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公开(公告)号：US10326952B2
公开(公告)日：2019-06-18
申请号：US15675494
申请日：2017-08-11
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Ran , Steve Swihart , Evan Thrush , Itay Barak
Abstract: In one application, an imaging device includes an image sensor having an array of pixels, and a mask coupled with the image sensor. The mask is configured to darken a plurality of isolated pixels or groups of pixels interspersed within the array of pixels. The imaging device also includes a processor coupled with the image sensor and configured to receive image data from the image sensor, and determine a dark current fixed pattern noise based on the image data received from the plurality of darkened pixels or groups of pixels.
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公开(公告)号：US10359397B2
公开(公告)日：2019-07-23
申请号：US14968400
申请日：2015-12-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yochanan Uri , Uri Issman , Igor Kochetkov , Itay Barak , Shai Aharon , Shai Nimri
IPC: G01N27/447 , G01N33/543
Abstract: Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.
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公开(公告)号：US20160006910A1
公开(公告)日：2016-01-07
申请号：US14789717
申请日：2015-07-01
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yochanan Uri , Boaz Ran , Itay Barak , Steven Swihart , Evan Thrush
IPC: H04N5/225
CPC classification number: H04N5/2252 , G01N21/76 , G01N21/763 , G01N2201/0221
Abstract: Provided herein are imaging cassettes for detecting a luminescent and/or radioactive signals. Such cassettes are useful in common biological assays, e.g., immunoassays, nucleotide detection assays, and other affinity assays.
Abstract translation: 本文提供了用于检测发光和/或放射性信号的成像盒。 这样的盒可用于常见的生物测定，例如免疫测定，核苷酸检测测定和其他亲和测定。
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公开(公告)号：US20160028976A1
公开(公告)日：2016-01-28
申请号：US14563411
申请日：2014-12-08
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Boaz Ran , Steve Swihart , Evan Thrush , Itay Barak
Abstract: One embodiment of the invention is directed to an imaging device comprising an image sensor comprising an array of pixels, and a mask coupled with the image sensor, the mask configured to darken at least one pixel in the array of pixels.
Abstract translation: 本发明的一个实施例涉及一种包括包括像素阵列的图像传感器和与图像传感器耦合的掩模的成像装置，该掩模被配置为使像素阵列中的至少一个像素变暗。
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公开(公告)号：US20130344623A1
公开(公告)日：2013-12-26
申请号：US14013068
申请日：2013-08-29
Applicant: Bio-Rad Laboratories Inc.
Inventor： Boaz RAN , Itay Barak
IPC: G01N21/55
CPC classification number: G01N21/553 , G02B3/005 , G02B5/008
Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.
Abstract translation: 一种用于在全内反射下测量ev逝波现象的系统，所述系统包括：a）感测表面，包括多个感兴趣的区域; b）照明子系统，包括光源，其在入射角范围上照射感测表面上的每个感兴趣区域; c）检测器，其响应于其在不同位置处接收的光的强度不同; 以及d）包括主要光学元件和多个次要元件的投影光学元件，所述主要光学器件将所述照射的感测表面的图像投影到所述次级元件上，所述次级元件将其接收的光投射到所述检测器上，使得可以确定， 根据检测器的响应，从感兴趣区域反射多少光，作为该区域的角度范围内的入射角的函数。
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Patent Agency Ranking
公开(公告)号：US12201974B2
公开(公告)日：2025-01-21
申请号：US16984852
申请日：2020-08-04
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yochanan Uri , Itay Barak , Robert Lovchik , David P. Taylor , Marcel Buerge , Govind V. Kaigala
IPC: B01L3/00
Abstract: The present disclosure is notably directed to a microfluidic probe head (202), or MFP head, comprising a processing surface (204) having liquid injection and liquid aspiration apertures, as well as projections (205) extending from the processing surface (204). The arrangement of injection and aspiration apertures provides for a hydrodynamic flow confinement within a processing region that is formed between the processing surface (204) and a substrate (104) or sample surface (for example, the bottom of a microtiter plate sample well (102)), typically located beneath the processing surface (204). The disclosure is further directed to related microfluidic probe devices, and methods of operation of such an MFP head, notably to deposit cells on a surface.
