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    Polymer-coated substrates for binding biological molecules
    2.
    发明申请
    Polymer-coated substrates for binding biological molecules 审中-公开
    用于结合生物分子的聚合物涂覆的底物

    公开(公告)号：US20060257919A1

    公开(公告)日：2006-11-16

    申请号：US11488228

    申请日：2006-07-18

    申请人： Anthony Frutos ,  Joydeep Lahiri ,  Thomas Leslie ,  Jinlin Peng

    发明人： Anthony Frutos ,  Joydeep Lahiri ,  Thomas Leslie ,  Jinlin Peng

    IPC分类号： C40B40/08 ,  C40B50/14

    CPC分类号： B82Y30/00 ,  G01N33/54393 ,  G01N33/548

    摘要： A substrate, which that is capable of attaching biomolecules, and a method for preparing the substrate are provided. The substrate has a reactive surface that can covalently attach a polymer coating containing functional groups, which can reduce nonspecific binding of biomolecules to the surface for a biological array. Optionally, at least a portion of the substrate may be coated with an intermediate tie layer, which enhances the covalent bonding between the polymer coating with the underlying substrate. The present invention also pertains to a method that uses electrostatic blocking agents to reduce non-specific binding of proteins to a substrate, especially anhydride-modified surfaces.

    摘要翻译： 提供了能够附着生物分子的基材和制备基材的方法。 基底具有可以共价连接含有官能团的聚合物涂层的反应性表面，其可以降低生物分子与生物分子的表面的非特异性结合。 任选地，衬底的至少一部分可以涂覆有中间粘结层，其增强聚合物涂层与下面的衬底之间的共价键。 本发明还涉及使用静电阻断剂以减少蛋白质与底物，特别是酸酐改性表面的非特异性结合的方法。

    Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors
    7.
    发明授权
    Method for depth resolved sensing of biological entities based on surface plasmon resonance sensors 失效
    基于表面等离子体共振传感器的生物实体深度解析感测方法

    公开(公告)号：US08163561B2

    公开(公告)日：2012-04-24

    申请号：US12627463

    申请日：2009-11-30

    申请人： Norman Henry Fontaine ,  Joydeep Lahiri ,  Guangshan Li ,  Anping Liu ,  Jinlin Peng

    发明人： Norman Henry Fontaine ,  Joydeep Lahiri ,  Guangshan Li ,  Anping Liu ,  Jinlin Peng

    IPC分类号： G01N21/00

    CPC分类号： G01N21/553

    摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

    摘要翻译： 一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。 传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。 这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。 本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。

    Variable Penetration Depth Biosensor Methods
    8.
    发明申请
    Variable Penetration Depth Biosensor Methods 失效
    可变穿透深度生物传感器方法

    公开(公告)号：US20110171746A1

    公开(公告)日：2011-07-14

    申请号：US12627463

    申请日：2009-11-30

    申请人： Norman Henry Fontaine ,  Joydeep Lahiri ,  Guangshan Li ,  Anping Liu ,  Jinlin Peng

    发明人： Norman Henry Fontaine ,  Joydeep Lahiri ,  Guangshan Li ,  Anping Liu ,  Jinlin Peng

    IPC分类号： G01N21/55

    CPC分类号： G01N21/553

    摘要： A surface plasmon resonance sensor system including a high refractive index prism, a sensor chip, a light source having multiple wavelengths over a broad range of wavelengths, optical lenses, a photodetector, a data acquisition unit, and as defined herein. The sensor chip can include, for example, a thin layer of silicon and gold on one face of a transparent substrate and the prism adjacent to the opposite face of the transparent substrate. Such an arrangement provides variable penetration depths up to about 1.5 micrometers with a dynamic range for sensing index of refraction changes in a sample that are several times greater than that of a conventional SPR sensor. The disclosure provides methods for using the surface plasmon resonance sensor system for cell assay or chemical assay related applications.

    摘要翻译： 一种表面等离子体共振传感器系统，包括高折射率棱镜，传感器芯片，在宽波长范围内具有多个波长的光源，光学透镜，光电检测器，数据采集单元，如本文所定义。 传感器芯片例如可以包括在透明基板的一个面上的硅和金的薄层和邻近透明基板的相对面的棱镜。 这种布置提供高达约1.5微米的可变穿透深度，具有用于感测样品中的折射改变的动态范围，其比常规SPR传感器的折射几倍大。 本公开提供了使用表面等离子体共振传感器系统用于细胞测定或化学测定相关应用的方法。