公开(公告)号：US20070092407A1

公开(公告)日：2007-04-26

申请号：US11259643

申请日：2005-10-26

申请人： Caibin Xiao ,  Radislav Potyrailo ,  William Morris ,  Scott Boyette ,  LiJie Yu ,  Theodore Cecconie ,  Andrew Leach ,  Prashant Shrikhande

发明人： Caibin Xiao ,  Radislav Potyrailo ,  William Morris ,  Scott Boyette ,  LiJie Yu ,  Theodore Cecconie ,  Andrew Leach ,  Prashant Shrikhande

IPC分类号： G01N21/29 ,  G01N21/41

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20070092975A1

公开(公告)日：2007-04-26

申请号：US11507689

申请日：2006-08-22

申请人： Radislav Potyrailo ,  Prashant Shrikhande ,  Scott Boyette ,  Caibin Xiao ,  Andrew Leach

发明人： Radislav Potyrailo ,  Prashant Shrikhande ,  Scott Boyette ,  Caibin Xiao ,  Andrew Leach

IPC分类号： G01N21/77

CPC分类号： G01N21/78 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2300/0806 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0427 ,  B01L2400/0448 ,  G01N21/80 ,  G01N35/00069 ,  G01N2021/7766 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2021/7786 ,  G01N2021/7793 ,  Y10T436/144444 ,  Y10T436/25 ,  Y10T436/2575

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以使用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20070146715A1

公开(公告)日：2007-06-28

申请号：US11668061

申请日：2007-01-29

申请人： Radislav Potyrailo ,  Scott Boyette ,  Caibin Xiao ,  William Morris ,  Andrew Leach ,  Ronald Wroczynski

发明人： Radislav Potyrailo ,  Scott Boyette ,  Caibin Xiao ,  William Morris ,  Andrew Leach ,  Ronald Wroczynski

IPC分类号： G01N21/00

CPC分类号： G01N21/5907 ,  G01N35/00069

摘要： system and method employing a substrate for supporting a highly reproducible sensor array for producing a prerecorded standard response for quantitative analysis of physical, chemical and biochemical parameters are provided. The system includes a substrate for supporting a highly reproducible sensor array, a light source for directing light onto the sensor spot, at least one optical pickup for detecting light transmitted through or reflected from a sensor spot, the transmitted or reflected light being indicative of a concentration of a compound, and an analog-to-digital converter for quantifying an intensity of the detected light.

摘要翻译： 提供了使用用于支持高度可重现的传感器阵列的基板的系统和方法，用于产生用于物理，化学和生物化学参数的定量分析的预先记录的标准响应。 该系统包括用于支持高度可重现的传感器阵列的基板，用于将光引导到传感器光点上的光源，用于检测透射通过传感器点或从传感器点反射的光的至少一个光学拾取器，所发射或反射的光指示 化合物的浓度，以及用于量化检测到的光的强度的模拟 - 数字转换器。

公开(公告)号：US20070092411A1

公开(公告)日：2007-04-26

申请号：US11440278

申请日：2006-05-25

申请人： Andrew Leach ,  Thomas Dunton ,  Christopher Goewey ,  Radislav Potyrailo ,  Caibin Xiao ,  Prashant Shrikhande

发明人： Andrew Leach ,  Thomas Dunton ,  Christopher Goewey ,  Radislav Potyrailo ,  Caibin Xiao ,  Prashant Shrikhande

IPC分类号： B01L11/00

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： A microfluidic channel is provided. The microfluidic channel includes a first substrate having at least one microfluidic channel pattern. Further, the microfluidic channel includes a porous material disposed on the first substrate and occupying the at least one microfluidic channel pattern.

摘要翻译： 提供微流体通道。 微流体通道包括具有至少一个微流体通道图案的第一基底。 此外，微流体通道包括设置在第一基板上并占据至少一个微流体通道图案的多孔材料。

公开(公告)号：US20070092973A1

公开(公告)日：2007-04-26

申请号：US11259506

申请日：2005-10-26

申请人： Radislav Potyrailo ,  Timothy Sivavec ,  Caibin Xiao ,  Theodore Cecconie ,  Lamyaa Hassib ,  Andrew Leach ,  David Engel

发明人： Radislav Potyrailo ,  Timothy Sivavec ,  Caibin Xiao ,  Theodore Cecconie ,  Lamyaa Hassib ,  Andrew Leach ,  David Engel

IPC分类号： G01N21/00

CPC分类号： G01N31/22 ,  G01N21/78 ,  Y10S436/80 ,  Y10S436/805

摘要： A method of quantitatively measuring the concentration of a chemical species in a sample solution with a sensor film. A hydrogel sensor film is prepared having a chemical composition comprising an indicator that changes its optical property in the ultra-violet, visible or near-infrared spectral range upon being exposed to the chemical species in the sample solution. The film is exposed to a fixed amount of the sample solution. The concentration of the chemical species in the sample solution is quantified using the average absorbance measured from the sensor film.

