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    Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products
    5.
    发明申请
    Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products 审中-公开
    提供用户与遗传表征血液制品供应商之间的实时互动

    公开(公告)号：US20140257858A1

    公开(公告)日：2014-09-11

    申请号：US14281190

    申请日：2014-05-19

    Applicant: Bioarray Solutions, Ltd.

    Inventor： Michael Seul ,  Robert Danehy

    IPC: G06F19/00

    CPC classification number: G16H40/20 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22 ,  G06Q50/24 ,  G16B20/00 ,  G16B40/00 ,  G16B50/00 ,  G16H10/60 ,  Y02A90/22 ,  Y02A90/26

    Abstract: Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be Integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.

    Abstract translation: 披露了一个注册系统，包括成员机构，其中输血捐赠者和接受者在基因分型之后注册，通常在成员机构中进行注册，或者成员机构如果在外部执行，则可以访问基因分型信息。 可以通过搜索特定类型的样本的成员访问和搜索注册表数据库。 公开了系统，用于通过最大限度地利用输入的候选捐赠者的数量最大化来维持与输血相关的基因分型的经济可行性。 潜在捐赠者的基因分型和产品供应与预测需求相匹配。 基因分型也可以限于更临床相关的标记物。 注册表系统也可以集成一种形式的测定法，其生成用于分析的图像，由此，成像结果可以由中心位置的专家分析和编辑，然后传送回患者或其代表。

    Optimization Of Gene Expression Analysis Using Immobilized Capture Probes
    8.
    发明申请
    Optimization Of Gene Expression Analysis Using Immobilized Capture Probes 有权
    使用固定化捕获探针优化基因表达分析

    公开(公告)号：US20160215327A1

    公开(公告)日：2016-07-28

    申请号：US14257294

    申请日：2014-04-21

    Applicant: BIOARRAY SOLUTIONS, LTD.

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/68

    CPC classification number: C12Q1/6832 ,  B01J2219/00459 ,  B01J2219/00576 ,  B01J2219/00608 ,  B01J2219/00648 ,  B01J2219/00722 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837 ,  C12Q2537/143 ,  C12Q2565/501 ,  C12Q2565/507 ,  C12Q2533/101 ,  C12Q2565/514 ,  C12Q2565/519

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including a method of preventing a significant reduction in duplexes detectable in a hybridization assay involving (i) selecting probe lengths for sets of oligonucleotide probes, wherein probes include different subsequences such that at least one subsequence is complementary to a subsequence in a cognate target; wherein probes for longer cognate targets are longer in length than probes for shorter cognate targets, (ii) selecting, for each set of probes, a density of oligonucleotides probes attached per unit area on a solid phase carrier which is below a limit at which the significant reduction in detectable duplexes is predicated to take place, (iii) producing the probes and affixing them to different solid phase carriers at the selected density, and (iv) annealing targets to the probes, wherein signal intensities of probes and targets of different lengths are about the same.

    Abstract translation: 公开了一种样品中寡核苷酸多重分析的方法，包括防止在杂交测定中可检测到的双链体显着降低的方法，其包括（i）选择寡核苷酸探针组的探针长度，其中探针包括不同的子序列，使得至少一个 子序列是同源目标中的一个子序列的补充; 其中用于较长同源靶的探针的长度长于针对较短同源靶的探针，（ii）为每组探针选择在固相载体上每单位面积连接的寡核苷酸探针的密度，其低于 预测发现可检测的双链体显着减少，（iii）产生探针并以选定的密度将它们固定在不同的固相载体上，和（iv）将靶标退火至探针，其中不同长度的探针和靶的信号强度 大致相同。

    Optimization of gene expression analysis using immobilized capture probes
    9.
    发明授权
    Optimization of gene expression analysis using immobilized capture probes 有权

    公开(公告)号：US10407718B2

    公开(公告)日：2019-09-10

    申请号：US15491127

    申请日：2017-04-19

    Applicant: BioArray Solutions, Ltd.

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/6832 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including a method of preventing a significant reduction in duplexes detectable in a hybridization assay involving (i) selecting probe lengths for sets of oligonucleotide probes, wherein probes include different subsequences such that at least one subsequence is complementary to a subsequence in a cognate target; wherein probes for longer cognate targets are longer in length than probes for shorter cognate targets, (ii) selecting, for each set of probes, a density of oligonucleotides probes attached per unit area on a solid phase carrier which is below a limit at which the significant reduction in detectable duplexes is predicated to take place, (iii) producing the probes and affixing them to different solid phase carriers at the selected density, and (iv) annealing targets to the probes, wherein signal intensities of probes and targets of different lengths are about the same.

    Selection of Genotyped Transfusion Donors by Cross-Matching to Genotyped Recipients
    10.
    发明申请
    Selection of Genotyped Transfusion Donors by Cross-Matching to Genotyped Recipients 审中-公开
    通过与基因型受体的交叉匹配选择基因型输血供体

    公开(公告)号：US20140358446A1

    公开(公告)日：2014-12-04

    申请号：US14256579

    申请日：2014-04-18

    Applicant: BIOARRAY SOLUTIONS, LTD.

    Inventor： Yi Zhang ,  Michael Seul

    IPC: G06F19/00

    CPC classification number: G06F19/3456 ,  G06F19/3481 ,  G16B20/00 ,  G16B25/00 ,  G16B30/00 ,  G16B40/00 ,  G16H10/60 ,  G16H50/70

    Abstract: Disclosed are methods for establishing the compatibility between two blood types on the basis of cross-matching (under a designated rule of stringency) the minor blood group genotypes of recipient and prospective donors. To determine compatibility, the blood group genotypes are mapped to corresponding phenotypes according to the expression states associated with a set of underlying haplotypes, and compatibility is established by establishing the compatibility of blood types constructed as a combination of constituent phenotypes. The bit strings are matched, preferably using an algorithm expression. Where ambiguity in mapping genotypes to haplotypes exists, it can be reduced based on frequency of occurrence of the haplotypes in the sample population, or resolved by gametic phasing. Such reduction or resolution of ambiguity is particularly desirable where mismatches in the antigens expressed by the constituent haplotypes have greater clinical significance.

    Abstract translation: 公开的是基于接受者和潜在供体的次要血型基因型的交叉匹配（在指定的严格规则）的基础上建立两种血型之间的相容性的方法。 为了确定相容性，根据与一组潜在单倍型相关联的表达状态，将血型基因型映射到相应的表型，并且通过建立构成为构成表型的组合的血型相容性建立相容性。 比特串匹配，最好使用算法表达式。 如果存在将基因型映射到单倍型的歧义，则可以根据样本群体中单倍型的发生频率来减少，或者通过配子定相来解决。 在组成单元型表达的抗原中的错配具有更大的临床意义的情况下，这种模糊的减少或解决是特别理想的。

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