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    Reactor systems having a light-interacting component
    1.
    发明申请
    Reactor systems having a light-interacting component 审中-公开
    具有光相互作用组分的反应器系统

    公开(公告)号：US20070099292A1

    公开(公告)日：2007-05-03

    申请号：US11584343

    申请日：2006-10-20

    申请人： Scott Miller ,  Sean LeBlanc ,  Seth Rodgers ,  Andrey Zarur

    发明人： Scott Miller ,  Sean LeBlanc ,  Seth Rodgers ,  Andrey Zarur

    IPC分类号： C12M1/34

    CPC分类号： B01L3/502715 ,  B01L2200/025 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/046 ,  G01N2021/0346

    摘要： Various aspects of the present invention relate to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like. If waveguides are used, they may be fashioned out of any material able to transmit light to or from the reaction site. The chip may contain a reaction site having a volume of less than about 1 ml. In some embodiments, the chip may be constructed in such a way as to be able to support a living cell. The chip may be used for imaging or analysis, or the chip may be used to facilitate a chemical or biological reaction, which may be light-sensitive or light-activated in certain cases. Other facilitated reactions may include the production or consumption of a chemical or biological species. In some embodiments, the chip may include more than one component or component type, or more than one reaction site.

    摘要翻译： 本发明的各个方面涉及适用于芯片和其它反应器系统的光相互作用组件。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。 如果使用波导，则它们可以从能够将光透射到反应位点的任何材料形成。 芯片可以含有体积小于约1ml的反应位点。 在一些实施例中，芯片可以以能够支撑活细胞的方式构造。 该芯片可以用于成像或分析，或者芯片可以用于促进在某些情况下可能是光敏感或光激活的化学或生物反应。 其他促进反应可能包括化学或生物物种的生产或消费。 在一些实施方案中，芯片可以包括多于一种组分或组分类型，或多于一个反应位点。

    Systems and methods for control of pH and other reactor environment conditions
    3.
    发明申请
    Systems and methods for control of pH and other reactor environment conditions 审中-公开
    用于控制pH和其他反应器环境条件的系统和方法

    公开(公告)号：US20050026134A1

    公开(公告)日：2005-02-03

    申请号：US10664068

    申请日：2003-09-16

    申请人： Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    发明人： Scott Miller ,  Gennady Malin ,  Howard Schreyer ,  Seth Rodgers ,  Andrey Zarur

    IPC分类号： C12M3/00

    CPC分类号： B01L3/502746 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0867 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/1838 ,  B01L2400/046 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M23/16 ,  C12M29/04 ,  C12M41/26

    摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor chips and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a chip or other reaction system may be constructed so as to promote cell growth within it. In certain embodiments, the chips or other reaction systems of the invention include one or more reaction sites. The reaction sites can be very small, for example, with a volume of less than about 1 ml. In one aspect of the invention, a chip is able to detect, measure and/or control an environmental factor such as the temperature, pressure, CO2 concentration, O2 concentration, relative humidity, pH, etc. associated with one or more reaction sites, by using one or more sensors, actuators, processors, and/or control systems. In another aspect, the present invention is directed to materials and systems having humidity and/or gas control, for example, for use with a chip. Such materials may have high oxygen permeability and/or low water vapor permeability. The present invention, in still another aspect, generally relates to light-interacting components suitable for use in chips and other reactor systems. These components may include waveguides, optical fibers, light sources, photodetectors, optical elements, and the like.

    摘要翻译： 本发明一般涉及化学，生物和/或生化反应堆芯片和其他反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，可以构建芯片或其它反应系统，以促进细胞内的细胞生长。 在某些实施方案中，本发明的芯片或其它反应体系包括一个或多个反应位点。 反应位点可以非常小，例如，体积小于约1ml。 在本发明的一个方面，芯片能够检测，测量和/或控制与一个或多个反应位点相关联的环境因素例如温度，压力，CO 2浓度，O 2浓度，相对湿度，pH等， 通过使用一个或多个传感器，致动器，处理器和/或控制系统。 在另一方面，本发明涉及具有例如用于芯片的湿度和/或气体控制的材料和系统。 这样的材料可以具有高氧渗透性和/或低水蒸汽渗透性。 在另一方面，本发明通常涉及适用于芯片和其它反应器系统的光相互作用组分。 这些组件可以包括波导，光纤，光源，光电检测器，光学元件等。

    Inlet channel volume in a reactor
    6.
    发明申请
    Inlet channel volume in a reactor 审中-公开
    反应器中的入口通道体积

    公开(公告)号：US20070036690A1

    公开(公告)日：2007-02-15

    申请号：US11146922

    申请日：2005-06-07

    申请人： Scott Miller ,  A. Russo ,  Sean LeBlanc ,  Timothy Johnson

    发明人： Scott Miller ,  A. Russo ,  Sean LeBlanc ,  Timothy Johnson

    IPC分类号： B01J19/00 ,  B01L3/00

    CPC分类号： B01J19/0093 ,  B01J2219/00837 ,  B01J2219/00862 ,  B01J2219/00869 ,  B01J2219/00907 ,  B01J2219/00952 ,  B01J2219/00963 ,  B01J2219/0097 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0684 ,  B01L2300/0816 ,  B01L2300/0825 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/10 ,  B01L2400/0457 ,  B01L2400/0688 ,  B01L2400/086

    摘要： The present invention generally relates to chemical, biological, and/or biochemical reactor microreactors and other reaction systems such as microreactor systems, as well as systems and methods for constructing and using such devices. In one aspect, a reactor on a chip has a container in fluid communication with a channel, and the channel is in fluid communication with a port for connecting the container to a source of fluid to be introduced into the container. The container can be very small, for example, with a volume of less than about 2 milliliters, and the fluid channel can have a channel volume of less than 1.5 percent of the container volume. According to another aspect, the combined volume of the port volume and the channel volume can be less than about 10 percent of the container volume. Such a configuration may increase the percentage of added fluid that reaches the container. In fed-batch operations, species may be added and removed via the same channel so that a gas headspace can be maintained within the reactor.

