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1.发明申请Farnesyl dibenzodiazepinone, processes for its production and its use as a pharmaceutical 有权法呢基二苯并二氮杂酮，其生产方法及其用作药物公开(公告)号：US20050043297A1
公开(公告)日：2005-02-24
申请号：US10762107
申请日：2004-01-21
IPC分类号： A61K38/00 , C07D243/38 , C12N9/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , A61K31/551 , C07D243/10
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译： 本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。 获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及小单孢菌属 应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或 其药学上可接受的盐或衍生物。 最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。
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2.发明申请Polyene polyketides, processes for their production and their use as pharmaceuticals 审中-公开聚烯烃聚合物，其生产工艺及其作为药物的使用公开(公告)号：US20050004185A1
公开(公告)日：2005-01-06
申请号：US10844701
申请日：2004-05-13
IPC分类号： A61P31/00 , C07C215/24 , C07C279/14 , C07C279/22 , C07C305/14 , C12P7/42 , C12P11/00 , C12P13/00 , C12P19/44 , C07D213/42 , C07D207/10
CPC分类号： C07C59/42 , C07C59/90 , C07C215/24 , C07C279/14 , C07C279/22 , C07C305/14 , C07C2601/14 , C07D207/16 , C07D213/53 , C07D213/82 , C07D303/36 , C07D317/30 , C12P7/42 , C12P11/00 , C12P13/001 , C12P13/02 , C12P19/44 , C12R1/465
摘要： This invention relates to a novel class of linear polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for their production. The compounds may be obtained by cultivation of Streptomyces melanosporafaciens species and isolation of the polyene polyketide, followed by optional chemical production of the isolated polyene polyketide. The compounds may also be produced by other known bacteria. The invention further includes the use of these compounds as inhibitors of fungal cell growth and inhibitors of cancer cell growth. Finally, the invention encompasses pharmaceutical compositions comprising these novel polyketide compounds, or their pharmaceutically acceptable salts or derivatives thereof.
摘要翻译： 本发明涉及新型线型多烯聚酮化合物，其药学上可接受的盐和衍生物及其生产方法。 可以通过培养黑色链霉菌属物种并分离多烯聚酮来获得化合物，然后任选化学制备分离的多烯聚酮化合物。 化合物也可以由其他已知细菌产生。 本发明还包括这些化合物作为真菌细胞生长抑制剂和癌细胞生长抑制剂的用途。 最后，本发明包括包含这些新型聚酮化合物或其药学上可接受的盐或衍生物的药物组合物。
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3.发明申请Method, system, and knowledge repository for identifying a secondary metabolite from a microorganism 审中-公开用于从微生物鉴定次生代谢物的方法，系统和知识库公开(公告)号：US20070061084A1
公开(公告)日：2007-03-15
申请号：US11262235
申请日：2005-10-28
申请人： Chris Farnet , James McAlpine , Brian Bachmann , Alfredo Staffa , Emmanuel Zazopoulos , Zhizi Zhao , Sai Man Wong , Nicolas Desjardins
发明人： Chris Farnet , James McAlpine , Brian Bachmann , Alfredo Staffa , Emmanuel Zazopoulos , Zhizi Zhao , Sai Man Wong , Nicolas Desjardins
摘要： Described are methods and systems for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
摘要翻译： 描述了用于鉴定由微生物内的靶基因簇合成的次级代谢物的方法和系统。 推定或确认的功能归因于基因簇内的基因，并且获得了怀疑含有由基因簇合成的次级代谢物的微生物提取物。 然后评估提取物的化学，物理或生物学性质，并鉴定和任选分离代谢物。 此外，本发明提供了知识库，其中基因簇信息与次级代谢产生数据相关联。 本发明还涉及用于访问知识库的图形用户界面和用于存储数据的存储器，其具有存储在存储器中的数据结构。
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公开(公告)号：US20050038090A1
公开(公告)日：2005-02-17
申请号：US10865767
申请日：2004-06-14
IPC分类号： A61P35/00 , C07D263/32 , C07D413/12 , C12P17/14 , C07D413/02 , A61K31/422
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： Novel polyene oxazole compounds of Formula I: are useful as cytotoxic agents. The polyene oxazoles may be made by fermentation of Streptomyces sparsogenes and optional post-biosynthesis chemical modification thereof.
