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1.发明授权Optical sensor array system for parallel processing of chemical and biochemical information 有权用于并行处理化学和生物化学信息的光学传感器阵列系统公开(公告)号：US08105552B2
公开(公告)日：2012-01-31
申请号：US12730550
申请日：2010-03-24
申请人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
发明人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样本量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。
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2.发明申请OPTICAL SENSOR ARRAY SYSTEM FOR PARALLEL PROCESSING OF CHEMICAL AND BIOCHEMICAL INFORMATION 有权用于平行处理化学和生物化学信息的光学传感器阵列系统公开(公告)号：US20100178208A1
公开(公告)日：2010-07-15
申请号：US12730550
申请日：2010-03-24
申请人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
发明人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样本量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。
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3.发明授权Optical sensor array system and method for parallel processing of chemical and biochemical information 有权光学传感器阵列系统和化学和生化信息并行处理方法公开(公告)号：US07723120B2
公开(公告)日：2010-05-25
申请号：US11259643
申请日：2005-10-26
申请人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
发明人： Caibin Xiao , Radislav A. Potyrailo , William G. Morris , Scott M. Boyette , LiJie Yu , Theodore J. Cecconie , Andrew M. Leach , Prashant V. Shrikhande
IPC分类号： G01N21/00 , G06K9/38 , C12Q1/68 , G01N33/543 , F16L7/00
CPC分类号： G01N21/78 , B01L3/50273 , B01L3/502746 , B01L2200/0621 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/088 , G01N21/253 , G01N21/80 , G01N31/22 , Y10T137/7036
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。
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公开(公告)号：US08420025B2
公开(公告)日：2013-04-16
申请号：US13359023
申请日：2012-01-26
申请人： Radislav A. Potyrailo , Prashant V. Shrikhande , Scott M. Boyette , Caibin Xiao , Andrew M. Leach
发明人： Radislav A. Potyrailo , Prashant V. Shrikhande , Scott M. Boyette , Caibin Xiao , Andrew M. Leach
CPC分类号： G01N21/78 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0642 , B01L2300/0806 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0406 , B01L2400/0427 , B01L2400/0448 , G01N21/80 , G01N35/00069 , G01N2021/7766 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , G01N2021/7793 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。
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公开(公告)号：US20120121466A1
公开(公告)日：2012-05-17
申请号：US13359023
申请日：2012-01-26
申请人： Radislav A. Potyrailo , Prashant V. Shrikhande , Scott M. Boyette , Caibin Xiao , Andrew M. Leach
发明人： Radislav A. Potyrailo , Prashant V. Shrikhande , Scott M. Boyette , Caibin Xiao , Andrew M. Leach
IPC分类号： G01N21/78
CPC分类号： G01N21/78 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0642 , B01L2300/0806 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0406 , B01L2400/0427 , B01L2400/0448 , G01N21/80 , G01N35/00069 , G01N2021/7766 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , G01N2021/7793 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。
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公开(公告)号：US08133741B2
公开(公告)日：2012-03-13
申请号：US11507689
申请日：2006-08-22
申请人： Radislav A. Potyrailo , Prashant V. Shrikhande , Scott M. Boyette , Caibin Xiao , Andrew M. Leach
发明人： Radislav A. Potyrailo , Prashant V. Shrikhande , Scott M. Boyette , Caibin Xiao , Andrew M. Leach
IPC分类号： G01N21/00
CPC分类号： G01N21/78 , B01L3/502715 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0642 , B01L2300/0806 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0406 , B01L2400/0427 , B01L2400/0448 , G01N21/80 , G01N35/00069 , G01N2021/7766 , G01N2021/7773 , G01N2021/7783 , G01N2021/7786 , G01N2021/7793 , Y10T436/144444 , Y10T436/25 , Y10T436/2575
摘要： Total analysis systems and methods for simultaneously monitoring a suite of biological and/or chemical species in water and/or other process systems are disclosed. The system provides a sample-volume controlled sensor array comprising a fluid delivery device and a plurality of optical sensor elements for determining the presence and total concentrations of multiple analytes in the process system simultaneously. Delivery means are provided to deliver a metered quantity of sample fluid to the sensor array. Image identification algorithms are provided for identifying the analytes based on image intensity, color pattern, positional arrangement, and the like. The methods incorporate multivariate optimization algorithms to analyze multiple sensor responses. This produces analytical results that are typically difficult to obtain without full system or variable compensation. The improved array response may then be utilized to measure, monitor, and control the concentration of analytes in the chemical or biological sample or water system.
