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公开(公告)号：US20090099096A1
公开(公告)日：2009-04-16
申请号：US11880067
申请日：2007-07-19
申请人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu
发明人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu
CPC分类号： C07D493/04 , C07D405/12 , C07D519/00
摘要： The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20090306112A1
公开(公告)日：2009-12-10
申请号：US12307674
申请日：2007-07-19
申请人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号： A61K31/505 , C07D405/02 , A61K31/443 , C12N5/00 , C12N7/04 , C07D405/14 , C07D215/38 , A61K31/47 , C07D417/02 , A61K31/4439 , C07D213/02 , A61K31/44 , C07D239/02 , C07D249/08 , A61K31/4196 , C07D257/04 , A61K31/41 , C07D277/22 , A61K31/426
CPC分类号： C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to compounds of Formula I or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，溶剂化物，酯和/或膦酸酯，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US20090105279A1
公开(公告)日：2009-04-23
申请号：US11880069
申请日：2007-07-19
申请人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号： C07D401/00 , C07D211/00 , A61K31/4427 , C07D405/00 , C07D215/38 , C07D249/08 , A61K31/4196 , C07D277/30 , C07D493/04 , C07F9/547 , C12N7/06 , A61K31/34 , C07D257/04 , A61K31/41 , C07D239/02 , A61K31/4709 , C07D417/00 , C07D409/00
CPC分类号： C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US07741345B2
公开(公告)日：2010-06-22
申请号：US11880067
申请日：2007-07-19
申请人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu
发明人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu
IPC分类号： A61K31/4427 , A61K31/443 , C07D405/02
CPC分类号： C07D493/04 , C07D405/12 , C07D519/00
摘要： The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US07723380B2
公开(公告)日：2010-05-25
申请号：US11880069
申请日：2007-07-19
申请人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
发明人： Carina E. Cannizzaro , James M. Chen , Manoj C. Desai , Michael L. Mitchell , Sundaramoorthi Swaminathan , Lianhong Xu , Zheng-Yu Yang
IPC分类号： A61K31/343 , A61K31/443 , A61K31/427 , A61K31/41 , A61K31/4196 , C07D493/02 , C07D277/30 , C07D249/08 , C07D215/38 , C07D257/04 , C07D239/02
CPC分类号： C07D405/12 , C07D213/56 , C07D401/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D417/12 , C07D493/04 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to compounds of Formula I: or a pharmaceutically acceptable salt, solvate, ester, and/or phosphonate thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐，溶剂合物，酯和/或膦酸盐，含有这些化合物的组合物，以及包括施用这些化合物的治疗方法。
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公开(公告)号：US07645747B2
公开(公告)日：2010-01-12
申请号：US11258621
申请日：2005-10-25
申请人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
发明人： Constantine G. Boojamra , Carina E. Cannizzaro , James M. Chen , Xiaowu Chen , Aesop Cho , Lee S. Chong , Manoj Desai , Maria Fardis , Craig S. Gibbs , Ralph F. Hirschmann , Alan X. Huang , Haolun Jin , Choung U. Kim , Thorsten A. Kirschberg , Steven Krawczyk , Christopher P. Lee , William A. Lee , Kuei-Ying Lin , Richard L. Mackman , David Y. Markevitch , Peter H. Nelson , David A. Oare , Vidya K. Prasad , Hyung-Jung Pyun , Adrian S. Ray , Rosemarie Sherlock , Sundaramoorthi Swaminathan , William J. Watkins , Jennifer R. Zhang , Lijun Zhang
IPC分类号： A61K31/661 , A61K31/662 , C07F9/06 , C07F9/28
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/4465 , C07F9/5304 , C07F9/650952 , C07F9/653 , C07F9/65507 , C07F9/65515 , C07F9/65517 , C07F9/65583 , C07F9/65586 , C07F9/6561
摘要： The invention is related to phosphorus substituted therapeutic agents, compositions containing such phosphorus substituted agents, and therapeutic methods that include the administration of such phosphorus substituted agents, as well as to processes and intermediates useful for preparing such agents.
