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    Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products
    5.
    发明申请
    Providing Real-time Interaction Between Users and Providers of Genetically Characterized Blood Products 审中-公开
    提供用户与遗传表征血液制品供应商之间的实时互动

    公开(公告)号：US20140257858A1

    公开(公告)日：2014-09-11

    申请号：US14281190

    申请日：2014-05-19

    Applicant: Bioarray Solutions, Ltd.

    Inventor： Michael Seul ,  Robert Danehy

    IPC: G06F19/00

    CPC classification number: G16H40/20 ,  G06F19/3481 ,  G06Q10/10 ,  G06Q50/22 ,  G06Q50/24 ,  G16B20/00 ,  G16B40/00 ,  G16B50/00 ,  G16H10/60 ,  Y02A90/22 ,  Y02A90/26

    Abstract: Disclosed is a registry system, including member institutions, in which transfusion donors and recipients are registered following genotyping, which would typically take place in a member institution, or a member institution would have access to the genotyping information, if performed outside. The registry database can be accessed and searched by members seeking samples of particular type(s). Systems are disclosed for maintaining economic viability of genotyping in connection with transfusions, by maximizing the number of units placed with the minimal number of candidate donors typed. Genotyping of potential donors, and product supply, is matched to forecasted demand. Genotyping can also be limited to the more clinically relevant markers. The registry system can also be Integrated with one format of assay which generates an image for analysis, whereby the imaged results can be analyzed and redacted by experts in a central location, and then transmitted back to the patient or their representative.

    Abstract translation: 披露了一个注册系统，包括成员机构，其中输血捐赠者和接受者在基因分型之后注册，通常在成员机构中进行注册，或者成员机构如果在外部执行，则可以访问基因分型信息。 可以通过搜索特定类型的样本的成员访问和搜索注册表数据库。 公开了系统，用于通过最大限度地利用输入的候选捐赠者的数量最大化来维持与输血相关的基因分型的经济可行性。 潜在捐赠者的基因分型和产品供应与预测需求相匹配。 基因分型也可以限于更临床相关的标记物。 注册表系统也可以集成一种形式的测定法，其生成用于分析的图像，由此，成像结果可以由中心位置的专家分析和编辑，然后传送回患者或其代表。

    Optimization of gene expression analysis using immobilized capture probes
    6.
    发明授权
    Optimization of gene expression analysis using immobilized capture probes 有权

    公开(公告)号：US10407718B2

    公开(公告)日：2019-09-10

    申请号：US15491127

    申请日：2017-04-19

    Applicant: BioArray Solutions, Ltd.

    Inventor： Michael Seul ,  Sukanta Banerjee ,  Jiacheng Yang ,  Tatiana Vener

    IPC: C12Q1/6832 ,  C12Q1/6809 ,  C12Q1/6834 ,  C12Q1/6837

    Abstract: Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including a method of preventing a significant reduction in duplexes detectable in a hybridization assay involving (i) selecting probe lengths for sets of oligonucleotide probes, wherein probes include different subsequences such that at least one subsequence is complementary to a subsequence in a cognate target; wherein probes for longer cognate targets are longer in length than probes for shorter cognate targets, (ii) selecting, for each set of probes, a density of oligonucleotides probes attached per unit area on a solid phase carrier which is below a limit at which the significant reduction in detectable duplexes is predicated to take place, (iii) producing the probes and affixing them to different solid phase carriers at the selected density, and (iv) annealing targets to the probes, wherein signal intensities of probes and targets of different lengths are about the same.

    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES
    9.
    发明申请
    ANALYSIS, SECURE ACCESS TO, AND TRANSMISSION OF ARRAY IMAGES 有权
    分析，安全访问和传输阵列图像

    公开(公告)号：US20160267650A1

    公开(公告)日：2016-09-15

    申请号：US15010597

    申请日：2016-01-29

    Applicant: BioArray Solutions, Ltd.

