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    Transition metal complexes in the controlled synthesis of polyolefins substituted with functional groups
    1.
    发明授权
    Transition metal complexes in the controlled synthesis of polyolefins substituted with functional groups 失效
    过渡金属络合物在被官能团取代的聚烯烃的控制合成中

    公开(公告)号：US07037990B2

    公开(公告)日：2006-05-02

    申请号：US10336666

    申请日：2003-01-03

    申请人： Christopher D. Tagge ,  Robert B. Wilson, Jr. ,  Hiroyuki Ono

    发明人： Christopher D. Tagge ,  Robert B. Wilson, Jr. ,  Hiroyuki Ono

    IPC分类号： C08F4/26 ,  C08F4/52 ,  C08F4/60 ,  C08F18/08 ,  C08F16/12

    CPC分类号： C07F15/008 ,  C08F10/00 ,  C08F4/7006 ,  C08F4/7004

    摘要： A method is provided for the polymerization of olefins substituted with a functional group using a transition metal catalyst that, by virtue of one or more stabilizing groups incorporated within the catalyst structure, “fixes” the stereoconfiguration of each olefinic monomer relative to the transition metal complex during each successive reaction in the polymerization process. The invention substantially reduces the likelihood of olefin rearrangement at the active site of the catalyst during polymerization. In one particular embodiment, the functional group is a polar, electron-donating group and the stabilizing group is a Lewis acid substituent; examples of polymers that can be prepared with such a system include poly(vinyl acetate), poly(vinyl alcohol), and poly(vinyl ethers). Novel complexes and catalyst systems useful in the polymerization method are also provided.

    摘要翻译： 提供了一种使用过渡金属催化剂聚合由官能团取代的烯烃的方法，其通过引入催化剂结构内的一个或多个稳定基团“固定”每个烯属单体相对于过渡金属络合物的立体构型 在聚合过程中的每个连续反应期间。 本发明基本上降低了聚合过程中催化剂活性位点烯烃重排的可能性。 在一个具体实施方案中，官能团是极性的给电子基团，稳定基团是路易斯酸取代基; 可以用这种体系制备的聚合物的实例包括聚（乙酸乙烯酯），聚（乙烯醇）和聚（乙烯基醚）。 还提供了可用于聚合方法的新型络合物和催化剂体系。

    Complexes of mid-transition metals and unsaturated nitrogenous ligands as single-site catalysts
    3.
    发明授权
    Complexes of mid-transition metals and unsaturated nitrogenous ligands as single-site catalysts 失效
    中间过渡金属和不饱和含氮配体的复合物作为单中心催化剂

    公开(公告)号：US06355746B1

    公开(公告)日：2002-03-12

    申请号：US09414132

    申请日：1999-10-06

    申请人： Christopher D. Tagge ,  Robert B. Wilson, Jr.

    发明人： Christopher D. Tagge ,  Robert B. Wilson, Jr.

    IPC分类号： C08F422

    CPC分类号： C07D213/53 ,  C07C251/12 ,  C07D241/12 ,  C07F7/003 ,  C07F11/005 ,  C08F10/00 ,  C08F4/69034 ,  C08F4/69043 ,  C08F4/64013

    摘要： Novel compounds are provided which are useful as catalysts, particularly in the polymerization of addition polymerizable monomers such as olefinic or vinyl monomers. The compounds are complexes of a mid-transition metal coordinated to at least two ligands, at least one of which is an unsaturated nitrogenous ligand. Depending on ligand substitution, stereospecific catalysts can be provided, including isospecific catalysts and syndiospecific catalysts. Catalyst systems containing the novel compounds in combination with a catalyst activator are provided as well, as are methods of using the novel compounds in the preparation of polyolefins.

