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    Apparatus and method for manipulating substrates
    5.
    发明申请
    Apparatus and method for manipulating substrates 失效
    用于操纵基板的装置和方法

    公开(公告)号：US20050019904A1

    公开(公告)日：2005-01-27

    申请号：US10863584

    申请日：2004-06-07

    Applicant: Andrey Zarur ,  Seth Rodgers ,  Todd Basque ,  Ian MacGregor ,  Timothy Johnson

    Inventor： Andrey Zarur ,  Seth Rodgers ,  Todd Basque ,  Ian MacGregor ,  Timothy Johnson

    IPC: B01F9/00 ,  B01F11/00 ,  B01L7/00 ,  B01L9/00 ,  C12M1/00 ,  C12N15/82 ,  C12N15/87

    CPC classification number: C12M23/08 ,  B01F9/0001 ,  B01F9/002 ,  B01F11/00 ,  B01L7/00 ,  B01L9/52 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2400/0409 ,  C12M23/10 ,  C12M23/48 ,  C12M27/10 ,  C12M41/14 ,  Y10S435/809

    Abstract: This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certain embodiments, the invention provides a technique for maintaining a plurality of substrates or chambers in a housing within which a predetermined environment is maintained, different from the environment external to the housing, and moving substrates or chambers in and out of the housing, in some cases without creating a large opening in the housing (e.g., by opening a door significantly larger than the substrates). A technique is provided, in certain embodiments, in which a plurality of substrates are mounted in fixed, secured relation to each other within a housing providing a predetermined, controlled environment, and are moved within the housing so that they can be evenly exposed to any differences in environment within the housing. In certain embodiments, the invention provides a technique for agitating a fluid within one or more chambers or substrates within a housing that can provide environmental control, in certain embodiments without physically stirring the fluid, such as with a stir bar or other stirring element in direct contact with the fluid. In still another embodiment, the invention provides a method for rotating a substrate or chamber about a substantially vertical and/or horizontal axis. In some cases, any of the above-described systems can be rotated at a speed sufficient to cause separation of a substance within the chamber or substrate.

    Abstract translation: 本公开总体上涉及用于在诸如培养箱的单元内操作用于化学，生物或生化样品（例如细胞培养物和其它室）的室和其它底物的系统和方法。 在某些实施例中，本发明提供了一种用于将多个基板或腔室保持在壳体内的技术，在壳体内保持预定环境，不同于壳体外部的环境，以及将基板或腔室移入和移出壳体， 一些情况下，在外壳中不会形成大的开口（例如，通过打开比基板大得多的门）。 在某些实施例中提供了一种技术，其中多个基板在壳体内以固定的，固定的关系安装在提供预定的受控环境的壳体内，并且在壳体内移动，使得它们可以均匀地暴露于任何 房屋环境差异。 在某些实施例中，本发明提供了一种用于在一个或多个腔室内的流体搅拌的技术，其可以在某些实施例中提供环境控制，而不用物理地搅拌流体，例如直接用搅拌棒或其它搅拌元件 与流体接触。 在另一个实施例中，本发明提供了一种用于围绕基本垂直和/或水平轴线旋转衬底或室的方法。 在一些情况下，任何上述系统可以以足以使物质在室或衬底内分离的速度旋转。

    Robotic end effector for frozen aliquotter and methods of taking a frozen aliquot from biological samples
    6.
    发明授权
    Robotic end effector for frozen aliquotter and methods of taking a frozen aliquot from biological samples 有权
    用于冷冻等分试样的机器人末端效应器和从生物样品中取出冷冻等分试样的方法

    公开(公告)号：US09134202B2

    公开(公告)日：2015-09-15

    申请号：US13359301

    申请日：2012-01-26

    Applicant: Michel Bruehwiler ,  Saeed Sokhanvar ,  Cole Constantineau ,  Melissa Rosen ,  Todd Basque

    Inventor： Michel Bruehwiler ,  Saeed Sokhanvar ,  Cole Constantineau ,  Melissa Rosen ,  Todd Basque