摘要翻译： 公开了用于在水和/或其它工艺系统中同时监测一套生物和/或化学物质的总分析系统和方法。 该系统提供了一个样品量控制的传感器阵列，其包括流体输送装置和多个光学传感器元件，用于同时确定过程系统中多个分析物的存在和总浓度。 提供输送装置以将计量的样品流体传送到传感器阵列。 提供图像识别算法，用于基于图像强度，颜色图案，位置排列等来识别分析物。 该方法结合了多变量优化算法来分析多个传感器响应。 这产生的分析结果通常难以在没有完整系统或可变补偿的情况下获得。 然后可以利用改进的阵列响应来测量，监测和控制化学或生物样品或水系统中分析物的浓度。
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7.发明授权Handheld device with a disposable element for chemical analysis of multiple analytes 有权具有一次性元件的手持式设备，用于多种分析物的化学分析公开(公告)号：US07283245B2
公开(公告)日：2007-10-16
申请号：US10760438
申请日：2004-01-20
CPC分类号： G01N21/7703 , G01N21/253 , G01N21/272 , G01N21/274 , G01N21/314 , G01N21/552 , G01N21/8483 , G01N2021/7783 , G01N2021/8488 , G01N2201/0221 , G01N2201/0245 , G01N2201/0461 , G01N2201/122
摘要： A portable system and method for measuring the concentration of multiple chemical or biological substances where an onsite analysis of such substances is needed. The new and original handheld sensor system uses a disposable optical test element and a spectroscopic detector that measures the test element response to specific analytes through a change in light absorbance, luminescence, and other forms of light-based response. In this way, reflection light intensities indicative of the test element response can be used to measure the concentration of the target analytes. The sensor system is also capable of being interfaced to an information processing unit or computer so that analytical data can be manipulated or stored electronically.
摘要翻译： 用于测量需要对这些物质进行现场分析的多种化学或生物物质的浓度的便携式系统和方法。 新的和原始的手持传感器系统使用一次性光学测试元件和光谱检测器，其通过光吸收，发光和其他形式的基于光的响应的变化来测量测试元件对特定分析物的响应。 以这种方式，可以使用指示测试元件响应的反射光强度来测量目标分析物的浓度。 传感器系统还能够连接到信息处理单元或计算机，从而可以电子地操纵或存储分析数据。
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公开(公告)号：US07077563B2
公开(公告)日：2006-07-18
申请号：US10717154
申请日：2003-11-19
申请人： Caibin Xiao , David A. Little , Scott M. Boyette
发明人： Caibin Xiao , David A. Little , Scott M. Boyette
CPC分类号： G01N17/008 , G01N25/18
摘要： An apparatus and method for the monitoring and measurement of chemical and/or biological deposition in heat exchangers and other fluid processing vessels. The new and original sensing system includes at least two hollow fluid vessels conductively mounted across a constant heat transfer path. Thin film heat flux sensors are attached to a heat transfer surface of the vessels in order to measure changes in differential heat flux that occur when deposition begins to accumulate in the vessel. In this way, it is shown that differential heat flux measurements can be used to detect and measure the early onset of chemical and/or biological deposition.
