公开(公告)号：US07105545B2

公开(公告)日：2006-09-12

申请号：US10472577

申请日：2002-04-02

申请人： Walter Kunz ,  Clemens Lamberth ,  Fredrik Cederbaum ,  Martin Zeller

发明人： Walter Kunz ,  Clemens Lamberth ,  Fredrik Cederbaum ,  Martin Zeller

IPC分类号： A01N43/40 ,  A01N43/06 ,  A01N43/08 ,  A01N37/44 ,  A01N37/18

CPC分类号： C07C327/44 ,  A01N37/36 ,  A01N43/08 ,  A01N43/10 ,  A01N43/12 ,  A01N43/30 ,  A01N43/32 ,  A01N43/40 ,  A01N43/54

摘要： The invention relates to N-propargyloxy-phenethyl thioacetic acid amide derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7 and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is hydroxy, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenysulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl, optionally substituted alkynylsulfonyl or a group —O—CO—R11, —O—CO—O—R11 or —O—CO—CO—O—R11 wherein R11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi

摘要翻译： 本发明涉及通式（I）的N-炔丙氧基 - 苯乙基硫代乙酰胺衍生物，其包括其旋光异构体和这些异构体的混合物，其中R 1是氢，烷基，环烷基或任选取代的 芳基，R 2和R 3各自独立地是氢或烷基，R 4是烷基，烯基或炔基，R 5， R 6，R 7，R 8和R 8各自独立地为氢或烷基，R 9为 氢，任选取代的烷基，任选取代的烯基或任选取代的炔基，R 10是任选取代的芳基或任选取代的杂芳基，Z是羟基，任选取代的芳氧基，任选取代的烷氧基，任选取代的炔氧基，任选地 取代的芳硫基，任选取代的烷硫基，任选取代的炔硫基，任选取代的烷基亚磺酰基，任选取代的烯基亚磺酰基，任选的 取代的炔基亚磺酰基，任选取代的烷基磺酰基，任选取代的链烯基磺酰基，任选取代的炔基磺酰基或基团-O-CO-R 11，-O-CO-OR 11或-O- 其中R 11是氢，任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂芳基。 这些化合物具有有用的植物保护性质，并且可有利地用于农业实践中以控制或防止由植物病原微生物特别是真菌侵染植物

公开(公告)号：US06683211B1

公开(公告)日：2004-01-27

申请号：US10276476

申请日：2002-11-15

申请人： Clemens Lamberth ,  Martin Zeller ,  Walter Kunz ,  Fredrik Cederbaum

发明人： Clemens Lamberth ,  Martin Zeller ,  Walter Kunz ,  Fredrik Cederbaum

IPC分类号： C07C23305

CPC分类号： C07D239/26 ,  A01N37/36 ,  C07C233/22 ,  C07C235/34 ,  C07C323/60 ,  C07C323/62 ,  C07C2602/10 ,  C07D213/56 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18 ,  C07D333/24 ,  C07D333/28

摘要： The invention relates to phenyl-propargylether derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl, R9 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkynyl, R10 is optionally substituted aryl or optionally substituted heteroaryl, and Z is halogen, optionally substituted aryloxy, optionally substituted alkoxy, optionally substituted alkenyloxy, optionally substituted alkynyloxy, optionally substituted arylthio, optionally substituted alkylthio, optionally substituted alkenylthio; optionally substituted alkynylthio, optionally substituted alkylsulfinyl, optionally substituted alkenylsulfinyl, optionally substituted alkynylsulfinyl, optionally substituted alkylsulfonyl, optionally substituted alkenylsulfonyl or optionally substituted alkynylsulfonyl. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

摘要翻译： 本发明涉及通式I的苯基 - 炔丙基醚衍生物，包括其光学异构体和这些异构体的混合物，其中R 1是氢，烷基，环烷基或任选取代的芳基，R 2和R 3各自独立地是氢或烷基，R 4是烷基， 或炔基，R 5，R 6，R 7和R 8各自独立地为氢或烷基，R 9为氢，任选取代的烷基，任选取代的烯基或任选取代的炔基，R 10为任选取代的芳基或任选取代的杂芳基，且Z为卤素， 芳氧基，任选取代的烷氧基，任选取代的烯氧基，任选取代的炔氧基，任选取代的芳硫基，任选取代的烷硫基，任选取代的烯硫基; 任选取代的炔基硫基，任选取代的烷基亚磺酰基，任选取代的烯基亚磺酰基，任选取代的炔基亚磺酰基，任选取代的烷基磺酰基，任选取代的链烯基磺酰基或任选取代的炔基磺酰基。 这些化合物具有有用的植物保护性质，并且可有利地用于农业实践中以控制或防止植物病原微生物特别是真菌侵染植物。

