公开(公告)号：US5320939A

公开(公告)日：1994-06-14

申请号：US953294

申请日：1992-09-30

申请人： Yoshio Hashizume ,  Ryuzo Hayashi ,  Akio Kariyone

发明人： Yoshio Hashizume ,  Ryuzo Hayashi ,  Akio Kariyone

IPC分类号： G01N27/26 ,  C12Q1/00 ,  G01N27/27 ,  G01N27/403 ,  G01N27/416

CPC分类号： C12Q1/001 ,  Y10S435/817

摘要： In a two-substrate measuring apparatus employing a first enzyme electrode for responding only to a first substrate to be measured and a second enzyme electrode for responding to both first and second substrates to be measured, in which the same enzymatic reactions are used for forming detectable substances and the substances to be finally detected by the electrodes are identical, when calculating the calibration curve for the second substrate to be measured, the output portion due to traces of the first substrate contained in the second substrate to be measured is removed, so that the second substrate is measured at a high sensitivity and high accuracy.

摘要翻译： 在使用第一酶电极仅响应待测量的第一基底的第二酶电极和用于响应于待测量的第一和第二基底的第二酶电极的双基底测量装置中，其中使用相同的酶反应形成可检测的 物质和由电极最终检测到的物质在计算待测量的第二基板的校准曲线时是相同的，除去由于包含在待测量的第二基板中的第一基板的痕迹引起的输出部分，从而 以高灵敏度和高精度测量第二基板。

公开(公告)号：US3935153A

公开(公告)日：1976-01-27

申请号：US566787

申请日：1975-04-10

申请人： Teizo Kudo ,  Yoshio Hashizume ,  Masatoshi Mikumo ,  Masanori Itoh

发明人： Teizo Kudo ,  Yoshio Hashizume ,  Masatoshi Mikumo ,  Masanori Itoh

IPC分类号： C08F279/02 ,  C08L25/06 ,  C08L51/04 ,  C08K5/11

CPC分类号： C08F279/02 ,  C08L25/06 ,  C08L51/04

摘要： Molding compositions having improved properties for low-pressure, low-shear molding techniques are prepared by carrying out a two-stage polymerization of an initial mixture comprising a polymerizable monomer selected from the group consisting of (1) a polymerizable aromatic monoalkenyl monomer or (2) a mixture of such aromatic monoalkenyl monomer with another polymerizable monovinyl monomer; in the presence of a butadiene rubber elastomer under bulk polymerization conditions, followed by suspension polymerization conditions; the process being characterized by the incorporation into the initial mixture of 1 to 10 wt. %, based on the polymerizable monomers, of a straight chain saturated polyester having an average molecular weight of 1,000 to 50,000.

摘要翻译： 通过进行包含选自（1）可聚合芳族单链烯基单体或（2）的可聚合单体的可聚合单体的初始混合物的两阶段聚合来制备具有改进的用于低压，低剪切模塑技术的性能的成型组合物 ）这种芳族单链烯基单体与另一种可聚合单乙烯基单体的混合物; 在本体聚合条件下在丁二烯橡胶弹性体存在下，随后进行悬浮聚合条件; 该方法的特征在于将初始混合物掺入1至10wt。 ％的基于可聚合单体的平均分子量为1,000至50,000的直链饱和聚酯。

公开(公告)号：US5242793A

公开(公告)日：1993-09-07

申请号：US490709

申请日：1990-03-07

申请人： Akio Kariyone ,  Ryuzo Hayashi ,  Yoshio Hashizume

发明人： Akio Kariyone ,  Ryuzo Hayashi ,  Yoshio Hashizume

IPC分类号： B01D69/14 ,  C12N11/02 ,  C12N11/10 ,  C12Q1/00 ,  G01N27/40

CPC分类号： C12Q1/003 ,  B01D69/141 ,  C12N11/02 ,  C12N11/10 ,  C12Q1/002 ,  G01N27/3271 ,  Y10S435/817

摘要： An electrode comprising an electrically conductive base, and a selectively permeable membrane which is produced by forming a membrane from a mixed solution comprising (a) albumin, (b) at least one type of crosslinking agent and (c) chitosan. The selectively permeable membrane is useful, e.g., in conjuction with an electrode. An enzyme electrode is also provided having the selectively permeable membrane disposed on the electrode and an immobilized enzyme membrane disposed on the selectively permeable membrane. The immobilized enzyme membrane is prepared by incorporating a carboxylate into the solution containing the enzyme and an aldehyde as the crosslinking agent. The crosslinking is effected by heating or drying.

