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公开(公告)号：US08084001B2
公开(公告)日：2011-12-27
申请号：US11119969
申请日：2005-05-02
申请人： Andrew A. Burns , Erik Herz , Tara C. Zedayko , Ulrich Wiesner
发明人： Andrew A. Burns , Erik Herz , Tara C. Zedayko , Ulrich Wiesner
IPC分类号： G01N33/00
CPC分类号： G01N21/6428 , G01N2021/6441
摘要： Sensor particles comprise a silica-based core and at least one photoluminescent dye. The silica-based core may comprise a plurality of pores and the at least one photoluminescent dye may comprise a reference dye, insensitive to its environment and analytes and a sensor dye, sensitive to either or both of the foregoing. The sensor particles may be employed to sense unknown environmental conditions or analytes in biological or non-biological systems, in vitro or in vivo.
摘要翻译： 传感器颗粒包含二氧化硅基核和至少一种光致发光染料。 二氧化硅基核可以包括多个孔，并且所述至少一种光致发光染料可以包含对其环境不敏感的参考染料和对前述中的任一个或两者敏感的分析物和传感器染料。 传感器颗粒可用于在体外或体内在生物或非生物系统中感测未知的环境条件或分析物。
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公开(公告)号：US20110263037A1
公开(公告)日：2011-10-27
申请号：US12992455
申请日：2009-05-12
申请人： Erik Herz , Erin Sue Hendrick , Margaret W. Frey , Ulrich Wiesner
发明人： Erik Herz , Erin Sue Hendrick , Margaret W. Frey , Ulrich Wiesner
摘要： Fibers, fabrics and textiles in which core-shell silica nanoparticles are incorporated are provided. The fibers, fabrics and textiles can be polymeric materials or natural cellulose-based or protein-based materials in which core-shell silica nanoparticles are incorporated. A variety of polymeric and natural materials can be employed, such as cellulose acetate, nylon, rayon, modacrylic, olefin, acrylic, polyester, polylactic acid, polylactic-co-glycolic acid (PLGA), polyurethane, aramid, wool, cotton, ramie, milk protein, soy protein, bamboo, etc. The core-shell silica nanoparticles can incorporate sensing, magnetic, thermal, electrical, chemical or RFID properties that can be imparted to the materials and that allow the materials to sense one or more conditions of interest, making them ideal for in situ sensing, treatment, or security applications.
摘要翻译： 提供掺入核 - 壳二氧化硅纳米粒子的纤维，织物和纺织品。 纤维，织物和纺织品可以是聚合材料或天然纤维素基或蛋白质基材料，其中掺入核 - 壳二氧化硅纳米颗粒。 可以使用各种聚合物和天然材料，例如醋酸纤维素，尼龙，人造丝，改性聚丙烯酸，烯烃，丙烯酸，聚酯，聚乳酸，聚乳酸共聚乙酸（PLGA），聚氨酯，芳族聚酰胺，羊毛，棉，苎麻 ，牛奶蛋白质，大豆蛋白质，竹子等。核 - 壳二氧化硅纳米颗粒可以包含可以赋予材料的感测，磁性，热性，电学，化学或RFID性质，并且允许材料感测一种或多种 使其成为原位感测，治疗或安全应用的理想选择。
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公开(公告)号：US20060245971A1
公开(公告)日：2006-11-02
申请号：US11119969
申请日：2005-05-02
申请人： Andrew Burns , Erik Herz , Tara Zedayko , Ulrich Wiesner
发明人： Andrew Burns , Erik Herz , Tara Zedayko , Ulrich Wiesner
IPC分类号： G01N31/22
CPC分类号： G01N21/6428 , G01N2021/6441
摘要： Sensor particles comprise a silica-based core and at least one photoluminescent dye. The silica-based core may comprise a plurality of pores and the at least one photoluminescent dye may comprise a reference dye, insensitive to its environment and analytes and a sensor dye, sensitive to either or both of the foregoing. The sensor particles may be employed to sense unknown environmental conditions or analytes in biological or non-biological systems, in vitro or in vivo.
