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公开(公告)号:US07901799B2
公开(公告)日:2011-03-08
申请号:US11900683
申请日:2007-09-13
申请人: Albert Feuerstein , Thomas Albert
发明人: Albert Feuerstein , Thomas Albert
IPC分类号: B32B9/00
CPC分类号: C23C14/0021 , C23C14/0641 , C23C14/0664 , C23C14/325 , C23C14/3492 , C23C28/044 , C23C28/42 , Y10T428/263 , Y10T428/265
摘要: This invention relates to erosion resistant coatings comprising at least 2 sublayer systems in which each sublayer system is separated from another by an interlayer, wherein (i) each sublayer system is the same or different and comprises at least 4 layers, (ii) said layers comprise alternating layers of a nitride-containing compound of stoichiometric composition and a nitride-containing compound of nonstoichiometric composition, (iii) each sublayer system has a thickness of greater than about 0.4 microns, and (iv) each interlayer is the same or different and comprises a metal-containing compound. This invention also relates to a method for producing the coatings and to articles, e.g., gas turbine compressor rotor blade and stator vanes, coated with the coatings.
摘要翻译: 本发明涉及抗侵蚀涂层,其包括至少两个子层系统,其中每个子层系统通过中间层与另一层分离,其中(i)每个子层系统相同或不同并且包含至少4层,(ii)所述层 包括化学计量组成的含氮化物化合物和非化学计量组合物的含氮化物化合物的交替层,(iii)每个子层系统具有大于约0.4微米的厚度,和(iv)每个中间层相同或不同, 包含含金属的化合物。 本发明还涉及一种制备涂层的方法以及涂覆有涂层的制品,例如燃气轮机压缩机转子叶片和定子叶片。
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公开(公告)号:US20110117276A1
公开(公告)日:2011-05-19
申请号:US13013090
申请日:2011-01-25
申请人: Albert Feuerstein , Thomas Albert
发明人: Albert Feuerstein , Thomas Albert
IPC分类号: C23C16/34 , C23C16/448 , C23C16/455
CPC分类号: C23C14/0021 , C23C14/0641 , C23C14/0664 , C23C14/325 , C23C14/3492 , C23C28/044 , C23C28/42 , Y10T428/263 , Y10T428/265
摘要: This invention relates to erosion resistant coatings comprising at least 2 sublayer systems in which each sublayer system is separated from another by an interlayer, wherein (i) each sublayer system is the same or different and comprises at least 4 layers, (ii) said layers comprise alternating layers of a nitride-containing compound of stoichiometric composition and a nitride-containing compound of nonstoichiometric composition, (iii) each sublayer system has a thickness of greater than about 0.4 microns, and (iv) each interlayer is the same or different and comprises a metal-containing compound. This invention also relates to a method for producing the coatings and to articles, e.g., gas turbine compressor rotor blade and stator vanes, coated with the coatings.
摘要翻译: 本发明涉及抗侵蚀涂层,其包括至少两个子层系统,其中每个子层系统通过中间层与另一层分离,其中(i)每个子层系统相同或不同并且包含至少4层,(ii)所述层 包括化学计量组成的含氮化物化合物和非化学计量组合物的含氮化物化合物的交替层,(iii)每个子层系统具有大于约0.4微米的厚度,和(iv)每个中间层相同或不同, 包含含金属的化合物。 本发明还涉及一种制备涂层的方法以及涂覆有涂层的制品,例如燃气轮机压缩机转子叶片和定子叶片。
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公开(公告)号:US20080118643A1
公开(公告)日:2008-05-22
申请号:US11900683
申请日:2007-09-13
申请人: Albert Feuerstein , Thomas Albert
发明人: Albert Feuerstein , Thomas Albert
CPC分类号: C23C14/0021 , C23C14/0641 , C23C14/0664 , C23C14/325 , C23C14/3492 , C23C28/044 , C23C28/42 , Y10T428/263 , Y10T428/265
摘要: This invention relates to erosion resistant coatings comprising at least 2 sublayer systems in which each sublayer system is separated from another by an interlayer, wherein (i) each sublayer system is the same or different and comprises at least 4 layers, (ii) said layers comprise alternating layers of a nitride-containing compound of stoichiometric composition and a nitride-containing compound of nonstoichiometric composition, (iii) each sublayer system has a thickness of greater than about 0.4 microns, and (iv) each interlayer is the same or different and comprises a metal-containing compound. This invention also relates to a method for producing the coatings and to articles, e.g., gas turbine compressor rotor blade and stator vanes, coated with the coatings.