公开(公告)号：US06469005B1

公开(公告)日：2002-10-22

申请号：US09903651

申请日：2001-07-11

申请人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth ,  Walter Kunz

发明人： Martin Zeller ,  André Jeanguenat ,  Clemens Lamberth ,  Walter Kunz

IPC分类号： A01N4358

CPC分类号： A01N43/40 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N37/50 ,  A01N43/08 ,  A01N43/10 ,  A01N43/28 ,  A01N43/30 ,  A01N43/32 ,  A01N43/54 ,  A01N47/12 ,  C07C235/34 ,  C07C235/80 ,  C07C251/40 ,  C07C271/22 ,  C07C323/62

摘要： Propargylether derivatives of formula I including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, alkyl, cycloalkyl or optionally substituted aryl, R2 and R3 are each independently hydrogen or alkyl, R4 is alkyl, alkenyl or alkynyl, R5, R6, R7, and R8 are each independently hydrogen or alkyl and R9 is a group R10 is optionally substituted aryl or optionally substituted heteroaryl, R11 is hydrogen or optionally substituted alkyl, alkenyl or alkynyl, Z is hydrogen —CO—R16, —COOR16, —CO—COOR16 or —CONR16R17, R12 is hydrogen, or optionally substituted alkyl, alkenyl or alkynyl, R13 is hydrogen or alkyl, R14 is hydrogen, alkyl, cycloalkyl or cycloalkyl-alkyl, R15 is alkyl, alkenyl, alkynyl, optionally substituted aryl or optionally substituted aryl-alkyl, and R16 and R17 are independently of each other hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted heteroaryl, have been found to be useful for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi. The invention relates the novel compounds and also to the preparation thereof and to the use of the compounds for plant protection, and to compositions suitable for applying the novel compounds in agricultural techniques.

摘要翻译： 式I的丙酰醚衍生物包括其光学异构体和这些异构体的混合物，其中R 1是氢，烷基，环烷基或任选取代的芳基，R 2和R 3各自独立地是氢或烷基，R 4是烷基，烯基或炔基，R 5，R 6，R 7 ，和R 8各自独立地为氢或烷基，R 9为基团R 10为任选取代的芳基或任选取代的杂芳基，R 11为氢或任选取代的烷基，烯基或炔基，Z为氢-CO-R 16，-COOR 16，-CO-COOR 16或 -CONR 16 R 17，R 12是氢或任选取代的烷基，烯基或炔基，R 13是氢或烷基，R 14是氢，烷基，环烷基或环烷基 - 烷基，R 15是烷基，烯基，炔基，任选取代的芳基或任选取代的芳基 - 烷基，R16和R17彼此独立地为氢，任选取代的烷基，任选取代的环烷基，任选取代的芳基或任选取代的杂芳基，已被发现是有用的 用于控制或防止由植物病原微生物，特别是真菌侵染植物。本发明涉及新化合物以及其制备方法以及本发明化合物用于植物保护的用途，以及适用于农业技术中的新型化合物的组合物 。

公开(公告)号：US07601674B2

公开(公告)日：2009-10-13

申请号：US10495094

申请日：2002-11-15

申请人： Martin Zeller ,  Clemens Lamberth ,  Miroslav Kriz

发明人： Martin Zeller ,  Clemens Lamberth ,  Miroslav Kriz

IPC分类号： A01N37/18 ,  C07C233/00

CPC分类号： C07C235/34 ,  A01N37/18 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N43/10 ,  C07C235/78 ,  C07C323/60