    Inventor： Michael SEUL ,  Xiongwu Xia ,  Chiu CHAU ,  Scott DETERMAN

    IPC: G06T7/00 ,  G01N33/566 ,  G06K9/00

    CPC classification number: G06T7/0012 ,  G01N33/566 ,  G06K9/00 ,  G06K9/00147 ,  G06K2209/07 ,  G06T7/11 ,  G06T7/155 ,  G06T7/33 ,  G06T2207/10064 ,  G06T2207/20152 ,  G06T2207/30072

    Abstract: Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and decoding image are aligned to effect the decoding. The images or data extracted from such images can be exchanged between de-centralized assay locations and a centralized location where the data are analyzed to indicate assay results. Access to data can be restricted to authorized parties in possession of certain encoding information, so as to preserve confidentiality.

    Abstract translation: 系统和方法提供了各方之间的自动对中，自动聚焦，获取，解码，对齐，分析和交换，其中图像是与配体 - 受体相互作用相关联的信号阵列，更具体地，配体 - 受体相互作用，其中 许多受体与微粒或微珠相关。 编码珠子以指示所连接的受体的身份，因此，分析图像和解码图像被对准以影响解码。 从这样的图像提取的图像或数据可以在非集中测定位置和数据被分析以指示测定结果的集中位置之间交换。 访问数据可以限于拥有某些编码信息的授权方，以保护机密性。

    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION
    10.
    发明申请
    AUTOMATED ANALYSIS OF MULTIPLEXED PROBE-TARGET INTERACTION PATTERNS: PATTERN MATCHING AND ALLELE IDENTIFICATION 审中-公开
    多重探测目标相互作用模式的自动分析：模式匹配与识别

    公开(公告)号：US20160002714A1

    公开(公告)日：2016-01-07

    申请号：US14851844

    申请日：2015-09-11

    Applicant: BioArray Solutions, Ltd.

    Inventor： Xiongwu XIA ,  Michael SEUL

    IPC: C12Q1/68 ,  G06F19/22

    CPC classification number: C12Q1/6827 ,  G16B20/00 ,  G16B30/00

    Abstract: Disclosed are methods and algorithms (and their implementation) supporting the automated analysis and interactive review and refinement (“redaction”) of the analysis within an integrated software environment, for automated allele assignments. The implementation, preferably with a software system and a program referred to as the Automated Allele Assignment (“AAA”) program, provides a multiplicity of functionalities including: data management by way of an integrated interface to a portable database to permit visualizing, importing, exporting and creating customizable summary reports; system configuration (“Set-up”) including user authorization, training set analysis and probe masking; Pattern Analysis including string matching and probe flipping; and Interactive Redaction combining real-time database computations and “cut-and-paste” editing, generating “warning” statements and supporting annotation. It also includes a thresholding function, a method of setting thresholds, a method of refining thresholds by matching an experimental binary string (“reaction pattern”) setting for that probe, probe masking of signals produced by probes which do not contribute significantly to discriminating among alleles.

    Abstract translation: 公开的方法和算法（及其实现）支持在集成软件环境中进行自动化等位基因分配的自动分析和交互式审查和细化（“编辑”）分析。 优选地使用软件系统和称为自动等位基因分配（“AAA”）程序的程序的实现提供了多种功能，包括：通过与便携式数据库的集成接口的数据管理，以允许可视化，导入， 出口和创建可定制的汇总报告; 系统配置（“设置”），包括用户授权，训练集分析和探测屏蔽; 模式分析包括字符串匹配和探针翻转; 和Interactive Redaction将实时数据库计算和“剪切和粘贴”编辑相结合，生成“警告”语句和支持注释。 它还包括阈值功能，设置阈值的方法，通过匹配用于该探针的实验二进制串（“反应模式”）设置来精确化阈值的方法，探针对由探针产生的信号进行探针掩蔽，所述探针不对显着区别于 等位基因

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