摘要翻译： 用传感器膜定量测定样品溶液中化学物质浓度的方法。 制备水凝胶传感器膜，其具有化学组成，该化学组成包括在暴露于样品溶液中的化学物质时在紫外线，可见光或近红外光谱范围内改变其光学性质的指示剂。 将该膜暴露于固定量的样品溶液。 使用从传感器膜测量的平均吸光度来量化样品溶液中化学物质的浓度。

公开(公告)号：US20050157304A1

公开(公告)日：2005-07-21

申请号：US10760438

申请日：2004-01-20

申请人： Caibin Xiao ,  Scott Boyette ,  Radislav Potyrailo

发明人： Caibin Xiao ,  Scott Boyette ,  Radislav Potyrailo

IPC分类号： G01N21/25 ,  G01N21/27 ,  G01N21/31 ,  G01N21/55 ,  G01N21/77 ,  G01N21/86 ,  G01N33/543 ,  G01N21/47

CPC分类号： G01N21/7703 ,  G01N21/253 ,  G01N21/272 ,  G01N21/274 ,  G01N21/314 ,  G01N21/552 ,  G01N21/8483 ,  G01N2021/7783 ,  G01N2021/8488 ,  G01N2201/0221 ,  G01N2201/0245 ,  G01N2201/0461 ,  G01N2201/122

摘要： A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.

摘要翻译： 用于测量需要对这些物质进行现场分析的多种化学或生物物质的浓度的便携式系统和方法。 新的和原始的手持传感器系统使用一次性光学测试元件和光谱检测器，其通过光吸收，发光和其他形式的基于光的响应的变化来测量测试元件对特定分析物的响应。 以这种方式，可以使用指示测试元件响应的反射光强度来测量目标分析物的浓度。 传感器系统还能够连接到信息处理单元或计算机，从而可以电子地操纵或存储分析数据。

公开(公告)号：US08105552B2

公开(公告)日：2012-01-31

申请号：US12730550

申请日：2010-03-24

申请人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

发明人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

IPC分类号： B01L3/00 ,  G01P3/00 ,  G01N31/00

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样本量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20100178208A1

公开(公告)日：2010-07-15

申请号：US12730550

申请日：2010-03-24

申请人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

发明人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

IPC分类号： G01N21/25 ,  G01N21/75 ,  B81B7/00

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样本量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US07723120B2

公开(公告)日：2010-05-25

申请号：US11259643

申请日：2005-10-26

申请人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

发明人： Caibin Xiao ,  Radislav A. Potyrailo ,  William G. Morris ,  Scott M. Boyette ,  LiJie Yu ,  Theodore J. Cecconie ,  Andrew M. Leach ,  Prashant V. Shrikhande

IPC分类号： G01N21/00 ,  G06K9/38 ,  C12Q1/68 ,  G01N33/543 ,  F16L7/00

CPC分类号： G01N21/78 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0621 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/088 ,  G01N21/253 ,  G01N21/80 ,  G01N31/22 ,  Y10T137/7036

摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.

摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。

公开(公告)号：US20090057210A1

公开(公告)日：2009-03-05

申请号：US12193198

申请日：2008-08-18

申请人： Kenneth Charles Barrett ,  Scott Boyette ,  Caibin Xiao ,  Zhaoyang Wan

发明人： Kenneth Charles Barrett ,  Scott Boyette ,  Caibin Xiao ,  Zhaoyang Wan

IPC分类号： B01D61/58 ,  B01D35/22 ,  B01D35/157 ,  C02F1/00 ,  B01D35/30 ,  B01D36/00

CPC分类号： B01D61/18 ,  B01D65/08 ,  B01D2315/08 ,  B01D2315/10 ,  B01D2321/2083 ,  C02F1/44 ,  C02F2303/16

摘要： A filtration system is disclosed that uses a combination of dead end filtration across opposing membranes with a sample take-off in the middle and cross-flow to prevent cake formation on these opposing filters. In one embodiment is a system that uses opposing filters with a central collection chamber that flips flow back and forth between the sides at a frequency that minimizes filter cake formation. In another embodiment, a combination flip-flip, cross flow system is disclosed. An additional embodiment discloses an actuator valve driven sampling system, in which valves collect the cross flow/counter flow filter cake samples as they are liberated from a filter surface and a quick through filter fluid pulse loosens the sample cake from the filter material. The invention increases effective operation time, allows for continuous filtration operation without interruption, and provides filtered samples that accurately represent the concentration of macromolecular species in industrial systems.

摘要翻译： 公开了一种过滤系统，其使用在相对的膜上的死端过滤的组合以及在中间的样品取出和交叉流动以防止在这些相对的过滤器上形成饼状物。 在一个实施例中是一种系统，其使用具有中心收集室的相对的过滤器，所述中央收集室翻转以使滤饼形成最小化的频率在侧面之间来回流动。 在另一个实施例中，公开了一种组合式翻盖式横流系统。 另外的实施例公开了一种致动器阀驱动的采样系统，其中阀门从过滤器表面释放时收集交叉流/逆流滤饼样品，并且快速通过的过滤器流体脉冲使样品滤饼从过滤材料松开。 本发明增加了有效的操作时间，允许不间断的连续过滤操作，并提供了准确表示工业系统中大分子物质浓度的过滤样品。