摘要翻译： 式I的新颖多烯恶唑化合物可用作细胞毒性剂。 多烯恶唑可以通过发酵链霉菌副产物和任选的后生物合成化学修饰来制备。
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5.发明申请System, knowledge repository and computer-readable medium for identifying a secondary metabolite from a microorganism 审中-公开用于从微生物鉴定次级代谢物的系统，知识库和计算机可读介质公开(公告)号：US20080010025A1
公开(公告)日：2008-01-10
申请号：US11551137
申请日：2006-10-19
IPC分类号： G01N33/50
CPC分类号： C12Q1/025
摘要： The invention relates to a method and system for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
摘要翻译： 本发明涉及鉴定由微生物内的靶基因簇合成的次级代谢物的方法和系统。 推定或确认的功能归因于基因簇内的基因，并且获得了怀疑含有由基因簇合成的次级代谢物的微生物提取物。 然后评估提取物的化学，物理或生物学性质，并鉴定和任选分离代谢物。 此外，本发明提供了知识库，其中基因簇信息与次级代谢产生数据相关联。 本发明还涉及用于访问知识库的图形用户界面和用于存储数据的存储器，其具有存储在存储器中的数据结构。
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6.发明申请Polyene polyketides, processes for their production and their use as a pharmaceutical 失效聚烯烃聚合物，其生产方法及其作为药物的用途公开(公告)号：US20050187167A1
公开(公告)日：2005-08-25
申请号：US10760493
申请日：2004-01-21
IPC分类号： A61K31/70 , A61P31/00 , C07C215/24 , C07C225/14 , C07C235/28 , C07C237/16 , C07C279/22 , C07C305/14 , C07H5/06 , C07H15/10 , C07H15/18 , C07H15/203 , C07H15/26 , C12P7/42 , C12P11/00 , C12P13/00 , C12P13/02 , C12P19/44 , C12R1/465
CPC分类号： C07H15/203 , C07C215/24 , C07C225/14 , C07C235/28 , C07C237/16 , C07C279/22 , C07C305/14 , C07C2601/10 , C07C2601/14 , C07H15/10 , C07H15/18 , C07H15/26 , C12P7/42 , C12P11/00 , C12P13/001 , C12P13/02 , C12P19/44 , C12R1/465 , Y10S435/886
摘要： This invention relates to a new class of polyene polyketides, their pharmaceutically acceptable salts and derivatives, and to methods for obtaining the compounds. One method of obtaining these compounds is by cultivation of novel strains of Streptomyces aizunensis; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to the novel strains of Streptomyces aizunensis used to produce these compounds, to the use of these compounds and their pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of fungal cell growth and cancer cell growth. The invention also relates to pharmaceutical compositions comprising these novel polyketides or a pharmaceutically acceptable salts or derivatives thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of these novel polyketides.
摘要翻译： 本发明涉及新类型的多烯聚酮化合物，其药学上可接受的盐和衍生物，以及获得化合物的方法。 获得这些化合物的一种方法是通过培养新的链霉菌链霉菌菌株; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及用于制备这些化合物的新型链霉菌Streptomyces aizunensis菌株，使用这些化合物及其药学上可接受的盐和衍生物作为药物，特别是其作为真菌细胞生长抑制剂和癌细胞生长的用途。 本发明还涉及包含这些新型聚酮化合物或其药学上可接受的盐或衍生物的药物组合物。 最后，本发明涉及参与这些新型聚酮化合物的生物合成的新型多核苷酸序列及其编码的蛋白质。
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公开(公告)号：US20050176653A1
公开(公告)日：2005-08-11
申请号：US10937379
申请日：2004-09-10
IPC分类号： A61K31/513 , A61K31/70 , A61K31/704 , A61P31/04 , C07C279/14 , C07D309/10 , C07H5/04 , C07H5/06 , C12N15/31 , C12N15/52 , C12P7/42 , C12P7/64 , C12P13/00 , C12P17/06 , C12P17/16 , C12P19/44
CPC分类号： C07C279/14 , C07C2601/10 , C07D309/10 , C07H5/04 , C07H5/06 , C12N15/52 , C12P7/42 , C12P13/001 , C12P13/02 , C12P17/06 , C12P17/16 , C12P19/44 , C12R1/01 , Y10S435/821
摘要： Novel polyene polyketides, their pharmaceutically acceptable salts, prodrugs and derivatives have been found to have antibiotic activity. One method for obtaining the compounds is by cultivation of Amycolatopsis orientalis ATCC™ 43491 or a mutant or variant such as the strain IDAC-220604-1. Another method for obtaining the compounds is post-biosynthesis chemical modification of the compounds obtained by cultivation. Novel polynucleotide sequences and encoded proteins for the biosynthesis of the polyene polyketides are also presented.
