公开(公告)号：US20080182293A1

公开(公告)日：2008-07-31

申请号：US11467091

申请日：2006-08-24

申请人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas A. Levinson ,  Alasdair Y. Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

发明人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas A. Levinson ,  Alasdair Y. Johnson ,  Orn Almarsson ,  Hongming Chen ,  Christopher McNulty

IPC分类号： G01N33/50 ,  G05B21/00

CPC分类号： G16C20/60 ,  G01N13/00 ,  G16B35/00

摘要： The present invention relates to computer-controlled high-throughput systems, computer-program products, and methods of use to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the use of computer-controlled high-throughput systems, computer-program products, and methods of high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.

摘要翻译： 本发明涉及计算机控制的高通量系统，计算机程序产品和用于同时以不同浓度和身份准备大量组分组合的方法和用于测试组织的高通量方法 每个组合中的组分的屏障转移，例如透皮转移。 本发明的方法允许测定非活性组分如溶剂，赋形剂，增强剂，粘合剂和添加剂对活性组分如药物的组织屏障转移的影响。 因此，本发明包括使用计算机控制的高通量系统，计算机程序产品和药物组合物或制剂的高通量测试方法，以便确定用于改善组织转运的总体最佳组合物或制剂，例如透皮 运输。

公开(公告)号：US07061605B2

公开(公告)日：2006-06-13

申请号：US11051517

申请日：2005-01-31

申请人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas A. Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

发明人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas A. Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

IPC分类号： G01J3/42 ,  G01J3/44 ,  G01N21/17

CPC分类号： G01N35/028 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01N21/253 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N35/0099 ,  G01N2021/651 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

摘要： Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

公开(公告)号：US06977723B2

公开(公告)日：2005-12-20

申请号：US10235922

申请日：2002-09-06

申请人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

发明人： Anthony V. Lemmo ,  Javier P. Gonzalez-Zugasti ,  Michael J. Cima ,  Douglas Levinson ,  Alasdair Y. Johnson ,  Örn Almarsson ,  Christopher McNulty

IPC分类号： B01J19/00 ,  B01L3/14 ,  B01L7/00 ,  C12M1/34 ,  C12Q1/68 ,  C30B7/00 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01J3/44 ,  G01N21/25 ,  G01N21/35 ,  G01N21/65 ,  G01N33/48 ,  G01N33/50 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G06F19/00

CPC分类号： G01N35/028 ,  B01J19/0046 ,  B01J2219/00274 ,  B01J2219/00283 ,  B01J2219/0031 ,  B01J2219/00335 ,  B01J2219/00344 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00587 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00756 ,  B01L3/5082 ,  B01L7/52 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/1805 ,  C30B7/00 ,  C30B29/58 ,  C40B60/14 ,  C40B70/00 ,  G01J3/28 ,  G01N21/253 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/65 ,  G01N35/0099 ,  G01N2021/651 ,  G01N2035/041 ,  G01N2035/042 ,  G01N2035/0425

摘要： Systems and methods are described that allow the high-throughput preparation, processing, and study of arrays of samples, each of which comprises at least one compound. Particular embodiments of the invention allow a large number of experiments to be performed in parallel on samples that comprised of one or more compounds on the milligram or microgram quantities of compounds. Other embodiments of the invention encompass methods and devices for the rapid screening of the results of such experiments, as well as methods and devices for rapidly determining whether or not similarities exist among groups of samples in an array. Particular embodiments of the invention encompass methods and devices for the high-throughput preparation of different forms of compounds (e.g., different crystalline forms), for the discovery of new forms of old compounds, and for the discovery of new methods of producing such forms. Embodiments of the invention also allow for the high-throughput determination of how specific compounds or forms of compounds behave when exposed to other chemicals or environmental conditions.

