公开(公告)号：US09499841B2

公开(公告)日：2016-11-22

申请号：US14750084

申请日：2015-06-25

Applicant: DSM IP ASSETS B.V.

Inventor： Paul Klaassen ,  Bianca Elisabeth Maria Gielesen ,  Gijsberdina Pieternella Van Suylekom ,  Wilbert Herman Marie Heijne

IPC: C07K14/395 ,  C12P7/10 ,  C12N1/36 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/12 ,  C12N9/16 ,  C12N9/24 ,  C12N9/26 ,  C12N9/42 ,  C12N9/38 ,  C12N9/50 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12P5/02 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P13/00 ,  C12P13/08 ,  C12P13/12 ,  C12P13/20 ,  C12P13/22 ,  C12P17/10 ,  C12P35/00

CPC classification number: C12P7/10 ,  C07K14/395 ,  C12N1/36 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/10 ,  C12N9/1205 ,  C12N9/16 ,  C12N9/2405 ,  C12N9/2411 ,  C12N9/2437 ,  C12N9/2468 ,  C12N9/248 ,  C12N9/50 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12P5/026 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P13/005 ,  C12P13/08 ,  C12P13/12 ,  C12P13/20 ,  C12P13/227 ,  C12P17/10 ,  C12P35/00 ,  C12Y101/01 ,  C12Y207/01016 ,  C12Y501/03004 ,  C12Y503/01004 ,  Y02E50/16 ,  Y02E50/17 ,  Y02E50/343

Abstract: The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.

公开(公告)号：US10100320B2

公开(公告)日：2018-10-16

申请号：US15612728

申请日：2017-06-02

Applicant: DSM IP ASSETS B.V.

Inventor： Paul Klaassen ,  Gijsberdina Pieternella Van Suylekom ,  Rene Marcel De Jong

IPC: C12N15/81 ,  C12N9/92 ,  C12P7/10 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P5/02 ,  C12P7/06 ,  C12P35/00

Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.

公开(公告)号：US10260075B2

公开(公告)日：2019-04-16

申请号：US15407341

申请日：2017-01-17

Applicant: DSM IP ASSETS B.V.

Inventor： Paul Klaassen ,  Gijsberdina Pieternella Van Suylekom ,  Bianca Elisabeth Maria Gielesen ,  Nicolette Jasmijn Broers ,  Beate Wiedemann ,  Wilhelmus Theodorus Antonius Maria De Laat

IPC: C12P7/10 ,  C12P7/46

Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia, and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.

公开(公告)号：US11649471B2

公开(公告)日：2023-05-16

申请号：US17199823

申请日：2021-03-12

Applicant: DSM IP ASSETS B.V.

Inventor： Paul Klaassen ,  Gijsberdina Pieternella Van Suylekom ,  Bianca Elisabeth Maria Gielesen ,  Nicolette Jasmijn Broers ,  Beate Wiedemann ,  Wilhelmus Theodorus Antonius Maria De Laat

IPC: C12P7/10 ,  C12P7/46 ,  C12N9/02 ,  C12N9/10 ,  C12N9/20 ,  C12N9/24 ,  C12N9/26 ,  C12N9/42 ,  C12N9/50 ,  C12N9/88

CPC classification number: C12P7/10 ,  C12P7/46 ,  Y02E50/10 ,  Y02E50/30

Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps:



a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia: and
b) recovery of the fermentation product,

wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.

公开(公告)号：US10982235B2

公开(公告)日：2021-04-20

申请号：US16283208

申请日：2019-02-22

Applicant: DSM IP ASSETS B.V.

Inventor： Paul Klaassen ,  Gijsberdina Pieternella Van Suylekom ,  Bianca Elisabeth Maria Gielesen ,  Nicolette Jasmijn Broers ,  Beate Wiedemann ,  Wilhelmus Theodorus Antonius Maria De Laat

IPC: C12P7/10 ,  C12P7/46 ,  C12N9/02 ,  C12N9/10 ,  C12N9/20 ,  C12N9/24 ,  C12N9/26 ,  C12N9/42 ,  C12N9/50 ,  C12N9/88 ,  C12P5/02 ,  C12P7/04 ,  C12P7/16

Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia: and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.

公开(公告)号：US20170268012A1

公开(公告)日：2017-09-21

申请号：US15612728

申请日：2017-06-02

Applicant: DSM IP ASSETS B.V.

Inventor： Paul KLAASSEN ,  Gijsberdina Pieternella Van Suylekom ,  Rene Marcel De Jong

IPC: C12N15/81 ,  C12P5/02 ,  C12P7/10 ,  C12P7/56 ,  C12P7/54 ,  C12P7/48 ,  C12P7/46 ,  C12P7/42 ,  C12P35/00 ,  C12P7/20 ,  C12P7/18 ,  C12P7/16 ,  C12P7/06 ,  C12P7/40 ,  C12N9/92

CPC classification number: C12N15/81 ,  C12N9/92 ,  C12N15/815 ,  C12P5/026 ,  C12P7/06 ,  C12P7/10 ,  C12P7/16 ,  C12P7/18 ,  C12P7/20 ,  C12P7/40 ,  C12P7/42 ,  C12P7/46 ,  C12P7/48 ,  C12P7/54 ,  C12P7/56 ,  C12P35/00 ,  C12Y503/01005 ,  Y02E50/16 ,  Y02E50/17

Abstract: The invention relates to a cell which comprises a nucleotide sequence encoding a xylose isomerase, wherein the amino acid sequence of the xylose isomerase has at least 75% sequence identity to the amino acid sequence set out in SEQ ID NO: 2 and wherein the nucleotide sequence is heterologous to the host. A cell of the invention may be used in a process for producing a fermentation product, such as ethanol. Such a process may comprise fermenting a medium containing a source of xylose with a cell of the invention such that the cell ferments xylose to the fermentation product.