    摘要翻译： 提供了可用作催化剂的新型化合物，特别是在可加聚单体如烯属或乙烯基单体的聚合中。 这些化合物是与至少两个配体配位的中间过渡金属的络合物，其中至少一个是不饱和含氮配体。 取决于配体取代，可以提供立体特异性催化剂，包括异相催化剂和间同立构催化剂。 还提供了含有新型化合物与催化剂活化剂组合的催化剂体系，以及在制备聚烯烃中使用新化合物的方法。

    Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
    4.
    发明授权
    Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries 失效
    用于高通量合成，筛选和表征组合文库的反应量热计和差示扫描量热计

    公开(公告)号：US07033840B1

    公开(公告)日：2006-04-25

    申请号：US09708687

    申请日：2000-11-09

    申请人： Christopher D. Tagge ,  Robert B. Wilson, Jr. ,  Seajin Oh ,  Albert S. Hirschon

    发明人： Christopher D. Tagge ,  Robert B. Wilson, Jr. ,  Seajin Oh ,  Albert S. Hirschon

    IPC分类号： G01N25/20 ,  G01N31/10

    CPC分类号： B01L3/50851 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00704 ,  B01J2219/00747 ,  B01L3/50853 ,  B01L2300/0654 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2400/065 ,  G01N25/4846 ,  H01J49/04

    摘要： Workstation, apparatuses and methods for the high-throughput synthesis, screening and/or characterization of combinatorial libraries. The invention relates to an array, which permits various high-throughput methods for synthesis, screening and/or characterization in the same array, without requiring sample transfer from the array. In a preferred embodiment, the synthesis, screening, and/or characterization steps are carried out in a highly parallel fashion, where more than one compound is synthesized, screened, and/or characterized at the same time. The invention may be practiced at the microscale. The array may comprise thermal channels, for regulating the temperature of the wells in the array. The wells of the array may comprise a membrane, which is used in various screening and characterization methods. The invention also relates to a covered array, comprising the array and an array cover, as well as an apparatus comprising the array, which comprises the array, an array cover and a stage. The array, array cover, and the stage may be modified as required for a variety of synthesis and/or analysis techniques. The array is easily interchangeable between different analytical instruments, and in an embodiment, the invention relates to an automated workstation, where the array is transferred between different synthesis, screening, and characterization stations. The invention also relates to a variety of methods for synthesis, screening, and characterization, which are adapted for combinatorial chemistry. Any of the embodiments of the invention may be used either alone or taken in various combinations.

    摘要翻译： 用于组合库的高通量合成，筛选和/或表征的工作站，设备和方法。 本发明涉及阵列，其允许在相同阵列中进行合成，筛选和/或表征的各种高通量方法，而不需要从阵列转移样品。 在优选实施方案中，合成，筛选和/或表征步骤以高度平行的方式进行，其中多于一种化合物被同时合成，筛选和/或表征。 本发明可以在微尺度下实施。 阵列可以包括用于调节阵列中的阱的温度的热通道。 阵列的孔可以包括膜，其用于各种筛选和表征方法。 本发明还涉及包括阵列和阵列盖的覆盖阵列，以及包括阵列的装置，其包括阵列，阵列盖和台。 可以根据各种合成和/或分析技术的要求来修改阵列，阵列覆盖物和载物台。 该阵列在不同的分析仪器之间易于互换，并且在一个实施例中，本发明涉及自动化工作站，其中阵列在不同的合成，筛选和表征台之间传送。 本发明还涉及适用于组合化学的各种合成，筛选和表征的方法。 本发明的任何实施方案可以单独使用或以各种组合使用。

    Complexes of mid-transition metals and unsaturated nitrogenous ligands as single-site catalysts
    5.
    发明授权
    Complexes of mid-transition metals and unsaturated nitrogenous ligands as single-site catalysts 失效
    中间过渡金属和不饱和含氮配体的复合物作为单中心催化剂

    公开(公告)号：US06841676B2

    公开(公告)日：2005-01-11

    申请号：US10023920

    申请日：2001-12-17

    申请人： Christopher D. Tagge ,  Robert B. Wilson, Jr.

    发明人： Christopher D. Tagge ,  Robert B. Wilson, Jr.

