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    Method and apparatus for changing relative concentrations of gases present within a gaseous sample for mass spectrometry
    1.
    发明授权
    Method and apparatus for changing relative concentrations of gases present within a gaseous sample for mass spectrometry 有权
    用于改变气相样品中存在的气体相对浓度的方法和装置用于质谱

    公开(公告)号：US09182325B2

    公开(公告)日：2015-11-10

    申请号：US11489150

    申请日：2006-07-18

    申请人： Arthur Schleifer

    发明人： Arthur Schleifer

    IPC分类号： G01N33/00 ,  B01L5/00 ,  G01N1/40 ,  B01L3/00

    CPC分类号： G01N1/4005 ,  B01L3/5027

    摘要： An apparatus for changing relative concentrations of first and second analyte substances in an analyte sample comprises a sample cell defining a sample chamber therewithin, and a semipermeable boundary member disposed in the sample chamber to define first and second sides of the sample chamber. Sample flow input and sample flow output ducts direct an analyte sample containing respective initial concentrations of the first and second analyte substances into the first side of the sample chamber. The semipermeable boundary member permits diffusion therethrough of the first and second analyte substances to the second side of the sample chamber at different rates. An analyte sample in the second side of the sample chamber, and an analyte sample exiting the first side via the sample flow output duct, have respective concentrations of the first and second analyte substances that are different from the initial concentrations.

    摘要翻译： 用于改变分析物样品中第一和第二分析物质的相对浓度的装置包括在其中限定样品室的样品池和设置在样品室中以限定样品室的第一和第二侧的半透性边界部件。 样品流入口和样品流输出管道将含有相应初始浓度的第一和第二分析物质的分析物样品引导到样品室的第一侧。 半透性边界构件允许第一和第二分析物质以不同的速率扩散到样品室的第二侧。 样品室第二侧中的分析物样品和经由样品流量输出管道离开第一侧的分析物样品具有不同于初始浓度的第一和第二分析物质的相应浓度。

    Methods and systems for selecting pathlength in absorbance measurements
    2.
    发明授权
    Methods and systems for selecting pathlength in absorbance measurements 失效
    用于在吸光度测量中选择光程的方法和系统

    公开(公告)号：US07365852B2

    公开(公告)日：2008-04-29

    申请号：US10996913

    申请日：2004-11-24

    申请人： Arthur Schleifer

    发明人： Arthur Schleifer

    IPC分类号： G01N21/00

    CPC分类号： G01N21/0303 ,  G01N21/31 ,  G01N2021/035 ,  G01N2021/036

    摘要： Methods and sub-systems for substantially optimizing the absorbance measurement in optical instruments are provided. A method comprises forming a liquid sample into a droplet extending between two opposing surfaces, passing a light beam through the sample, and varying the distance between the two opposing surfaces until a distance substantially corresponding to a optimum absorbance is obtained.

    摘要翻译： 提供了用于基本上优化光学仪器中的吸光度测量的方法和子系统。 一种方法包括将液体样品形成为在两个相对表面之间延伸的液滴，使光束通过样品，并改变两个相对表面之间的距离，直到获得基本上对应于最佳吸光度的距离。

    Plasma generating devices and methods for using the same
    3.
    发明申请
    Plasma generating devices and methods for using the same 审中-公开
    等离子体发生装置及其使用方法

    公开(公告)号：US20070170995A1

    公开(公告)日：2007-07-26

    申请号：US11485222

    申请日：2006-07-11

    申请人： David Dutton ,  Arthur Schleifer ,  Robert Taber ,  Karen Seward

    发明人： David Dutton ,  Arthur Schleifer ,  Robert Taber ,  Karen Seward

    IPC分类号： H03B7/14

    CPC分类号： H05H1/46 ,  H05H2001/4622

    摘要： Aspects of the invention include plasma generating devices and systems thereof, as well as methods of using the same in plasma generation. Embodiments of the plasma generating devices include a resonator having a discharge gap and a ground plane disposed on opposing sides of a substrate; and a gas flow element configured to flow gas through the discharge gap. In using the plasma generating devices, a gas is flowed through the discharge gap and sufficient power is applied to the resonator to produce a plasma, e.g., in the form of a plasma jet, at the discharge gap. The subject devices and methods find use in a variety of different applications.

    摘要翻译： 本发明的方面包括等离子体生成装置及其系统，以及在等离子体生成中使用该装置的方法。 等离子体产生装置的实施例包括具有放电间隙的谐振器和设置在基板的相对侧上的接地平面; 以及气体流动元件，其构造成使气体流过所述放电间隙。 在使用等离子体产生装置时，气体流过放电间隙，并且向谐振器施加足够的功率以在放电间隙处产生例如等离子体射流形式的等离子体。 主题设备和方法可用于各种不同的应用。

    Capsule Injection System for Gas Chromatography
    5.
    发明申请
    Capsule Injection System for Gas Chromatography 有权
    胶囊注射系统用于气相色谱

    公开(公告)号：US20110146380A1

    公开(公告)日：2011-06-23

    申请号：US12642843

    申请日：2009-12-20

    申请人： Arthur Schleifer ,  Carl A. Myerholtz

    发明人： Arthur Schleifer ,  Carl A. Myerholtz

    IPC分类号： G01N30/16 ,  B01L3/00

    CPC分类号： G01N30/16 ,  G01N2030/025

    摘要： The present invention includes a heat sealable capsule adapted for use in analysis devices such as GCs, and methods for using the capsules to perform analysis in such devices. The capsules include a tube having an end that is heat-sealed to contain a sample that is to be analyzed at an injection temperature. The tube includes a heat sealable medium having a heat seal that closes the end, the tube having an inner and outer surface, both of the surfaces being substantially chemically inert with respect to the sample. The tube is substantially free of any material that outgases at the injection temperature. The tube is openable without breaking into pieces, and remains intact at the injection temperature. The capsule can include a programmable tag that stores information related to the sample contained therein.