    IPC: G01N1/08 ,  G01F17/00 ,  G01N1/42 ,  G01N35/00 ,  G01N35/10

    CPC classification number: G01N1/08 ,  B25J15/0019 ,  G01F17/00 ,  G01N1/42 ,  G01N35/0099 ,  G01N35/10 ,  G01N2035/1025 ,  Y10S901/41

    Abstract: A robotic end effector for collecting frozen aliquots from an array of frozen samples in a plurality of containers has a coring bit for taking frozen sample cores from the frozen samples and a frozen sample core extraction system adapted to extract frozen sample cores from the frozen samples. A fill level detection system is adapted to detect the positions of the surfaces of the frozen samples. A processor is adapted to receive signals from the fill level detection system and use the signals and information concerning operation of the frozen sample core extraction system to determine at least one of the following: (a) the amount of material contained in a frozen sample core obtained by the coring bit; and (b) the number of frozen sample cores needed from a particular frozen sample to obtain a predetermined amount of material from that frozen sample.

    Abstract translation: 用于从多个容器中的冷冻样品阵列收集冷冻等分试样的机器人末端执行器具有用于从冷冻样品中取出冷冻样品核心的取芯钻头和适于从冷冻样品中提取冷冻样品核心的冷冻样品芯提取系统。 填充水平检测系统适于检测冷冻样品的表面的位置。 处理器适于接收来自填充水平检测系统的信号，并且使用关于冷冻样品芯提取系统的操作的信号和信息来确定以下中的至少一个：（a）冷冻样品核心中所含的材料的量 由取芯钻头获得; 和（b）特定冷冻样品所需的冷冻样品核心的数量，以从该冷冻样品获得预定量的材料。

    Robotic End Effector for Frozen Aliquotter and Methods of Taking a Frozen Aliquot from Biological Samples
    7.
    发明申请
    Robotic End Effector for Frozen Aliquotter and Methods of Taking a Frozen Aliquot from Biological Samples 有权
    用于冷冻等分试样的机器人终端效应器和从生物样品中取出冷冻等分试样的方法

    公开(公告)号：US20130192391A1

    公开(公告)日：2013-08-01

    申请号：US13359301

    申请日：2012-01-26

    Applicant: Michel Bruehwiler ,  Saeed Sokhanvar ,  Cole Constantineau ,  Melissa Rosen ,  Todd Basque

    Inventor： Michel Bruehwiler ,  Saeed Sokhanvar ,  Cole Constantineau ,  Melissa Rosen ,  Todd Basque

    IPC: G01N1/08 ,  B25J15/00

    CPC classification number: G01N1/08 ,  B25J15/0019 ,  G01F17/00 ,  G01N1/42 ,  G01N35/0099 ,  G01N35/10 ,  G01N2035/1025 ,  Y10S901/41

    Abstract: A robotic end effector for collecting frozen aliquots from an array of frozen samples in a plurality of containers has a coring bit for taking frozen sample cores from the frozen samples and a frozen sample core extraction system adapted to extract frozen sample cores from the frozen samples. A fill level detection system is adapted to detect the positions of the surfaces of the frozen samples. A processor is adapted to receive signals from the fill level detection system and use the signals and information concerning operation of the frozen sample core extraction system to determine at least one of the following: (a) the amount of material contained in a frozen sample core obtained by the coring bit; and (b) the number of frozen sample cores needed from a particular frozen sample to obtain a predetermined amount of material from that frozen sample.

    Abstract translation: 用于从多个容器中的冷冻样品阵列收集冷冻等分试样的机器人末端执行器具有用于从冷冻样品中取出冷冻样品核心的取芯钻头和适于从冷冻样品中提取冷冻样品核心的冷冻样品芯提取系统。 填充水平检测系统适于检测冷冻样品的表面的位置。 处理器适于接收来自填充水平检测系统的信号，并且使用关于冷冻样品芯提取系统的操作的信号和信息来确定以下中的至少一个：（a）冷冻样品核心中所含的材料的量 由取芯钻头获得; 和（b）特定冷冻样品所需的冷冻样品核心的数量，以从该冷冻样品获得预定量的材料。

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