    摘要翻译： 本发明一般涉及化学，生物和/或生化反应器微反应器和其它反应系统，例如微反应器系统，以及用于构建和使用这些装置的系统和方法。 在一个方面，芯片上的反应器具有与通道流体连通的容器，并且通道与用于将容器连接到待引入容器的流体源的端口流体连通。 容器可以非常小，例如，体积小于约2毫升，并且流体通道可以具有小于容器体积的1.5％的通道体积。 根据另一方面，端口容积和通道容积的组合体积可以小于容器体积的约10％。 这种构造可以增加到达容器的添加流体的百分比。 在补料分批操作中，可以通过相同的通道添加和除去物质，使得可以在反应器内保持气体顶部空间。

    VARIABLE PRESSURE CLEANING DEVICE AND METHOD
    7.
    发明申请
    VARIABLE PRESSURE CLEANING DEVICE AND METHOD 有权

    公开(公告)号：US20220125287A1

    公开(公告)日：2022-04-28

    申请号：US17509304

    申请日：2021-10-25

    申请人： Scott Miller ,  Frank Carter ,  Carl Gauger

    发明人： Scott Miller ,  Frank Carter ,  Carl Gauger

    IPC分类号： A61B1/12 ,  B08B9/043

    摘要： Endoscopic instruments, such as endoscopes, and devices and methods for cleaning endoscopic instruments are provided. A cleaning device for use with an endoscopic instrument comprises an elongate member configured for advancement through an internal lumen within the endoscopic instrument and a cleaning member removably coupled to a portion of the elongate member. The cleaning element comprises a variable pressure region shaped and configured to increase the hydrodynamic fluid friction force and fluid pressure force of a cleaner or detergent against the wall of the internal lumen of the endoscope to more effectively clean all internal surfaces of an endoscopic instrument, including crevasses, scratches or other irregularities, without further damaging these surfaces.

    TEMPERATURE REGULATION DEVICE
    8.
    发明申请
    TEMPERATURE REGULATION DEVICE 有权

    公开(公告)号：US20210403219A1

    公开(公告)日：2021-12-30

    申请号：US17355817

    申请日：2021-06-23

    申请人： Storm Miller ,  Sloan Miller ,  Mansour AbdulBaki ,  Scott Miller

    发明人： Storm Miller ,  Sloan Miller ,  Mansour AbdulBaki ,  Scott Miller

    IPC分类号： B65D81/18 ,  F25D5/00

    摘要： A nested temperature regulation device includes a watertight pouch having a gas valve, a first plurality of reactive spheres and a rupturable fluid bag. The first reactive spheres are configured to create an endothermic reaction or an exothermic reaction for a set period of time when engaged by the fluid. At least one soluble barrier is positioned within the pouch and includes a hollow interior space that contains another plurality of reactive spheres. Each soluble barrier is constructed to dissolve and to permit the fluid from the bag to engage a subsequent plurality of reactive spheres after a predetermined period of time that is equal to the effective reaction time of the plurality of reactive spheres immediately previously engaged by the fluid. One or more of the plurality of reactive spheres includes a coating that delays the fluid from accessing the reactive material of the sphere having the coating.

    SYSTEM AND METHOD FOR USE OF FLEXIBLE ANTI-REFLUX URETERAL STENT
    10.
    发明申请
    SYSTEM AND METHOD FOR USE OF FLEXIBLE ANTI-REFLUX URETERAL STENT 审中-公开
    使用柔性抗反射阻塞器的系统和方法

    公开(公告)号：US20160038273A1

    公开(公告)日：2016-02-11

    申请号：US14774513

    申请日：2014-03-13

    申请人： Brian H. EISNER ,  Scott MILLER

    发明人： Brian Howard Eisner ,  Scott Miller

    IPC分类号： A61F2/04

    CPC分类号： A61F2/042 ,  A61F2/04 ,  A61F2002/047 ,  A61F2002/048 ,  A61F2230/0069 ,  A61M27/008

    摘要： The multi-material stent includes a renal portion and a bladder portion with respective, different hardness. A valve is disposed within the stent to guide liquid from the renal portion of the stent to the bladder portion of the stent. The present invention relates towards systems and method for stents. More particularly, the invention relates to a stent designed to increase patient comfort by minimizing irritation and reflux through the use of a stent that incorporates one or more flexible elements, which may involve materials with varying degrees of hardness, and a valve disposed therein.

    摘要翻译： 多材料支架包括具有不同硬度的肾部分和膀胱部分。 将瓣膜设置在支架内以将液体从支架的肾部引导到支架的膀胱部分。 本发明涉及用于支架的系统和方法。 更具体地，本发明涉及一种支架，其设计成通过使用包括一个或多个柔性元件的支架（其可能涉及具有不同硬度的材料）和设置在其中的阀来最小化刺激和回流来增加患者的舒适度。