摘要： The invention relates to α-oxygenated or α-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substituted aryl or optionally substituted heteroaryl; X is oxygen or sulfur; Y is oxygen or sulfur; R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl or halocycloalkyl; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl-alkenyl-, alkynyl-, or cycloalkyl-groups me be optionally substituted by halogen; or optionally substituted arylalkyl, optionally substituted-aryl-alkenyl, optionally substituted aryl-alkynyl or optionally substituted aryloxy-alkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl-alkenyl-, alkynyl-, or cycloalkyl-groups me be optionally substituted by halogen; or is optionally substituted aryl-alkyl, optionally substituted aryl-alkenyl, optionally substituted aryl-alkynyl, optionally substituted aryloxy-alkyl, optionally substituted heteroaryl-alkyl, optionally substituted heteroaryl-alkenyl or optionally substituted heteroaryl-alkynyl; R4 is alkyl, alkenyl, alkynyl, alkoxy-alkyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkanoyl, alkylamino, dialkylamino, alkoxycarbonyl, whereof all alkyl-alkenyl or alkynyl-groups may be optionally substituted by halogen; or is halogen, cyano, nitro, amino, formyl or carboxyl; R5 is hydrogen, alkyl, alkenyl or alkynyl; n is an integer 0, 1, 2, 3, or 4; B1 represents a bridge member —(CR10R11)q— or —(CHR10R11)r-Z-(CR12R13)8, wherein q is an integer 2, 3 or 4; r is an integer 0, 1; 2, 3; s is an integer 1, 2 or 3, provided that (r+s) is either 1, 2 or 3; Z is —O—, —S—, —SO— —SO2-, NR6—, —CO—, —OOC—, —COO—, —NR6—CO— or —CO—NR6—; R6 is hydrogen or alkyl; R10, R11, R12 and R13 independently of each other are hydrogen or alkyl; and B2 is an alkylene bridge. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

公开(公告)号：US20050245607A1

公开(公告)日：2005-11-03

申请号：US10522077

申请日：2003-07-23

申请人： Clemens Lamberth ,  Martin Zeller ,  Tibor Goegh

发明人： Clemens Lamberth ,  Martin Zeller ,  Tibor Goegh

IPC分类号： C07D333/24 ,  C07C215/64 ,  C07C215/74 ,  C07C217/74 ,  C07C217/80 ,  C07C235/36 ,  C07C235/38 ,  C07C323/62 ,  C07D213/56 ,  C07D213/61 ,  C07D307/54 ,  C07D333/28 ,  C07F7/18 ,  A61K31/277 ,  A61K31/165

CPC分类号： C07C235/36 ,  C07C215/64 ,  C07C215/74 ,  C07C217/74 ,  C07C217/80 ,  C07C235/38 ,  C07C2601/14 ,  C07F7/1804

摘要： The invention relates to N-bisaryl- and N-aryl-cycloalkylidenyl-a-hydroxy- and a-alkoxy acetic acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, C1-C12alkyl; C2-C12alkenyl; C2-C12alkynyl; C1-C12haloalkyl; R2 is hydrogen; optionally substituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl; R3 is optionally substituted aryl or optionally substituted heteroaryl; A is an optionally substituted saturated or unsaturated C3-C8-cycloalkylidene, optionally substituted phenylidene or optionally substituted saturated or unsaturated heterocyclylidene bridge, R4 and R5 are each independently hydrogen or an organic radical, and R6 is hydrogen; tri-C1-C4alkyl-silyl; di-C1-C4alkyl-phenylsilyl; C1-C4alkyl-diphenylsilyl; triphenylsilyl; optionally substituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl. The compounds possess plant-protecting properties and are suitable for protecting plants against infestation by phytopathogenic miroorganism, especially fungi.

摘要翻译： 本发明涉及通式（I）的N-双芳基 - 和N-芳基 - 环丙烯基-α-羟基 - 和α-烷氧基乙酰胺，其包括其旋光异构体和这些异构体的混合物，其中R 1 氢，C 1 -C 12烷基; C 2 -C 12链烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; R 2是氢; 任选取代的烷基; 任选取代的烯基或任选取代的炔基; R 3是任选取代的芳基或任选取代的杂芳基; A是任选取代的饱和或不饱和C 3 -C 8 - 亚烷基，任选取代的亚苯基或任选取代的饱和或不饱和杂环亚烷基桥，R 4 >和R 5各自独立地为氢或有机基团，并且R 6为氢; 三-C 1 -C 4烷基 - 甲硅烷基; 二-C 1 -C 4烷基 - 苯基甲硅烷基; C 1 -C 4烷基 - 二苯基甲硅烷基; 三苯基甲硅烷基; 任选取代的烷基; 任选取代的烯基或任选取代的炔基。 该化合物具有植物保护性质，适用于保护植物免受植物病原微生物特别是真菌的侵袭。