摘要翻译： 传感器颗粒包含二氧化硅基核和至少一种光致发光染料。 二氧化硅基核可以包括多个孔，并且所述至少一种光致发光染料可以包含对其环境不敏感的参考染料和对前述中的任一个或两者敏感的分析物和传感器染料。 传感器颗粒可用于在体外或体内在生物或非生物系统中感测未知的环境条件或分析物。
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公开(公告)号：US10472229B2
公开(公告)日：2019-11-12
申请号：US13582525
申请日：2011-03-04
申请人： Ulrich Wiesner , Michael Thompson , Hitesh Arora
发明人： Ulrich Wiesner , Michael Thompson , Hitesh Arora
摘要： A method for fabricating a nanostructure utilizes a templated monocrystalline substrate. The templated monocrystalline substrate is energetically (i.e., preferably thermally) treated, with an optional precleaning and an optional amorphous material layer located thereupon, to form a template structured monocrystalline substrate that includes the monocrystalline substrate with a plurality of epitaxially aligned contiguous monocrystalline pillars extending therefrom. The monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars may comprise the same or different monocrystalline materials. The method provides the nanostructure where when the monocrystalline substrate and the plurality of epitaxial aligned contiguous monocrystalline pillars comprise different monocrystalline materials having a bulk crystal structure mismatch of up to about 10 percent, lattice mismatch induced crystal structure defects may be avoided interposed between the monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars, which may have an irregular sidewall shape.
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5.发明申请公开(公告)号：US20130052421A1
公开(公告)日：2013-02-28
申请号：US13582525
申请日：2011-03-04
申请人： Ulrich Wiesner , Michael Thompson , Hitesh Arora
发明人： Ulrich Wiesner , Michael Thompson , Hitesh Arora
CPC分类号： B81C1/00031 , B81C2201/0149 , B81C2201/0169 , C30B1/023 , C30B29/08 , C30B29/605 , H01L21/02381 , H01L21/02532 , H01L21/02603 , H01L21/02642 , H01L21/28518 , Y10T428/24372 , Y10T428/24413
摘要： A method for fabricating a nanostructure utilizes a templated monocrystalline substrate. The templated monocrystalline substrate is energetically (i.e., preferably thermally) treated, with an optional precleaning and an optional amorphous material layer located thereupon, to form a template structured monocrystalline substrate that includes the monocrystalline substrate with a plurality of epitaxially aligned contiguous monocrystalline pillars extending therefrom. The monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars may comprise the same or different monocrystalline materials. The method provides the nanostructure where when the monocrystalline substrate and the plurality of epitaxial aligned contiguous monocrystalline pillars comprise different monocrystalline materials having a bulk crystal structure mismatch of up to about 10 percent, lattice mismatch induced crystal structure defects may be avoided interposed between the monocrystalline substrate and the plurality of epitaxially aligned contiguous monocrystalline pillars, which may have an irregular sidewall shape.
摘要翻译： 制造纳米结构的方法使用模板化单晶衬底。 模板化的单晶衬底在能量上（即，优选热处理），具有可选的预清洗和位于其上的任选的非晶材料层，以形成模板结构的单晶衬底，其包括具有从其延伸的多个外延比对的邻接单晶柱的单晶衬底 。 单晶衬底和多个外延排列的邻接单晶柱可以包括相同或不同的单晶材料。 该方法提供纳米结构，其中当单晶衬底和多个外延对准的邻接单晶柱包含具有高达约10％的体晶结构失配的不同单晶材料时，晶格失配诱发的晶体结构缺陷可以避免插入在单晶衬底 以及可能具有不规则侧壁形状的多个外延排列的邻接单晶柱。
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6.发明申请PEG-COATED CORE-SHELL SILICA NANOPARTICLES AND METHODS OF MANUFACTURE AND USE 审中-公开PEG涂层核心二氧化硅纳米粒子及其制造和使用方法公开(公告)号：US20110028662A1
公开(公告)日：2011-02-03
申请号：US12675210
申请日：2008-08-29
申请人： Ulrich Wiesner , Hooisweng Ow
发明人： Ulrich Wiesner , Hooisweng Ow
IPC分类号： C08G77/00
CPC分类号： C09K11/025 , A61K49/0032 , A61K49/0093 , C09K11/06
摘要： Described herein are PEG-coated, core-shell nanoparticles, which display reduced aggregation and/or reduced non-specific or undesired attachment characteristics. These fluorescent nanoparticle include: a silica-based core having an organic functional group that includes a mercapto substituent, an organic fluorescent compound, a silica shell; and a silane-PEG compound. The silica shell of the nanoparticle encapsulates the silica-based core and the silane-PEG compound is conjugated to the silica shell.