摘要翻译: 本发明涉及抗侵蚀涂层,其包括至少两个子层系统,其中每个子层系统通过中间层与另一层分离,其中(i)每个子层系统相同或不同并且包含至少4层,(ii)所述层 包括化学计量组成的含氮化物化合物和非化学计量组合物的含氮化物化合物的交替层,(iii)每个子层系统具有大于约0.4微米的厚度,和(iv)每个中间层相同或不同, 包含含金属的化合物。 本发明还涉及一种制备涂层的方法以及涂覆有涂层的制品,例如燃气轮机压缩机转子叶片和定子叶片。
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公开(公告)号:US08097129B2
公开(公告)日:2012-01-17
申请号:US13013090
申请日:2011-01-25
申请人: Albert Feuerstein , Thomas Albert
发明人: Albert Feuerstein , Thomas Albert
IPC分类号: C23C16/00
CPC分类号: C23C14/0021 , C23C14/0641 , C23C14/0664 , C23C14/325 , C23C14/3492 , C23C28/044 , C23C28/42 , Y10T428/263 , Y10T428/265
摘要: This invention relates to erosion resistant coatings comprising at least 2 sublayer systems in which each sublayer system is separated from another by an interlayer, wherein (i) each sublayer system is the same or different and comprises at least 4 layers, (ii) said layers comprise alternating layers of a nitride-containing compound of stoichiometric composition and a nitride-containing compound of nonstoichiometric composition, (iii) each sublayer system has a thickness of greater than about 0.4 microns, and (iv) each interlayer is the same or different and comprises a metal-containing compound. This invention also relates to a method for producing the coatings and to articles, e.g., gas turbine compressor rotor blade and stator vanes, coated with the coatings.
摘要翻译: 本发明涉及抗侵蚀涂层,其包括至少两个子层系统,其中每个子层系统通过中间层与另一层分离,其中(i)每个子层系统相同或不同并且包含至少4层,(ii)所述层 包括化学计量组成的含氮化物化合物和非化学计量组合物的含氮化物化合物的交替层,(iii)每个子层系统具有大于约0.4微米的厚度,和(iv)每个中间层相同或不同, 包含含金属的化合物。 本发明还涉及一种制备涂层的方法以及涂覆有涂层的制品,例如燃气轮机压缩机转子叶片和定子叶片。
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公开(公告)号:US20120046175A1
公开(公告)日:2012-02-23
申请号:US13239585
申请日:2011-09-22
申请人: Matthew Rodesch , Thomas Albert
发明人: Matthew Rodesch , Thomas Albert
CPC分类号: C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要: The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
摘要翻译: 本发明提供用于捕获和富集靶核酸的方法和系统以及富集的靶核酸的分析。 特别地,本发明提供了以基于溶液的格式富集目标序列。
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6.
公开(公告)号:US20100331204A1
公开(公告)日:2010-12-30
申请号:US12695447
申请日:2010-01-28
申请人: Jeff Jeddeloh , Todd Richmond , Matthew Rodesch , Daniel Gerhardt , Paul Marrione , Thomas Albert
发明人: Jeff Jeddeloh , Todd Richmond , Matthew Rodesch , Daniel Gerhardt , Paul Marrione , Thomas Albert
CPC分类号: C12Q1/6806 , C12Q1/6809 , C12Q1/6837 , C12Q2565/515 , C12Q2539/101 , C12Q2563/131 , C12Q2537/149
摘要: The present invention provides methods and systems for targeted nucleic acid sequence enrichment in a sample. In particular, the present invention provides for enriching for targeted nucleic acid sequences during hybridizations in hybridization assays by first depleting non-target nucleic acid sequences.
