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    Graphene-encapsulated nanoparticle-based biosensor for the selective detection of biomarkers
    3.
    发明授权
    Graphene-encapsulated nanoparticle-based biosensor for the selective detection of biomarkers 有权
    石墨烯包裹的基于纳米粒子的生物传感器用于生物标志物的选择性检测

    公开(公告)号：US09162885B2

    公开(公告)日：2015-10-20

    申请号：US13400021

    申请日：2012-02-17

    申请人： Ki-Bum Lee ,  Sung Myung ,  Aniruddh Solanki

    发明人： Ki-Bum Lee ,  Sung Myung ,  Aniruddh Solanki

    IPC分类号： G01N33/551 ,  G01N33/553 ,  B82Y30/00 ,  H01L29/49 ,  H01L29/786 ,  G01N27/414

    CPC分类号： B82Y30/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/4908 ,  H01L29/7869 ,  H01L29/78696

    摘要： A field effect transistor (FET) with a source electrode and a drain electrode distanced apart from each other on a semi-conductor substrate, and a gate electrode consisting of a uniform layer of reduced graphene oxide encapsulated semiconductor nanoparticles (rGO-NPs), wherein the gate electrode is disposed between and contacts both the source and drain electrodes. Methods of making and assay methods using the FETs are also disclosed, including methods in which the rGO-NPs are functionalized with binding partners for biomarkers.

    摘要翻译： 具有在半导体衬底上彼此分开的源电极和漏电极的场效应晶体管（FET）和由均匀的还原型氧化烯石氧化物封装的半导体纳米颗粒层（rGO-NP）组成的栅电极，其中 栅电极设置在源极和漏极之间并且与源电极和漏电极接触。 还公开了使用FET的制备方法和测定方法，包括其中rGO-NPs用于生物标志物的结合伴侣功能化的方法。

    Stem cell differentiation using novel light-responsive hydrogels
    4.
    发明授权
    Stem cell differentiation using novel light-responsive hydrogels 有权
    使用新的光响应水凝胶的干细胞分化

    公开(公告)号：US09234171B2

    公开(公告)日：2016-01-12

    申请号：US13314891

    申请日：2011-12-08

    申请人： Ki-Bum Lee ,  Shreyas Shah

    发明人： Ki-Bum Lee ,  Shreyas Shah

    IPC分类号： C12N5/071 ,  C12N5/00 ,  A61K47/30 ,  C12N5/079

    CPC分类号： C12N5/0618 ,  C12N2506/45 ,  C12N2529/10 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2535/10 ,  C12N2537/10

    摘要： This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI).

    摘要翻译： 该申请公开了一种光反应性水凝胶基平台，其可以调节多种微环境信号以将人诱导的多能干细胞衍生的神经祖细胞（hiPSC-NPC）分化为神经元细胞。 本发明提供了用于将神经干细胞分化为用于治疗退行性疾病或病症（包括但不限于阿尔茨海默病，帕金森病或脊髓损伤（SCI））的神经元的新颖方法。

    STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS
    6.
    发明申请
    STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS 有权
    使用新型反应性水凝胶的干细胞分化

    公开(公告)号：US20120149781A1

    公开(公告)日：2012-06-14

    申请号：US13314891

    申请日：2011-12-08

    申请人： Ki-Bum Lee ,  Shreyas Shah

    发明人： Ki-Bum Lee ,  Shreyas Shah

    IPC分类号： A61K47/42 ,  C12N5/0797

    CPC分类号： C12N5/0618 ,  C12N2506/45 ,  C12N2529/10 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2535/10 ,  C12N2537/10

    摘要： This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI).

    摘要翻译： 该申请公开了一种光反应性水凝胶基平台，其可以调节多种微环境信号以将人诱导的多能干细胞衍生的神经祖细胞（hiPSC-NPC）分化为神经元细胞。 本发明提供了用于将神经干细胞分化为用于治疗退行性疾病或病症（包括但不限于阿尔茨海默病，帕金森病或脊髓损伤（SCI））的神经元的新颖方法。

    GRAPHENE-ENCAPSULATED NANOPARTICLE-BASED BIOSENSOR FOR THE SELECTIVE DETECTION OF BIOMARKERS
    8.
    发明申请
    GRAPHENE-ENCAPSULATED NANOPARTICLE-BASED BIOSENSOR FOR THE SELECTIVE DETECTION OF BIOMARKERS 有权
    用于生物标志物选择性检测的基于纳帕纳基的生物传感器

    公开(公告)号：US20120220053A1

    公开(公告)日：2012-08-30

    申请号：US13400021

    申请日：2012-02-17

    申请人： Ki-Bum Lee ,  Sung Myung ,  Aniruddh Solanki

    发明人： Ki-Bum Lee ,  Sung Myung ,  Aniruddh Solanki

    IPC分类号： G01N27/00 ,  G01N27/414 ,  H01L21/335 ,  B82Y40/00 ,  B82Y99/00

    CPC分类号： B82Y30/00 ,  G01N27/4145 ,  G01N27/4146 ,  H01L29/4908 ,  H01L29/7869 ,  H01L29/78696

    摘要： A field effect transistor (FET) with a source electrode and a drain electrode distanced apart from each other on a semi-conductor substrate, and a gate electrode consisting of a uniform layer of reduced graphene oxide encapsulated semiconductor nanoparticles (rGO-NPs), wherein the gate electrode is disposed between and contacts both the source and drain electrodes. Methods of making and assay methods using the FETs are also disclosed, including methods in which the rGO-NPs are functionalized with binding partners for biomarkers.

    摘要翻译： 具有在半导体衬底上彼此分开的源电极和漏电极的场效应晶体管（FET）和由均匀的还原型氧化烯石氧化物封装的半导体纳米颗粒层（rGO-NP）组成的栅电极，其中 栅电极设置在源极和漏极之间并且与源电极和漏电极接触。 还公开了使用FET的制备方法和测定方法，包括其中rGO-NPs用于生物标志物的结合伴侣功能化的方法。