公开(公告)号：US06758099B2

公开(公告)日：2004-07-06

申请号：US09904725

申请日：2001-07-13

申请人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory ,  Anthony V. Lemmo

发明人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory ,  Anthony V. Lemmo

IPC分类号： G01F100

CPC分类号： G01N33/5044 ,  B01L3/50255 ,  G01N13/00 ,  G01N33/5008 ,  G01N33/5088 ,  G01N2500/00

摘要： The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.

摘要翻译： 本发明涉及高通量系统和方法，以同时以不同的浓度和同一性制备大量组分组合，以及高通量方法来测试组织屏障转移，例如透皮转移 每个组合。 本发明的方法允许测定非活性组分如溶剂，赋形剂，增强剂，粘合剂和添加剂对活性组分如药物的组织屏障转移的影响。 因此，本发明包括药物组合物或制剂的高通量测试，以便确定用于改善组织转运的总体最佳组合物或制剂，例如透皮转运。

公开(公告)号：US06852526B2

公开(公告)日：2005-02-08

申请号：US10282505

申请日：2002-10-28

申请人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory

发明人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory

IPC分类号： B01L3/00 ,  C12M1/34 ,  C12M3/00 ,  G01N13/00 ,  G01N33/15 ,  G01N33/50

CPC分类号： G01N33/5088 ,  B01L3/50255 ,  G01N13/00 ,  G01N33/5008 ,  G01N33/5044 ,  G01N2500/00

摘要： The transdermal assay apparatus includes first, second, and third members. The first member has one or more sample surfaces, each of which is configured to receive a sample thereon. The second member defines one or more reservoirs, each of which has an opening on a surface of the second member. Each sample surface is substantially the same size as each opening. The transdermal assay apparatus also includes a magnetic clamp configured to clamp a tissue specimen between the sample surface and the opening. The magnetic clamp preferably includes a magnet having a strength that is selected based on the clamping force required between the first member and the second member. The invention also provides a method for using a transdermal assay apparatus.

摘要翻译： 透皮测定装置包括第一，第二和第三构件。 第一构件具有一个或多个样品表面，每个样品表面被配置为在其上接收样品。 第二构件限定一个或多个储存器，每个储存器在第二构件的表面上具有开口。 每个样品表面的大小与每个开口大致相同。 透皮测定装置还包括构造成在样品表面和开口之间夹持组织样本的磁性夹具。 磁夹具优选地包括具有基于第一构件和第二构件之间所需的夹紧力选择的强度的磁体。 本发明还提供了一种使用透皮测定装置的方法。

公开(公告)号：US07172859B2

公开(公告)日：2007-02-06

申请号：US10371372

申请日：2003-02-20

申请人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory

发明人： Michael J. Cima ,  Hongming Chen ,  J. Richard Gyory

IPC分类号： C12Q1/00

CPC分类号： G01N33/5088 ,  G01N13/00

摘要： The present invention relates to high-throughput systems and methods to prepare a large number of component combinations, at varying concentrations and identities, at the same time, and high-throughput methods to test tissue barrier transfer, such as transdermal transfer, of components in each combination. The methods of the present invention allow determination of the effects of inactive components, such as solvents, excipients, enhancers, adhesives and additives, on tissue barrier transfer of active components, such as pharmaceuticals. The invention thus encompasses the high-throughput testing of pharmaceutical compositions or formulations in order to determine the overall optimal composition or formulation for improved tissue transport, such as transdermal transport.

摘要翻译： 本发明涉及高通量系统和方法，以同时以不同的浓度和同一性制备大量组分组合，以及高通量方法来测试组织屏障转移，例如透皮转移 每个组合。 本发明的方法允许测定非活性组分如溶剂，赋形剂，增强剂，粘合剂和添加剂对活性组分如药物的组织屏障转移的影响。 因此，本发明包括药物组合物或制剂的高通量测试，以便确定用于改善组织转运的总体最佳组合物或制剂，例如透皮转运。

公开(公告)号：US09918656B2

公开(公告)日：2018-03-20

申请号：US13806348

申请日：2011-06-27

申请人： Michael J. Cima ,  Paul Huang ,  Yibo Ling ,  Terrence Pong ,  Christophoros C. Vassiliou