    摘要翻译： 本发明包括适用于诸如GC之类的分析装置的可热封胶囊，以及使用该胶囊在这些装置中进行分析的方法。 胶囊包括具有热封端以容纳在注射温度下待分析的样品的管。 管包括具有封闭端部的热封的热封介质，管具有内表面和外表面，两个表面相对于样品基本上是化学惰性的。 该管基本上不含任何在注射温度下会出现的物质。 管可打开而不会碎片，并且在注射温度下保持完好。 胶囊可以包括可编程标签，其存储与其中包含的样品有关的信息。

    Microarray washing apparatus and method
    9.
    发明申请
    Microarray washing apparatus and method 审中-公开
    微阵列洗涤装置及方法

    公开(公告)号：US20050268943A1

    公开(公告)日：2005-12-08

    申请号：US10864229

    申请日：2004-06-08

    申请人： Arthur Schleifer

    发明人： Arthur Schleifer

    IPC分类号： G01N33/53 ,  B01L99/00 ,  C12Q1/68 ,  G01N1/00 ,  G01N1/28 ,  G01N1/34 ,  G01N35/00 ,  G01N37/00 ,  B08B3/00

    CPC分类号： B01L13/02 ,  B01J2219/00281 ,  B01J2219/00389 ,  B01J2219/00529 ,  B01J2219/00659 ,  B01L9/52 ,  B01L2200/147 ,  B01L2300/0819 ,  B01L2400/0487 ,  Y10T436/25

    摘要： Apparatus for contacting an array substrate with a fluid and novel methods for washing an array substrate are disclosed. In an embodiment, the apparatus includes a housing defining a wash chamber, a fluid inlet in fluid communication with the wash chamber, a drain in fluid communication with the wash chamber, a gas inlet adapted to direct a stream of gas over a surface of the array substrate, and a program controller in operable relation to the wash chamber, the program controller operable to perform a washing protocol which includes automatically filling the wash chamber with said fluid. A method as described includes placing the array substrate in a wash chamber, triggering a first drain and fill step, automatically performing a second drain and fill step, and automatically performing a slow drain step.

    摘要翻译： 公开了用于使阵列基板与流体接触的装置和用于清洗阵列基板的新颖方法。 在一个实施例中，该设备包括限定洗涤室的壳体，与洗涤室流体连通的流体入口，与洗涤室流体连通的排水口，适于将气流引导到 阵列基板和与洗涤室可操作的程序控制器，所述程序控制器可操作以执行洗涤协议，所述清洗协议包括用所述流体自动填充所述洗涤室。 所描述的方法包括将阵列基板放置在洗涤室中，触发第一排水和填充步骤，自动执行第二排水和填充步骤，以及自动执行缓慢排水步骤。

    Matrix-assisted laser desorption/ionization sample holders and methods of using the same
    10.
    发明授权
    Matrix-assisted laser desorption/ionization sample holders and methods of using the same 失效
    基质辅助激光解吸/电离样品架及其使用方法

    公开(公告)号：US06822230B2

    公开(公告)日：2004-11-23

    申请号：US10328733

    申请日：2002-12-23

    申请人： Arthur Schleifer ,  Viorica Lopez-Avila ,  Magdalena Anna Ostrowski ,  Jean Luc Truche ,  Jian Bai

    发明人： Arthur Schleifer ,  Viorica Lopez-Avila ,  Magdalena Anna Ostrowski ,  Jean Luc Truche ,  Jian Bai

    IPC分类号： H01J4926

    CPC分类号： H01J49/0418

    摘要： MALDI sample holders and methods of using and making the same are provided. The MALDI sample holders are configured for use in matrix assisted laser desorption/ionization and include a planar substrate having a surface and at least one fluid retaining structure present on the surface. The fluid retaining structure includes a material that changes from a first fluid state to a second solid state in response to a stimulus. Also provided are methods of using the subject MALDI sample holders in a matrix-assisted laser desorption/ionization protocol, as well as methods of producing the subject MALDI sample holders. Kits for use in practicing the subject methods are also provided.

    摘要翻译： 提供了MALDI样品持有者及其使用和制作方法。 MALDI样品保持器被配置用于基质辅助激光解吸/电离，并且包括具有表面和存在于表面上的至少一种流体保持结构的平面基底。 流体保持结构包括响应于刺激而从第一流体状态变为第二固态的材料。 还提供了在基质辅助激光解吸/电离方案中使用本发明的MALDI样品保持器的方法以及生产所述MALDI样品保持器的方法。 还提供了用于实践主题方法的套件。