公开(公告)号：US20130288287A1

公开(公告)日：2013-10-31

申请号：US13836722

申请日：2013-03-15

Applicant: Agency For Science, Technology And Research

Inventor： Andrew Chwee Aun WAN ,  Tze Chiun Lim ,  Meng Fatt Leong ,  Jackie Y. Ying ,  Jerry Kah Chin TOH

IPC: G01N33/50

CPC classification number: C12Q1/025 ,  A61K35/35 ,  A61K35/36 ,  A61K47/26 ,  C12N5/0627 ,  C12N5/0666 ,  C12N11/10 ,  C12N2501/12 ,  C12N2501/15 ,  G01N33/5088

Abstract: A fibrous structure comprising an assembly of hair follicle cells within a fibrous matrix.

Abstract translation: 纤维结构，其包含在纤维基质内的毛囊细胞的组合。

公开(公告)号：US20180044640A1

公开(公告)日：2018-02-15

申请号：US15553285

申请日：2016-05-16

Applicant: Agency for Science, Technology and Research

Inventor： Hong Fang Lu ,  Meng Fatt Leong ,  Tze Chiun Lim ,  Andrew Chwee Aun WAN, Wan

IPC: C12N5/077 ,  G01N33/50 ,  G01N33/483

CPC classification number: C12N5/0657 ,  C12N5/0068 ,  C12N2500/36 ,  C12N2500/90 ,  C12N2500/98 ,  C12N2501/15 ,  C12N2501/415 ,  C12N2501/999 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2506/45 ,  C12N2513/00 ,  C12N2533/30 ,  C12N2533/90 ,  C12N2535/00 ,  G01N33/4833 ,  G01N33/502 ,  G01N33/5061 ,  G01N33/5082

Abstract: The present invention relates to a method for producing a contractile cellular construct, comprising the steps of: a) seeding pre-selected cells onto a mold, wherein the pre-selected cells comprise signal emitting agents; and b) culturing the pre-selected cells to produce the cellular construct. The said method is exemplified by mixing cardiomyocytes with fluorescent microbeads, seeding the suspension on a polydimethylsiloxane (PDMS) mold and culturing to form a contractile device comprising of cardiac muscles. The present invention also relates to a method for measuring the contractility of the cellular construct by measuring the displacement of the signal emitting agents, and a method for screening a method for screening one or more agents for modulating the contractility of a contractile cellular construct.

公开(公告)号：US09663874B2

公开(公告)日：2017-05-30

申请号：US14385562

申请日：2013-03-18

Applicant: Agency for Science, Technology and Research

Inventor： Andrew Chwee Aun Wan ,  Meng Fatt Leong ,  Tze Chiun Lim ,  Jackie Y. Ying ,  Jerry Kah Chin Toh

IPC: D01D5/12 ,  D01D5/30 ,  D01D5/38 ,  A61L27/24 ,  A61L27/38 ,  A61L27/56 ,  C12N11/04

CPC classification number: D01D5/12 ,  A61L27/24 ,  A61L27/38 ,  A61L27/56 ,  C12N11/04 ,  C12N2500/34 ,  C12N2500/50 ,  D01D5/30 ,  D01D5/38

Abstract: There is provided a device, and related method and uses, for drawing a polymer fiber, the device comprising: a. at least two polymer compartments, wherein each polymer compartment is capable of retaining a polymer solution, and wherein adjacent compartments comprise different polymer solutions; and b. a slider comprising at least one prong, wherein the prong is capable of contacting the different polymer solutions, and wherein the slider is arranged in a retractable manner from the at least two polymer compartments. There is further provided a system and a related method for manufacturing a polymer fiber.

公开(公告)号：US09029099B2

公开(公告)日：2015-05-12

申请号：US13867533

申请日：2013-04-22

Applicant: Agency for Science, Technology and Research

Inventor： Andrew Chwee Aun Wan ,  Tze Chiun Lim ,  Meng Fatt Leong ,  Jackie Y. Ying ,  Jerry Kah Chin Toh

IPC: A61K47/36 ,  A61K35/36 ,  C12Q1/02 ,  C12N11/10 ,  G01N33/50 ,  C12N5/071 ,  C12N5/0775 ,  A61K47/26

CPC classification number: C12Q1/025 ,  A61K35/35 ,  A61K35/36 ,  A61K47/26 ,  C12N5/0627 ,  C12N5/0666 ,  C12N11/10 ,  C12N2501/12 ,  C12N2501/15 ,  G01N33/5088

Abstract: A fibrous structure comprising an assembly of hair follicle cells within a fibrous matrix.

Abstract translation: 纤维结构，其包含在纤维基质内的毛囊细胞的组合。