    IPC分类号： C07C251/12 ,  C07D213/53 ,  C07D241/12 ,  C07F7/00 ,  C07F11/00 ,  C08F4/02 ,  C08F4/22 ,  C08F4/78 ,  C08F10/00 ,  C07F9/80

    CPC分类号： C07D213/53 ,  C07C251/12 ,  C07D241/12 ,  C07F7/003 ,  C07F11/005 ,  C08F10/00 ,  C08F4/69034 ,  C08F4/69043 ,  C08F4/64013

    摘要： Novel compounds are provided which are useful as catalysts, particularly in the polymerization of addition polymerizable monomers such as olefinic or vinyl monomers. The compounds are complexes of a mid-transition metal coordinated to at least two ligands, at least one of which is an unsaturated nitrogenous ligand. Depending on ligand substitution, stereospecific catalysts can be provided, including isospecific catalysts and syndiospecific catalysts. Catalyst systems containing the novel compounds in combination with a catalyst activator are provided as well, as are methods of using the novel compounds in the preparation of polyolefins. One embodiment of the present invention is a compound having the formula L1[MQ1Q2]L2 in which M is Nb, Ta, Mo, W, Mn or Re, Q1 and Q2 are each a univalent substituent, and L1 and L2 are ligands coordinated to M, wherein L1 contains a first coordinating nitrogen atom within a C═N group, and a second coordinating atom that is either a second nitrogen atom, optionally present in a second C═N group, or an oxygen, sulfur or phosphorus atom. The L2 group contains a coordinating atom that is either a second nitrogen atom, optionally within a C═N group, or a sulfur or phosphorus atom.

    摘要翻译： 提供了可用作催化剂的新型化合物，特别是在可加聚单体如烯属或乙烯基单体的聚合中。 这些化合物是与至少两个配体配位的中间过渡金属的络合物，其中至少一个是不饱和含氮配体。 取决于配体取代，可以提供立体特异性催化剂，包括异相催化剂和间同立构催化剂。 还提供了含有新型化合物与催化剂活化剂组合的催化剂体系，以及在制备聚烯烃中使用新化合物的方法。 本发明的一个实施方案是具有式L 1 [MQ 1 Q 2] L 2的化合物，其中M是Nb，Ta，Mo，W，Mn或Re，Q 1， 和Q 2各自是一价取代基，L 1和L 2是与M配位的配位体，其中L 1在C = N基团中含有第一配位氮原子，第二配位原子 即第二个氮原子，任选存在于第二个C = N基团中，或者是氧，硫或磷原子。 L 2基团包含任选在C = N基团中的第二氮原子或硫或磷原子的配位原子。

    Viscosity and mass sensor for the high-throughput synthesis, screening and characterization of combinatorial libraries
    6.
    发明授权
    Viscosity and mass sensor for the high-throughput synthesis, screening and characterization of combinatorial libraries 失效
    用于高通量合成，筛选和表征组合文库的粘度和质量传感器

    公开(公告)号：US06602714B1

    公开(公告)日：2003-08-05

    申请号：US09708688

    申请日：2000-11-09

    申请人： Christopher D. Tagge ,  Robert B. Wilson, Jr. ,  Seajin Oh ,  Albert S Hirschon ,  Dale W. Ploeger

    发明人： Christopher D. Tagge ,  Robert B. Wilson, Jr. ,  Seajin Oh ,  Albert S Hirschon ,  Dale W. Ploeger

    IPC分类号： G01N3100

    CPC分类号： G01N25/4846 ,  B01J19/0046 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00423 ,  B01J2219/00484 ,  B01J2219/00495 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00691 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01L3/50851 ,  B01L3/50853 ,  B01L2300/0627 ,  C40B40/04 ,  C40B40/14 ,  C40B50/08 ,  C40B60/12 ,  C40B70/00 ,  G01N5/04 ,  G01N11/00 ,  G01N15/088 ,  G01N29/036 ,  G01N31/10 ,  G01N2035/00237 ,  G01N2291/0256