公开(公告)号：US20050014950A1

公开(公告)日：2005-01-20

申请号：US10495257

申请日：2002-11-15

申请人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

发明人： Martin Zeller ,  Dominik Faber ,  Thomas Vettiger ,  Clemens Lamberth

IPC分类号： C07C231/02 ,  C07C213/02 ,  C07C231/00 ,  C07C233/00 ,  C07C235/08 ,  C07C235/32 ,  C07C235/34 ,  C07D213/56

CPC分类号： C07C233/22

摘要： The invention concerns a novel process for the preparation of 2-phenyl-2-hydroxy-N-[2-(3-alkoxy-4-hydroxyphenyl)-ethyl]-acetamides of the formula (I), wherein R1 is alkyl, R2 and R3 are each independently hydrogen or alkyl, and R4 is optionally substituted aryl or optionally substituted heteroaryl, which process comprises reacting a 2-(3-alkoxy-4-hydroxyphenyl)-ethylamine of the formula (II), wherein R1 R2 and R3 are as defined above with a α-hydoxycarboxylic acid ester of the formula (III) or a dioxolanone of the formula (III)a, wherein R4 is as defined above, and R5, R6 and R7 independently of each other are lower alkyl. The compounds of formula (I) are important intermediates for a novel group of fungicides derived from mandelic acid amides.

摘要翻译： 本发明涉及制备式（I）的2-苯基-2-羟基-N- [2-（3-烷氧基-4-羟基苯基） - 乙基] - 乙酰胺的新方法，其中R1是烷基，R2 和R 3各自独立地为氢或烷基，R 4为任选取代的芳基或任选取代的杂芳基，该方法包括使式（II）的2-（3-烷氧基-4-羟基苯基） - 乙胺反应，其中R1R2和R3 （III）的α-羟基羧酸酯或式（III）a的二氧戊环酮，其中R 4如上所定义，R 5，R 6和R 7彼此独立地为低级烷基。 式（I）化合物是衍生自扁桃酸酰胺的新型杀真菌剂组的重要中间体。

公开(公告)号：US06864392B2

公开(公告)日：2005-03-08

申请号：US10257085

申请日：2001-04-11

申请人： Martin Zeller ,  Clemens Lamberth ,  Henry Szczepanski ,  Alain De Mesmaeker

发明人： Martin Zeller ,  Clemens Lamberth ,  Henry Szczepanski ,  Alain De Mesmaeker

IPC分类号： C07D295/22 ,  A01N41/06 ,  A01N43/10 ,  A01N43/36 ,  A01N43/40 ,  A01N43/42 ,  A01N43/60 ,  C07C303/34 ,  C07C303/38 ,  C07C307/06 ,  C07C311/06 ,  C07C313/06 ,  C07D213/30 ,  C07D213/61 ,  C07D215/14 ,  C07D241/12 ,  C07D333/16 ,  C07D333/28 ,  C07C311/03

CPC分类号： A01N41/06 ,  C07C307/06 ,  C07C311/06 ,  C07C313/06

摘要： The invention relates to novel pesticidally active α-sulfin- and α-sulfonamino acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein n is a number zero or one, R1-R7 have the meanings given in the specification. R8 is either hydrogen, (a), (b), (c), (d) or (e) wherein R11, R12, R14, R15 and R17 are each independently hydrogen or C1-C4alkyl, R13 is C4-C12alkyl; C1-C12 halogenalkyl; C3-C8 cycloalkyl; optionally substituted aryl or optionally substituted heteroaryl, R16 is optionally substituted aryl or optionally substituted heteroaryl; and Z is oxygen, sulfur —CR18R19— or —NR20—, wherein R18, R19, R20 independently of each other are hydrogen or C1-C4alkyl. The novel compounds possess plant-protecting properties and are suitable for protecting plants against infestation by phytopathogenic microorganisms

