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公开(公告)号：US11104923B2
公开(公告)日：2021-08-31
申请号：US16273273
申请日：2019-02-12
Applicant: DSM IP Assets B.V.
Inventor： James Casey Lippmeier , Joseph W. Pfeifer, III , Jon Milton Hansen , Kirk E. Apt , William Robert Barclay , Paul Warren Behrens , David Christian Martin
Abstract: The present invention provides biological oils and methods and uses thereof. The biological oils are preferably produced by heterotrophic fermentation of one or more microorganisms using cellulose-containing feedstock as a main source of carbon. The present invention also provides methods of producing lipid-based biofuels and food, nutritional, and pharmaceutical products using the biological oils.
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公开(公告)号：US10925850B2
公开(公告)日：2021-02-23
申请号：US15947208
申请日：2018-04-06
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC: A61K31/202 , C12P7/64 , A23K20/158 , A23L33/12 , A23L33/00 , A23L2/52 , A61K8/36 , A61Q19/00 , A23K50/80
Abstract: The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
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3.发明申请公开(公告)号：US20170191023A1
公开(公告)日：2017-07-06
申请号：US15400224
申请日：2017-01-06
Applicant: DSM IP ASSETS B.V.
Inventor： James Casey LIPPMEIER , Kirk E. Apt
CPC classification number: C12N1/10 , A23K50/00 , A23K50/80 , A23L2/52 , A23L33/10 , A23V2002/00 , C12N1/22 , C12N15/52 , C12N15/79 , C12P7/649 , Y02E50/13
Abstract: The present invention is directed to recombinant thraustochytrids that grow on xylose and cell cultures comprising the recombinant thraustochytrids as well as methods of producing cell cultures, biomasses, microbial oils, compositions, and biofuels using the recombinant thraustochytrids.
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公开(公告)号：US09668499B2
公开(公告)日：2017-06-06
申请号：US14709927
申请日：2015-05-12
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC: A23D9/00 , C11B1/00 , C12P7/64 , A61K31/202 , A23K1/16 , A61K8/36 , A61K31/201 , A61Q19/00 , A23L2/52 , A23C9/152 , A23D9/007 , C11B1/10 , C11B3/04 , C12R1/89 , C12R1/90 , A61K35/68 , A23K10/12 , A23K20/158 , A23K50/00 , A23K50/40 , A23K50/80 , A23L33/00 , A23L33/115
CPC classification number: A23K20/158 , A23C9/1528 , A23D9/00 , A23D9/007 , A23K10/12 , A23K50/00 , A23K50/40 , A23K50/80 , A23L2/52 , A23L33/115 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K31/201 , A61K31/202 , A61K35/68 , A61K2800/10 , A61Q19/00 , C11B1/10 , C11B3/04 , C12P7/6427 , C12P7/6472 , C12R1/89 , C12R1/90
Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
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5.发明授权Polyunsaturated fatty acid synthase nucleic acid molecules and polypeptides, compositions, and methods of making and uses thereof 有权多不饱和脂肪酸合成酶核酸分子及其多肽，组合物及其制备方法和用途公开(公告)号：US09540666B2
公开(公告)日：2017-01-10
申请号：US14566458
申请日：2014-12-10
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , Leslie Richter , David Simpson , Ross Zirkle
CPC classification number: C12N15/52 , A61K38/00 , C12N9/0006 , C12N9/001 , C12N9/1029 , C12N9/88 , C12N15/8247 , C12P7/6427 , C12P7/6472 , C12Y101/01 , C12Y103/01 , C12Y203/01039 , C12Y203/01041 , C12Y402/01 , C12Y402/01059 , Y02P20/52
Abstract: The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
Abstract translation: 本发明涉及涉及PUFA生产的分离的核酸分子和多烯突变多不饱和脂肪酸（PUFA）合成酶，包括富含二十二碳六烯酸（DHA），二十碳五烯酸（EPA）或其组合的PUFA。 本发明涉及包含核酸分子，核酸分子编码的多肽，包含核酸分子或多肽的组合物及其制备和用途的载体和宿主细胞。
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Patent Agency Ranking
公开(公告)号：US10798952B2
公开(公告)日：2020-10-13
申请号：US15435335
申请日：2017-02-17
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC: A23D9/00 , C11B1/00 , C12P7/64 , A61K31/202 , A23K20/158 , A61K8/36 , A61K31/201 , A61Q19/00 , A23L2/52 , A23C9/152 , A23D9/007 , C11B1/10 , C11B3/04 , C12R1/89 , C12R1/90 , A23L33/00 , A23L33/115 , A61K35/68 , A23K10/12 , A23K50/00 , A23K50/40 , A23K50/80
Abstract: The present invention is directed to isolated microorganisms as well as strains and mutants thereof, biomasses, microbial oils, compositions, and cultures; methods of producing the microbial oils, biomasses, and mutants; and methods of using the isolated microorganisms, biomasses, and microbial oils.
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公开(公告)号：US10757959B2
公开(公告)日：2020-09-01
申请号：US16132992
申请日：2018-09-17
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC: A61K31/232 , A23K20/158 , A61K31/20 , C12P7/64 , C12R1/89 , A23L33/115 , A23L33/135 , A23K50/80 , A23D9/00 , A23K50/00 , A23L33/12 , A61K8/99 , A61K31/202 , A61K36/02 , A61Q19/00 , A61K35/00
Abstract: The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
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公开(公告)号：US20190000114A1
公开(公告)日：2019-01-03
申请号：US16132992
申请日：2018-09-17
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC: A23K20/158 , C12R1/89 , A23K50/00 , C12P7/64 , A61Q19/00 , A23K50/80 , A23L33/12 , A61K36/02 , A61K31/202 , A61K31/20 , A61K8/99 , A23D9/00 , A23L33/135 , A23L33/115 , A61K35/00
Abstract: The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
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公开(公告)号：US09611488B2
公开(公告)日：2017-04-04
申请号：US14698498
申请日：2015-04-28
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , Paul Warren Behrens , Jon Milton Hansen , Joseph W. Pfeifer, III , Tracey Lynn Stahl , Ross Zirkle
IPC: A23D9/00 , C12P7/64 , A61K31/202
CPC classification number: A61K31/202 , A23K20/158 , A23K50/80 , A23L2/52 , A23L33/12 , A23L33/40 , A23V2002/00 , A61K8/361 , A61K2800/10 , A61Q19/00 , C12P7/6427 , A61K2300/00
Abstract: The invention is directed to microbial oils containing omega-3 polyunsaturated fatty acids comprising docosahexaenoic acid, eicosapentaenoic acid, and optionally docosapentaenoic acid and dosage forms containing such oils.
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10.发明授权Polypeptide for improving protein production in microorganisms of the phylum Labyrinthulomycota 有权用于改善门静脉微生物中蛋白质产生的多肽Labyrinthulomycota公开(公告)号：US09518102B2
公开(公告)日：2016-12-13
申请号：US14548054
申请日：2014-11-19
Applicant: DSM IP Assets B.V.
Inventor： Kirk E. Apt , James Casey Lippmeier , David Simpson , Jun Wang , James P. Wynn , Ross Zirkle
CPC classification number: C12P21/00 , C07K14/37 , C07K14/705 , C12N9/2431 , C12N15/79 , C12N15/80 , C12P21/005 , C12R1/90 , C12Y302/01026
Abstract: The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.
Abstract translation: 本发明涉及神经胶霉病菌门的重组细胞和微生物及其在异源蛋白质生产中的用途。 用于有效生产和任选地从重组宿主细胞和微生物分泌多肽的新型启动子，终止子和信号序列也包括在本发明中。
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