    摘要： Workstation, apparatuses and methods for the high-throughput synthesis, screening and/or characterization of combinatorial libraries. The invention relates to an array, which permits various high-throughput methods for synthesis, screening and/or characterization in the same array, without requiring sample transfer from the array. In a preferred embodiment, the synthesis, screening, and/or characterization steps are carried out in a highly parallel fashion, where more than one compound is synthesized, screened, and/or characterized at the same time. The invention may be practiced at the microscale. The array may comprise thermal channels, for regulating the temperature of the wells in the array. The wells of the array may comprise a membrane, which is used in various screening and characterization methods. The invention also relates to a covered array, comprising the array and an array cover, as well as an apparatus comprising the array, which comprises the array, an array cover and a stage. The array, array cover, and the stage may be modified as required for a variety of synthesis and/or analysis techniques. The array is easily interchangeable between different analytical instruments, and in an embodiment, the invention relates to an automated workstation, where the array is transferred between different synthesis, screening, and characterization stations. The invention also relates to a variety of methods for synthesis, screening, and characterization, which are adapted for combinatorial chemistry. Any of the embodiments of the invention may be used either alone or taken in various combinations.

    摘要翻译： 组合库的高通量合成，筛选和/或表征的工作站，设备和方法。 本发明涉及阵列，其允许在相同阵列中进行合成，筛选和/或表征的各种高通量方法，而不需要从阵列转移样品。 在优选实施方案中，合成，筛选和/或表征步骤以高度平行的方式进行，其中多于一种化合物被同时合成，筛选和/或表征。 本发明可以在微尺度下实施。 阵列可以包括用于调节阵列中的阱的温度的热通道。 阵列的孔可以包括膜，其用于各种筛选和表征方法。 本发明还涉及包括阵列和阵列盖的覆盖阵列，以及包括阵列的装置，其包括阵列，阵列盖和台。 可以根据各种合成和/或分析技术的要求来修改阵列，阵列覆盖物和载物台。 该阵列在不同的分析仪器之间易于互换，并且在一个实施例中，本发明涉及自动化工作站，其中阵列在不同的合成，筛选和表征台之间传送。 本发明还涉及适用于组合化学的各种合成，筛选和表征的方法。 本发明的任何实施方案可以单独使用或以各种组合使用。

    Olefin copolymers containing hydrolytically cleavable linkages and use thereof in degradable products
    8.
    发明授权
    Olefin copolymers containing hydrolytically cleavable linkages and use thereof in degradable products 失效
    含有水解可切割键的烯烃共聚物及其在降解产物中的用途

    公开(公告)号：US07592408B2

    公开(公告)日：2009-09-22

    申请号：US12128411

    申请日：2008-05-28

    申请人： Robert B. Wilson, Jr. ,  Sigridur Jonasdottir

    发明人： Robert B. Wilson, Jr. ,  Sigridur Jonasdottir

    IPC分类号： C08F130/02

    CPC分类号： C08F210/02 ,  Y10S526/943

    摘要： The invention is directed to olefin copolymers composed of nonhydrolyzable monomer units and hydrolyzable monomer units, the latter resulting from copolymerization of monomers containing a linkage that is hydrolytically cleavable in the presence of aqueous base or aqueous acid. Generally, the hydrolyzable monomer units represent a significant fraction of the copolymer, such that upon hydrolysis, a substantial portion of the copolymer is degraded into low molecular weight fragments. Also provided are degradable articles that are at least partially composed of a degradable copolymer in which hydrolyzable monomer units represent at least 20 mole % of the copolymer. These degradable articles include agricultural film products, adhesive tape substrates, bed linens, containers, disposable absorbent articles, packaging materials, bags, labels, pillow cases, protective clothing, surgical drapes, sponges, tampon applicators, disposable syringes, temporary enclosures and temporary siding, toys, wipes, foamed plastic products, and controlled release pellets, strips and tabs.

    摘要翻译： 本发明涉及由不可水解的单体单元和可水解单体单元组成的烯烃共聚物，后者是由在含水碱或含水酸存在下可水解切割的连接体的单体的共聚得到的。 通常，可水解单体单元代表共聚物的显着部分，使得在水解时，共聚物的大部分降解成低分子量片段。 还提供了至少部分由可水解单体单元占共聚物的至少20摩尔％的可降解共聚物组成的可降解制品。 这些可降解制品包括农用薄膜产品，胶带基材，床上用品，容器，一次性吸收制品，包装材料，袋子，标签，枕头套，防护服，手术用纱，海绵，棉塞施用器，一次性注射器，临时外壳和临时壁板 ，玩具，擦拭物，发泡塑料制品和控制释放的颗粒，条和片。