摘要翻译： 本发明涉及磷取代的治疗剂，含有这种磷取代剂的组合物，以及包括施用这种磷取代剂的治疗方法，以及可用于制备这种药剂的方法和中间体。
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公开(公告)号：US08558001B2
公开(公告)日：2013-10-15
申请号：US13537536
申请日：2012-06-29
申请人： Carina E. Cannizzaro , Michael Graupe , Juan A. Guerrero , Yafan Lu , Robert G. Strickley , Chandrasekar Venkataramani , Jeff Zablocki
发明人： Carina E. Cannizzaro , Michael Graupe , Juan A. Guerrero , Yafan Lu , Robert G. Strickley , Chandrasekar Venkataramani , Jeff Zablocki
IPC分类号： C07D213/62 , A61K31/44
CPC分类号： A61K31/675 , A61K31/4418 , C07D213/64 , C07F9/58
摘要： Disclosed are novel compounds having the structure of Formula (I): which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.
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公开(公告)号：US20140142085A1
公开(公告)日：2014-05-22
申请号：US14130882
申请日：2012-07-05
申请人： Steven S. Bondy , Carina E. Cannizzaro , Chien-hung Chou , Randall L. Halcomb , Yunfeng Eric Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
发明人： Steven S. Bondy , Carina E. Cannizzaro , Chien-hung Chou , Randall L. Halcomb , Yunfeng Eric Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC分类号： C07D401/12 , A61K45/06 , C07D403/12 , A61K31/506 , C07D471/04 , A61K31/444 , C07D401/14 , A61K31/4545 , C07D409/14 , A61K31/4709 , A61K31/5377 , A61K31/4985 , C07D413/14 , C07D491/052 , A61K31/50 , A61K31/4439
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供包含式（I）化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗逆转录病毒科病毒感染的治疗方法，包括由HIV病毒引起的感染 。
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公开(公告)号：US09540343B2
公开(公告)日：2017-01-10
申请号：US14130882
申请日：2012-07-05
申请人： Steven S. Bondy , Carina E. Cannizzaro , Chien-hung Chou , Randall L. Halcomb , Yunfeng Eric Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
发明人： Steven S. Bondy , Carina E. Cannizzaro , Chien-hung Chou , Randall L. Halcomb , Yunfeng Eric Hu , John O. Link , Qi Liu , Scott D. Schroeder , Winston C. Tse , Jennifer R. Zhang
IPC分类号： A01N43/00 , A61K31/00 , C07D401/12 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D409/14 , C07D413/14 , C07D491/052
CPC分类号： C07D401/12 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4985 , A61K31/50 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D213/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04
摘要： The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
摘要翻译： 本发明提供了本文所述的式（I）化合物或其盐。 本发明还提供包含式（I）化合物的药物组合物，制备式（I）化合物的方法，用于制备式I化合物的中间体和治疗逆转录病毒科病毒感染的治疗方法，包括由HIV病毒引起的感染 。
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公开(公告)号：US20130005689A1
公开(公告)日：2013-01-03
申请号：US13537536
申请日：2012-06-29
申请人： Carina E. Cannizzaro , Michael Graupe , Juan A. Guerrero , Yafan Lu , Robert G. Strickley , Chandrasekar Venkataramani , Jeff Zablocki
发明人： Carina E. Cannizzaro , Michael Graupe , Juan A. Guerrero , Yafan Lu , Robert G. Strickley , Chandrasekar Venkataramani , Jeff Zablocki
IPC分类号： A61K31/675 , C07F9/06 , C07D213/64 , A61P3/04 , A61P25/36 , A61P25/34 , A61P25/32 , A61K31/4412 , A61P25/30
CPC分类号： A61K31/675 , A61K31/4418 , C07D213/64 , C07F9/58
摘要： Disclosed are novel compounds having the structure of Formula (I): which are useful for treating mammals for dependence upon substances of addiction, for example addiction to a dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and/or alcohol. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of a compound of Formula (I) and methods of using the compounds of Formula (I) in the treatment of addiction to a dopamine-producing agent.
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