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18 条记录 (耗时 0.028 秒)

    Fluid transfer device
    3.
    发明申请
    Fluid transfer device 审中-公开
    流体输送装置

    公开(公告)号：US20070015276A1

    公开(公告)日：2007-01-18

    申请号：US11474050

    申请日：2006-06-23

    申请人： Sean LeBlanc ,  Ian MacGregor ,  Bernardo Aumond ,  George Vella ,  A. Russo ,  Seth Rodgers ,  Andrey Zarur

    发明人： Sean LeBlanc ,  Ian MacGregor ,  Bernardo Aumond ,  George Vella ,  A. Russo ,  Seth Rodgers ,  Andrey Zarur

    IPC分类号： C12M3/00 ,  A61M31/00

    CPC分类号： B01L3/0275 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0672 ,  B01L2300/0681

    摘要： Fluid transfer devices described herein can include a body portion and a tip portion. A fluid pathway extends through the body and tip portions through which fluid may be transferred, for example, from a fluid-dispensing apparatus to a fluidic chamber of a microreactor. In some embodiments, the fluid transfer device is connected to the fluid-dispensing apparatus with an engaging element. The engaging element may be part of the body, and can enable the dispensing apparatus to repeatedly engage the body at one predetermined position. The body is capable of storing the fluid received from the dispensing apparatus. The tip portion may be formed of a rigid material (e.g., a metal), and/or may be configured to repeatedly pierce a septum without damaging either the tip or the body. Advantageously, in certain embodiments, the fluid transfer device can controllably transfer small volumes of fluid (e.g., 1 μL) with a high degree of accuracy.

    摘要翻译： 本文所述的流体输送装置可以包括主体部分和尖端部分。 流体通道延伸穿过主体和尖端部分，流体可通过该尖端部分例如从流体分配装置传送到微反应器的流体室。 在一些实施例中，流体输送装置用接合元件连接到流体分配装置。 接合元件可以是主体的一部分，并且能够使得分配装置能够在一个预定位置反复地接合身体。 身体能够存储从分配装置接收的流体。 尖端部分可以由刚性材料（例如，金属）形成，和/或可以构造成反复刺穿隔膜而不损坏尖端或者身体。 有利地，在某些实施方案中，流体转移装置可以高度准确地可控地传递小体积的流体（例如，1μl）。

    Apparatus and method for manipulating substrates
    6.
    发明申请
    Apparatus and method for manipulating substrates 失效
    用于操纵基板的装置和方法

    公开(公告)号：US20050019904A1

    公开(公告)日：2005-01-27

    申请号：US10863584

    申请日：2004-06-07

    申请人： Andrey Zarur ,  Seth Rodgers ,  Todd Basque ,  Ian MacGregor ,  Timothy Johnson

    发明人： Andrey Zarur ,  Seth Rodgers ,  Todd Basque ,  Ian MacGregor ,  Timothy Johnson

    IPC分类号： B01F9/00 ,  B01F11/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/00 ,  C12N15/82 ,  C12N15/87

    CPC分类号： C12M23/08 ,  B01F9/0001 ,  B01F9/002 ,  B01F11/00 ,  B01L7/00 ,  B01L9/52 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2400/0409 ,  C12M23/10 ,  C12M23/48 ,  C12M27/10 ,  C12M41/14 ,  Y10S435/809

    摘要： This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.

    摘要翻译： 本公开总体上涉及用于在诸如培养箱的单元内操作用于化学，生物或生化样品（例如细胞培养物和其它室）的室和其它底物的系统和方法。 在某些实施例中，本发明提供了一种用于将多个基板或腔室保持在壳体内的技术，在壳体内保持预定环境，不同于壳体外部的环境，以及将基板或腔室移入和移出壳体， 一些情况下，在外壳中不会形成大的开口（例如，通过打开比基板大得多的门）。 在某些实施例中提供了一种技术，其中多个基板在壳体内以固定的，固定的关系安装在提供预定的受控环境的壳体内，并且在壳体内移动，使得它们可以均匀地暴露于任何 房屋环境差异。 在某些实施例中，本发明提供了一种用于在一个或多个腔室内的流体搅拌的技术，其可以在某些实施例中提供环境控制，而不用物理地搅拌流体，例如直接用搅拌棒或其它搅拌元件 与流体接触。 在另一个实施例中，本发明提供了一种用于围绕基本垂直和/或水平轴线旋转衬底或室的方法。 在一些情况下，任何上述系统可以以足以使物质在室或衬底内分离的速度旋转。