摘要翻译： 本文描述的是PEG-包覆的核 - 壳纳米颗粒，其显示减少的聚集和/或降低的非特异性或不期望的附着特征。 这些荧光纳米粒子包括：具有巯基取代基的有机官能团的二氧化硅系核心，有机荧光化合物，二氧化硅壳; 和硅烷-PEG化合物。 纳米颗粒的二氧化硅壳包封二氧化硅基核，硅烷-PEG化合物与二氧化硅壳结合。
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公开(公告)号：US20060001008A1
公开(公告)日：2006-01-05
申请号：US10880602
申请日：2004-07-01
IPC分类号： H01B1/00
CPC分类号： F04B19/24 , B01L3/50273 , B01L2400/0475 , B01L2400/0478 , B01L2400/0672 , F04B19/006
摘要： Movement of a gel structure is propagated by successively applying external stimuli to cause volume phase transition in the gel structure by alternately causing the gel structure to collapse and swell to move the center of mass of the gel structure in the direction of successive stimuli application. The movement is mediated by confining structure for the gel and anchoring—the starting side of the gel in the swelling cycle.
摘要翻译： 凝胶结构的运动通过连续地施加外部刺激来传播，以通过交替地使凝胶结构塌陷和膨胀以使凝胶结构的质心在连续刺激施加的方向上引起体积相变。 该运动由凝胶的限制结构介导，并且在溶胀循环中锚定凝胶的起始侧。
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8.发明申请High temperature SiCN and SiC-type nanostructured ceramic material from block copolymer mesophases 有权来自嵌段共聚物中间相的高温SiCN和SiC型纳米结构陶瓷材料公开(公告)号：US20050036931A1
公开(公告)日：2005-02-17
申请号：US10687917
申请日：2003-10-20
申请人： Carlos Garcia , Ulrich Wiesner
发明人： Carlos Garcia , Ulrich Wiesner
IPC分类号： C01B21/082 , C01B31/36 , C04B35/565 , C04B35/584 , C08F8/42 , C08F293/00 , C08L53/00
CPC分类号： C04B35/565 , C01B21/0828 , C01B32/956 , C01P2002/01 , C01P2002/72 , C01P2002/78 , C04B35/584 , C04B2235/3856 , C04B2235/465 , C08F8/42 , C08F293/005 , C08L53/00 , C08L53/005
摘要： A block copolymer, preferably a block copolymer such as poly(isoprene-block-ethylene oxide), PI-b-PEO, is used as a structure directing agent for a polymer derived ceramic (PDC) precursor, preferably a silazane, most preferably a silazane commercially known as Ceraset. The PDC precursor is preferably polymerized after mixing with the block copolymer to form a nanostructured composite material. Through further heating steps, the nanostructured composite material can be transformed into a nanostructured non-oxide ceramic material, preferably a high temperature SiCN or SiC material.