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7.发明申请HORIZONTAL ELECTROPHORESIS SEPARATION DEVICE WITHOUT SEAL AND METHOD OF EXTRACTING GEL WITHOUT OPENING CASSETTE 审中-公开没有密封的水平电泳分离装置和不开放CASSETTE提取凝胶的方法公开(公告)号：US20160299099A1
公开(公告)日：2016-10-13
申请号：US14968400
申请日：2015-12-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Yochanan Uri , Uri Issman , Igor Kochetkov , Itay Barak , Shai Aharon , Shai Nimri
IPC: G01N27/447 , G01N33/543
CPC classification number: G01N27/44756 , G01N27/44721 , G01N27/44726 , G01N27/44739 , G01N27/44743 , G01N27/44782 , G01N33/54366
Abstract: Horizontal gel electrophoresis devices and methods of extracting a gel from a gel housing are provided. The devices allow for extraction of gels without having to open the housing comprising the gel. The devices include gel cassettes that simplify the automation of gel electrophoresis and electroblotting of proteins. Also provided are devices that allow for horizontal gel electrophoresis without the need to from a liquid seal between the buffer reservoir and the gel housing. Also described are methods for extracting a gel from a housing without opening the housing.
Abstract translation: 提供了水凝胶电泳装置和从凝胶壳体提取凝胶的方法。 该装置允许提取凝胶，而不必打开包含凝胶的壳体。 该装置包括凝胶盒，其简化了凝胶电泳的自动化和蛋白质的电印迹。 还提供了允许水平凝胶电泳而不需要在缓冲储存器和凝胶壳体之间的液体密封的装置。 还描述了在不打开壳体的情况下从壳体中提取凝胶的方法。
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公开(公告)号：US09383311B2
公开(公告)日：2016-07-05
申请号：US14013068
申请日：2013-08-29
Applicant: Bio-Rad Laboratories Inc.
Inventor： Boaz Ran , Itay Barak
IPC: G01N21/00 , G01N21/552 , G02B3/00 , G02B5/00
CPC classification number: G01N21/553 , G02B3/005 , G02B5/008
Abstract: A system for measuring an evanescent wave phenomenon at total internal reflection, the system comprising: a) a sensing surface comprising a plurality of areas of interest; b) an illumination sub-system comprising a light source, which illuminates each area of interest on the sensing surface over a range of angles of incidence; c) a detector which responds differently to an intensity of light received by it at different locations; and d) projection optics comprising primary optics and a plurality of secondary elements, the primary optics projecting an image of the illuminated sensing surface onto the secondary elements, which project their received light onto the detector in such a way that it is possible to determine, from the response of the detector, how much light is reflected from each area of interest, as a function of angle of incidence over the range of angles for that area.
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公开(公告)号：US11644359B2
公开(公告)日：2023-05-09
申请号：US17346873
申请日：2021-06-14
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Itay Barak
CPC classification number: G01J1/0403 , G01J1/0407 , G01N21/76 , G01N33/5302 , G01N21/6428 , G01N2021/6439
Abstract: A combination imaging system includes a housing having a base and a lid, the lid having a closed position against the base and having an open position. The imaging device further includes a contact area image sensor. The lid shields the contact area image sensor from ambient light when the lid is in the closed position. The imaging device also includes a camera. The camera includes a lens, and the field of view of the camera encompasses at least a portion of an imaging area of the contact area image sensor when the lid is in the open position. The device may be especially useful for capturing a chemiluminescent image of an electrophoretic assay result, and capturing a colorimetric image of the same result, so that non-chemiluminescent protein standards may be located with respect to chemiluminescent analytes of interest.
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公开(公告)号：US11035722B2
公开(公告)日：2021-06-15
申请号：US16219715
申请日：2018-12-13
Applicant: Bio-Rad Laboratories, Inc.
Inventor： Itay Barak
Abstract: A combination imaging system includes a housing having a base and a lid, the lid having a closed position against the base and having an open position. The imaging device further includes a contact area image sensor. The lid shields the contact area image sensor from ambient light when the lid is in the closed position. The imaging device also includes a camera. The camera includes a lens, and the field of view of the camera encompasses at least a portion of an imaging area of the contact area image sensor when the lid is in the open position. The device may be especially useful for capturing a chemiluminescent image of an electrophoretic assay result, and capturing a colorimetric image of the same result, so that non-chemiluminescent protein standards may be located with respect to chemiluminescent analytes of interest.
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