摘要翻译: 本发明提供了样品中目标核酸序列富集的方法和系统。 特别地,本发明提供了通过首先消耗非靶核酸序列在杂交测定中的杂交期间富集靶向的核酸序列。
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公开(公告)号:US07745118B2
公开(公告)日:2010-06-29
申请号:US11101841
申请日:2005-04-08
申请人: Roland D Green , Steve Smith , Thomas Albert , Emile F. Nuwaysir
发明人: Roland D Green , Steve Smith , Thomas Albert , Emile F. Nuwaysir
CPC分类号: C12Q1/689 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156 , Y10S977/791 , Y10S977/795 , C12Q2565/515 , C12Q2539/101
摘要: The present invention is an improved method of resequencing DNA using microarrays to rapidly map and identify SNPs, deletions and amplification events present in the genome of an organism. The method is performed by hybridizing a reference and a test genome to two separate arrays with each array exhibiting a specific intensity pattern. The intensity differences between the reference and the test genome arrays are used to produce a mutation map. The mapped differences are resequenced on a set of resequencing arrays to identify specific genetic mutations.
摘要翻译: 本发明是使用微阵列重新测序DNA以快速映射和鉴定存在于生物体基因组中的SNP,缺失和扩增事件的改进方法。 该方法通过将参考和测试基因组杂交到具有每个阵列呈现特定强度模式的两个分离的阵列来进行。 参考和测试基因组数组之间的强度差异用于产生突变图。 映射的差异在一组重新排序数组上重新排列,以识别特定的遗传突变。
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公开(公告)号:US20050282209A1
公开(公告)日:2005-12-22
申请号:US11156439
申请日:2005-06-20
申请人: Thomas Albert , Jason Norton , Roland Green
发明人: Thomas Albert , Jason Norton , Roland Green
CPC分类号: G06F19/20 , C12Q1/6837 , C12Q1/6874 , C12Q2527/107 , C12Q2525/185
摘要: The present invention provides novel method for increasing the efficiency and accuracy of high-throughput mutation mapping and genome resequencing by using a variable length probe selection algorithm to rationally select probes used in designing oligonucleotide arrays synthesized by Maskless Array Synthesis (MAS) technology. Also disclosed is a variable length probe selection algorithm used in designing such oligonucleotide arrays.
摘要翻译: 本发明提供了通过使用可变长度探针选择算法合理选择用于设计通过无掩模阵列合成(MAS)技术合成的寡核苷酸阵列的探针的探针来提高高通量突变图谱和基因组重排序的效率和准确性的新方法。 还公开了用于设计这种寡核苷酸阵列的可变长度探针选择算法。
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公开(公告)号:US09790543B2
公开(公告)日:2017-10-17
申请号:US13239585
申请日:2011-09-22
申请人: Matthew Rodesch , Thomas Albert
发明人: Matthew Rodesch , Thomas Albert
CPC分类号: C12Q1/6813 , C12N15/1006 , C12Q1/6806 , C12Q1/6844 , C12Q2565/501 , C12Q2537/159
摘要: The present invention provides methods and systems for the capture and enrichment of target nucleic acids and analysis of the enriched target nucleic acids. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.
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10.
公开(公告)号:US07904250B2
公开(公告)日:2011-03-08
申请号:US11043294
申请日:2005-01-26
申请人: Michael Molla , Todd Richmond , Steven Smith , Thomas Albert
发明人: Michael Molla , Todd Richmond , Steven Smith , Thomas Albert
IPC分类号: G01N33/50
CPC分类号: G06F19/24 , G06F19/20 , G06F19/22 , Y10S977/792
摘要: The present invention is a method to assist in the identification of single nucleotide polymorphisms (SNP) from microarray hybridization data. Data from hybridization protocols run on microarrays often have variations in the data resulting from variations in hybridization conditions and efficiencies and variations in optical intensities. An algorithm is described to screen the results to identify those data points most likely to be real SNPs as opposed to variations in the hybridization or sensing data.
摘要翻译: 本发明是一种帮助从微阵列杂交数据鉴定单核苷酸多态性(SNP)的方法。 在微阵列上运行的杂交方案的数据通常在杂交条件和效率的变化以及光学强度的变化中导致的数据变化。 描述了一种算法来筛选结果以识别最可能是真实SNP的那些数据点,而不是杂交或感测数据的变化。
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