摘要翻译： 嵌段共聚物，优选嵌段共聚物如聚（异戊二烯 - 嵌段 - 环氧乙烷），PI-b-PEO，用作聚合物衍生的陶瓷（PDC）前体，优选硅氮烷的结构导向剂，最优选 商业上称为Ceraset的硅氮烷。 PDC前体优选在与嵌段共聚物混合后聚合以形成纳米结构复合材料。 通过进一步的加热步骤，纳米结构复合材料可以转变成纳米结构非氧化物陶瓷材料，优选高温SiCN或SiC材料。
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公开(公告)号：US08298677B2
公开(公告)日：2012-10-30
申请号：US10536569
申请日：2003-11-26
申请人： Ulrich Wiesner , Hooisweng Ow , Daniel R. Larson , Watt W. Webb
发明人： Ulrich Wiesner , Hooisweng Ow , Daniel R. Larson , Watt W. Webb
CPC分类号： C09K11/025 , B82Y30/00 , C01B33/18 , C01P2002/80 , C01P2004/03 , C01P2004/64 , C07K16/00 , C07K2317/52 , C09K11/06 , G01N33/5005 , G01N33/54346 , G01N33/582 , G01N33/587 , Y10T428/2438 , Y10T428/31663
摘要： The invention generally relates to fluorescent nanoparticles and more specifically to silica-based fluorescent nanoparticles of less than 30 nm with covalently attached organic dyes. The invention provides a fluorescent monodisperse silica nanoparticle comprising fluorophore center core and a silica shell wherein the radiative properties of the nanoparticle are dependent upon the chemistry (composition) of the core and presence of the silica shell. In one aspect of the invention, the core-shell architecture provides an enhancement in fluorescence quantum efficiency. The invention generally provides control of photophysical properties of dye molecules encapsulated within silica particles with sizes down to 30 nm and below. This control is accomplished through changes in silica chemistry and particle architecture on the nanometer size scale and results in significant brightness enhancement compared to free dye.
摘要翻译： 本发明通常涉及荧光纳米颗粒，更具体地涉及小于30nm的具有共价连接的有机染料的二氧化硅基荧光纳米颗粒。 本发明提供了包含荧光团中心核和二氧化硅壳的荧光单分散二氧化硅纳米颗粒，其中纳米颗粒的辐射性质取决于核的化学（组成）和二氧化硅壳的存在。 在本发明的一个方面，核 - 壳结构提供荧光量子效率的增强。 本发明通常提供了封装在尺寸低至30nm及以下的二氧化硅颗粒内的染料分子的光物理性质的控制。 这种控制是通过二氧化硅化学和粒子结构在纳米尺度尺度上的变化来实现的，并且与游离染料相比导致显着的亮度增强。
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10.发明申请公开(公告)号：US20110027572A1
公开(公告)日：2011-02-03
申请号：US12747649
申请日：2008-12-12
申请人： Ulrich Wiesner
发明人： Ulrich Wiesner
CPC分类号： C01G23/0536 , C01B13/18 , C01G1/02 , C01G23/047 , C01G23/053 , C01G33/00 , C01P2002/88 , C01P2004/04 , C01P2006/12 , C01P2006/14 , C01P2006/17 , C01P2006/40 , C04B35/45 , C04B38/062 , C04B2111/0081 , Y10T428/249921 , Y10T428/249978 , C04B35/46 , C04B38/0054
摘要： Highly crystalline metal oxide-carbon composites, as precursors to thermally stable mesoporous metal oxides, are coated with a layer of amorphous carbon. Using a ‘one-pot’ method, highly crystalline metal oxide-carbon composites are converted to thermally stable mesoporous metal oxides, having highly crystalline mesopore walls, without causing the concomitant collapse of the mesostructure. The ‘one-pot’ method uses block copolymers with an sp or sp2 hybridized carbon containing hydrophobic block as structure directing agents which converts to a sturdy, amorphous carbon material under appropriate heating conditions, providing an in-situ rigid support which maintains the pores of the oxides intact while crystallizing at temperatures as high as 1000 deg C. A highly crystalline metal oxide-carbon composite can be heated to produce a thermally stable mesoporous metal oxide consisting of a single polymorph.
摘要翻译： 作为热稳定介孔金属氧化物的前体的高度结晶的金属氧化物 - 碳复合材料被涂覆有无定形碳层。 使用“一锅”方法，将高度结晶的金属氧化物 - 碳复合材料转化为具有高度结晶的中孔壁的热稳定的中孔金属氧化物，而不会引起介观结构的伴随崩溃。 “一锅”方法使用具有sp或sp2杂化碳的疏水性嵌段的嵌段共聚物作为结构导向剂，其在合适的加热条件下转化为坚固的无定形碳材料，提供原位刚性载体，其保持孔 氧化物完整，同时在高达1000℃的温度下结晶。可以加热高度结晶的金属氧化物 - 碳复合材料，以产生由单一多晶型物组成的热稳定介孔金属氧化物。
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