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35 条记录 (耗时 0.044 秒)

    CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES
    3.
    发明申请
    CONTROL OF MATERIALS AND POROUS MAGNETIC PARTICLES 有权
    材料和多孔磁性颗粒的控制

    公开(公告)号：US20090179171A1

    公开(公告)日：2009-07-16

    申请号：US12300369

    申请日：2007-05-16

    申请人： Michael J. Sailor ,  Ji-Ho Park ,  Austin M. Derfus ,  Ester Segal ,  Kenneth S. Vecchio ,  Sangeeta N. Bhatia

    发明人： Michael J. Sailor ,  Ji-Ho Park ,  Austin M. Derfus ,  Ester Segal ,  Kenneth S. Vecchio ,  Sangeeta N. Bhatia

    IPC分类号： H01F1/00 ,  H05B6/02

    CPC分类号： H05B6/02 ,  B82Y25/00 ,  H01F1/0063 ,  Y10T428/29 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T428/32

    摘要： The present invention uses externally applied electromagnetic stimulus to control and heat porous magnetic particles and material associated with the particles. The particles contain magnetic material, such as superparamagnetic iron oxide and are associated with a material. Application of a DC magnetic field allows them to be moved with their associated material, and application of an AC RF electromagnetic field allows them to be heated with their associated material. The material can be associated with the particles by being contained in the pores of the particles, or in other cases the particles can adhere to the associated material, which can be an aqueous droplet. The present invention also provides a multi-layer porous magnetic particle. The particle includes a host layer having pores sized to accept magnetic nanoparticles. Magnetic nanoparticles are infused within pores of the host layer An encoding layer includes pores that define a spectral code. The pores in the encoding layer are sized to substantially exclude the magnetic nanoparticles. The encoding layer can also be a multi-layer, exhibiting, for example, a complex spectral code.

    摘要翻译： 本发明使用外部施加的电磁刺激来控制和加热与颗粒相关联的多孔磁性颗粒和材料。 颗粒含有磁性材料，例如超顺磁性氧化铁，并与材料相关联。 DC磁场的应用允许它们与其相关材料一起移动，并且AC RF电磁场的应用允许它们与其相关材料一起被加热。 该材料可以通过包含在颗粒的孔中与颗粒相关联，或者在其它情况下，颗粒可以附着到可以是水性液滴的相关材料上。 本发明还提供一种多层多孔磁性颗粒。 颗粒包括具有尺寸以接受磁性纳米颗粒的孔的主体层。 磁性纳米颗粒注入到主体层的孔内编码层包括限定光谱代码的孔。 编码层中的孔的大小被确定为基本排除磁性纳米颗粒。 编码层也可以是多层，表现出例如复谱谱。

    Multi-well micropatterning by ablation
    4.
    发明申请
    Multi-well micropatterning by ablation 审中-公开
    消融多孔微图案

    公开(公告)号：US20080220516A1

    公开(公告)日：2008-09-11

    申请号：US11974341

    申请日：2007-10-12

    申请人： David T. Eddington ,  Sangeeta N. Bhatia

    发明人： David T. Eddington ,  Sangeeta N. Bhatia

    IPC分类号： C12M1/22 ,  B44C1/22

    CPC分类号： G01N33/5067 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00587 ,  B01J2219/0898 ,  B01L3/5025 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0636 ,  C12M23/12 ,  C12M23/20 ,  C12M25/04 ,  C12N5/0671 ,  C12N2502/14 ,  C12N2535/10 ,  G01N33/5008 ,  G01N33/54353 ,  G01N33/5436

    摘要： The present invention is drawn to the generation of micropatterns of biomolecules and cells on standard laboratory materials through selective ablation of a physisorbed biomolecule with oxygen plasma. In certain embodiments, oxygen plasma is able to ablate selectively physisorbed layers of biomolecules (e.g., type-I collagen, fibronectin, laminin, and Matrigel) along complex non-linear paths which are difficult or impossible to pattern using alternative methods. In addition, certain embodiments of the present invention relate to the micropatterning of multiple cell types on curved surfaces, multiwell plates, and flat bottom flasks. The invention also features kits for use with the subject methods.

    摘要翻译： 本发明涉及通过用氧等离子体选择性消融物理吸附的生物分子来生成标准实验室材料上的生物分子和细胞的微图案。 在某些实施方案中，氧等离子体能够沿着复杂的非线性路径选择性地吸收生物分子（例如，I型胶原，纤连蛋白，层粘连蛋白和Matrigel）的物理吸附层，这些复杂的非线性路径难以或不可能使用替代方法进行模式化。 此外，本发明的某些实施例涉及在曲面，多孔板和平底烧瓶上的多种细胞类型的微图案化。 本发明还具有用于本发明方法的试剂盒。

    Micromechanical devices for control of cell-cell interaction, and methods of use thereof
    6.
    发明授权
    Micromechanical devices for control of cell-cell interaction, and methods of use thereof 有权

    公开(公告)号：US09611453B2

    公开(公告)日：2017-04-04

    申请号：US12449994

    申请日：2008-03-10

    申请人： Sangeeta N. Bhatia ,  Elliot Hui

    发明人： Sangeeta N. Bhatia ,  Elliot Hui

    IPC分类号： C12Q1/02 ,  C12M1/42 ,  C12M1/12 ,  C12M1/00

    CPC分类号： C12M35/08 ,  C12M23/04 ,  C12M23/20

    摘要： The development and function of living tissues depends largely on interactions between cells that can vary in both time and space; however, temporal control of cell-cell interaction is experimentally challenging. By employing a micromachined silicon substrate with moving parts, herein is disclosed the dynamic regulation of cell-cell interactions via direct manipulation of adherent cells with micron-scale precision. The inventive devices and methods allow mechanical control of both tissue composition and spatial organization. The inventive device and methods enable the investigation of dynamic cell-cell interaction in a multitude of applications, such as intercellular communication, spanning embryogenesis, homeostasis, and pathogenic processes.

    Microfabricated biopolymer scaffolds and method of making same
    8.
    发明授权
    Microfabricated biopolymer scaffolds and method of making same 有权
    微生物聚合物支架及其制备方法

    公开(公告)号：US08715436B2

    公开(公告)日：2014-05-06

    申请号：US10750293

    申请日：2003-12-31

    申请人： Sangeeta N. Bhatia ,  Giovanni Vozzi

    发明人： Sangeeta N. Bhatia ,  Giovanni Vozzi

    IPC分类号： A61F2/00 ,  B29C65/00 ,  B32B3/10

    CPC分类号： A61F2/00 ,  B29C67/202 ,  Y10T428/24273 ,  Y10T428/24322 ,  Y10T428/26 ,  Y10T428/269

    摘要： The invention is a series of soft lithographic methods for the microfabrication of biopolymer scaffolds for use in tissue engineering and the development of artificial organs. The methods present a wide range of possibilities to construct two- and three-dimensional scaffolds with desired characteristics according to the final application. The methods utilize an elastomer mold which the biopolymer scaffold is cast. The methods allow for the rapid and inexpensive production of biopolymer scaffolds with limited specialized equipment and user expertise.

    摘要翻译： 本发明是用于组织工程和人造器官发育的生物聚合物支架的微细加工的一系列软平版印刷方法。 根据最终应用，该方法具有广泛的可能性来构建具有所需特征的二维和三维支架。 该方法利用生物聚合物支架铸造的弹性体模具。 该方法允许以有限的专门设备和用户专业知识快速而廉价地生产生物聚合物支架。