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    FLUID FREE INTERFACE FOR A FLUIDIC ANALYZER
    4.
    发明申请
    FLUID FREE INTERFACE FOR A FLUIDIC ANALYZER 有权
    流体分析仪的流体免费接口

    公开(公告)号：US20070144277A1

    公开(公告)日：2007-06-28

    申请号：US11306401

    申请日：2005-12-27

    申请人： Aravind Padmanabhan ,  Tom Rezachek ,  Ron Bardell ,  Douglas Bird ,  Bernard Fritz

    发明人： Aravind Padmanabhan ,  Tom Rezachek ,  Ron Bardell ,  Douglas Bird ,  Bernard Fritz

    IPC分类号： G01N1/38 ,  B65D83/00

    CPC分类号： B01L9/527 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0809 ,  B01L2300/0877 ,  B01L2300/123 ,  B01L2400/0481 ,  F04C2/18 ,  F04C13/001 ,  G01N33/18 ,  G01N2035/00158

    摘要： Instrument-cartridge interfaces for fluidic analyzers that have an instrument and a removable cartridge are disclosed. For example, and in one illustrative embodiment, the instrument may include a needle that is adapted to penetrate a septum on a removable cartridge. In another illustrative embodiment, the instrument may include a plunger that is adapted to deform a deformable membrane on a removable cartridge. In yet another illustrative embodiment, the instrument may include a nozzle that is adapted to mate and seal with a flow channel on a removable cartridge. Techniques for detecting the flow rate in a flow channel on a removable cartridge, as well as the position of fluid in a flow channel of a removable cartridge, are also disclosed.

    摘要翻译： 公开了具有仪器和可移除盒的流体分析仪的盒式磁带接口。 例如，在一个说明性实施例中，仪器可以包括适于穿透可移除盒的隔膜的针。 在另一说明性实施例中，仪器可以包括适于使可移除盒上的可变形膜变形的柱塞。 在另一个说明性实施例中，仪器可以包括适于与可移除盒上的流动通道配合和密封的喷嘴。 还公开了用于检测可移除盒上的流动通道中的流速以及可移除盒的流动通道中的流体位置的技术。

    Raman detection based flow cytometer
    7.
    发明申请
    Raman detection based flow cytometer 有权
    基于拉曼检测的流式细胞仪

    公开(公告)号：US20060103840A1

    公开(公告)日：2006-05-18

    申请号：US10991001

    申请日：2004-11-17

    申请人： Bernard Fritz ,  Aravind Padmanabhan ,  Cleopatra Cabuz

    发明人： Bernard Fritz ,  Aravind Padmanabhan ,  Cleopatra Cabuz

    IPC分类号： G01J3/44 ,  G01N21/65

    CPC分类号： G01N21/658 ,  G01N15/147

    摘要： A method and apparatus for enabling chemical identification of individual particles, cells of molecules by obtaining a Raman spectrum of a particle, cell or molecule as it flows past a sensing point in a flow cytometer. The particles, which may be cells or molecules, are associated with a suitable noble metal colloid or colloidal aggregate. Cellular particles may be associated with gold or silver colloidal particles by ultra-sonic sonification while in a sample preparation reservoir containing the gold or silver colloidal suspension. The colloid associated particles are then hydrodynamically focused into a single file by a fluid control module. The surface-enhance Raman Spectrum of individual particles are obtained by illuminating the particle with a laser as the particle flows past a sensing point and gathering the light that is non-elastically scattered (Raman scattered) by the particle. The surface-enhanced Raman spectrum is then analyzed to identify the particle.

    摘要翻译： 一种方法和装置，用于通过在流式细胞计数器中流过感测点时获得粒子，细胞或分子的拉曼光谱，从而能够化学鉴定单个颗粒，分子细胞。 可以是细胞或分子的颗粒与合适的贵金属胶体或胶体聚集体相关联。 在含有金或银胶体悬浮液的样品制备储存器中，细胞颗粒可以通过超声波超声处理与金或银胶体颗粒结合。 然后通过流体控制模块将胶体相关颗粒流体动力聚焦成单个文件。 当颗粒流过感测点并通过颗粒收集非弹性散射（拉曼散射）的光时，通过用激光照射颗粒来获得单个颗粒的表面增强拉曼光谱。 然后分析表面增强拉曼光谱以鉴定颗粒。

    Optical alignment for flow cytometry
    8.
    发明授权
    Optical alignment for flow cytometry 有权
    流式细胞仪的光学校准

    公开(公告)号：US07215425B2

    公开(公告)日：2007-05-08

    申请号：US10824859

    申请日：2004-04-14

    申请人： Tom Rezachek ,  Aravind Padmanabhan ,  Bernard Fritz

    发明人： Tom Rezachek ,  Aravind Padmanabhan ,  Bernard Fritz

    IPC分类号： G01B11/00

    CPC分类号： G01B11/272 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1459 ,  G01N35/085 ,  G01N2015/0069 ,  G01N2015/0073 ,  G01N2015/008 ,  G01N2015/0238 ,  G01N2015/1075 ,  G01N2015/1413

    摘要： An optical alignment system for aligning a light beam with a core flow in a flow stream. The flow stream may have a sheath fluid and a core flow, where the core flow has a current position within the flow stream. A light source may be used to produce a light beam, and an optical element may be used to direct the light beam at the core flow. In some illustrative embodiments, an actuator is provided for moving the optical element, light source and/or flow stream such that the light directed by the optical element is aligned with the current position of the core flow.

    摘要翻译： 一种用于将光束与流动流中的核心流对准的光学对准系统。 流动流可以具有护套流体和芯流，其中核心流具有流动流内的当前位置。 可以使用光源来产生光束，并且可以使用光学元件来引导光束在核心流动。 在一些说明性实施例中，提供致动器用于移动光学元件，光源和/或流动流，使得由光学元件引导的光与核心流的当前位置对准。