发明人： Michael J. Cima ,  Paul Huang ,  Yibo Ling ,  Terrence Pong ,  Christophoros C. Vassiliou

IPC分类号： A61B5/055 ,  A61B5/00 ,  A61B5/145 ,  G01R33/56 ,  G01R33/30 ,  G01R33/50

CPC分类号： A61B5/055 ,  A61B5/0031 ,  A61B5/14546 ,  A61B2562/0285 ,  G01R33/302 ,  G01R33/50 ,  G01R33/5601

摘要： An implantable magnetic relaxation sensor is provided that comprises superparamagnetic nanoparticies functionalized with one or more agents that bond with a biomarker of interest. The sensor is configured for minimally-invasive implantation into a human or animal, and is configured to indicate the implanted sensor's cumulative exposure to the biomarker of interest by analysis using magnetic resonance relaxometry.

公开(公告)号：US09017312B2

公开(公告)日：2015-04-28

申请号：US12851494

申请日：2010-08-05

申请人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

发明人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

IPC分类号： A61K9/22 ,  A61M31/00 ,  A61K9/00 ,  A61K31/167

CPC分类号： A61K9/0092 ,  A61K9/0004 ,  A61K9/0034 ,  A61K31/167 ,  A61M31/002

摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.

摘要翻译： 提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。 在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。 在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

公开(公告)号：US08801694B2

公开(公告)日：2014-08-12

申请号：US11463956

申请日：2006-08-11

申请人： Heejin Lee ,  Karen Daniel ,  Hong Linh Ho Duc ,  Michael J. Cima ,  Mario Castillo ,  Steven Froelich ,  Jordan Dimitrakov ,  Grace Y. Kim

发明人： Heejin Lee ,  Karen Daniel ,  Hong Linh Ho Duc ,  Michael J. Cima ,  Mario Castillo ,  Steven Froelich ,  Jordan Dimitrakov ,  Grace Y. Kim

IPC分类号： A61F2/00 ,  A61M31/00 ,  A61L29/16 ,  A61K9/00 ,  A61L29/06

CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61L29/06 ,  A61L29/16 ,  A61L2300/402 ,  A61L2300/406 ,  A61L2300/45 ,  A61L2300/63 ,  A61M2202/06 ,  A61M2205/0216 ,  A61M2210/1085 ,  C08L83/04

摘要： Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.

摘要翻译： 用于膀胱内给药和局部药物输送的植入装置。 该装置具有包括由生物相容性材料形成的中空管的主体; 管中含有药物的至少一个储存器; 以及可以释放药物的一个或多个孔。 该装置构造成用于微创地插入诸如膀胱的体腔中。 中空管可以是弹性的，以允许该装置从其初始形状弹性变形成细长形状以便通过导管，其中随后通过该装置可以返回或朝向其初始形状，以便于将装置保持在 体腔。 身体可以具有有效的狭窄的细长形状，以允许药物递送装置通过导管插入，而不必使身体变形，而包括有效地保持在体腔内的弹性突起。

公开(公告)号：US08690840B2

公开(公告)日：2014-04-08

申请号：US13267560

申请日：2011-10-06

申请人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

发明人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

IPC分类号： A61M31/00

CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0039 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

摘要： Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.

摘要翻译： 提供了可植入的医疗装置和治疗方法，特别用于膀胱。 该装置构造成在膀胱中保留药物递送期的至少一部分，并且包括至少一种可生物降解的组分，使得在选定时间内经过生物降解后，保留功能丧失并且其装置或部分被吸收， /或排泄。 该方法可以包括向患者的膀胱中部署具有容纳包含药物的药物制剂的装置结构的装置; 将药物从装置结构释放到膀胱中; 然后，例如通过改变pH来改变膀胱中尿液的组成，以触发装置结构的至少一部分的降解，使装置结构或其部分能够从膀胱排出。