    Microreactor architecture and methods
    7.
    发明申请
    Microreactor architecture and methods 审中-公开
    微反应器结构和方法

    公开(公告)号：US20050032204A1

    公开(公告)日：2005-02-10

    申请号：US10664067

    申请日：2003-09-16

    申请人： Seth Rodgers ,  Andrey Zarur ,  A. Russo ,  Sean Leblanc ,  Xinyu Li ,  Howard Schreyer

    发明人： Seth Rodgers ,  Andrey Zarur ,  A. Russo ,  Sean Leblanc ,  Xinyu Li ,  Howard Schreyer

    IPC分类号： C12M1/34 ,  C12Q1/20

    CPC分类号： B01L3/5027 ,  B01L2200/028 ,  B01L2300/0874 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2400/046

    摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    摘要翻译： 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

    Reactor systems having a light-interacting component
    8.
    发明申请
    Reactor systems having a light-interacting component 审中-公开
    具有光相互作用组分的反应器系统

    公开(公告)号：US20070099292A1

    公开(公告)日：2007-05-03

    申请号：US11584343

    申请日：2006-10-20

    申请人： Scott Miller ,  Sean LeBlanc ,  Seth Rodgers ,  Andrey Zarur

    发明人： Scott Miller ,  Sean LeBlanc ,  Seth Rodgers ,  Andrey Zarur

    IPC分类号： C12M1/34

    CPC分类号： B01L3/502715 ,  B01L2200/025 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/046 ,  G01N2021/0346

    摘要： Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light to or from the reaction site. The chip may contain a reaction site having a volume of less than about 1 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, or more than one reaction site.

    摘要翻译： 本发明的各个方面涉及适用于芯片和其它反应器系统的光相互作用组件。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。 如果使用波导，则它们可以从能够将光透射到反应位点的任何材料形成。 芯片可以含有体积小于约1ml的反应位点。 在一些实施例中，芯片可以以能够支撑活细胞的方式构造。 该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。 其他促进反应可能包括化学或生物物种的生产或消费。 在一些实施方案中，芯片可以包括多于一种组分或组分类型，或多于一个反应位点。

    Materials and reactor systems having humidity and gas control
    10.
    发明申请
    Materials and reactor systems having humidity and gas control 审中-公开
    具有湿度和气体控制的材料和反应堆系统

    公开(公告)号：US20070037244A1

    公开(公告)日：2007-02-15

    申请号：US11584149

    申请日：2006-10-20

    申请人： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

    发明人： Seth Rodgers ,  A. Russo ,  Howard Schreyer ,  Andrey Zarur

    IPC分类号： C12Q1/02

    CPC分类号： C12M25/02 ,  C12M23/12 ,  C12M23/24 ,  C12M29/04 ,  C12M41/34

    摘要： The present invention is directed to materials and reactor systems having humidity and/or gas control. The material may have high oxygen permeability and/or low water vapor permeability. In some cases, the material may have sufficient permeance and/or permeability to allow cell culture to occur in a chip or other reactor system using the material. In certain embodiments, the material may be positioned adjacent to or abut a reaction site within a chip or reactor; in other embodiments, the material may be positioned such that it is in fluidic communication with the reaction site. The material may also be porous and/or transparent in some cases. In one set of embodiments, the material include a polymer that is branched, and/or contains bulky side groups that allow the polymer to have a more open structure. In some cases, the material may include two or more layers. Each layer may have a desired property, which may include, for example, permeability, transparency, cytophilicity, biophilicity, hydrophilicity, or a structural feature. In some embodiments, the material may be chosen so as to promote cell growth within the chip or reactor.

    摘要翻译： 本发明涉及具有湿气和/或气体控制的材料和反应器系统。 该材料可能具有高的透氧性和/或低水蒸气渗透性。 在一些情况下，该材料可具有足够的渗透性和/或渗透性，以允许细胞培养在使用该材料的芯片或其它反应器系统中发生。 在某些实施方案中，材料可以位于与芯片或反应器内的反应位置相邻或邻接的位置; 在其它实施方案中，材料可以被定位成使其与反应部位流体连通。 在某些情况下，材料也可以是多孔的和/或透明的。 在一组实施方案中，材料包括分支的聚合物和/或包含允许聚合物具有更开放结构的庞大的侧基。 在一些情况下，材料可以包括两层或更多层。 每个层可以具有期望的性质，其可以包括例如渗透性，透明度，细胞毒性，生物亲和力，亲水性或结构特征。 在一些实施方案中，可以选择材料以促进芯片或反应器内的细胞生长。