公开(公告)号：US5081037A

公开(公告)日：1992-01-14

申请号：US321165

申请日：1989-03-09

申请人： Akio Kariyone ,  Yoshio Hashizume ,  Ryuzo Hayashi

发明人： Akio Kariyone ,  Yoshio Hashizume ,  Ryuzo Hayashi

IPC分类号： G01N27/327 ,  C12M1/40 ,  C12Q1/00 ,  G01N27/30 ,  G01N27/416

CPC分类号： C12Q1/005 ,  Y10S435/817 ,  Y10S435/913 ,  Y10S435/939

摘要： An enzyme electrode for measuring malto-oligosaccharides having a co-immobilized enzyme membrane containing glucoamylase and a glucose oxidizing enzyme such as glucose oxidase or pyranose oxidase.The glucoamylase and glucose oxidizing enzyme are immobilized at a ratio of ##EQU1## where Va is the maximum reaction rate of glucoamylase as expressed in the glucose formation rate from maltose, and Vo is the maximum reaction rate of glucose oxidizing enzyme as expressed in the hydrogen peroxide formation rate from glucose.In such enzyme electrode, malto-oligosaccharides are detected at the response value proportional to their degree of polymerization. Therefore, the malto-oligosaccharides can be measured at the glucose converted concentration.

公开(公告)号：US4299748A

公开(公告)日：1981-11-10

申请号：US969373

申请日：1978-12-14

申请人： Yoshio Hashizume ,  Masanori Itoh ,  Yasumasa Sakai ,  Akiyosi Kamita

发明人： Yoshio Hashizume ,  Masanori Itoh ,  Yasumasa Sakai ,  Akiyosi Kamita

IPC分类号： C08L51/00 ,  C08F2/00 ,  C08F2/16 ,  C08F2/22 ,  C08F265/04 ,  C08F291/00 ,  C08J7/04 ,  C08L1/00 ,  C08L27/00 ,  C08L33/00 ,  C08L33/02 ,  C08L77/00 ,  C08L91/06 ,  C09D5/00 ,  C09D5/24 ,  C09D133/04 ,  C09D133/06 ,  C09D151/00 ,  C08L41/00

CPC分类号： C08J7/047 ,  C08F265/04 ,  C09D133/066 ,  C09D5/24 ,  C08J2433/00 ,  C08L91/06 ,  Y10S524/901 ,  Y10T428/31855

摘要： An aqueous coating composition in the form of an aqueous dispersion of acrylic copolymer prepared by polymerizing a mixture of acrylic monomers in an aqueous medium containing an electroconductive copolymer. The composition forms coatings having both heat sealing properties and antistatic properties and also possessing transparency, anti-blocking properties, slipping properties and resistance to weather and to water.

摘要翻译： 丙烯酸共聚物的水分散体形式的水性涂料组合物，其通过在含有导电共聚物的水性介质中聚合丙烯酸单体的混合物制备。 该组合物形成具有热封性和抗静电性的涂层，并且还具有透明性，防粘连性，滑动性，耐天气和耐水性。

公开(公告)号：US5221521A

公开(公告)日：1993-06-22

申请号：US735911

申请日：1991-07-25

申请人： Yoshio Hashizume ,  Akio Kariyone ,  Ryuzo Hayashi

发明人： Yoshio Hashizume ,  Akio Kariyone ,  Ryuzo Hayashi

IPC分类号： G01N1/38 ,  G01N35/08

CPC分类号： G01N1/38 ,  G01N35/085 ,  Y10T436/117497 ,  Y10T436/118339 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： A liquid dilution system which dilutes a sample to be analyzed with a carrier to supply a diluted sample-containing liquid to an analytical measurement apparatus of flow type. The inventive dilution system features simplicity and versatility as compared to conventional automatic apparatus with robot concept, and the present system comprises: a first carrier pump for feeding a first carrier; a sample injection unit for injecting the sample into the first carrier; a main passage for flowing a liquid from the sample injection unit to a detector unit of an analytical measurement apparatus; a branching device located downstream of the sample injection unit for forming a branched passage to remove a liquid mass partially from the main passage; a confluence unit located downstream of the branching unit for confluencing a second carrier; and a second carrier pump for feeding the second carrier to the confluence unit. Dilution and mixing of the sample with a carrier is done twice, once at the sample injection and then again at confluence.

公开(公告)号：US5190872A

公开(公告)日：1993-03-02

申请号：US573066

申请日：1990-08-27

申请人： Yoshio Hashizume ,  Akio Kariyone ,  Ryuzo Hayashi ,  Minako Oka

发明人： Yoshio Hashizume ,  Akio Kariyone ,  Ryuzo Hayashi ,  Minako Oka

IPC分类号： G01N27/327 ,  C12N11/00 ,  C12N11/06 ,  C12N11/14 ,  C12Q1/00 ,  G01N27/416

CPC分类号： C12N11/06 ,  C12Q1/003 ,  Y10S435/817

摘要： Alcohol oxidase is immobilized by bonding an aminosilane coupling agent to a carrier, bonding a multifunctional aldehyde such as glutaraldehyde to an amino group of the aminosilane, washing the carrier to remove free multifunctional aldehyde and bonding alcohol oxidase to the multifunctional aldehyde bonded to the aminosilane. Washing to remove free multifunctional aldehyde enables immobilizing a one molecule thickness of alcohol oxidase on the carrier since free multifunctional aldehyde is not present to cross-link alcohol oxidase molecules together. A thin layer of alcohol oxidase is advantageous when assaying for alcohol since a thin layer does not retain hydrogen peroxide that can deactivate alcohol oxidase. The carrier preferably contains hydroxyl groups and is porous, and can be a silicate-containing carrier such as diatomaceous earth or fire brick. The immobilized alcohol oxidase is used in a column as part of an apparatus for measuring alcohol or as part of an apparatus containing immobilized glucose oxidase for measuring glucose and alcohol.