摘要翻译： 本发明涉及通式（I）的新型农药活性α-亚磺酸和α-磺氨基酰胺，其包括其旋光异构体和这些异构体的混合物，其中n为数个零或一个，R 1 -R 7具有 在规范中给出。 R8是氢，（a），（b），（c），（d）或（e）其中R11，R12，R14，R15和R17各自独立地是氢或C1-C4烷基，R13是C4-C12烷基; C1-C12卤代烷基; C3-C8环烷基; 任选取代的芳基或任选取代的杂芳基，R 16是任选取代的芳基或任选取代的杂芳基; Z为氧，硫-CR 18 R 19 - 或-NR 20 - ，其中R 18，R 19，R 20彼此独立地为氢或C 1 -C 4烷基。 新型化合物具有植物保护性质，适用于保护植物免受植物病原微生物侵扰

公开(公告)号：US07700522B2

公开(公告)日：2010-04-20

申请号：US10495256

申请日：2002-11-15

申请人： Martin Zeller ,  Clemens Lamberth

发明人： Martin Zeller ,  Clemens Lamberth

IPC分类号： A01N37/18 ,  C07C233/00

CPC分类号： A01N37/36

摘要： The invention relates to α-oxygenated or α-thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substituted aryl or optionally substituted heteroaryl; X is oxygen or sulfur; Y is oxygen or sulfur; R1, is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl or halocycloalkyl; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl- alkenyl-, alkynyl-, or cycloalkyl-groups may be optionally substituted by halogen; or optionally substituted aryl-alkyl, optionally substituted aryl-alkenyl, optionally substituted aryl-alkynyl or optionally substituted aryloxy-alkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl- alkenyl-, alkynyl-, or cycloalkyl-groups may be optionally substituted by halogen; or is optionally substituted aryl-alkyl, optionally substituted aryl-alkenyl, optionally substituted aryl-alkynyl, optionally substituted aryloxy-alkyl, optionally substituted heteroaryl-alkyl, optionally substituted heteroaryl-alkenyl or optionally substituted heteroaryl-alkynyl; R4 is alkyl, alkenyl, alkynyl, alkoxy-alkyl, alkoxy, alkenyloxy, alkenyloxy, alkylthio, alkanoyl, alkylamino, dialkylamino, alkoxycarbonyl, whereof all alkyl- alkenyl or alkynyl-groups may be optionally substituted by halogen; or is halogen, cyano, nitro, amino, formyl or carboxyl; R5 is hydrogen, alkyl, alkenyl or alkynyl; n is an integer 0, 1, 2, 3, or 4; B, represents a bridge member —CR10R11—, wherein R10 and R11 independently of each other are hydrogen or alkyl; and B2 is an alkylene bridge. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.

公开(公告)号：US07166746B2

公开(公告)日：2007-01-23

申请号：US10522077

申请日：2003-07-23

申请人： Clemens Lamberth ,  Martin Zeller ,  Tibor Goegh

发明人： Clemens Lamberth ,  Martin Zeller ,  Tibor Goegh

IPC分类号： C07C233/58 ,  A01N37/18

CPC分类号： C07C235/36 ,  C07C215/64 ,  C07C215/74 ,  C07C217/74 ,  C07C217/80 ,  C07C235/38 ,  C07C2601/14 ,  C07F7/1804

摘要： The invention relates to N-bisaryl- and N-aryl-cycloalkylidenyl-a-hydroxy- and a-alkoxy acetic acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, C1–C12alkyl; C2–C12alkenyl; C2–C12alkynyl; C1–C12haloalkyl; R2 is hydrogen; optionally substituted alkyl; or optionally substituted alkynyl; R3 is optionally substituted aryl or optionally substituted heteroaryl; A is an optionally substituted saturated or unsaturated C3–C8-cycloalkylidene, optionally substituted phenylidene or optionally substituted saturated or unsaturated heterocyclylidene bridge, R4 and R5 are each independently hydrogen or an organic radical, and R6 is hydrogen; tri-C1–C4alkyl-silyl; di-C1–C4alkyl-phenylsilyl; C1–C4alkyl-diphenylsilyl; triphenylsilyl; optionally substituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl. The compounds possess plant-protecting properties and are suitable for protecting plants against infestation by phytopathogenic microorganism, especially fungi.