摘要翻译： 用于监测和测量热交换器和其它流体处理容器中的化学和/或生物沉积的装置和方法。 新的和原始的感测系统包括至少两个导电地安装在恒定传热路径上的中空流体容器。 薄膜热通量传感器连接到容器的传热表面，以便测量当沉积开始在容器中积聚时发生的差热通量的变化。 以这种方式，可以看出差示热通量测量可用于检测和测量化学和/或生物沉积的早期发生。
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公开(公告)号：US20100112682A1
公开(公告)日：2010-05-06
申请号：US12472024
申请日：2009-05-26
申请人： Scott M. Boyette , Hong Cai , Yan Jin , Jie Li , Kechao Yang , Rong Xu , Yu Wang
发明人： Scott M. Boyette , Hong Cai , Yan Jin , Jie Li , Kechao Yang , Rong Xu , Yu Wang
IPC分类号： C12M1/00
CPC分类号： C12Q1/04 , G01N21/274 , G01N21/6486 , G01N2021/6439
摘要： A system for measuring total microbiological content in an aqueous medium by adding a fluorescent dye to the aqueous medium, measuring the fluorescent signal in the aqueous medium to obtain a baseline fluorescent signal, releasing intracellular content of the microbiological matter into the aqueous medium by lysing the microbiological matter. The system then measures the fluorescent signal in the aqueous medium with the released intracellular content of the microbiological matter to obtain a second fluorescent signal. Next, the system subtracts the baseline signal from the second fluorescent signal to obtain a net fluorescent signal and equates the net fluorescent signal with a microbiological content.
摘要翻译： 一种用于通过向水介质中加入荧光染料来测量水性介质中的总微生物含量的系统，测量水性介质中的荧光信号以获得基线荧光信号，通过裂解所述微生物物质将微生物物质释放到水介质中 微生物。 然后，系统在微生物物质释放的细胞内含量的水介质中测量荧光信号以获得第二荧光信号。 接下来，系统从第二荧光信号中减去基线信号以获得净荧光信号，并将净荧光信号与微生物含量相等。
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10.发明授权Apparatus and method for automatically achieving and maintaining congruent control in an industrial boiler 失效在工业锅炉中自动实现和保持一致控制的装置和方法
公开(公告)号：US5696696A
公开(公告)日：1997-12-09
申请号：US321338
申请日：1994-10-11
申请人： John C. Gunther , Scott M. Boyette , Eric A. Thungstrom , Norman B. Worrell , Paul R. Burgmayer
发明人： John C. Gunther , Scott M. Boyette , Eric A. Thungstrom , Norman B. Worrell , Paul R. Burgmayer
CPC分类号： C02F5/025 , G01N33/18 , G05D21/02 , Y10S706/907
摘要： A control system for automatically achieving and maintaining a desired sodium/phosphate ratio and phosphate concentration of the boiler water in an industrial boiler for minimizing corrosion. The system uses an adaptive controller that models the boiler which enables the system to predict boiler pH and phosphate concentrations at any future time given the feed rates, feed concentrations of high and low sodium/phosphate stocks, blowdown rate, mass of the boiler water, initial boiler phosphate concentration and initial pH. Once these future concentrations are determined, the controller then determines which feed rates will return the current boiler water state to, and then maintain the boiler water at, the desired sodium/phosphate congruency ratio in the least amount of time. Where the controller determines that it is not possible to move the current boiler water state to the desired congruency setpoint, the controller determines a feed rate program that will move the current boiler water state to the attainable steady state point closest to the desired setpoint. An alternative embodiment fixes the phosphate concentration by ratioing the phosphate feed with the blowdown rate while continuously monitoring blowdown pH. This arrangement allows for the control of sodium by switching between the high and low ratio sodium/phosphate stocks based on the measured pH with respect to the pH setpoint.
摘要翻译： 一种用于在工业锅炉中自动实现和维持所需的钠/磷酸盐比例和锅炉水的磷酸盐浓度的控制系统，以最小化腐蚀。 该系统使用自适应控制器来对锅炉进行建模，使得系统能够在进料速率，高低钠/磷酸盐原料的进料浓度，排污速率，锅炉水的质量，任何未来时间预测锅炉pH和磷酸盐浓度， 初始锅炉磷酸盐浓度和初始pH。 一旦确定了这些未来的浓度，控制器将确定哪个进料速率将使当前的锅炉水状态恢复到最小时间内，然后将锅炉水保持在所需的钠/磷酸盐一致性比例。 在控制器确定不可能将当前锅炉水状态移动到期望的一致设定点的情况下，控制器确定将当前锅炉水状态移动到最接近所需设定点的可达到的稳态点的进给速率程序。 一个替代实施方案通过将磷酸盐进料与排污速率进行比例来固定磷酸盐浓度，同时连续监测排污pH。 这种布置允许通过基于测量的pH相对于pH设定点在高和低比例的钠/磷酸盐原料之间切换来控制钠。
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