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公开(公告)号：US20050176019A1
公开(公告)日：2005-08-11
申请号：US10775409
申请日：2004-02-10
申请人： Bruce Beutel , Claude Lerner , Stephan Kakavas
发明人： Bruce Beutel , Claude Lerner , Stephan Kakavas
CPC分类号： C12N15/1079 , C12Q1/683 , Y02A50/57 , C12Q2521/301
摘要： This invention provides a method for identifying the precise locations of mutations in whole genomes using restriction enzymes and transformation frequency data.
摘要翻译： 本发明提供了一种使用限制酶和转化频率数据鉴定全基因组中突变的精确位置的方法。
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公开(公告)号：US20050159423A1
公开(公告)日：2005-07-21
申请号：US10762002
申请日：2004-01-21
申请人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
发明人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
IPC分类号： C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04 , C07D513/04 , A61K31/506 , A61K31/4439 , A61K31/497 , A61K31/501 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译： 公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。
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公开(公告)号：US5707796A
公开(公告)日：1998-01-13
申请号：US198670
申请日：1994-02-22
申请人： Larry Gold , Bruce Beutel
发明人： Larry Gold , Bruce Beutel
IPC分类号： C07B61/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/00 , C12N15/10 , C12N15/115 , C12Q1/37 , C12Q1/68 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/569 , G01N33/68 , G01N33/76 , C07H21/04 , C07H21/02 , C12P19/34
CPC分类号： C12N15/115 , A61K47/48076 , A61K47/48092 , B82Y5/00 , C07H19/06 , C07H19/10 , C07H21/00 , C07K14/001 , C12N15/1048 , C12Q1/37 , C12Q1/6811 , G01N33/531 , G01N33/532 , G01N33/535 , G01N33/56988 , G01N33/68 , G01N33/76 , C40B40/00 , G01N2333/163 , G01N2333/575 , G01N2333/62 , G01N2333/8125 , G01N2333/96433 , G01N2333/96436 , G01N2333/96455 , G01N2333/96486 , G01N2333/966 , G01N2333/9726 , G01N2333/974 , G01N2333/976 , Y10S435/962 , Y10S435/973
摘要： A method of selecting nucleic acids on the basis of physical structure is disclosed. A modification of the Systematic Evolution of Ligands by Exponential enrichment (SELEX) is used in conjunction with methods for differentiating between nucleic acid molecules on the basis of physical structure, such as chromatography, gel electrophoresis, solubility, and solvent partitioning. The disclosed method may be used in selecting single stranded DNA or RNA, or double stranded DNA or RNA. An example of the method selected nucleic acids of bent DNA. This method represents a new and powerful approach to select nucleic acid molecules with the physical structure required for specific biological activity, for example, in the regulation of gene expression.
摘要翻译： 公开了基于物理结构选择核酸的方法。 通过指数富集（SELEX）对配体的系统演化的修改与基于物理结构如色谱，凝胶电泳，溶解度和溶剂分配的核酸分子区分的方法结合使用。 所公开的方法可用于选择单链DNA或RNA或双链DNA或RNA。 所选方法的一个例子是选择的DNA的核酸。 该方法代表了选择具有特定生物活性所需的物理结构的核酸分子的新的和有效的方法，例如调节基因表达。
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公开(公告)号：US20070142353A1
公开(公告)日：2007-06-21
申请号：US11675160
申请日：2007-02-15
申请人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
发明人： David Anderson , Bruce Beutel , Curt Cooper , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Robert Keyes , Xenia Searle , Rolf Wagner
IPC分类号： A61K31/519 , A61K31/506 , A61K31/501 , A61K31/497 , A61K31/4743 , C07D498/02 , C07D487/02
CPC分类号： C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要： Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译： 公开了具有式（I）的具有式（I）的细菌蛋白质合成抑制化合物及其前体药物的前体药物，其制备方法，含该化合物的组合物，使用该化合物的方法。
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5.发明申请Novel acetyl-CoA carboxylase (ACC) inhibitors and their use in diabetes, obesity and metabolic syndrome 审中-公开新型乙酰辅酶A羧化酶（ACC）抑制剂及其在糖尿病，肥胖症和代谢综合征中的应用公开(公告)号：US20060178400A1
公开(公告)日：2006-08-10
申请号：US11268698
申请日：2005-11-07
申请人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
发明人： Bruce Beutel , Heidi Camp , Richard Clark , Yu-Gui Gu , Todd Hansen , Robert Keyes , Qun Li , Gang Liu , Hing Sham , Xiaojun Wang , Moshe Weitzberg , Zhili Xin , Xiangdong Xu , Tianyuan Zhang
IPC分类号： C07D211/68 , A61K31/445
CPC分类号： C07D211/68
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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公开(公告)号：US08163769B2
公开(公告)日：2012-04-24
申请号：US10387318
申请日：2003-03-12
申请人： David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
发明人： David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D471/04
摘要： Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.
摘要翻译： 公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。
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7.发明申请NOVEL ACETYL-COA CARBOXYLASE (ACC) INHIBITORS AND THEIR USE IN DIABETES, OBESITY AND METABOLIC SYNDROME 失效新型乙酰胆碱酯酶（ACC）抑制剂及其在糖尿病，肥胖和代谢综合征中的应用公开(公告)号：US20070225332A1
公开(公告)日：2007-09-27
申请号：US11675410
申请日：2007-02-15
申请人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
发明人： Yu Gui Gu , Moshe Weitzberg , Xiangdong Xu , Richard Clark , Tianyuan Zhang , Qun Li , Todd Hansen , Hing Sham , Bruce Beutel , Heidi Camp , Xiaojun Wang
IPC分类号： A61K31/444 , A61K31/4439 , A61K31/433 , A61K31/427 , A61K31/42 , C07D417/14 , C07D413/02
CPC分类号： C07D277/34 , C07D261/08 , C07D277/56 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), which inhibit acetyl-CoA carboxylase (ACC) and are useful for the prevention or treatment of metabolic syndrome, type II diabetes, obesity, atherosclerosis and cardiovascular diseases in humans.
摘要翻译： 本发明涉及抑制乙酰辅酶A羧化酶（ACC）并可用于预防或治疗人类代谢综合征，II型糖尿病，肥胖症，动脉粥样硬化和心血管疾病的式（I）化合物。
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公开(公告)号：US06818654B2
公开(公告)日：2004-11-16
申请号：US10386816
申请日：2003-03-12
申请人： David Anderson , Bruce Beutel , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Linda Lynch , Zhenkun Ma , Christopher Motter , Teresa Rosenberg , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong
发明人： David Anderson , Bruce Beutel , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Mira Hinman , Douglas Kalvin , Linda Lynch , Zhenkun Ma , Christopher Motter , Teresa Rosenberg , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong
IPC分类号： C07D21500
CPC分类号： C07D471/04
摘要： Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.
摘要翻译： 公开了具有式（I）的抗菌剂及其前体药物的盐，前药和盐，用于制备本方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及使用该化合物预防和治疗细菌感染的方法。
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