuma
IPC分类号： A01K67/033 , C07K14/00 , C12N9/16 , C07H21/00 , C12N15/63 , C12N5/00 , C12P21/00 , C07K16/00
CPC分类号： C12P21/02 , A01K2217/05 , A01K2267/0306 , A61K38/00 , C07K14/4703
摘要： [PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc.[MEANS FOR SOLVING PROBLEMS] A novel soluble polypeptide protein.
摘要翻译： [问题]提供具有新结构并显示出抑制血管发生的活性或抑制破骨细胞发生的活性的多肽，并通过构建纯化上述蛋白质的方法来提供重组蛋白质。 提供用于设计腱炎，类风湿性关节炎，关节畸形症，恶性肿瘤等的补充剂的成分。[解决问题的方法]一种新型可溶性多肽蛋白质。
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公开(公告)号：US07579805B2
公开(公告)日：2009-08-25
申请号：US10587283
申请日：2004-01-26
申请人： Atsushi Saito , Katsuhiro Higuchi , Osamu Otsuka , Hidekazu Nishidai , Hiroshi Houzouji , Toshiaki Morita , Yoshimasa Takahashi , Toshiya Sato
发明人： Atsushi Saito , Katsuhiro Higuchi , Osamu Otsuka , Hidekazu Nishidai , Hiroshi Houzouji , Toshiaki Morita , Yoshimasa Takahashi , Toshiya Sato
IPC分类号： H02P27/04
CPC分类号： H02M7/003 , H05K7/20927
摘要： A semiconductor device in which the lifetime of mounted components can be prolonged. A cooling system for controlling the temperature of a refrigerant through a heating section and a radiator is provided. The semiconductor device is connected to the cooling system and is cooled. A variation width (ΔT1) of temperature controlled by the cooling system through the heating section and the radiator is smaller than a temperature variation (ΔT2) of the refrigerant caused by variations in operating conditions of the semiconductor device (ΔT1≦ΔT2).
摘要翻译： 可以延长安装部件的寿命的半导体器件。 提供一种用于通过加热部和散热器控制制冷剂的温度的冷却系统。 半导体器件连接到冷却系统并被冷却。 由冷却系统通过加热部和散热器控制的温度的变化宽度（DeltaT1）小于由半导体器件的工作条件变化（DeltaT1 <= DeltaT2）引起的制冷剂的温度变化（DeltaT2）。
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公开(公告)号：US4087835A
公开(公告)日：1978-05-02
申请号：US749281
申请日：1976-12-10
IPC分类号： H04N9/31
CPC分类号： H04N9/31
摘要： A projection type color television system of the present disclosure comprises three cathode ray tubes each adapted to produce one of three different primary color light beams, a projecting screen and three lens assemblies positioned between the projecting screen and respective cathode ray tubes. The glass faceplate or phosphor screen of the three cathode ray tubes are positioned on an imaginary plane which is in parallel relation to the projecting screen, and principle planes of the three lens assemblies are also position in an another imaginary plane which is in parallel relation to the projecting screen, so that the projected image from any one of cathode ray tubes geometrically overlaps with another projected image from another cathode ray tube. Each cathode ray tube is coupled with a brightness correction circuit for correcting the brightness of the projected image on the projecting screen to be uniform. The projecting screen is formed with two layers for widening the horizontal diffusion and narrowing the vertical diffusion.
摘要翻译： 本公开的投影型彩色电视系统包括三个阴极射线管，每个阴极射线管适于产生三种不同的原色光束之一，投射屏幕和位于投影屏幕和相应阴极射线管之间的三个透镜组件。 三个阴极射线管的玻璃面板或荧光屏位于与投影屏平行的虚拟平面上，三个透镜组件的主平面也位于另一虚拟平面中，该平面与 投影屏幕，使得来自任何一个阴极射线管的投影图像与另一个阴极射线管的另一个投影图像几何重叠。 每个阴极射线管与亮度校正电路耦合，用于校正投射屏幕上的投影图像的亮度均匀。 投影屏幕形成有两层，用于扩大水平扩散并使垂直扩散变窄。
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