公开(公告)号：US5081015A

公开(公告)日：1992-01-14

申请号：US401132

申请日：1989-08-30

申请人： Ryuzo Hayashi ,  Akio Kariyone ,  Yoshio Hashizume

发明人： Ryuzo Hayashi ,  Akio Kariyone ,  Yoshio Hashizume

IPC分类号： C12Q1/00

CPC分类号： C12Q1/005 ,  Y10S435/817 ,  Y10S435/921 ,  Y10S435/938

摘要： An enzyme electrode possessing an immobilized enzyme membrane or an immobilized enzyme layer composed by applying a solution containing alcohol oxidase and a crosslinking agent, in which the solution further contains reduced glutathione.According to the invention it is possible to immobilize alcohol oxidase stably, and an excellent immobilized enzyme electrode for alcohol measurement is obtained. Furthermore, by this invention, a highly sensitive and stable measuring method is conducted quite easily.

公开(公告)号：US4252697A

公开(公告)日：1981-02-24

申请号：US83924

申请日：1979-10-11

申请人： Yoshio Hashizume ,  Masatoshi Mikumo ,  Fumio Takenaka

发明人： Yoshio Hashizume ,  Masatoshi Mikumo ,  Fumio Takenaka

IPC分类号： C08F2/00 ,  C08F2/16 ,  C08F2/44 ,  C08L1/12

CPC分类号： C08F2/16

摘要： An aqueous dispersion of synthetic resin mutually dissolved with a cellulose acetate alkylate is prepared by mixing water, a protective colloid and/or a surfactant, a cellulose acetate alkylate, an oil-soluble radical polymerization initiator and at least one monomer in which the cellulose acetate alkylate and the oil-soluble radical polymerization initiator are soluble, under stirring, to form an aqueous dispersion and then subjecting the monomer to radical polymerization to form a homogeneous mixture of the cellulose acetate alkylate and at least one polymer in the particles in the aqueous dispersion.

摘要翻译： 通过混合水，保护胶体和/或表面活性剂，乙酸纤维素乙酸酯，油溶性自由基聚合引发剂和至少一种单体，制备与乙酸纤维素乙酸酯相互溶解的合成树脂的水性分散体，其中乙酸纤维素 烷基化物和油溶性自由基聚合引发剂在搅拌下是可溶的，以形成水分散体，然后使单体进行自由基聚合以形成水分散体中颗粒中的乙酸纤维素乙酸酯和至少一种聚合物的均匀混合物 。

公开(公告)号：US3954903A

公开(公告)日：1976-05-04

申请号：US513541

申请日：1974-10-10

申请人： Teizo Kudo ,  Yoshio Hashizume ,  Masanori Itoh ,  Makoto Shiga

发明人： Teizo Kudo ,  Yoshio Hashizume ,  Masanori Itoh ,  Makoto Shiga

IPC分类号： C08L67/00 ,  B29C31/00 ,  B29C41/00 ,  B29C41/04 ,  B29C41/52 ,  C08F279/00 ,  C08F279/04 ,  C08L7/00 ,  C08L21/00 ,  C08L25/00 ,  C08L51/00 ,  C08L51/02 ,  C08L55/02 ,  C08L67/06

CPC分类号： C08F279/04 ,  C08L55/02 ,  Y10S525/942

摘要： A new impact-resistant ABS resin composition is disclosed comprising (1) 100 parts by weight of a graft copolymer of vinyl aromatic monomer and vinyl cyanide monomer, said copolymer being grafted onto butadiene rubber particles of a size of from 0.5 to 2.0 .mu. dispersed in the graft copolymer and (2) 1 to 10 parts by weight of a straight chain saturated polyester having an average molecular weight of from 1000 to 50000. The composition is prepared by the bulk-suspension two stage polymerization of vinyl aromatic monomer and vinyl cyanide monomer in the presence of butadiene rubber component. The polyester is incorporated during either the bulk polymerization stage or the suspension polymerization stage, or it is blended with the ABS polymer after the two stage polymerization is completed.

摘要翻译： 公开了一种新的耐冲击ABS树脂组合物，其包含（1）100重量份的乙烯基芳族单体和乙烯基氰单体的接枝共聚物，所述共聚物接枝到尺寸为0.5至2.0μm的丁二烯橡胶颗粒上，分散在 接枝共聚物和（2）1至10重量份的平均分子量为1000-50000的直链饱和聚酯。该组合物通过乙烯基芳族单体和乙烯基氰单体的本体悬浮两阶段聚合制备 在丁二烯橡胶组分的存在下。 在本体聚合阶段或悬浮聚合阶段期间引入聚酯，或者在两阶段聚合完成后与ABS聚合物共混。