摘要翻译： 本发明涉及通式（I）的N-双芳基 - 和N-芳基 - 环丙烯基-α-羟基 - 和α-烷氧基乙酰胺，其包括其旋光异构体和这些异构体的混合物，其中R 1 氢，C 1 -C 12烷基; C 2 -C 12链烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基; R 2是氢; 任选取代的烷基; 或任选取代的炔基; R 3是任选取代的芳基或任选取代的杂芳基; A是任选取代的饱和或不饱和C 3 -C 8 - 亚烷基，任选取代的亚苯基或任选取代的饱和或不饱和杂环亚烷基桥，R 4 >和R 5各自独立地为氢或有机基团，并且R 6为氢; 三-C 1 -C 4烷基 - 甲硅烷基; 二-C 1 -C 4烷基 - 苯基甲硅烷基; C 1 -C 4烷基 - 二苯基甲硅烷基; 三苯基甲硅烷基; 任选取代的烷基; 任选取代的烯基或任选取代的炔基。 该化合物具有植物保护性质，适用于保护植物免受植物病原微生物特别是真菌感染。

公开(公告)号：US20050020450A1

公开(公告)日：2005-01-27

申请号：US10495094

申请日：2002-11-15

申请人： Martin Zeller ,  Clemens Lamberth ,  Miroslav Kriz

发明人： Martin Zeller ,  Clemens Lamberth ,  Miroslav Kriz

IPC分类号： C07D237/08 ,  A01N20060101 ,  A01N37/18 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N41/10 ,  A01N41/12 ,  A01N43/00 ,  C07C20060101 ,  C07C231/02 ,  C07C235/34 ,  C07C237/20 ,  C07C317/22 ,  C07C323/22 ,  C07C323/58 ,  C07C323/63 ,  C07C327/44 ,  C07D213/24 ,  C07D213/60 ,  C07D215/06 ,  C07D215/08 ,  C07D237/10 ,  C07D239/26 ,  C07D239/28 ,  C07D241/12 ,  C07D241/14 ,  C07D261/08 ,  C07D261/10 ,  C07D277/20 ,  C07D277/22 ,  C07D277/32 ,  C07D307/38 ,  C07D307/56 ,  C07D307/78 ,  C07D317/50 ,  C07D317/62 ,  C07D319/18 ,  C07D333/06 ,  C07D333/26

CPC分类号： C07C235/34 ,  A01N37/18 ,  A01N37/36 ,  A01N37/38 ,  A01N37/42 ,  A01N43/10 ,  C07C235/78 ,  C07C323/60

摘要： The invention relates to α-oxygenated or α-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substituted aryl or optionally substituted heteroaryl; X is oxygen or sulfur; Y is oxygen or sulfur; R1 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, haloalkenyl, haloalkynyl or halocycloalkyl; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl- alkenyl-, alkynyl-, or cycloalkyl-groups me be optionally substituted by halogen; or optionally substituted arylalkyl, optionally substituted-aryl-alkenyl, optionally substituted aryl-alkynyl or optionally substituted aryloxy-alkyl; R3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, alkoxy-alkyl, alkoxy-alkenyl, alkoxy-alkynyl, whereof all alkyl- alkenyl-, alkynyl-, or cycloalkyl-groups me be optionally substituted by halogen; or is optionally substituted aryl-alkyl, optionally substituted aryl-alkenyl, optionally substituted aryl-alkynyl, optionally substituted aryloxy-alkyl, optionally substituted heteroaryl-alkyl, optionally substituted heteroaryl-alkenyl or optionally substituted heteroaryl-alkynyl; R4 is alkyl, alkenyl, alkynyl, alkoxy-alkyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkanoyl, alkylamino, dialkylamino, alkoxycarbonyl, whereof all alkyl- alkenyl or alkynyl-groups me be optionally substituted by halogen; or is halogen, cyano, nitro, amino, formyl or carboxyl; R5 is hydrogen, alkyl, alkenyl or alkynyl; n is an integer 0, 1, 2, 3, or 4; B1 represents a bridge member —(CR10R11)q— or —(CHR10R11)r—Z—(CR12R13)8, wherein q is an integer 2, 3 or 4; r is an integer 0, 1; 2, 3; s is an integer 1, 2 or 3, provided that (r+s) is either 1, 2 or 3; Z is —O—, —S—, —SO— —SO2—, NR6—, —CO—, —OOC—, —COO, —NR6—CO—or —CO—NR6—; R6 is hydrogen or alkyl; R10, R11, R12 and R13 independently of each other are hydrogen or alkyl; and B2 is an alkylene bridge. These compounds possess useful plant protecting properties and may advantageously be employed in agricultural practice for controlling or preventing the infestation of plants by phytopathogenic microorganisms, especially fungi.