摘要翻译： 已经发现新型多烯聚酮化合物，其药学上可接受的盐，前药和衍生物具有抗生素活性。 获得化合物的一种方法是通过种植侧寄生菌ATCC 43491或突变体或变体例如菌株IDAC-220604-1。 获得化合物的另一种方法是通过培养获得的化合物的后生物合成化学修饰。 还提出了用于多烯聚酮化合物的生物合成的新型多核苷酸序列和编码的蛋白质。
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公开(公告)号：US07101872B2
公开(公告)日：2006-09-05
申请号：US10762107
申请日：2004-01-21
IPC分类号： C07D243/10 , A61K31/55
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译： 本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。 获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及小单孢菌属 应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或 其药学上可接受的盐或衍生物。 最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。
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公开(公告)号：US20080199940A1
公开(公告)日：2008-08-21
申请号：US11511586
申请日：2006-08-28
CPC分类号： C12N9/93 , A61K38/00 , C07D243/38 , C07D405/06 , C07D405/14 , C12N9/0004 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/88 , C12N9/90 , C12N15/52 , C12P17/10 , C12R1/29 , Y02A50/473
摘要： This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain of Micromonospora sp., 046-ECO11; another method involves expression of biosynthetic pathway genes in transformed host cells. The present invention further relates to Micromonospora sp. strain 046-ECO11, to the use of ECO-04601 and its pharmaceutically acceptable salts and derivatives as pharmaceuticals, in particular to their use as inhibitors of cancer cell growth, bacterial cell growth, mammalian lipoxygenase, and to pharmaceutical compositions comprising ECO-04601 or a pharmaceutically acceptable salt or derivative thereof. Finally, the invention relates to novel polynucleotide sequences and their encoded proteins, which are involved in the biosynthesis of ECO-04601.
摘要翻译： 本发明涉及名为ECO-04601的新型法呢基化二苯并二氮杂酮，其药学上可接受的盐和衍生物，以及获得这些化合物的方法。 获得ECO-04601化合物的一种方法是通过培养一种新型的小单孢菌属菌株046-ECO11; 另一种方法涉及在转化的宿主细胞中表达生物合成途径基因。 本发明还涉及小单孢菌属 应用046-ECO11，使用ECO-04601及其药学上可接受的盐和衍生物作为药物，特别是其作为癌细胞生长抑制剂，细菌细胞生长，哺乳动物脂氧合酶的用途，以及包含ECO-04601或 其药学上可接受的盐或衍生物。 最后，本发明涉及参与ECO-04601的生物合成的新型多核苷酸序列及其编码的蛋白质。
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10.发明授权Cyclic hexadepsipeptides, processes for their production and their use as pharmaceuticals 失效环十六肽，其制备方法及其作为药物的用途公开(公告)号：US08076287B2
公开(公告)日：2011-12-13
申请号：US12294213
申请日：2007-03-28
IPC分类号： A61K38/12
CPC分类号： C07K7/06 , A61K38/00 , C12P17/188 , C12P21/02 , C12R1/465
摘要： The present invention provides cyclic hexadepsipeptides and their pharmaceutically acceptable salts, solvates and prodrugs, and methods for obtaining the compounds, by fermentation, optionally followed by post-biosynthesis chemical modification. The present invention further provides uses of cyclic hexadepsipeptides, and their pharmaceutically acceptable salts, solvates and prodrugs as pharmaceuticals, in particular to their use as antibacterial, antifungal or antineoplastic agents, and to pharmaceutical compositions comprising a cyclic hexadepsipeptide, or a pharmaceutically acceptable salt, solvate or prodrug thereof, together with a carrier.
摘要翻译： 本发明提供环状十六肽及其药学上可接受的盐，溶剂合物和前药，以及通过发酵，任选地随后进行生物合成化学修饰来获得化合物的方法。 本发明进一步提供了环状十六肽及其药学上可接受的盐，溶剂合物和前药作为药物，特别是其作为抗细菌剂，抗真菌剂或抗肿瘤剂的用途的用途，以及包含环十六肽或其药学上可接受的盐， 溶剂化物或前药，以及载体。
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